Skip to main content
Livermore
Livermore
ZHEN

Spyre Therapeutics, Inc.

SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001636282

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

13F holders, Q3 2023

Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
29
−15 vs. Q2 2023
Shares held
3.58M
+740.7K (+26.1%) vs. Q2 2023Converted for a 1-for-25 split
Total value
$43.9M
+$11.9M (+37.4%) vs. Q2 2023
New holders
3
11 more added
Sold out
18
8 more reduced

Compare with Q2 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2023: 29 institutions
Q1 2021: 84 institutionsQ2 2021: 78 institutionsQ3 2021: 77 institutionsQ4 2021: 86 institutionsQ1 2022: 84 institutionsQ2 2022: 67 institutionsQ3 2022: 55 institutionsQ4 2022: 51 institutionsQ1 2023: 45 institutionsQ2 2023: 44 institutionsQ3 2023: 29 institutionsQ4 2023: 54 institutionsQ1 2024: 103 institutionsQ2 2024: 107 institutionsQ3 2024: 119 institutionsQ4 2024: 131 institutionsQ1 2025: 129 institutionsQ2 2025: 129 institutionsQ3 2025: 137 institutionsQ4 2025: 153 institutionsQ1 2026: 198 institutionsQ2 2026: 265 institutions
Value heldQ3 2023: $43.9M
Q1 2021: $328.7MQ2 2021: $285.8MQ3 2021: $322.5MQ4 2021: $189.4MQ1 2022: $95.4MQ2 2022: $24.8MQ3 2022: $23.5MQ4 2022: $19.2MQ1 2023: $12.0MQ2 2023: $31.9MQ3 2023: $43.9MQ4 2023: $601.0MQ1 2024: $1.21BQ2 2024: $1.18BQ3 2024: $1.51BQ4 2024: $1.39BQ1 2025: $1.00BQ2 2025: $952.6MQ3 2025: $1.08BQ4 2025: $2.65BQ1 2026: $4.16BQ2 2026: $8.52B
Institutions holding SYRE and their total value by quarter
QuarterHoldersValue
Q2 2026265$8.52B
Q1 2026198$4.16B
Q4 2025153$2.65B
Q3 2025137$1.08B
Q2 2025129$952.6M
Q1 2025129$1.00B
Q4 2024131$1.39B
Q3 2024119$1.51B
Q2 2024107$1.18B
Q1 2024103$1.21B
Q4 202354$601.0M
Q3 202329$43.9M
Q2 202344$31.9M
Q1 202345$12.0M
Q4 202251$19.2M
Q3 202255$23.5M
Q2 202267$24.8M
Q1 202284$95.4M
Q4 202186$189.4M
Q3 202177$322.5M
Q2 202178$285.8M
Q1 202184$328.7M

Institutions, Q3 2023

Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2023.

Institutions holding SYRE in Q3 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Driehaus Capital Management LLC800,853$9.81M0.13%+615,119+331.2%AddedConverted for a 1-for-25 split
Fairmount Funds Management LLC378,421$4.64M0.56%00.0%UnchangedConverted for a 1-for-25 split
Polar Capital Holdings Plc300,000$3.67M0.03%+300,000New
Wellington Management Group LLP299,929$3.67M0.00%−52,838−15.0%ReducedConverted for a 1-for-25 split
VR Adviser, LLC295,034$3.61M0.38%+41,305+16.3%AddedConverted for a 1-for-25 split
Affinity Asset Advisors, LLC242,297$2.97M0.97%+46,297+23.6%AddedConverted for a 1-for-25 split
Logos Global Management LP210,000$2.57M0.37%+84,285+67.0%AddedConverted for a 1-for-25 split
EcoR1 Capital, LLC199,996$2.45M0.08%00.0%UnchangedConverted for a 1-for-25 split
Suvretta Capital Management, LLC162,395$1.99M0.11%00.0%UnchangedConverted for a 1-for-25 split
Rock Springs Capital Management LP136,556$1.67M0.04%00.0%UnchangedConverted for a 1-for-25 split
Commodore Capital LP116,324$1.42M0.17%00.0%UnchangedConverted for a 1-for-25 split
Citadel Advisors LLC97,053$1.19M0.00%+97,053New
Perceptive Advisors LLC81,116$993.7K0.03%+81,116New
Aisling Capital Management LP67,645$828.7K0.34%00.0%UnchangedConverted for a 1-for-25 split
Millennium Management LLC37,813$463.2K0.00%−60,316−61.5%ReducedConverted for a 1-for-25 split
Vanguard Group Inc33,077$405.2K0.00%+7,155+27.6%AddedConverted for a 1-for-25 split
Fan Yu20,592$347.8K24.67%+16,110+359.5%AddedConverted for a 1-for-25 split
Geode Capital Management, LLC26,800$328.4K0.00%+2,782+11.6%AddedConverted for a 1-for-25 split
Renaissance Technologies LLC23,229$285.0K0.00%+7,509+47.8%AddedConverted for a 1-for-25 split
BlackRock Inc.19,768$242.2K0.00%−1,388−6.6%ReducedConverted for a 1-for-25 split
Acadian Asset Management LLC11,888$145.0K0.00%−43,767−78.6%ReducedConverted for a 1-for-25 split
Avoro Capital Advisors LLC11,458$140.4K0.00%00.0%UnchangedConverted for a 1-for-25 split
Tower Research Capital LLC (TRC)422$5.17K0.00%−488−53.6%ReducedConverted for a 1-for-25 split
Royal Bank of Canada437$5.00K0.00%+384+729.5%AddedConverted for a 1-for-25 split
Advisor Group Holdings, Inc.283$3.47K0.00%+83+41.5%AddedConverted for a 1-for-25 split
IFP Advisors, Inc2,974$3.12K0.00%+2,860+2,499.7%AddedConverted for a 1-for-25 split
Morgan Stanley46$5640.00%−86−65.2%ReducedConverted for a 1-for-25 split
JPMorgan Chase & Co41$5020.00%−2−4.0%ReducedConverted for a 1-for-25 split
Wells Fargo & Company22$2700.00%−328−93.7%ReducedConverted for a 1-for-25 split
Nantahala Capital Management, LLC0$00.00%−164,048−100.0%Sold outConverted for a 1-for-25 split
Baker Bros. Advisors LP0$00.00%−136,404−100.0%Sold outConverted for a 1-for-25 split
Samsara BioCapital, LLC0$00.00%−35,349−100.0%Sold outConverted for a 1-for-25 split
Goldman Sachs Group Inc0$00.00%−22,346−100.0%Sold outConverted for a 1-for-25 split
University of Texas/Texas Am Investment Managment Co0$00.00%−9,827−100.0%Sold outConverted for a 1-for-25 split
Carlyle Group Inc.0$00.00%−9,620−100.0%Sold outConverted for a 1-for-25 split
State Street Corp0$00.00%−7,804−100.0%Sold outConverted for a 1-for-25 split
HRT Financial LP0$00.00%−6,581−100.0%Sold outConverted for a 1-for-25 split
Northern Trust Corp0$00.00%−3,917−100.0%Sold outConverted for a 1-for-25 split
Jane Street Group, LLC0$00.00%−2,171−100.0%Sold outConverted for a 1-for-25 split
Susquehanna International Group, LLP0$00.00%−1,447−100.0%Sold outConverted for a 1-for-25 split
Franklin Resources Inc0$00.00%−1,255−100.0%Sold outConverted for a 1-for-25 split
Bank of New York Mellon Corp0$00.00%−929−100.0%Sold outConverted for a 1-for-25 split
UBS Group AG0$00.00%−324−100.0%Sold outConverted for a 1-for-25 split
Simplex Trading, LLC0$00.00%−112−100.0%Sold outConverted for a 1-for-25 split
Group One Trading, L.P.0$00.00%−23−100.0%Sold outConverted for a 1-for-25 split
Barclays PLC0$00.00%−4−100.0%Sold outConverted for a 1-for-25 split
BNP Paribas Arbitrage, SA0$00.00%−0−100.0%Sold outConverted for a 1-for-25 split