Spyre Therapeutics, Inc.

SYRE

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001636282

SEC filings (opens in a new tab)

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

Q2 2026 vs. Q1 2026

How the institutions holding Spyre Therapeutics, Inc. changed between Q1 2026 and Q2 2026.

All holders in Q2 2026 All holders in Q1 2026

13F holders of SYRE: Q1 2026 compared with Q2 2026
Measure	Q1 2026	Of which not filed for Q2 2026	Q2 2026	Change
Holders	198	2	265	+69
Shares	82.7M	1.66M	95.8M	+14.8M (+18.3%)
Value	$4.16B	$83.7M	$8.52B	+$4.44B (+108.8%)

2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (91)

Institutions that held Spyre Therapeutics, Inc. at the end of Q2 2026 but not at the end of Q1 2026.

Institutions new to SYRE in Q2 2026
Institution	Shares	Value	% of portfolio
Jupiter Topco LLC	2,206,936	$195.9M	0.08%
Adage Capital Partners GP, L.L.C.	1,722,300	$152.9M	0.21%
Holocene Advisors, LP	1,015,170	$90.1M	0.21%
Integral Health Asset Management, LLC	325,000	$28.9M	1.18%
Jennison Associates LLC	303,180	$26.9M	0.02%
Bellevue Group AG	229,931	$20.4M	0.43%
Cormorant Asset Management, LP	225,000	$20.0M	1.02%
Eventide Asset Management, LLC	201,616	$17.9M	0.24%
OrbiMed Advisors LLC	186,145	$16.5M	0.31%
Frontier Capital Management Co LLC	182,931	$16.2M	0.15%
Neuberger Berman Group LLC	180,884	$16.1M	0.01%
Soleus Capital Management, L.P.	147,000	$13.1M	0.45%
Squarepoint Ops LLC	139,605	$12.4M	0.02%
Rhenman & Partners Asset Management AB	119,300	$10.6M	1.00%
Boxer Capital Management, LLC	100,000	$8.88M	0.67%
Federated Hermes, Inc.	85,950	$7.63M	0.01%
Granahan Investment Management Inc	82,991	$7.37M	0.26%
Trexquant Investment LP	67,007	$5.95M	0.04%
EAM Investors, LLC	60,393	$5.36M	0.48%
Hudson Bay Capital Management LP	58,387	$5.18M	0.02%
Royce & Associates LP	51,789	$4.60M	0.04%
Monashee Investment Management LLC	50,000	$4.44M	7.45%
PFM Health Sciences, LP	46,217	$4.10M	0.36%
Nomura Asset Management International Inc.	43,071	$3.82M	0.01%
Moody Aldrich Partners LLC	42,458	$3.77M	0.68%
Rock Springs Capital Management LP	42,254	$3.75M	0.18%
Maven Securities LTD	40,000	$3.55M	0.24%
Engineers Gate Manager LP	38,474	$3.42M	0.04%
Caption Management, LLC	36,000	$3.20M	0.11%
Ghisallo Capital Management LLC	30,000	$2.66M	0.05%
D. E. Shaw & Co., Inc.	26,452	$2.35M	0.00%
Castleark Management LLC	26,420	$2.35M	0.06%
Handelsbanken Fonder AB	26,000	$2.31M	0.01%
Aquatic Capital Management LLC	25,222	$2.24M	0.08%
Freestone Grove Partners LP	22,777	$2.02M	0.01%
Schonfeld Strategic Advisors LLC	19,089	$1.69M	0.01%
Algert Global LLC	16,460	$1.46M	0.02%
Diadema Partners LP	15,000	$1.33M	0.47%
Allianz Asset Management GmbH	14,100	$1.25M	0.00%
Two Sigma Investments, LP	12,771	$1.13M	0.00%
Atom Investors LP	12,457	$1.11M	0.10%
Calamos Advisors LLC	11,323	$1.01M	0.00%
Diametric Capital, LP	10,000	$887.8K	0.09%
Glenmede Trust Co NA	9,966	$884.8K	0.00%
Brevan Howard Capital Management LP	8,288	$735.8K	0.01%
Envestnet Asset Management Inc	7,666	$680.6K	0.00%
State of Wyoming	6,690	$593.9K	0.06%
Harvest Investment Services, LLC	6,432	$571.0K	0.09%
Fieldview Capital Management, LLC	6,392	$567.5K	0.16%
Allspring Global Investments Holdings, LLC	6,090	$541.3K	0.00%
Omers Administration Corp	5,200	$461.7K	0.00%
Dark Forest Capital Management LP	5,192	$460.9K	0.03%
Captrust Financial Advisors	5,023	$445.9K	0.00%
Connor, Clark & Lunn Investment Management Ltd.	4,801	$426.2K	0.00%
CIBC Bancorp USA Inc.	4,122	$366.0K	0.00%
Wexford Capital LP	4,000	$355.1K	0.05%
Artia Global Partners LP	4,000	$355.1K	0.07%
Jump Financial, LLC	3,813	$338.5K	0.00%
Swiss Life Asset Management Ltd	3,601	$319.7K	0.00%
Stifel Financial Corp	3,011	$267.3K	0.00%
Jane Street Group, LLC	2,909	$258.3K	0.00%
VARCOV Co.	2,895	$257.0K	0.10%
Aster Capital Management (DIFC) Ltd	2,865	$254.4K	0.05%
Amundi	2,793	$248.0K	0.00%
Empowered Funds, LLC	2,731	$242.5K	0.00%
DnB Asset Management AS	2,661	$236.2K	0.00%
Brinker Capital Investments, LLC	2,577	$228.8K	0.00%
CIBC Asset Management Inc	2,429	$215.6K	0.00%
Bayforest Capital Ltd	2,305	$204.6K	0.19%
Acadian Asset Management LLC	2,296	$203.0K	0.00%
CFC Planning Co LLC	2,277	$202.2K	0.12%
Fulcrum Asset Management LLP	2,114	$190.6K	0.02%
Nykredit A/S	1,953	$173.4K	0.00%
Mitsubishi UFJ Trust & Banking Corp	1,844	$163.7K	0.00%
Pacer Advisors, Inc.	614	$55.0K	0.00%
Simplex Trading, LLC	278	$24.7K	0.00%
Toronto Dominion Bank	270	$24.0K	0.00%
Axiom Investment Management LLC	200	$17.8K	0.01%
J.Safra Asset Management Corp	167	$14.8K	0.00%
IFG Advisory, LLC	161	$14.3K	0.00%
National Bank of Canada	124	$11.0K	0.00%
Jones Financial Companies LLLP	103	$9.05K	0.00%
Meeder Asset Management Inc	30	$2.66K	0.00%
Ares Financial Consulting, LLC	11	$977	0.00%
UMA Financial Services, Inc.	5	$444	0.00%
Stone House Investment Management, LLC	4	$355	0.00%
Hughes Financial Services, LLC	4	$355	0.00%
Silver Grove Financial Group, Inc.	3	$266	0.00%
Quarry LP	2	$178	0.00%
Zions Bancorporation, National Association	1	$89	0.00%
ABS Investment Management LLC	89	–	–

Sold out (22)

Institutions that held Spyre Therapeutics, Inc. at the end of Q1 2026 and filed for Q2 2026 without it.

Institutions that sold out of SYRE in Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Fairmount Funds Management LLC	4,018,101	$202.7M
Ra Capital Management, L.P.	1,621,620	$81.8M
Baker Bros. Advisors LP	1,000,000	$50.4M
Caligan Partners LP	878,127	$44.3M
ExodusPoint Capital Management, LP	87,065	$4.39M
Alps Advisors Inc	63,939	$3.23M
Assenagon Asset Management S.A.	18,647	$940.6K
Carlyle Group Inc.	9,620	$485.2K
RWC Asset Management LLP	8,166	$411.9K
Capstone Investment Advisors, LLC	7,537	$380.2K
Scientech Research LLC	7,088	$357.5K
Arrowpoint Investment Partners (Singapore) Pte. Ltd.	6,140	$309.7K
DeepCurrents Investment Group LLC	4,740	$239.1K
ABS Direct Equity Fund LLC	2,800	$193.6K
Patient Square Capital LP	1,000	$50.4K
Group One Trading, L.P.	901	$45.4K
Clear Street Markets LLC	562	$28.3K
Delos Wealth Advisors, LLC	250	$12.6K
Quadrant Capital Group LLC	146	$7.37K
MAI Capital Management	13	$656
Massmutual Trust Co FSB	3	$151
Twin Peaks Wealth Advisors, LLC	3	$151

Not filed for Q2 2026 yet (2)

Institutions that held Spyre Therapeutics, Inc. at the end of Q1 2026 and haven't filed a 13F for Q2 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding SYRE in Q1 2026 that haven't filed for Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Janus Henderson Group PLC	1,656,164	$83.6M
CWM, LLC	2,105	$106.2K