Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2024
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 107
- +5 vs. Q1 2024
- Shares held
- 50.4M
- +18.0M (+55.7%) vs. Q1 2024
- Total value
- $1.18B
- −$28.4M (−2.3%) vs. Q1 2024
- New holders
- 29
- 47 more added
- Sold out
- 24
- 17 more reduced
1 institution that held it in Q1 2024 haven't filed for Q2 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CWM, LLC | 1 | $0 | 0.00% | +1 | New |
| Rothschild Investment LLC | 5 | $118 | 0.00% | +5 | New |
| Pacific Capital Wealth Advisors, Inc | 8 | $188 | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 64 | $1.00K | 0.00% | +64 | New |
| Advisor Group Holdings, Inc. | 83 | $1.95K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 114 | $2.68K | 0.00% | 00.0% | Unchanged |
| Pacer Advisors, Inc. | 382 | $8.98K | 0.00% | +382 | New |
| Amalgamated Bank | 1,198 | $28.0K | 0.00% | +1,198 | New |
| Quest Partners LLC | 1,523 | $35.8K | 0.00% | +1,523 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 2,526 | $57.4K | 0.00% | +2,526 | New |
| Virtus ETF Advisers LLC | 2,797 | $65.8K | 0.03% | −3,041−52.1% | Reduced |
| Royal Bank of Canada | 3,256 | $77.0K | 0.00% | +3,200+5,714.3% | Added |
| Tower Research Capital LLC (TRC) | 3,384 | $79.6K | 0.00% | −444−11.6% | Reduced |
| Ameritas Investment Partners, Inc. | 3,392 | $79.7K | 0.00% | +3,392 | New |
| SG Americas Securities, LLC | 5,545 | $130.0K | 0.00% | +5,545 | New |
| MetLife Investment Management | 8,788 | $206.6K | 0.00% | +8,788 | New |
| State Board of Administration of Florida Retirement System | 9,030 | $212.3K | 0.00% | +9,030 | New |
| Carlyle Group Inc. | 9,620 | $226.9K | 0.02% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 9,842 | $231.4K | 0.00% | −3,513−26.3% | Reduced |
| Virtu Financial LLC | 11,016 | $259.0K | 0.02% | −5,197−32.1% | Reduced |
| Jane Street Group, LLC | 11,551 | $271.6K | 0.00% | +4,341+60.2% | Added |
| Voya Investment Management LLC | 11,607 | $272.9K | 0.00% | +11,607 | New |
| Aquatic Capital Management LLC | 11,800 | $277.4K | 0.01% | +11,800 | New |
| Profund Advisors LLC | 12,606 | $296.4K | 0.01% | +12,606 | New |
| Qube Research & Technologies Ltd | 12,672 | $297.9K | 0.00% | −45,006−78.0% | Reduced |
| State of Wisconsin Investment Board | 13,932 | $327.5K | 0.00% | −700−4.8% | Reduced |
| New York State Common Retirement Fund | 14,365 | $337.7K | 0.00% | −305−2.1% | Reduced |
| Deutsche Bank AG | 16,245 | $381.9K | 0.00% | +15,947+5,351.3% | Added |
| Invesco Ltd. | 16,364 | $384.7K | 0.00% | −136,214−89.3% | Reduced |
| Wells Fargo & Company | 17,175 | $403.8K | 0.00% | +14,933+666.1% | Added |
| EAM Investors, LLC | 17,938 | $421.7K | 0.07% | 00.0% | Unchanged |
| Global Endowment Management, LP | 18,184 | $427.5K | 0.05% | 00.0% | Unchanged |
| Corebridge Financial, Inc. | 18,625 | $438.1K | 0.00% | +18,625 | New |
| California State Teachers Retirement System | 19,105 | $449.2K | 0.00% | +1,302+7.3% | Added |
| Citigroup Inc | 19,320 | $454.2K | 0.00% | −12,437−39.2% | Reduced |
| JPMorgan Chase & Co | 22,772 | $535.4K | 0.00% | +22,761+206,918.2% | Added |
| Legal & General Group Plc | 23,263 | $546.9K | 0.00% | +6,231+36.6% | Added |
| UBS Asset Management Americas Inc | 30,121 | $708.1K | 0.00% | +30,121 | New |
| Alpine Global Management, LLC | 33,858 | $796.0K | 0.14% | +33,858 | New |
| NBW Capital LLC | 34,360 | $807.8K | 0.16% | 00.0% | Unchanged |
| TD Asset Management Inc | 35,168 | $826.8K | 0.00% | −25,800−42.3% | Reduced |
| ADAR1 Capital Management, LLC | 35,180 | $827.1K | 0.17% | −14,320−28.9% | Reduced |
| Swiss National Bank | 36,100 | $848.7K | 0.00% | −3,000−7.7% | Reduced |
| Bridgeway Capital Management, LLC | 36,100 | $848.7K | 0.02% | +36,100 | New |
| Alliancebernstein L.P. | 36,230 | $851.8K | 0.00% | +36,230 | New |
| EFG Asset Management (North America) Corp. | 36,781 | $868.8K | 0.15% | +25,630+229.8% | Added |
| Manufacturers Life Insurance Company, The | 37,782 | $888.3K | 0.00% | +13,125+53.2% | Added |
| UBS Group AG | 44,504 | $1.05M | 0.00% | +41,903+1,611.0% | Added |
| Superstring Capital Management LP | 45,571 | $1.07M | 1.35% | +45,571 | New |
| Rhumbline Advisers | 51,896 | $1.22M | 0.00% | +51,896 | New |
| Barclays PLC | 64,043 | $1.51M | 0.00% | +18,081+39.3% | Added |
| Jump Financial, LLC | 64,900 | $1.53M | 0.03% | +42,100+184.6% | Added |
| Rafferty Asset Management, LLC | 67,109 | $1.58M | 0.01% | +67,109 | New |
| Norges Bank | 70,843 | $1.67M | 0.00% | +70,843 | New |
| Schonfeld Strategic Advisors LLC | 78,500 | $1.85M | 0.01% | +43,000+121.1% | Added |
| Ensign Peak Advisors, Inc | 82,475 | $1.94M | 0.00% | +82,475 | New |
| Northern Trust Corp | 85,588 | $2.01M | 0.00% | +19,248+29.0% | Added |
| Jefferies Financial Group Inc. | 97,573 | $2.29M | 0.05% | +97,573 | New |
| Charles Schwab Investment Management Inc | 98,181 | $2.31M | 0.00% | +83,181+554.5% | Added |
| Integral Health Asset Management, LLC | 100,000 | $2.35M | 0.23% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 105,000 | $2.47M | 0.01% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 107,310 | $2.52M | 0.10% | −55,085−33.9% | Reduced |
| HighVista Strategies LLC | 113,550 | $2.67M | 0.98% | −40,831−26.4% | Reduced |
| Nuveen Asset Management, LLC | 117,140 | $2.75M | 0.00% | +117,140 | New |
| Bank of New York Mellon Corp | 117,686 | $2.77M | 0.00% | +111,636+1,845.2% | Added |
| Great Point Partners LLC | 134,612 | $3.16M | 0.61% | +9,612+7.7% | Added |
| Armistice Capital, LLC | 136,000 | $3.20M | 0.08% | +136,000 | New |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 145,000 | $3.41M | 0.08% | +114,962+382.7% | Added |
| StemPoint Capital LP | 150,450 | $3.54M | 1.04% | +88,197+141.7% | Added |
| Walleye Capital LLC | 150,820 | $3.55M | 0.04% | +39,342+35.3% | Added |
| Bank of America Corp | 191,169 | $4.49M | 0.00% | +154,837+426.2% | Added |
| Avidity Partners Management LP | 195,000 | $4.58M | 0.19% | +195,000 | New |
| Ghost Tree Capital, LLC | 250,237 | $5.88M | 2.05% | +150,237+150.2% | Added |
| Woodline Partners LP | 262,616 | $6.17M | 0.06% | +162,089+161.2% | Added |
| Balyasny Asset Management LLC | 272,636 | $6.41M | 0.02% | +240,239+741.5% | Added |
| Voloridge Investment Management, LLC | 275,226 | $6.47M | 0.02% | +87,173+46.4% | Added |
| Blackstone Group Inc. | 292,995 | $6.89M | 0.03% | +273,004+1,365.6% | Added |
| Price T Rowe Associates Inc | 307,976 | $7.24M | 0.00% | +229,447+292.2% | Added |
| Pictet Asset Management Holding SA | 386,617 | $9.09M | 0.01% | +386,617 | New |
| Morgan Stanley | 408,853 | $9.61M | 0.00% | +357,665+698.7% | Added |
| Darwin Global Management, Ltd. | 452,040 | $10.3M | 1.19% | −21,160−4.5% | Reduced |
| First Turn Management, LLC | 464,435 | $10.9M | 1.78% | 00.0% | Unchanged |
| Polar Capital Holdings Plc | 500,000 | $11.8M | 0.07% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 513,420 | $12.1M | 1.90% | +103,420+25.2% | Added |
| Logos Global Management LP | 575,000 | $13.5M | 1.56% | +325,000+130.0% | Added |
| Farallon Capital Management, L.L.C. | 666,000 | $15.7M | 0.09% | +200,000+42.9% | Added |
| Janus Henderson Group PLC | 673,867 | $15.9M | 0.01% | +659,890+4,721.3% | Added |
| Driehaus Capital Management LLC | 687,080 | $16.2M | 0.16% | 00.0% | Unchanged |
| Boxer Capital, LLC | 696,480 | $16.4M | 0.86% | +446,480+178.6% | Added |
| Citadel Advisors LLC | 707,586 | $16.6M | 0.02% | −40.0% | Reduced |
| Franklin Resources Inc | 741,904 | $17.4M | 0.01% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 765,834 | $18.0M | 0.00% | +435,609+131.9% | Added |
| Wellington Management Group LLP | 795,946 | $18.7M | 0.00% | −16,914−2.1% | Reduced |
| Goldman Sachs Group Inc | 893,083 | $21.0M | 0.00% | +653,168+272.2% | Added |
| Adage Capital Partners GP, L.L.C. | 1,152,411 | $27.1M | 0.05% | +47,211+4.3% | Added |
| State Street Corp | 1,409,659 | $33.1M | 0.00% | +1,275,233+948.7% | Added |
| Deep Track Capital, LP | 1,756,667 | $41.3M | 1.23% | +543,247+44.8% | Added |
| Avoro Capital Advisors LLC | 1,839,138 | $43.2M | 0.58% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,911,566 | $44.9M | 0.00% | +1,414,385+284.5% | Added |
| Commodore Capital LP | 1,988,084 | $46.7M | 3.19% | +104,000+5.5% | Added |