Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 78
- −6 vs. Q1 2021
- Shares held
- 41.1M
- −436.4K (−1.1%) vs. Q1 2021
- Total value
- $285.8M
- −$42.9M (−13.0%) vs. Q1 2021
- New holders
- 3
- 29 more added
- Sold out
- 9
- 26 more reduced
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 4,015,524 | $27.9M | 0.29% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 3,410,106 | $23.7M | 0.10% | 00.0% | Unchanged |
| BlackRock Inc. | 3,103,879 | $21.6M | 0.00% | −246,433−7.4% | Reduced |
| Adage Capital Partners GP, L.L.C. | 3,049,581 | $21.2M | 0.04% | +101,440+3.4% | Added |
| Bain Capital Life Sciences Investors, LLC | 2,700,000 | $18.8M | 1.23% | 00.0% | Unchanged |
| Pictet Asset Management Ltd | 2,532,799 | $17.6M | 0.02% | +13,465+0.5% | Added |
| Vanguard Group Inc | 2,097,166 | $14.6M | 0.00% | −76,896−3.5% | Reduced |
| Suvretta Capital Management, LLC | 2,094,100 | $14.6M | 0.22% | +727,027+53.2% | Added |
| Aisling Capital Management LP | 1,691,151 | $11.8M | 1.88% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 1,677,036 | $11.7M | 0.64% | −35,052−2.0% | Reduced |
| Rock Springs Capital Management LP | 1,577,296 | $11.0M | 0.22% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,131,059 | $7.87M | 0.00% | −5,614−0.5% | Reduced |
| Artal Group S.A. | 1,045,000 | $7.27M | 0.17% | 00.0% | Unchanged |
| Great Point Partners LLC | 900,000 | $6.26M | 1.40% | +397,100+79.0% | Added |
| Samsara BioCapital, LLC | 883,720 | $6.15M | 0.81% | 00.0% | Unchanged |
| State Street Corp | 757,500 | $5.27M | 0.00% | +39,025+5.4% | Added |
| Geode Capital Management, LLC | 677,726 | $4.72M | 0.00% | +19,856+3.0% | Added |
| Marshall Wace, LLP | 651,403 | $4.53M | 0.02% | −539,836−45.3% | Reduced |
| Altium Capital Management LP | 609,689 | $4.24M | 0.98% | +341,936+127.7% | Added |
| Dimensional Fund Advisors LP | 604,112 | $4.21M | 0.00% | +10,695+1.8% | Added |
| Boxer Capital, LLC | 550,000 | $3.83M | 0.14% | 00.0% | Unchanged |
| Millennium Management LLC | 543,185 | $3.78M | 0.00% | +172,049+46.4% | Added |
| Point72 Asset Management, L.P. | 469,765 | $3.27M | 0.02% | −1,030,235−68.7% | Reduced |
| AXA S.A. | 424,352 | $2.95M | 0.01% | +432+0.1% | Added |
| Sio Capital Management, LLC | 402,653 | $2.80M | 0.76% | 00.0% | Unchanged |
| Northern Trust Corp | 368,340 | $2.56M | 0.00% | −82,980−18.4% | Reduced |
| Lion Point Capital, LP | 300,000 | $2.09M | 0.49% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 282,068 | $1.96M | 0.01% | +134,278+90.9% | Added |
| University of Texas/Texas Am Investment Managment Co | 269,578 | $1.88M | 1.44% | −10,100−3.6% | Reduced |
| Abingworth LLP | 240,500 | $1.67M | 0.52% | 00.0% | Unchanged |
| Morgan Stanley | 195,535 | $1.36M | 0.00% | +84,445+76.0% | Added |
| Nuveen Asset Management, LLC | 184,271 | $1.28M | 0.00% | +26,400+16.7% | Added |
| Ritholtz Wealth Management | 174,646 | $1.22M | 0.09% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 147,401 | $1.03M | 0.00% | +4,128+2.9% | Added |
| Fan Yu | 112,044 | $780.0K | 8.81% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 105,779 | $737.0K | 0.00% | −5,004−4.5% | Reduced |
| Franklin Street Advisors Inc | 103,600 | $721.0K | 0.06% | 00.0% | Unchanged |
| AlphaCentric Advisors LLC | 92,500 | $644.0K | 0.17% | +71,500+340.5% | Added |
| JPMorgan Chase & Co | 87,633 | $610.0K | 0.00% | +58,637+202.2% | Added |
| Jacobs Levy Equity Management, Inc | 59,294 | $413.0K | 0.00% | −130,139−68.7% | Reduced |
| California State Teachers Retirement System | 55,861 | $389.0K | 0.00% | −12,414−18.2% | Reduced |
| Rhumbline Advisers | 52,667 | $367.0K | 0.00% | +6,335+13.7% | Added |
| Blair William & Co | 52,204 | $363.0K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 52,077 | $362.0K | 0.00% | +2,104+4.2% | Added |
| Renaissance Technologies LLC | 50,787 | $353.0K | 0.00% | +40,287+383.7% | Added |
| D. E. Shaw & Co., Inc. | 45,981 | $320.0K | 0.00% | −16,766−26.7% | Reduced |
| Algert Global LLC | 41,500 | $289.0K | 0.10% | −25,320−37.9% | Reduced |
| Ergoteles LLC | 34,100 | $237.0K | 0.01% | +34,100 | New |
| Parametric Portfolio Associates LLC | 33,148 | $231.0K | 0.00% | +6,558+24.7% | Added |
| New York State Common Retirement Fund | 31,484 | $219.0K | 0.00% | +384+1.2% | Added |
| Manufacturers Life Insurance Company, The | 26,523 | $185.0K | 0.00% | −2,574−8.8% | Reduced |
| Alliancebernstein L.P. | 25,600 | $178.0K | 0.00% | +2,200+9.4% | Added |
| Deutsche Bank AG | 23,993 | $167.0K | 0.00% | −6,725−21.9% | Reduced |
| Russell Investments Group, Ltd. | 24,035 | $165.0K | 0.00% | −60,446−71.5% | Reduced |
| American International Group, Inc. | 22,645 | $158.0K | 0.00% | −3,665−13.9% | Reduced |
| California Public Employees Retirement System | 20,841 | $145.0K | 0.00% | −64,459−75.6% | Reduced |
| Bank of America Corp | 20,216 | $141.0K | 0.00% | −19,474−49.1% | Reduced |
| Voya Investment Management LLC | 19,878 | $138.0K | 0.00% | −1,616−7.5% | Reduced |
| ProShare Advisors LLC | 19,293 | $134.0K | 0.00% | +596+3.2% | Added |
| Cerity Partners LLC | 18,000 | $125.0K | 0.00% | +18,000 | New |
| Invesco Ltd. | 13,045 | $90.0K | 0.00% | +13,045 | New |
| Cubist Systematic Strategies, LLC | 11,722 | $82.0K | 0.00% | −6,113−34.3% | Reduced |
| Personal Cfo Solutions, LLC | 11,388 | $79.0K | 0.02% | 00.0% | Unchanged |
| Barclays PLC | 5,668 | $40.0K | 0.00% | −32,294−85.1% | Reduced |
| Citigroup Inc | 4,983 | $35.0K | 0.00% | +872+21.2% | Added |
| BNP Paribas Arbitrage, SA | 4,705 | $32.7K | 0.00% | −2,255−32.4% | Reduced |
| IFP Advisors, Inc | 3,980 | $27.0K | 0.00% | +500+14.4% | Added |
| Ameritas Investment Partners, Inc. | 3,710 | $26.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 3,264 | $23.0K | 0.00% | −1,509−31.6% | Reduced |
| Tower Research Capital LLC (TRC) | 3,021 | $21.0K | 0.00% | +372+14.0% | Added |
| Royal Bank of Canada | 2,966 | $20.0K | 0.00% | −983−24.9% | Reduced |
| Wells Fargo & Company | 2,212 | $16.0K | 0.00% | −9,619−81.3% | Reduced |
| O'Shaughnessy Asset Management, LLC | 1,654 | $12.0K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 1,137 | $8.00K | 0.00% | 00.0% | Unchanged |
| Penserra Capital Management LLC | 1,115 | $7.00K | 0.00% | +25+2.3% | Added |
| Group One Trading, L.P. | 300 | $2.00K | 0.00% | +100+50.0% | Added |
| Daiwa Securities Group Inc. | 98 | $1.00K | 0.00% | 00.0% | Unchanged |
| Ellevest, Inc. | 150 | $1.00K | 0.00% | +37+32.7% | Added |
| Driehaus Capital Management LLC | 0 | $0 | 0.00% | −175,000−100.0% | Sold out |
| State of Wisconsin Investment Board | 0 | $0 | 0.00% | −60,300−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −33,800−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −20,285−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −18,332−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −12,039−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −10,800−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −3,727−100.0% | Sold out |
| FNY Investment Advisers, LLC | 0 | $0 | 0.00% | −1,500−100.0% | Sold out |