Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 198
- +47 vs. Q4 2025
- Shares held
- 82.7M
- +5.74M (+7.5%) vs. Q4 2025
- Total value
- $4.16B
- +$1.64B (+65.2%) vs. Q4 2025
- New holders
- 58
- 67 more added
- Sold out
- 11
- 49 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 4 | $0 | 0.00% | −2−33.3% | Reduced |
| Essential Partners LLC | 2 | $101 | 0.00% | +2 | New |
| Massmutual Trust Co FSB | 3 | $151 | 0.00% | +3 | New |
| Twin Peaks Wealth Advisors, LLC | 3 | $151 | 0.00% | +3 | New |
| Keating Financial Advisory Services, Inc. | 4 | $202 | 0.00% | +4 | New |
| SBI Securities Co., Ltd. | 5 | $252 | 0.00% | 00.0% | Unchanged |
| Fifth Third Bancorp | 5 | $252 | 0.00% | +5 | New |
| MAI Capital Management | 13 | $656 | 0.00% | +13 | New |
| Bare Financial Services, Inc | 16 | $807 | 0.00% | +16 | New |
| SRS Capital Advisors, Inc. | 18 | $908 | 0.00% | +18 | New |
| IFP Advisors, Inc | 24 | $1.21K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 32 | $1.61K | 0.00% | +32 | New |
| Parkside Financial Bank & Trust | 35 | $1.77K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 36 | $1.82K | 0.00% | −108−75.0% | Reduced |
| Signaturefd, LLC | 70 | $3.53K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 74 | $3.62K | 0.00% | +37+100.0% | Added |
| EverSource Wealth Advisors, LLC | 79 | $3.98K | 0.00% | +14+21.5% | Added |
| Quantbot Technologies LP | 88 | $4.44K | 0.00% | +88 | New |
| US Bancorp | 97 | $4.89K | 0.00% | +87+870.0% | Added |
| Rothschild Investment LLC | 99 | $4.99K | 0.00% | +17+20.7% | Added |
| Allworth Financial LP | 117 | $5.90K | 0.00% | +59+101.7% | Added |
| The PNC Financial Services Group, Inc. | 123 | $6.20K | 0.00% | +37+43.0% | Added |
| Smartleaf Asset Management LLC | 157 | $7.13K | 0.00% | +157 | New |
| Quadrant Capital Group LLC | 146 | $7.37K | 0.00% | +146 | New |
| Delos Wealth Advisors, LLC | 250 | $12.6K | 0.01% | +250 | New |
| Caitong International Asset Management Co., Ltd | 286 | $14.4K | 0.00% | +286 | New |
| Optiver Holding B.V. | 288 | $14.5K | 0.00% | +48+20.0% | Added |
| Advisor Group Holdings, Inc. | 498 | $25.1K | 0.00% | +131+35.7% | Added |
| GAMMA Investing LLC | 523 | $26.4K | 0.00% | +193+58.5% | Added |
| Clear Street Markets LLC | 562 | $28.3K | 0.01% | +562 | New |
| Kemnay Advisory Services Inc. | 574 | $29.0K | 0.00% | +574 | New |
| Neo Ivy Capital Management | 598 | $30.2K | 0.01% | −17,663−96.7% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 888 | $44.8K | 0.00% | +232+35.4% | Added |
| Group One Trading, L.P. | 901 | $45.4K | 0.00% | +501+125.3% | Added |
| Patient Square Capital LP | 1,000 | $50.4K | 0.01% | −149,000−99.3% | Reduced |
| Sterling Capital Management LLC | 1,051 | $53.0K | 0.00% | −559−34.7% | Reduced |
| KBC Group NV | 1,372 | $69.0K | 0.00% | +1,372 | New |
| Public Employees Retirement Association of Colorado | 1,589 | $80.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,743 | $87.9K | 0.00% | +220+14.4% | Added |
| Nisa Investment Advisors, LLC | 1,916 | $96.6K | 0.00% | +1,211+171.8% | Added |
| CWM, LLC | 2,105 | $106.2K | 0.00% | +135+6.9% | Added |
| Union Bancaire Privee, UBP SA | 3,880 | $158.8K | 0.00% | +3,880 | New |
| Royal Bank of Canada | 3,250 | $164.0K | 0.00% | +1,262+63.5% | Added |
| ABS Direct Equity Fund LLC | 2,800 | $193.6K | 0.15% | +2,800 | New |
| Mirae Asset Global Investments Co., Ltd. | 4,097 | $206.7K | 0.00% | +327+8.7% | Added |
| Principal Financial Group Inc | 4,299 | $216.8K | 0.00% | +4,299 | New |
| JustInvest LLC | 4,397 | $221.8K | 0.00% | +4,397 | New |
| STRS Ohio | 4,500 | $227.0K | 0.00% | +4,500 | New |
| Quantinno Capital Management LP | 4,561 | $230.1K | 0.00% | +4,561 | New |
| DeepCurrents Investment Group LLC | 4,740 | $239.1K | 0.01% | +4,740 | New |
| Persistent Asset Partners Ltd | 4,803 | $242.3K | 0.09% | +2,557+113.8% | Added |
| PSP Research LLC | 5,159 | $260.2K | 0.18% | −10,681−67.4% | Reduced |
| Landscape Capital Management, L.L.C. | 5,200 | $262.3K | 0.02% | +5,200 | New |
| Ameritas Investment Partners, Inc. | 5,593 | $282.1K | 0.01% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 5,858 | $295.5K | 0.00% | −7,024−54.5% | Reduced |
| High Net Worth Advisory Group LLC | 6,000 | $302.6K | 0.07% | +6,000 | New |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6,140 | $309.7K | 0.45% | −7,584−55.3% | Reduced |
| Teacher Retirement System of Texas | 6,280 | $316.8K | 0.00% | −893−12.4% | Reduced |
| Xponance, Inc. | 6,445 | $325.1K | 0.00% | +6,445 | New |
| AlphaCentric Advisors LLC | 6,634 | $334.6K | 0.33% | +6,634 | New |
| Two Sigma Securities, LLC | 6,851 | $345.6K | 0.04% | +6,851 | New |
| Scientech Research LLC | 7,088 | $357.5K | 0.30% | +7,088 | New |
| E Fund Management Co., Ltd. | 7,156 | $360.9K | 0.01% | +7,156 | New |
| Capstone Investment Advisors, LLC | 7,537 | $380.2K | 0.00% | +7,537 | New |
| Virtu Financial LLC | 8,091 | $408.0K | 0.02% | +8,091 | New |
| Virtus Investment Advisers, Inc. | 8,110 | $409.1K | 0.11% | +197+2.5% | Added |
| RWC Asset Management LLP | 8,166 | $411.9K | 0.02% | +8,166 | New |
| Tudor Investment Corp Et Al | 8,364 | $421.9K | 0.00% | −1,763−17.4% | Reduced |
| Bridgefront Capital, LLC | 8,652 | $436.4K | 0.11% | +8,652 | New |
| Tower Research Capital LLC (TRC) | 8,790 | $443.4K | 0.01% | +8,365+1,968.2% | Added |
| SEI Investments Co | 8,975 | $452.7K | 0.00% | +2,858+46.7% | Added |
| Martingale Asset Management L P | 9,080 | $458.0K | 0.01% | +2,150+31.0% | Added |
| Man Group plc | 9,546 | $481.5K | 0.00% | +9,546 | New |
| Carlyle Group Inc. | 9,620 | $485.2K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 9,931 | $500.9K | 0.00% | +4,377+78.8% | Added |
| KLP Kapitalforvaltning AS | 10,900 | $549.8K | 0.00% | +500+4.8% | Added |
| Citigroup Inc | 12,006 | $605.6K | 0.00% | −88,052−88.0% | Reduced |
| Brown Advisory Inc | 12,400 | $625.5K | 0.00% | +12,400 | New |
| Vanguard Investments Australia, Ltd. | 12,813 | $646.3K | 0.00% | +12,813 | New |
| SG Americas Securities, LLC | 13,396 | $676.0K | 0.00% | −9,947−42.6% | Reduced |
| Arizona State Retirement System | 13,438 | $677.8K | 0.00% | −359−2.6% | Reduced |
| ProShare Advisors LLC | 13,498 | $680.8K | 0.00% | −2,491−15.6% | Reduced |
| State Board of Administration of Florida Retirement System | 13,905 | $701.4K | 0.00% | +4,875+54.0% | Added |
| China Universal Asset Management Co., Ltd. | 13,938 | $703.0K | 0.05% | +1,294+10.2% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,955 | $703.9K | 0.00% | +2,791+25.0% | Added |
| Creative Planning | 15,486 | $781.1K | 0.00% | +15,486 | New |
| Intech Investment Management LLC | 16,443 | $829.4K | 0.01% | −1,831−10.0% | Reduced |
| State of New Jersey Common Pension Fund D | 16,720 | $843.4K | 0.00% | +22+0.1% | Added |
| Kennedy Capital Management, Inc. | 16,873 | $851.1K | 0.02% | +16,873 | New |
| Global Endowment Management, LP | 18,184 | $917.0K | 0.10% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $926.1K | 0.01% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 18,630 | $939.7K | 0.00% | +6,786+57.3% | Added |
| Assenagon Asset Management S.A. | 18,647 | $940.6K | 0.00% | −3,489−15.8% | Reduced |
| Seven Fleet Capital Management LP | 19,690 | $993.2K | 0.31% | +19,690 | New |
| Raymond James Financial Inc | 19,755 | $996.4K | 0.00% | +19,755 | New |
| AQR Capital Management LLC | 20,874 | $1.05M | 0.00% | +3,054+17.1% | Added |
| Ellsworth Advisors, LLC | 21,963 | $1.11M | 0.21% | +21,963 | New |
| New York State Common Retirement Fund | 22,265 | $1.12M | 0.00% | +3,100+16.2% | Added |
| XTX Topco Ltd | 24,435 | $1.23M | 0.02% | +24,435 | New |
| Teachers Retirement System of the State of Kentucky | 25,799 | $1.30M | 0.01% | 00.0% | Unchanged |