Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2024
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 107
- +5 vs. Q1 2024
- Shares held
- 50.4M
- +18.0M (+55.7%) vs. Q1 2024
- Total value
- $1.18B
- −$28.4M (−2.3%) vs. Q1 2024
- New holders
- 29
- 47 more added
- Sold out
- 24
- 17 more reduced
1 institution that held it in Q1 2024 haven't filed for Q2 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 7,507,983 | $176.5M | 0.01% | +924,228+14.0% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $94.5M | 10.67% | +3,639,680+961.8% | Added |
| RTW Investments, LP | 3,258,360 | $76.6M | 1.19% | +1,025,600+45.9% | Added |
| Perceptive Advisors LLC | 3,031,018 | $71.3M | 1.72% | +474,339+18.6% | Added |
| VR Adviser, LLC | 2,685,448 | $63.1M | 4.02% | +513,666+23.7% | Added |
| Braidwell LP | 2,514,538 | $59.1M | 1.85% | +1,999,538+388.3% | Added |
| BlackRock Inc. | 2,403,441 | $56.5M | 0.00% | +1,846,750+331.7% | Added |
| Commodore Capital LP | 1,988,084 | $46.7M | 3.19% | +104,000+5.5% | Added |
| Vanguard Group Inc | 1,911,566 | $44.9M | 0.00% | +1,414,385+284.5% | Added |
| Avoro Capital Advisors LLC | 1,839,138 | $43.2M | 0.58% | 00.0% | Unchanged |
| Deep Track Capital, LP | 1,756,667 | $41.3M | 1.23% | +543,247+44.8% | Added |
| State Street Corp | 1,409,659 | $33.1M | 0.00% | +1,275,233+948.7% | Added |
| Adage Capital Partners GP, L.L.C. | 1,152,411 | $27.1M | 0.05% | +47,211+4.3% | Added |
| Goldman Sachs Group Inc | 893,083 | $21.0M | 0.00% | +653,168+272.2% | Added |
| Wellington Management Group LLP | 795,946 | $18.7M | 0.00% | −16,914−2.1% | Reduced |
| Geode Capital Management, LLC | 765,834 | $18.0M | 0.00% | +435,609+131.9% | Added |
| Franklin Resources Inc | 741,904 | $17.4M | 0.01% | 00.0% | Unchanged |
| Citadel Advisors LLC | 707,586 | $16.6M | 0.02% | −40.0% | Reduced |
| Boxer Capital, LLC | 696,480 | $16.4M | 0.86% | +446,480+178.6% | Added |
| Driehaus Capital Management LLC | 687,080 | $16.2M | 0.16% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 673,867 | $15.9M | 0.01% | +659,890+4,721.3% | Added |
| Farallon Capital Management, L.L.C. | 666,000 | $15.7M | 0.09% | +200,000+42.9% | Added |
| Logos Global Management LP | 575,000 | $13.5M | 1.56% | +325,000+130.0% | Added |
| Affinity Asset Advisors, LLC | 513,420 | $12.1M | 1.90% | +103,420+25.2% | Added |
| Polar Capital Holdings Plc | 500,000 | $11.8M | 0.07% | 00.0% | Unchanged |
| First Turn Management, LLC | 464,435 | $10.9M | 1.78% | 00.0% | Unchanged |
| Darwin Global Management, Ltd. | 452,040 | $10.3M | 1.19% | −21,160−4.5% | Reduced |
| Morgan Stanley | 408,853 | $9.61M | 0.00% | +357,665+698.7% | Added |
| Pictet Asset Management Holding SA | 386,617 | $9.09M | 0.01% | +386,617 | New |
| Price T Rowe Associates Inc | 307,976 | $7.24M | 0.00% | +229,447+292.2% | Added |
| Blackstone Group Inc. | 292,995 | $6.89M | 0.03% | +273,004+1,365.6% | Added |
| Voloridge Investment Management, LLC | 275,226 | $6.47M | 0.02% | +87,173+46.4% | Added |
| Balyasny Asset Management LLC | 272,636 | $6.41M | 0.02% | +240,239+741.5% | Added |
| Woodline Partners LP | 262,616 | $6.17M | 0.06% | +162,089+161.2% | Added |
| Ghost Tree Capital, LLC | 250,237 | $5.88M | 2.05% | +150,237+150.2% | Added |
| Avidity Partners Management LP | 195,000 | $4.58M | 0.19% | +195,000 | New |
| Bank of America Corp | 191,169 | $4.49M | 0.00% | +154,837+426.2% | Added |
| Walleye Capital LLC | 150,820 | $3.55M | 0.04% | +39,342+35.3% | Added |
| StemPoint Capital LP | 150,450 | $3.54M | 1.04% | +88,197+141.7% | Added |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 145,000 | $3.41M | 0.08% | +114,962+382.7% | Added |
| Armistice Capital, LLC | 136,000 | $3.20M | 0.08% | +136,000 | New |
| Great Point Partners LLC | 134,612 | $3.16M | 0.61% | +9,612+7.7% | Added |
| Bank of New York Mellon Corp | 117,686 | $2.77M | 0.00% | +111,636+1,845.2% | Added |
| Nuveen Asset Management, LLC | 117,140 | $2.75M | 0.00% | +117,140 | New |
| HighVista Strategies LLC | 113,550 | $2.67M | 0.98% | −40,831−26.4% | Reduced |
| Suvretta Capital Management, LLC | 107,310 | $2.52M | 0.10% | −55,085−33.9% | Reduced |
| Candriam Luxembourg S.C.A. | 105,000 | $2.47M | 0.01% | 00.0% | Unchanged |
| Integral Health Asset Management, LLC | 100,000 | $2.35M | 0.23% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 98,181 | $2.31M | 0.00% | +83,181+554.5% | Added |
| Jefferies Financial Group Inc. | 97,573 | $2.29M | 0.05% | +97,573 | New |
| Northern Trust Corp | 85,588 | $2.01M | 0.00% | +19,248+29.0% | Added |
| Ensign Peak Advisors, Inc | 82,475 | $1.94M | 0.00% | +82,475 | New |
| Schonfeld Strategic Advisors LLC | 78,500 | $1.85M | 0.01% | +43,000+121.1% | Added |
| Norges Bank | 70,843 | $1.67M | 0.00% | +70,843 | New |
| Rafferty Asset Management, LLC | 67,109 | $1.58M | 0.01% | +67,109 | New |
| Jump Financial, LLC | 64,900 | $1.53M | 0.03% | +42,100+184.6% | Added |
| Barclays PLC | 64,043 | $1.51M | 0.00% | +18,081+39.3% | Added |
| Rhumbline Advisers | 51,896 | $1.22M | 0.00% | +51,896 | New |
| Superstring Capital Management LP | 45,571 | $1.07M | 1.35% | +45,571 | New |
| UBS Group AG | 44,504 | $1.05M | 0.00% | +41,903+1,611.0% | Added |
| Manufacturers Life Insurance Company, The | 37,782 | $888.3K | 0.00% | +13,125+53.2% | Added |
| EFG Asset Management (North America) Corp. | 36,781 | $868.8K | 0.15% | +25,630+229.8% | Added |
| Alliancebernstein L.P. | 36,230 | $851.8K | 0.00% | +36,230 | New |
| Swiss National Bank | 36,100 | $848.7K | 0.00% | −3,000−7.7% | Reduced |
| Bridgeway Capital Management, LLC | 36,100 | $848.7K | 0.02% | +36,100 | New |
| ADAR1 Capital Management, LLC | 35,180 | $827.1K | 0.17% | −14,320−28.9% | Reduced |
| TD Asset Management Inc | 35,168 | $826.8K | 0.00% | −25,800−42.3% | Reduced |
| NBW Capital LLC | 34,360 | $807.8K | 0.16% | 00.0% | Unchanged |
| Alpine Global Management, LLC | 33,858 | $796.0K | 0.14% | +33,858 | New |
| UBS Asset Management Americas Inc | 30,121 | $708.1K | 0.00% | +30,121 | New |
| Legal & General Group Plc | 23,263 | $546.9K | 0.00% | +6,231+36.6% | Added |
| JPMorgan Chase & Co | 22,772 | $535.4K | 0.00% | +22,761+206,918.2% | Added |
| Citigroup Inc | 19,320 | $454.2K | 0.00% | −12,437−39.2% | Reduced |
| California State Teachers Retirement System | 19,105 | $449.2K | 0.00% | +1,302+7.3% | Added |
| Corebridge Financial, Inc. | 18,625 | $438.1K | 0.00% | +18,625 | New |
| Global Endowment Management, LP | 18,184 | $427.5K | 0.05% | 00.0% | Unchanged |
| EAM Investors, LLC | 17,938 | $421.7K | 0.07% | 00.0% | Unchanged |
| Wells Fargo & Company | 17,175 | $403.8K | 0.00% | +14,933+666.1% | Added |
| Invesco Ltd. | 16,364 | $384.7K | 0.00% | −136,214−89.3% | Reduced |
| Deutsche Bank AG | 16,245 | $381.9K | 0.00% | +15,947+5,351.3% | Added |
| New York State Common Retirement Fund | 14,365 | $337.7K | 0.00% | −305−2.1% | Reduced |
| State of Wisconsin Investment Board | 13,932 | $327.5K | 0.00% | −700−4.8% | Reduced |
| Qube Research & Technologies Ltd | 12,672 | $297.9K | 0.00% | −45,006−78.0% | Reduced |
| Profund Advisors LLC | 12,606 | $296.4K | 0.01% | +12,606 | New |
| Aquatic Capital Management LLC | 11,800 | $277.4K | 0.01% | +11,800 | New |
| Voya Investment Management LLC | 11,607 | $272.9K | 0.00% | +11,607 | New |
| Jane Street Group, LLC | 11,551 | $271.6K | 0.00% | +4,341+60.2% | Added |
| Virtu Financial LLC | 11,016 | $259.0K | 0.02% | −5,197−32.1% | Reduced |
| Two Sigma Investments, LP | 9,842 | $231.4K | 0.00% | −3,513−26.3% | Reduced |
| Carlyle Group Inc. | 9,620 | $226.9K | 0.02% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 9,030 | $212.3K | 0.00% | +9,030 | New |
| MetLife Investment Management | 8,788 | $206.6K | 0.00% | +8,788 | New |
| SG Americas Securities, LLC | 5,545 | $130.0K | 0.00% | +5,545 | New |
| Ameritas Investment Partners, Inc. | 3,392 | $79.7K | 0.00% | +3,392 | New |
| Tower Research Capital LLC (TRC) | 3,384 | $79.6K | 0.00% | −444−11.6% | Reduced |
| Royal Bank of Canada | 3,256 | $77.0K | 0.00% | +3,200+5,714.3% | Added |
| Virtus ETF Advisers LLC | 2,797 | $65.8K | 0.03% | −3,041−52.1% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 2,526 | $57.4K | 0.00% | +2,526 | New |
| Quest Partners LLC | 1,523 | $35.8K | 0.00% | +1,523 | New |
| Amalgamated Bank | 1,198 | $28.0K | 0.00% | +1,198 | New |