Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 51
- −4 vs. Q3 2022
- Shares held
- 42.7M
- −2.05M (−4.6%) vs. Q3 2022
- Total value
- $19.2M
- −$4.32M (−18.4%) vs. Q3 2022
- New holders
- 9
- 12 more added
- Sold out
- 13
- 11 more reduced
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 5,347,689 | $2.41M | 0.27% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 4,611,302 | $2.07M | 0.19% | +900,524+24.3% | Added |
| Suvretta Capital Management, LLC | 4,059,894 | $1.83M | 0.08% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 3,413,906 | $1.54M | 0.04% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 3,410,106 | $1.53M | 0.01% | 00.0% | Unchanged |
| Millennium Management LLC | 3,131,479 | $1.41M | 0.00% | +2,316,807+284.4% | Added |
| Sio Capital Management, LLC | 3,004,959 | $1.35M | 0.72% | −1,663,577−35.6% | Reduced |
| Vanguard Group Inc | 1,997,597 | $898.7K | 0.00% | +110,201+5.8% | Added |
| OrbiMed Advisors LLC | 1,797,221 | $808.6K | 0.02% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,691,151 | $761.0K | 0.50% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $674.9K | 0.00% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 1,391,381 | $625.0K | 0.00% | +922,823+196.9% | Added |
| Pura Vida Investments, LLC | 1,048,697 | $471.8K | 0.08% | +1,048,697 | New |
| Samsara BioCapital, LLC | 883,720 | $397.6K | 0.09% | 00.0% | Unchanged |
| Ghost Tree Capital, LLC | 800,000 | $360.0K | 0.15% | −200,000−20.0% | Reduced |
| BlackRock Inc. | 645,954 | $290.6K | 0.00% | −386,711−37.4% | Reduced |
| Geode Capital Management, LLC | 600,455 | $270.0K | 0.00% | +206,435+52.4% | Added |
| Sphera Funds Management Ltd. | 440,837 | $198.3K | 0.06% | +440,837 | New |
| Two Sigma Investments, LP | 393,638 | $177.1K | 0.00% | +290,049+280.0% | Added |
| Assenagon Asset Management S.A. | 318,451 | $143.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 272,800 | $122.7K | 0.00% | −137,100−33.4% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $111.0K | 0.04% | 00.0% | Unchanged |
| Abingworth LLP | 240,500 | $108.2K | 0.04% | 00.0% | Unchanged |
| State Street Corp | 214,989 | $96.7K | 0.00% | +56,000+35.2% | Added |
| Renaissance Technologies LLC | 151,100 | $68.0K | 0.00% | −98,700−39.5% | Reduced |
| Bridgeway Capital Management, LLC | 150,000 | $67.5K | 0.00% | +150,000 | New |
| Fan Yu | 112,044 | $50.4K | 0.68% | 00.0% | Unchanged |
| Franklin Street Advisors Inc | 105,800 | $48.0K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 105,262 | $47.0K | 0.00% | +105,262 | New |
| Northern Trust Corp | 86,425 | $38.9K | 0.00% | +17,216+24.9% | Added |
| Morgan Stanley | 80,461 | $36.2K | 0.00% | −87,797−52.2% | Reduced |
| Blair William & Co | 76,594 | $34.5K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $34.4K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 50,943 | $22.9K | 0.00% | +50,943 | New |
| HRT Financial LP | 49,978 | $22.0K | 0.00% | +49,978 | New |
| Franklin Resources Inc | 31,364 | $14.1K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 23,233 | $10.5K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 17,844 | $8.00K | 0.00% | −9,042−33.6% | Reduced |
| Prudential Financial Inc | 17,200 | $7.74K | 0.00% | +17,200 | New |
| Bank of America Corp | 15,770 | $7.08K | 0.00% | +4,094+35.1% | Added |
| Citadel Advisors LLC | 15,472 | $6.96K | 0.00% | −45,303−74.5% | Reduced |
| Ergoteles LLC | 14,722 | $6.62K | 0.00% | +14,722 | New |
| Two Sigma Securities, LLC | 11,272 | $5.07K | 0.00% | −19,771−63.7% | Reduced |
| Group One Trading, L.P. | 3,182 | $1.43K | 0.00% | +82+2.6% | Added |
| BNP Paribas Arbitrage, SA | 2,968 | $1.33K | 0.00% | +1,393+88.4% | Added |
| Wells Fargo & Company | 2,543 | $1.15K | 0.00% | +13+0.5% | Added |
| Barclays PLC | 99 | $45 | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 8 | $4 | 0.00% | +8 | New |
| Simplex Trading, LLC | 56 | $0 | 0.00% | −13,065−99.6% | Reduced |
| JPMorgan Chase & Co | 1,068 | $0 | 0.00% | −2,578−70.7% | Reduced |
| IFP Advisors, Inc | 2,860 | – | – | 00.0% | Unchanged |
| Pictet Asset Management SA | 0 | $0 | 0.00% | −2,542,925−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −2,500,000−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −915,695−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −36,475−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −34,478−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −19,220−100.0% | Sold out |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −10,439−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −1,401−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −1,930−100.0% | Sold out |
| Citigroup Inc | 0 | $0 | 0.00% | −633−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −98−100.0% | Sold out |
| China Universal Asset Management Co., Ltd. | 0 | $0 | 0.00% | −573−100.0% | Sold out |