Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 265
- +69 vs. Q1 2026
- Shares held
- 95.8M
- +14.8M (+18.3%) vs. Q1 2026
- Total value
- $8.52B
- +$4.44B (+108.8%) vs. Q1 2026
- New holders
- 91
- 105 more added
- Sold out
- 22
- 55 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Monashee Investment Management LLC | 50,000 | $4.44M | 7.45% | +50,000 | New |
| Legal & General Group Plc | 49,141 | $4.36M | 0.00% | +4,349+9.7% | Added |
| Cinctive Capital Management LP | 48,978 | $4.35M | 0.17% | +21,548+78.6% | Added |
| Dimensional Fund Advisors LP | 47,698 | $4.23M | 0.00% | +10.0% | Added |
| Rockefeller Capital Management L.P. | 47,466 | $4.21M | 0.01% | −16,536−25.8% | Reduced |
| PFM Health Sciences, LP | 46,217 | $4.10M | 0.36% | +46,217 | New |
| Schroder Investment Management Group | 44,586 | $4.02M | 0.00% | −19,098−30.0% | Reduced |
| State of Wisconsin Investment Board | 45,030 | $4.00M | 0.01% | +18,507+69.8% | Added |
| MetLife Investment Management | 43,316 | $3.85M | 0.02% | +4,909+12.8% | Added |
| Nomura Asset Management International Inc. | 43,071 | $3.82M | 0.01% | +43,071 | New |
| Moody Aldrich Partners LLC | 42,458 | $3.77M | 0.68% | +42,458 | New |
| Rock Springs Capital Management LP | 42,254 | $3.75M | 0.18% | +42,254 | New |
| Maven Securities LTD | 40,000 | $3.55M | 0.24% | +40,000 | New |
| Susquehanna International Group, LLP | 39,311 | $3.49M | 0.00% | +10,349+35.7% | Added |
| Vanguard Asset Management, Ltd | 39,220 | $3.48M | 0.00% | +5,988+18.0% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 38,439 | $3.42M | 0.00% | +2,116+5.8% | Added |
| Engineers Gate Manager LP | 38,474 | $3.42M | 0.04% | +38,474 | New |
| Rafferty Asset Management, LLC | 36,767 | $3.26M | 0.01% | −20,153−35.4% | Reduced |
| Caption Management, LLC | 36,000 | $3.20M | 0.11% | +36,000 | New |
| Vanguard Global Advisers, LLC | 34,500 | $3.06M | 0.00% | +3,359+10.8% | Added |
| Ghisallo Capital Management LLC | 30,000 | $2.66M | 0.05% | +30,000 | New |
| Fred Alger Management, LLC | 28,834 | $2.56M | 0.01% | −30,619−51.5% | Reduced |
| D. E. Shaw & Co., Inc. | 26,452 | $2.35M | 0.00% | +26,452 | New |
| Castleark Management LLC | 26,420 | $2.35M | 0.06% | +26,420 | New |
| New York State Common Retirement Fund | 26,165 | $2.32M | 0.00% | +3,900+17.5% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 26,143 | $2.32M | 0.00% | +12,188+87.3% | Added |
| Handelsbanken Fonder AB | 26,000 | $2.31M | 0.01% | +26,000 | New |
| Teachers Retirement System of the State of Kentucky | 25,799 | $2.29M | 0.02% | 00.0% | Unchanged |
| Creative Planning | 25,713 | $2.28M | 0.00% | +10,227+66.0% | Added |
| Warren Averett Asset Management, LLC | 25,512 | $2.26M | 0.01% | −454−1.7% | Reduced |
| Aquatic Capital Management LLC | 25,222 | $2.24M | 0.08% | +25,222 | New |
| AQR Capital Management LLC | 22,937 | $2.04M | 0.00% | +2,063+9.9% | Added |
| Freestone Grove Partners LP | 22,777 | $2.02M | 0.01% | +22,777 | New |
| Police & Firemen's Retirement System of New Jersey | 21,968 | $1.95M | 0.01% | +3,608+19.7% | Added |
| Profund Advisors LLC | 19,419 | $1.72M | 0.05% | −6,624−25.4% | Reduced |
| Schonfeld Strategic Advisors LLC | 19,089 | $1.69M | 0.01% | +19,089 | New |
| Ellsworth Advisors, LLC | 16,553 | $1.69M | 0.28% | −5,410−24.6% | Reduced |
| Advisor Group Holdings, Inc. | 18,146 | $1.61M | 0.00% | +17,648+3,543.8% | Added |
| State of New Jersey Common Pension Fund D | 18,129 | $1.61M | 0.01% | +1,409+8.4% | Added |
| State Board of Administration of Florida Retirement System | 18,076 | $1.60M | 0.00% | +4,171+30.0% | Added |
| Intech Investment Management LLC | 17,628 | $1.57M | 0.01% | +1,185+7.2% | Added |
| Kennedy Capital Management, Inc. | 17,310 | $1.54M | 0.03% | +437+2.6% | Added |
| Algert Global LLC | 16,460 | $1.46M | 0.02% | +16,460 | New |
| Fifth Third Bancorp | 15,638 | $1.39M | 0.00% | +15,633+312,660.0% | Added |
| Arizona State Retirement System | 15,471 | $1.37M | 0.01% | +2,033+15.1% | Added |
| Diadema Partners LP | 15,000 | $1.33M | 0.47% | +15,000 | New |
| Vanguard Investments Australia, Ltd. | 14,752 | $1.31M | 0.00% | +1,939+15.1% | Added |
| Neo Ivy Capital Management | 14,551 | $1.29M | 0.30% | +13,953+2,333.3% | Added |
| Allianz Asset Management GmbH | 14,100 | $1.25M | 0.00% | +14,100 | New |
| SEI Investments Co | 13,941 | $1.24M | 0.00% | +4,966+55.3% | Added |
| China Universal Asset Management Co., Ltd. | 13,821 | $1.23M | 0.07% | −117−0.8% | Reduced |
| Brown Advisory Inc | 13,550 | $1.20M | 0.00% | +1,150+9.3% | Added |
| Seven Fleet Capital Management LP | 13,300 | $1.18M | 0.19% | −6,390−32.5% | Reduced |
| KLP Kapitalforvaltning AS | 12,800 | $1.14M | 0.00% | +1,900+17.4% | Added |
| Two Sigma Investments, LP | 12,771 | $1.13M | 0.00% | +12,771 | New |
| SG Americas Securities, LLC | 12,727 | $1.13M | 0.00% | −669−5.0% | Reduced |
| ProShare Advisors LLC | 12,599 | $1.12M | 0.00% | −899−6.7% | Reduced |
| Atom Investors LP | 12,457 | $1.11M | 0.10% | +12,457 | New |
| Global Endowment Management, LP | 12,123 | $1.08M | 0.11% | −6,061−33.3% | Reduced |
| STRS Ohio | 11,500 | $1.02M | 0.00% | +7,000+155.6% | Added |
| Calamos Advisors LLC | 11,323 | $1.01M | 0.00% | +11,323 | New |
| Virginia Retirement Systems Et Al | 11,250 | $998.8K | 0.01% | −16,300−59.2% | Reduced |
| Diametric Capital, LP | 10,000 | $887.8K | 0.09% | +10,000 | New |
| Glenmede Trust Co NA | 9,966 | $884.8K | 0.00% | +9,966 | New |
| First Trust Advisors LP | 9,779 | $868.2K | 0.00% | −168,610−94.5% | Reduced |
| Quantbot Technologies LP | 8,884 | $788.7K | 0.03% | +8,796+9,995.5% | Added |
| Persistent Asset Partners Ltd | 8,760 | $777.7K | 0.25% | +3,957+82.4% | Added |
| Brevan Howard Capital Management LP | 8,288 | $735.8K | 0.01% | +8,288 | New |
| Man Group plc | 7,714 | $684.8K | 0.00% | −1,832−19.2% | Reduced |
| Envestnet Asset Management Inc | 7,666 | $680.6K | 0.00% | +7,666 | New |
| Xponance, Inc. | 7,291 | $647.3K | 0.00% | +846+13.1% | Added |
| Ameritas Investment Partners, Inc. | 6,760 | $600.2K | 0.02% | +1,167+20.9% | Added |
| State of Wyoming | 6,690 | $593.9K | 0.06% | +6,690 | New |
| AlphaCentric Advisors LLC | 6,670 | $592.2K | 0.50% | +36+0.5% | Added |
| Teacher Retirement System of Texas | 6,554 | $581.9K | 0.00% | +274+4.4% | Added |
| Boothbay Fund Management, LLC | 6,453 | $572.9K | 0.01% | −186,578−96.7% | Reduced |
| Harvest Investment Services, LLC | 6,432 | $571.0K | 0.09% | +6,432 | New |
| Fieldview Capital Management, LLC | 6,392 | $567.5K | 0.16% | +6,392 | New |
| Allspring Global Investments Holdings, LLC | 6,090 | $541.3K | 0.00% | +6,090 | New |
| Quantinno Capital Management LP | 6,015 | $534.0K | 0.00% | +1,454+31.9% | Added |
| High Net Worth Advisory Group LLC | 6,000 | $532.7K | 0.11% | 00.0% | Unchanged |
| Omers Administration Corp | 5,200 | $461.7K | 0.00% | +5,200 | New |
| Dark Forest Capital Management LP | 5,192 | $460.9K | 0.03% | +5,192 | New |
| E Fund Management Co., Ltd. | 5,184 | $460.2K | 0.01% | −1,972−27.6% | Reduced |
| JustInvest LLC | 5,118 | $454.4K | 0.00% | +721+16.4% | Added |
| Captrust Financial Advisors | 5,023 | $445.9K | 0.00% | +5,023 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 4,801 | $426.2K | 0.00% | +4,801 | New |
| Martingale Asset Management L P | 4,425 | $392.9K | 0.01% | −4,655−51.3% | Reduced |
| Virtu Financial LLC | 4,351 | $386.0K | 0.01% | −3,740−46.2% | Reduced |
| CIBC Bancorp USA Inc. | 4,122 | $366.0K | 0.00% | +4,122 | New |
| Virtus Investment Advisers, Inc. | 4,050 | $359.6K | 0.08% | −4,060−50.1% | Reduced |
| PSP Research LLC | 4,000 | $355.1K | 0.19% | −1,159−22.5% | Reduced |
| Wexford Capital LP | 4,000 | $355.1K | 0.05% | +4,000 | New |
| Artia Global Partners LP | 4,000 | $355.1K | 0.07% | +4,000 | New |
| Mirae Asset Global Investments Co., Ltd. | 3,884 | $344.8K | 0.00% | −213−5.2% | Reduced |
| Landscape Capital Management, L.L.C. | 3,875 | $344.0K | 0.02% | −1,325−25.5% | Reduced |
| Jump Financial, LLC | 3,813 | $338.5K | 0.00% | +3,813 | New |
| Swiss Life Asset Management Ltd | 3,601 | $319.7K | 0.00% | +3,601 | New |
| Bridgefront Capital, LLC | 3,577 | $317.6K | 0.08% | −5,075−58.7% | Reduced |
| Stifel Financial Corp | 3,011 | $267.3K | 0.00% | +3,011 | New |