Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 129
- −1 vs. Q4 2024
- Shares held
- 62.1M
- +2.35M (+3.9%) vs. Q4 2024
- Total value
- $1.00B
- −$386.9M (−27.8%) vs. Q4 2024
- New holders
- 20
- 52 more added
- Sold out
- 21
- 35 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 9,038,553 | $145.8M | 0.01% | +237,287+2.7% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $64.8M | 10.06% | 00.0% | Unchanged |
| RTW Investments, LP | 3,621,996 | $58.4M | 0.89% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,572,674 | $57.6M | 0.00% | +173,083+5.1% | Added |
| Vanguard Group Inc | 2,898,267 | $46.8M | 0.00% | +51,794+1.8% | Added |
| Driehaus Capital Management LLC | 2,717,312 | $43.8M | 0.42% | −86,343−3.1% | Reduced |
| VR Adviser, LLC | 2,685,448 | $43.3M | 3.69% | 00.0% | Unchanged |
| Braidwell LP | 2,578,404 | $41.6M | 1.46% | 00.0% | Unchanged |
| Capital International Investors | 2,392,541 | $38.6M | 0.01% | +2,392,541 | New |
| Perceptive Advisors LLC | 2,313,272 | $37.3M | 1.32% | −261,451−10.2% | Reduced |
| Paradigm Biocapital Advisors LP | 2,127,205 | $34.3M | 1.58% | +600,000+39.3% | Added |
| Tang Capital Management LLC | 2,050,000 | $33.1M | 1.83% | +2,050,000 | New |
| Commodore Capital LP | 1,988,084 | $32.1M | 2.36% | 00.0% | Unchanged |
| State Street Corp | 1,697,115 | $27.4M | 0.00% | +16,179+1.0% | Added |
| Wellington Management Group LLP | 1,593,678 | $25.7M | 0.00% | −10,830−0.7% | Reduced |
| Jefferies Financial Group Inc. | 1,248,854 | $20.2M | 0.35% | +31,900+2.6% | Added |
| Janus Henderson Group PLC | 1,041,410 | $18.7M | 0.01% | −415,330−28.5% | Reduced |
| Pictet Asset Management Holding SA | 1,068,892 | $17.2M | 0.02% | −23,232−2.1% | Reduced |
| Geode Capital Management, LLC | 1,059,563 | $17.1M | 0.00% | +93,434+9.7% | Added |
| Polar Capital Holdings Plc | 825,000 | $13.3M | 0.08% | +75,000+10.0% | Added |
| Adage Capital Partners GP, L.L.C. | 803,200 | $13.0M | 0.02% | −226,800−22.0% | Reduced |
| Franklin Resources Inc | 760,628 | $12.3M | 0.00% | −140.0% | Reduced |
| UBS Group AG | 552,243 | $8.91M | 0.00% | +160,046+40.8% | Added |
| Emerald Advisers, LLC | 547,827 | $8.84M | 0.40% | +1,036+0.2% | Added |
| Blackstone Group Inc. | 489,248 | $7.89M | 0.03% | +40,047+8.9% | Added |
| Affinity Asset Advisors, LLC | 481,678 | $7.77M | 1.22% | −342,650−41.6% | Reduced |
| Woodline Partners LP | 464,808 | $7.50M | 0.05% | +112,128+31.8% | Added |
| Deerfield Management Company, L.P. (Series C) | 450,000 | $7.26M | 0.14% | 00.0% | Unchanged |
| Bank of America Corp | 427,075 | $6.89M | 0.00% | +419,933+5,879.8% | Added |
| Emerald Mutual Fund Advisers Trust | 389,422 | $6.28M | 0.45% | +3,038+0.8% | Added |
| Charles Schwab Investment Management Inc | 382,636 | $6.17M | 0.00% | +2,986+0.8% | Added |
| Northern Trust Corp | 379,875 | $6.13M | 0.00% | +30,892+8.9% | Added |
| Siren, L.L.C. | 368,598 | $5.95M | 0.34% | −5,402−1.4% | Reduced |
| Capital World Investors | 350,774 | $5.66M | 0.00% | −27,799−7.3% | Reduced |
| Morgan Stanley | 335,467 | $5.41M | 0.00% | +80,211+31.4% | Added |
| Voloridge Investment Management, LLC | 257,432 | $4.15M | 0.02% | +141,962+122.9% | Added |
| Victory Capital Management Inc | 251,846 | $4.06M | 0.00% | −16,230−6.1% | Reduced |
| Price T Rowe Associates Inc | 248,542 | $4.01M | 0.00% | −257,908−50.9% | Reduced |
| Candriam Luxembourg S.C.A. | 246,030 | $3.97M | 0.02% | −1,561−0.6% | Reduced |
| Deep Track Capital, LP | 219,015 | $3.53M | 0.11% | 00.0% | Unchanged |
| Barclays PLC | 214,606 | $3.46M | 0.00% | +91,535+74.4% | Added |
| Armistice Capital, LLC | 200,000 | $3.23M | 0.09% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 197,068 | $3.18M | 0.00% | −550,484−73.6% | Reduced |
| Nuveen, LLC | 140,129 | $2.26M | 0.00% | +140,129 | New |
| StemPoint Capital LP | 136,139 | $2.20M | 0.70% | +136,139 | New |
| Citadel Advisors LLC | 130,884 | $2.11M | 0.00% | −948,423−87.9% | Reduced |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 125,000 | $2.02M | 0.04% | −125,000−50.0% | Reduced |
| Schroder Investment Management Group | 108,504 | $1.95M | 0.00% | −5,116−4.5% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 120,321 | $1.94M | 0.00% | −1,832−1.5% | Reduced |
| Bank of New York Mellon Corp | 114,240 | $1.84M | 0.00% | +10,552+10.2% | Added |
| HighVista Strategies LLC | 95,159 | $1.54M | 0.59% | 00.0% | Unchanged |
| Citigroup Inc | 83,464 | $1.35M | 0.00% | +9,712+13.2% | Added |
| EFG Asset Management (North America) Corp. | 82,472 | $1.33M | 0.22% | −346−0.4% | Reduced |
| Prosight Management, LP | 74,921 | $1.21M | 0.40% | −5,079−6.3% | Reduced |
| Squarepoint Ops LLC | 72,011 | $1.16M | 0.00% | +56,780+372.8% | Added |
| Rafferty Asset Management, LLC | 70,323 | $1.13M | 0.00% | −6,417−8.4% | Reduced |
| B Group, Inc. | 70,000 | $1.13M | 0.98% | +20,000+40.0% | Added |
| Swiss National Bank | 68,600 | $1.11M | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 58,696 | $947.1K | 0.00% | +35,607+154.2% | Added |
| Rhumbline Advisers | 56,023 | $903.9K | 0.00% | −1,634−2.8% | Reduced |
| BNP Paribas Arbitrage, SA | 55,833 | $900.9K | 0.00% | +37,049+197.2% | Added |
| Manufacturers Life Insurance Company, The | 53,901 | $869.7K | 0.00% | +1,139+2.2% | Added |
| UBS Asset Management Americas Inc | 52,138 | $841.2K | 0.00% | +3,157+6.4% | Added |
| F/M Investments LLC | 51,844 | $836.5K | 0.03% | +3,038+6.2% | Added |
| JPMorgan Chase & Co | 41,556 | $670.5K | 0.00% | +6,308+17.9% | Added |
| Wexford Capital LP | 38,292 | $617.8K | 0.16% | +38,292 | New |
| Legal & General Group Plc | 37,844 | $610.6K | 0.00% | +354+0.9% | Added |
| Alliancebernstein L.P. | 36,230 | $584.6K | 0.00% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 34,901 | $563.1K | 0.00% | +3,417+10.9% | Added |
| California State Teachers Retirement System | 32,598 | $526.0K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 30,035 | $484.6K | 0.00% | +5,317+21.5% | Added |
| XTX Topco Ltd | 28,499 | $459.8K | 0.02% | +28,499 | New |
| Deutsche Bank AG | 28,483 | $459.7K | 0.00% | −2,935−9.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 27,018 | $441.8K | 0.00% | +4,277+18.8% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $416.0K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 25,207 | $406.7K | 0.00% | +5,544+28.2% | Added |
| MetLife Investment Management | 23,733 | $382.9K | 0.00% | +2,351+11.0% | Added |
| Assenagon Asset Management S.A. | 22,726 | $366.7K | 0.00% | +74+0.3% | Added |
| TD Asset Management Inc | 22,368 | $360.9K | 0.00% | −42,600−65.6% | Reduced |
| Intech Investment Management LLC | 20,428 | $329.6K | 0.00% | +6,385+45.5% | Added |
| Corebridge Financial, Inc. | 19,595 | $316.2K | 0.00% | +2,382+13.8% | Added |
| NBW Capital LLC | 19,430 | $313.5K | 0.07% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 19,430 | $313.5K | 0.00% | +19,430 | New |
| Global Endowment Management, LP | 18,184 | $293.4K | 0.04% | 00.0% | Unchanged |
| Natixis Advisors, L.P. | 16,401 | $265.0K | 0.00% | −899−5.2% | Reduced |
| ExodusPoint Capital Management, LP | 15,055 | $243.0K | 0.00% | −1,636−9.8% | Reduced |
| ADAR1 Capital Management, LLC | 15,033 | $242.6K | 0.05% | +15,033 | New |
| Profund Advisors LLC | 14,662 | $236.6K | 0.01% | −200−1.3% | Reduced |
| Aquatic Capital Management LLC | 12,903 | $208.2K | 0.01% | +1,136+9.7% | Added |
| China Universal Asset Management Co., Ltd. | 12,087 | $195.0K | 0.02% | −353−2.8% | Reduced |
| ProShare Advisors LLC | 11,378 | $183.6K | 0.00% | −1,153−9.2% | Reduced |
| Voya Investment Management LLC | 10,348 | $167.0K | 0.00% | −147−1.4% | Reduced |
| New York State Common Retirement Fund | 10,265 | $165.6K | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 10,017 | $161.6K | 0.00% | −98−1.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 8,767 | $141.5K | 0.00% | +1,389+18.8% | Added |
| KLP Kapitalforvaltning AS | 7,800 | $125.9K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 7,122 | $115.0K | 0.00% | +7,122 | New |
| Virtus Investment Advisers, Inc. | 6,861 | $110.7K | 0.03% | +6,861 | New |
| Ameritas Investment Partners, Inc. | 4,046 | $65.3K | 0.00% | +654+19.3% | Added |
| Quest Partners LLC | 3,191 | $51.5K | 0.01% | +993+45.2% | Added |