Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 129
- −1 vs. Q4 2024
- Shares held
- 62.1M
- +2.35M (+3.9%) vs. Q4 2024
- Total value
- $1.00B
- −$386.9M (−27.8%) vs. Q4 2024
- New holders
- 20
- 52 more added
- Sold out
- 21
- 35 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 4 | $0 | 0.00% | 00.0% | Unchanged |
| Amundi | 5 | $70 | 0.00% | −27−84.4% | Reduced |
| SBI Securities Co., Ltd. | 5 | $81 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 9 | $145 | 0.00% | +9 | New |
| Allworth Financial LP | 13 | $195 | 0.00% | +4+44.4% | Added |
| Parallel Advisors, LLC | 14 | $226 | 0.00% | +14 | New |
| Stephens Consulting, LLC | 20 | $323 | 0.00% | +20 | New |
| EverSource Wealth Advisors, LLC | 24 | $387 | 0.00% | +16+200.0% | Added |
| Caitong International Asset Management Co., Ltd | 28 | $452 | 0.00% | +14+100.0% | Added |
| CoreCap Advisors, LLC | 41 | $662 | 0.00% | +41 | New |
| Larson Financial Group LLC | 44 | $710 | 0.00% | +44 | New |
| Rothschild Investment LLC | 50 | $807 | 0.00% | +10+25.0% | Added |
| Lindbrook Capital, LLC | 78 | $1.26K | 0.00% | +78 | New |
| IFP Advisors, Inc | 109 | $1.92K | 0.00% | 00.0% | Unchanged |
| Clear Street Markets LLC | 133 | $2.15K | 0.00% | +133 | New |
| Aster Capital Management (DIFC) Ltd | 126 | $2.48K | 0.00% | +126 | New |
| Nisa Investment Advisors, LLC | 184 | $2.97K | 0.00% | +64+53.3% | Added |
| Daiwa Securities Group Inc. | 206 | $3.00K | 0.00% | +206 | New |
| Advisor Group Holdings, Inc. | 238 | $3.84K | 0.00% | +133+126.7% | Added |
| GAMMA Investing LLC | 270 | $4.36K | 0.00% | +270 | New |
| CWM, LLC | 374 | $6.00K | 0.00% | +366+4,575.0% | Added |
| Sterling Capital Management LLC | 629 | $10.1K | 0.00% | −380−37.7% | Reduced |
| Amalgamated Bank | 1,379 | $22.0K | 0.00% | +181+15.1% | Added |
| Huntington National Bank | 1,470 | $23.7K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,502 | $24.2K | 0.00% | +270+21.9% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $26.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 2,044 | $33.0K | 0.00% | −6,530−76.2% | Reduced |
| Royal Bank of Canada | 2,172 | $35.0K | 0.00% | −1,850−46.0% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 2,016 | $36.2K | 0.00% | +61+3.1% | Added |
| Quest Partners LLC | 3,191 | $51.5K | 0.01% | +993+45.2% | Added |
| Ameritas Investment Partners, Inc. | 4,046 | $65.3K | 0.00% | +654+19.3% | Added |
| Virtus Investment Advisers, Inc. | 6,861 | $110.7K | 0.03% | +6,861 | New |
| SG Americas Securities, LLC | 7,122 | $115.0K | 0.00% | +7,122 | New |
| KLP Kapitalforvaltning AS | 7,800 | $125.9K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 8,767 | $141.5K | 0.00% | +1,389+18.8% | Added |
| Arizona State Retirement System | 10,017 | $161.6K | 0.00% | −98−1.0% | Reduced |
| New York State Common Retirement Fund | 10,265 | $165.6K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 10,348 | $167.0K | 0.00% | −147−1.4% | Reduced |
| ProShare Advisors LLC | 11,378 | $183.6K | 0.00% | −1,153−9.2% | Reduced |
| China Universal Asset Management Co., Ltd. | 12,087 | $195.0K | 0.02% | −353−2.8% | Reduced |
| Aquatic Capital Management LLC | 12,903 | $208.2K | 0.01% | +1,136+9.7% | Added |
| Profund Advisors LLC | 14,662 | $236.6K | 0.01% | −200−1.3% | Reduced |
| ADAR1 Capital Management, LLC | 15,033 | $242.6K | 0.05% | +15,033 | New |
| ExodusPoint Capital Management, LP | 15,055 | $243.0K | 0.00% | −1,636−9.8% | Reduced |
| Natixis Advisors, L.P. | 16,401 | $265.0K | 0.00% | −899−5.2% | Reduced |
| Global Endowment Management, LP | 18,184 | $293.4K | 0.04% | 00.0% | Unchanged |
| NBW Capital LLC | 19,430 | $313.5K | 0.07% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 19,430 | $313.5K | 0.00% | +19,430 | New |
| Corebridge Financial, Inc. | 19,595 | $316.2K | 0.00% | +2,382+13.8% | Added |
| Intech Investment Management LLC | 20,428 | $329.6K | 0.00% | +6,385+45.5% | Added |
| TD Asset Management Inc | 22,368 | $360.9K | 0.00% | −42,600−65.6% | Reduced |
| Assenagon Asset Management S.A. | 22,726 | $366.7K | 0.00% | +74+0.3% | Added |
| MetLife Investment Management | 23,733 | $382.9K | 0.00% | +2,351+11.0% | Added |
| Invesco Ltd. | 25,207 | $406.7K | 0.00% | +5,544+28.2% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $416.0K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 27,018 | $441.8K | 0.00% | +4,277+18.8% | Added |
| Deutsche Bank AG | 28,483 | $459.7K | 0.00% | −2,935−9.3% | Reduced |
| XTX Topco Ltd | 28,499 | $459.8K | 0.02% | +28,499 | New |
| Wells Fargo & Company | 30,035 | $484.6K | 0.00% | +5,317+21.5% | Added |
| California State Teachers Retirement System | 32,598 | $526.0K | 0.00% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 34,901 | $563.1K | 0.00% | +3,417+10.9% | Added |
| Alliancebernstein L.P. | 36,230 | $584.6K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 37,844 | $610.6K | 0.00% | +354+0.9% | Added |
| Wexford Capital LP | 38,292 | $617.8K | 0.16% | +38,292 | New |
| JPMorgan Chase & Co | 41,556 | $670.5K | 0.00% | +6,308+17.9% | Added |
| F/M Investments LLC | 51,844 | $836.5K | 0.03% | +3,038+6.2% | Added |
| UBS Asset Management Americas Inc | 52,138 | $841.2K | 0.00% | +3,157+6.4% | Added |
| Manufacturers Life Insurance Company, The | 53,901 | $869.7K | 0.00% | +1,139+2.2% | Added |
| BNP Paribas Arbitrage, SA | 55,833 | $900.9K | 0.00% | +37,049+197.2% | Added |
| Rhumbline Advisers | 56,023 | $903.9K | 0.00% | −1,634−2.8% | Reduced |
| Susquehanna International Group, LLP | 58,696 | $947.1K | 0.00% | +35,607+154.2% | Added |
| Swiss National Bank | 68,600 | $1.11M | 0.00% | 00.0% | Unchanged |
| B Group, Inc. | 70,000 | $1.13M | 0.98% | +20,000+40.0% | Added |
| Rafferty Asset Management, LLC | 70,323 | $1.13M | 0.00% | −6,417−8.4% | Reduced |
| Squarepoint Ops LLC | 72,011 | $1.16M | 0.00% | +56,780+372.8% | Added |
| Prosight Management, LP | 74,921 | $1.21M | 0.40% | −5,079−6.3% | Reduced |
| EFG Asset Management (North America) Corp. | 82,472 | $1.33M | 0.22% | −346−0.4% | Reduced |
| Citigroup Inc | 83,464 | $1.35M | 0.00% | +9,712+13.2% | Added |
| HighVista Strategies LLC | 95,159 | $1.54M | 0.59% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 114,240 | $1.84M | 0.00% | +10,552+10.2% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 120,321 | $1.94M | 0.00% | −1,832−1.5% | Reduced |
| Schroder Investment Management Group | 108,504 | $1.95M | 0.00% | −5,116−4.5% | Reduced |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 125,000 | $2.02M | 0.04% | −125,000−50.0% | Reduced |
| Citadel Advisors LLC | 130,884 | $2.11M | 0.00% | −948,423−87.9% | Reduced |
| StemPoint Capital LP | 136,139 | $2.20M | 0.70% | +136,139 | New |
| Nuveen, LLC | 140,129 | $2.26M | 0.00% | +140,129 | New |
| Goldman Sachs Group Inc | 197,068 | $3.18M | 0.00% | −550,484−73.6% | Reduced |
| Armistice Capital, LLC | 200,000 | $3.23M | 0.09% | 00.0% | Unchanged |
| Barclays PLC | 214,606 | $3.46M | 0.00% | +91,535+74.4% | Added |
| Deep Track Capital, LP | 219,015 | $3.53M | 0.11% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 246,030 | $3.97M | 0.02% | −1,561−0.6% | Reduced |
| Price T Rowe Associates Inc | 248,542 | $4.01M | 0.00% | −257,908−50.9% | Reduced |
| Victory Capital Management Inc | 251,846 | $4.06M | 0.00% | −16,230−6.1% | Reduced |
| Voloridge Investment Management, LLC | 257,432 | $4.15M | 0.02% | +141,962+122.9% | Added |
| Morgan Stanley | 335,467 | $5.41M | 0.00% | +80,211+31.4% | Added |
| Capital World Investors | 350,774 | $5.66M | 0.00% | −27,799−7.3% | Reduced |
| Siren, L.L.C. | 368,598 | $5.95M | 0.34% | −5,402−1.4% | Reduced |
| Northern Trust Corp | 379,875 | $6.13M | 0.00% | +30,892+8.9% | Added |
| Charles Schwab Investment Management Inc | 382,636 | $6.17M | 0.00% | +2,986+0.8% | Added |
| Emerald Mutual Fund Advisers Trust | 389,422 | $6.28M | 0.45% | +3,038+0.8% | Added |