Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 198
- +47 vs. Q4 2025
- Shares held
- 82.7M
- +5.74M (+7.5%) vs. Q4 2025
- Total value
- $4.16B
- +$1.64B (+65.2%) vs. Q4 2025
- New holders
- 58
- 67 more added
- Sold out
- 11
- 49 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 11,781,024 | $594.2M | 0.03% | +142,205+1.2% | Added |
| BlackRock, Inc. | 5,521,221 | $278.5M | 0.00% | −8800.0% | Reduced |
| RTW Investments, LP | 4,171,996 | $210.4M | 2.09% | 00.0% | Unchanged |
| Fairmount Funds Management LLC | 4,018,101 | $202.7M | 14.64% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 3,783,225 | $190.8M | 3.77% | +714,000+23.3% | Added |
| VR Adviser, LLC | 3,685,448 | $185.9M | 6.94% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 3,057,401 | $154.2M | 0.00% | +3,057,401 | New |
| Driehaus Capital Management LLC | 2,790,785 | $140.8M | 1.03% | −91,635−3.2% | Reduced |
| State Street Corp | 2,607,031 | $131.5M | 0.00% | +344,192+15.2% | Added |
| Paradigm Biocapital Advisors LP | 1,957,266 | $98.7M | 2.02% | +490,000+33.4% | Added |
| Commodore Capital LP | 1,912,380 | $96.5M | 5.58% | −475,865−19.9% | Reduced |
| TCG Crossover Management, LLC | 1,900,582 | $95.9M | 2.74% | 00.0% | Unchanged |
| Tang Capital Management LLC | 1,892,200 | $95.4M | 4.85% | 00.0% | Unchanged |
| Wellington Management Group LLP | 1,824,811 | $92.0M | 0.02% | +275,527+17.8% | Added |
| Capital International Investors | 1,746,129 | $88.1M | 0.02% | −1,746,412−50.0% | Reduced |
| Geode Capital Management, LLC | 1,720,912 | $86.8M | 0.01% | +61,772+3.7% | Added |
| Janus Henderson Group PLC | 1,656,164 | $83.6M | 0.04% | −172,845−9.5% | Reduced |
| Ra Capital Management, L.P. | 1,621,620 | $81.8M | 0.87% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 1,598,730 | $80.6M | 0.01% | −3,152−0.2% | Reduced |
| Remedium Capital Partners, LLC | 1,456,231 | $73.5M | 26.13% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 1,279,134 | $64.5M | 3.78% | −153,457−10.7% | Reduced |
| Bank of America Corp | 1,228,093 | $61.9M | 0.00% | +808,366+192.6% | Added |
| Baker Bros. Advisors LP | 1,000,000 | $50.4M | 0.29% | 00.0% | Unchanged |
| Braidwell LP | 932,823 | $47.1M | 1.57% | −701,792−42.9% | Reduced |
| Franklin Resources Inc | 882,833 | $44.5M | 0.01% | −226,441−20.4% | Reduced |
| JPMorgan Chase & Co | 979,299 | $44.5M | 0.00% | +916,348+1,455.7% | Added |
| Caligan Partners LP | 878,127 | $44.3M | 3.13% | +878,127 | New |
| Siren, L.L.C. | 818,598 | $41.3M | 1.14% | 00.0% | Unchanged |
| Polar Capital Holdings Plc | 792,847 | $40.0M | 0.17% | +52,521+7.1% | Added |
| UBS Group AG | 671,235 | $33.9M | 0.01% | −9,331−1.4% | Reduced |
| Capital World Investors | 666,564 | $33.6M | 0.00% | +466,392+233.0% | Added |
| Emerald Advisers, LLC | 613,365 | $30.9M | 0.98% | −22,744−3.6% | Reduced |
| Candriam Luxembourg S.C.A. | 610,282 | $30.8M | 0.16% | +184,748+43.4% | Added |
| Vanguard Portfolio Management LLC | 585,130 | $29.5M | 0.00% | +585,130 | New |
| Northern Trust Corp | 578,907 | $29.2M | 0.00% | +17,884+3.2% | Added |
| Charles Schwab Investment Management Inc | 562,653 | $28.4M | 0.00% | −11,969−2.1% | Reduced |
| Pictet Asset Management Holding SA | 491,649 | $24.8M | 0.03% | −422,311−46.2% | Reduced |
| Vanguard Fiduciary Trust Co | 464,651 | $23.4M | 0.01% | +464,651 | New |
| Emerald Mutual Fund Advisers Trust | 408,113 | $20.6M | 1.00% | −4,258−1.0% | Reduced |
| Samlyn Capital, LLC | 396,661 | $20.0M | 0.34% | +396,661 | New |
| ADAR1 Capital Management, LLC | 338,323 | $17.1M | 1.03% | +304,272+893.6% | Added |
| Blackstone Group Inc. | 292,847 | $14.8M | 0.06% | −208,151−41.5% | Reduced |
| Victory Capital Management Inc | 292,126 | $14.7M | 0.01% | +146,047+100.0% | Added |
| Goldman Sachs Group Inc | 269,938 | $13.6M | 0.00% | −5,127−1.9% | Reduced |
| Woodline Partners LP | 265,892 | $13.4M | 0.05% | 00.0% | Unchanged |
| Morgan Stanley | 246,719 | $12.4M | 0.00% | +63,985+35.0% | Added |
| UBS Asset Management Americas Inc | 207,314 | $10.5M | 0.00% | +145,098+233.2% | Added |
| Boothbay Fund Management, LLC | 193,031 | $9.74M | 0.23% | +193,031 | New |
| Bank of New York Mellon Corp | 191,395 | $9.65M | 0.00% | −1,435−0.7% | Reduced |
| Silverarc Capital Management, LLC | 186,618 | $9.41M | 1.11% | −1,119−0.6% | Reduced |
| First Trust Advisors LP | 178,389 | $9.00M | 0.01% | +178,389 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170,381 | $8.59M | 0.01% | −830−0.5% | Reduced |
| StemPoint Capital LP | 167,606 | $8.45M | 1.62% | +135,229+417.7% | Added |
| Ameriprise Financial Inc | 159,217 | $8.03M | 0.00% | +120,961+316.2% | Added |
| Nuveen, LLC | 153,899 | $7.76M | 0.00% | +2,919+1.9% | Added |
| Ensign Peak Advisors, Inc | 148,537 | $7.49M | 0.01% | +148,537 | New |
| Millennium Management LLC | 146,639 | $7.40M | 0.01% | +70,445+92.5% | Added |
| HighVista Strategies LLC | 146,264 | $7.38M | 2.04% | −41,942−22.3% | Reduced |
| Marshall Wace, LLP | 139,259 | $7.02M | 0.01% | +139,259 | New |
| TD Asset Management Inc | 137,390 | $6.93M | 0.01% | −12,432−8.3% | Reduced |
| Invesco Ltd. | 132,390 | $6.68M | 0.00% | −18,544−12.3% | Reduced |
| Deutsche Bank AG | 129,242 | $6.52M | 0.00% | +7,301+6.0% | Added |
| Armistice Capital, LLC | 120,931 | $6.10M | 0.20% | −75,495−38.4% | Reduced |
| Manufacturers Life Insurance Company, The | 112,841 | $5.69M | 0.00% | −16,172−12.5% | Reduced |
| Citadel Advisors LLC | 108,135 | $5.45M | 0.00% | +44,231+69.2% | Added |
| Seven Grand Managers, LLC | 100,000 | $5.04M | 0.34% | 00.0% | Unchanged |
| B Group, Inc. | 100,000 | $5.04M | 3.74% | 00.0% | Unchanged |
| F/M Investments LLC | 99,460 | $5.02M | 0.33% | −4,258−4.1% | Reduced |
| Swiss National Bank | 96,500 | $4.87M | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 87,065 | $4.39M | 0.04% | +49,194+129.9% | Added |
| Rhumbline Advisers | 85,121 | $4.29M | 0.00% | +2,165+2.6% | Added |
| Mercer Global Advisors Inc | 71,091 | $3.59M | 0.01% | −35,225−33.1% | Reduced |
| HealthInvest Partners AB | 62,735 | $3.49M | 1.13% | +62,735 | New |
| Rockefeller Capital Management L.P. | 64,002 | $3.23M | 0.01% | +63,453+11,557.9% | Added |
| Alps Advisors Inc | 63,939 | $3.23M | 0.02% | +231+0.4% | Added |
| Prudential Financial Inc | 59,555 | $3.00M | 0.00% | +59,555 | New |
| Fred Alger Management, LLC | 59,453 | $3.00M | 0.01% | +59,453 | New |
| California State Teachers Retirement System | 59,242 | $2.99M | 0.00% | +11,204+23.3% | Added |
| Schroder Investment Management Group | 63,684 | $2.89M | 0.00% | +2,110+3.4% | Added |
| Rafferty Asset Management, LLC | 56,920 | $2.87M | 0.01% | +3,510+6.6% | Added |
| Balyasny Asset Management LLC | 55,477 | $2.80M | 0.01% | −17,988−24.5% | Reduced |
| Voya Investment Management LLC | 53,970 | $2.72M | 0.00% | +26,693+97.9% | Added |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $2.68M | 0.04% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 47,697 | $2.41M | 0.00% | −29,593−38.3% | Reduced |
| Alliancebernstein L.P. | 70,900 | $2.32M | 0.00% | +3,400+5.0% | Added |
| Barclays PLC | 45,786 | $2.31M | 0.00% | −136,738−74.9% | Reduced |
| Legal & General Group Plc | 44,792 | $2.26M | 0.00% | −11,656−20.6% | Reduced |
| MetLife Investment Management | 38,407 | $1.94M | 0.01% | +396+1.0% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 36,323 | $1.81M | 0.00% | +1,179+3.4% | Added |
| Vanguard Asset Management, Ltd | 33,232 | $1.68M | 0.00% | +33,232 | New |
| Wells Fargo & Company | 33,208 | $1.68M | 0.00% | −49,208−59.7% | Reduced |
| Vanguard Global Advisers, LLC | 31,141 | $1.57M | 0.00% | +31,141 | New |
| Susquehanna International Group, LLP | 28,962 | $1.46M | 0.00% | +22,851+373.9% | Added |
| Virginia Retirement Systems Et Al | 27,550 | $1.39M | 0.01% | +2,600+10.4% | Added |
| Cinctive Capital Management LP | 27,430 | $1.38M | 0.09% | −8,505−23.7% | Reduced |
| State of Wisconsin Investment Board | 26,523 | $1.34M | 0.00% | −729−2.7% | Reduced |
| Profund Advisors LLC | 26,043 | $1.31M | 0.05% | +5,450+26.5% | Added |
| Warren Averett Asset Management, LLC | 25,966 | $1.31M | 0.01% | +120.0% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $1.30M | 0.01% | 00.0% | Unchanged |
| XTX Topco Ltd | 24,435 | $1.23M | 0.02% | +24,435 | New |