Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 265
- +69 vs. Q1 2026
- Shares held
- 95.8M
- +14.8M (+18.3%) vs. Q1 2026
- Total value
- $8.52B
- +$4.44B (+108.8%) vs. Q1 2026
- New holders
- 91
- 105 more added
- Sold out
- 22
- 55 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 13,026,187 | $1.16B | 0.05% | +1,245,163+10.6% | Added |
| BlackRock, Inc. | 6,506,605 | $577.7M | 0.01% | +985,384+17.8% | Added |
| Perceptive Advisors LLC | 4,319,496 | $383.5M | 5.95% | +536,271+14.2% | Added |
| RTW Investments, LP | 4,251,996 | $377.5M | 3.22% | +80,000+1.9% | Added |
| Paradigm Biocapital Advisors LP | 3,840,778 | $341.0M | 6.38% | +1,883,512+96.2% | Added |
| Vanguard Capital Management LLC | 3,448,681 | $306.2M | 0.01% | +391,280+12.8% | Added |
| State Street Corp | 3,057,416 | $271.4M | 0.01% | +450,385+17.3% | Added |
| VR Adviser, LLC | 2,985,448 | $265.0M | 8.04% | −700,000−19.0% | Reduced |
| Price T Rowe Associates Inc | 2,960,855 | $262.9M | 0.03% | +1,362,125+85.2% | Added |
| Driehaus Capital Management LLC | 2,799,166 | $248.5M | 1.44% | +8,381+0.3% | Added |
| Geode Capital Management, LLC | 2,562,265 | $239.3M | 0.01% | +841,353+48.9% | Added |
| Vanguard Portfolio Management LLC | 2,330,098 | $206.9M | 0.01% | +1,744,968+298.2% | Added |
| Capital World Investors | 2,315,553 | $205.6M | 0.02% | +1,648,989+247.4% | Added |
| Jupiter Topco LLC | 2,206,936 | $195.9M | 0.08% | +2,206,936 | New |
| TCG Crossover Management, LLC | 1,900,582 | $168.7M | 4.06% | 00.0% | Unchanged |
| Tang Capital Management LLC | 1,892,200 | $168.0M | 7.63% | 00.0% | Unchanged |
| Bank of America Corp | 1,777,854 | $157.8M | 0.01% | +549,761+44.8% | Added |
| Adage Capital Partners GP, L.L.C. | 1,722,300 | $152.9M | 0.21% | +1,722,300 | New |
| Wellington Management Group LLP | 1,581,505 | $140.4M | 0.02% | −243,306−13.3% | Reduced |
| Goldman Sachs Group Inc | 1,478,059 | $131.2M | 0.01% | +1,208,121+447.6% | Added |
| Franklin Resources Inc | 1,472,943 | $130.8M | 0.03% | +590,110+66.8% | Added |
| Remedium Capital Partners, LLC | 1,464,169 | $130.0M | 28.78% | +7,938+0.5% | Added |
| Affinity Asset Advisors, LLC | 1,279,134 | $113.6M | 5.55% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,093,026 | $98.9M | 0.01% | +113,727+11.6% | Added |
| Holocene Advisors, LP | 1,015,170 | $90.1M | 0.21% | +1,015,170 | New |
| Marshall Wace, LLP | 991,693 | $88.0M | 0.07% | +852,434+612.1% | Added |
| Polar Capital Holdings Plc | 988,009 | $87.7M | 0.25% | +195,162+24.6% | Added |
| Siren, L.L.C. | 968,598 | $86.0M | 1.75% | +150,000+18.3% | Added |
| Capital International Investors | 955,196 | $84.8M | 0.02% | −790,933−45.3% | Reduced |
| Braidwell LP | 879,467 | $78.1M | 2.89% | −53,356−5.7% | Reduced |
| Commodore Capital LP | 846,786 | $75.2M | 4.48% | −1,065,594−55.7% | Reduced |
| UBS Group AG | 843,071 | $74.8M | 0.01% | +171,836+25.6% | Added |
| Northern Trust Corp | 674,529 | $59.9M | 0.01% | +95,622+16.5% | Added |
| Charles Schwab Investment Management Inc | 652,958 | $58.0M | 0.01% | +90,305+16.0% | Added |
| Pictet Asset Management Holding SA | 628,138 | $55.8M | 0.05% | +136,489+27.8% | Added |
| Emerald Advisers, LLC | 567,430 | $50.4M | 1.19% | −45,935−7.5% | Reduced |
| Victory Capital Management Inc | 553,980 | $49.2M | 0.03% | +261,854+89.6% | Added |
| Vanguard Fiduciary Trust Co | 551,389 | $49.0M | 0.01% | +86,738+18.7% | Added |
| Candriam Luxembourg S.C.A. | 546,312 | $48.5M | 0.22% | −63,970−10.5% | Reduced |
| UBS Asset Management Americas Inc | 522,071 | $46.3M | 0.01% | +314,757+151.8% | Added |
| Morgan Stanley | 499,963 | $44.4M | 0.00% | +253,244+102.6% | Added |
| Voya Investment Management LLC | 431,694 | $38.3M | 0.03% | +377,724+699.9% | Added |
| Emerald Mutual Fund Advisers Trust | 401,271 | $35.6M | 1.25% | −6,842−1.7% | Reduced |
| Samlyn Capital, LLC | 400,075 | $35.5M | 0.59% | +3,414+0.9% | Added |
| Ameriprise Financial Inc | 356,082 | $31.6M | 0.01% | +196,865+123.6% | Added |
| Integral Health Asset Management, LLC | 325,000 | $28.9M | 1.18% | +325,000 | New |
| Woodline Partners LP | 306,049 | $27.2M | 0.08% | +40,157+15.1% | Added |
| Jennison Associates LLC | 303,180 | $26.9M | 0.02% | +303,180 | New |
| ADAR1 Capital Management, LLC | 283,982 | $25.2M | 1.19% | −54,341−16.1% | Reduced |
| BNP Paribas Arbitrage, SA | 259,923 | $23.1M | 0.01% | +241,293+1,295.2% | Added |
| Bank of New York Mellon Corp | 245,193 | $21.8M | 0.00% | +53,798+28.1% | Added |
| Bellevue Group AG | 229,931 | $20.4M | 0.43% | +229,931 | New |
| Seven Grand Managers, LLC | 225,000 | $20.0M | 0.80% | +125,000+125.0% | Added |
| Cormorant Asset Management, LP | 225,000 | $20.0M | 1.02% | +225,000 | New |
| Eventide Asset Management, LLC | 201,616 | $17.9M | 0.24% | +201,616 | New |
| Millennium Management LLC | 196,712 | $17.5M | 0.01% | +50,073+34.1% | Added |
| OrbiMed Advisors LLC | 186,145 | $16.5M | 0.31% | +186,145 | New |
| Frontier Capital Management Co LLC | 182,931 | $16.2M | 0.15% | +182,931 | New |
| Nuveen, LLC | 181,105 | $16.1M | 0.00% | +27,206+17.7% | Added |
| Neuberger Berman Group LLC | 180,884 | $16.1M | 0.01% | +180,884 | New |
| Deutsche Bank AG | 174,459 | $15.5M | 0.00% | +45,217+35.0% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 172,923 | $15.4M | 0.02% | +2,542+1.5% | Added |
| Balyasny Asset Management LLC | 147,042 | $13.1M | 0.02% | +91,565+165.1% | Added |
| Soleus Capital Management, L.P. | 147,000 | $13.1M | 0.45% | +147,000 | New |
| Squarepoint Ops LLC | 139,605 | $12.4M | 0.02% | +139,605 | New |
| Armistice Capital, LLC | 137,588 | $12.2M | 0.34% | +16,657+13.8% | Added |
| Russell Investments Group, Ltd. | 134,757 | $12.0M | 0.01% | +124,826+1,256.9% | Added |
| Ensign Peak Advisors, Inc | 126,620 | $11.2M | 0.02% | −21,917−14.8% | Reduced |
| Invesco Ltd. | 120,541 | $10.7M | 0.00% | −11,849−9.0% | Reduced |
| Blackstone Group Inc. | 120,177 | $10.7M | 0.03% | −172,670−59.0% | Reduced |
| Rhenman & Partners Asset Management AB | 119,300 | $10.6M | 1.00% | +119,300 | New |
| TD Asset Management Inc | 115,990 | $10.3M | 0.01% | −21,400−15.6% | Reduced |
| Swiss National Bank | 112,500 | $9.99M | 0.01% | +16,000+16.6% | Added |
| StemPoint Capital LP | 106,926 | $9.49M | 1.64% | −60,680−36.2% | Reduced |
| Manufacturers Life Insurance Company, The | 104,516 | $9.28M | 0.01% | −8,325−7.4% | Reduced |
| Citadel Advisors LLC | 103,100 | $9.15M | 0.01% | −5,035−4.7% | Reduced |
| Boxer Capital Management, LLC | 100,000 | $8.88M | 0.67% | +100,000 | New |
| Rhumbline Advisers | 94,763 | $8.41M | 0.01% | +9,642+11.3% | Added |
| Barclays PLC | 94,069 | $8.35M | 0.00% | +48,283+105.5% | Added |
| F/M Investments LLC | 92,618 | $8.22M | 0.42% | −6,842−6.9% | Reduced |
| Prudential Financial Inc | 87,370 | $7.76M | 0.01% | +27,815+46.7% | Added |
| Federated Hermes, Inc. | 85,950 | $7.63M | 0.01% | +85,950 | New |
| Granahan Investment Management Inc | 82,991 | $7.37M | 0.26% | +82,991 | New |
| Citigroup Inc | 82,593 | $7.33M | 0.00% | +70,587+587.9% | Added |
| Wells Fargo & Company | 82,506 | $7.32M | 0.00% | +49,298+148.5% | Added |
| HighVista Strategies LLC | 77,807 | $6.91M | 1.57% | −68,457−46.8% | Reduced |
| Mercer Global Advisors Inc | 71,145 | $6.32M | 0.01% | +54+0.1% | Added |
| B Group, Inc. | 70,000 | $6.21M | 3.53% | −30,000−30.0% | Reduced |
| Trexquant Investment LP | 67,007 | $5.95M | 0.04% | +67,007 | New |
| California State Teachers Retirement System | 64,687 | $5.74M | 0.01% | +5,445+9.2% | Added |
| EAM Investors, LLC | 60,393 | $5.36M | 0.48% | +60,393 | New |
| Silverarc Capital Management, LLC | 59,959 | $5.32M | 0.59% | −126,659−67.9% | Reduced |
| Principal Financial Group Inc | 59,747 | $5.30M | 0.00% | +55,448+1,289.8% | Added |
| Hudson Bay Capital Management LP | 58,387 | $5.18M | 0.02% | +58,387 | New |
| HealthInvest Partners AB | 57,030 | $5.06M | 1.36% | −5,705−9.1% | Reduced |
| Raymond James Financial Inc | 53,627 | $4.76M | 0.00% | +33,872+171.5% | Added |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $4.71M | 0.08% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 92,540 | $4.67M | 0.00% | +21,640+30.5% | Added |
| Royce & Associates LP | 51,789 | $4.60M | 0.04% | +51,789 | New |
| XTX Topco Ltd | 50,483 | $4.48M | 0.06% | +26,048+106.6% | Added |