Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 78
- −6 vs. Q1 2021
- Shares held
- 41.1M
- −436.4K (−1.1%) vs. Q1 2021
- Total value
- $285.8M
- −$42.9M (−13.0%) vs. Q1 2021
- New holders
- 3
- 29 more added
- Sold out
- 9
- 26 more reduced
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 98 | $1.00K | 0.00% | 00.0% | Unchanged |
| Ellevest, Inc. | 150 | $1.00K | 0.00% | +37+32.7% | Added |
| Group One Trading, L.P. | 300 | $2.00K | 0.00% | +100+50.0% | Added |
| Penserra Capital Management LLC | 1,115 | $7.00K | 0.00% | +25+2.3% | Added |
| Quadrant Capital Group LLC | 1,137 | $8.00K | 0.00% | 00.0% | Unchanged |
| O'Shaughnessy Asset Management, LLC | 1,654 | $12.0K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 2,212 | $16.0K | 0.00% | −9,619−81.3% | Reduced |
| Royal Bank of Canada | 2,966 | $20.0K | 0.00% | −983−24.9% | Reduced |
| Tower Research Capital LLC (TRC) | 3,021 | $21.0K | 0.00% | +372+14.0% | Added |
| Legal & General Group Plc | 3,264 | $23.0K | 0.00% | −1,509−31.6% | Reduced |
| Ameritas Investment Partners, Inc. | 3,710 | $26.0K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 3,980 | $27.0K | 0.00% | +500+14.4% | Added |
| BNP Paribas Arbitrage, SA | 4,705 | $32.7K | 0.00% | −2,255−32.4% | Reduced |
| Citigroup Inc | 4,983 | $35.0K | 0.00% | +872+21.2% | Added |
| Barclays PLC | 5,668 | $40.0K | 0.00% | −32,294−85.1% | Reduced |
| Personal Cfo Solutions, LLC | 11,388 | $79.0K | 0.02% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 11,722 | $82.0K | 0.00% | −6,113−34.3% | Reduced |
| Invesco Ltd. | 13,045 | $90.0K | 0.00% | +13,045 | New |
| Cerity Partners LLC | 18,000 | $125.0K | 0.00% | +18,000 | New |
| ProShare Advisors LLC | 19,293 | $134.0K | 0.00% | +596+3.2% | Added |
| Voya Investment Management LLC | 19,878 | $138.0K | 0.00% | −1,616−7.5% | Reduced |
| Bank of America Corp | 20,216 | $141.0K | 0.00% | −19,474−49.1% | Reduced |
| California Public Employees Retirement System | 20,841 | $145.0K | 0.00% | −64,459−75.6% | Reduced |
| American International Group, Inc. | 22,645 | $158.0K | 0.00% | −3,665−13.9% | Reduced |
| Russell Investments Group, Ltd. | 24,035 | $165.0K | 0.00% | −60,446−71.5% | Reduced |
| Deutsche Bank AG | 23,993 | $167.0K | 0.00% | −6,725−21.9% | Reduced |
| Alliancebernstein L.P. | 25,600 | $178.0K | 0.00% | +2,200+9.4% | Added |
| Manufacturers Life Insurance Company, The | 26,523 | $185.0K | 0.00% | −2,574−8.8% | Reduced |
| New York State Common Retirement Fund | 31,484 | $219.0K | 0.00% | +384+1.2% | Added |
| Parametric Portfolio Associates LLC | 33,148 | $231.0K | 0.00% | +6,558+24.7% | Added |
| Ergoteles LLC | 34,100 | $237.0K | 0.01% | +34,100 | New |
| Algert Global LLC | 41,500 | $289.0K | 0.10% | −25,320−37.9% | Reduced |
| D. E. Shaw & Co., Inc. | 45,981 | $320.0K | 0.00% | −16,766−26.7% | Reduced |
| Renaissance Technologies LLC | 50,787 | $353.0K | 0.00% | +40,287+383.7% | Added |
| UBS Group AG | 52,077 | $362.0K | 0.00% | +2,104+4.2% | Added |
| Blair William & Co | 52,204 | $363.0K | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 52,667 | $367.0K | 0.00% | +6,335+13.7% | Added |
| California State Teachers Retirement System | 55,861 | $389.0K | 0.00% | −12,414−18.2% | Reduced |
| Jacobs Levy Equity Management, Inc | 59,294 | $413.0K | 0.00% | −130,139−68.7% | Reduced |
| JPMorgan Chase & Co | 87,633 | $610.0K | 0.00% | +58,637+202.2% | Added |
| AlphaCentric Advisors LLC | 92,500 | $644.0K | 0.17% | +71,500+340.5% | Added |
| Franklin Street Advisors Inc | 103,600 | $721.0K | 0.06% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 105,779 | $737.0K | 0.00% | −5,004−4.5% | Reduced |
| Fan Yu | 112,044 | $780.0K | 8.81% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 147,401 | $1.03M | 0.00% | +4,128+2.9% | Added |
| Ritholtz Wealth Management | 174,646 | $1.22M | 0.09% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 184,271 | $1.28M | 0.00% | +26,400+16.7% | Added |
| Morgan Stanley | 195,535 | $1.36M | 0.00% | +84,445+76.0% | Added |
| Abingworth LLP | 240,500 | $1.67M | 0.52% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 269,578 | $1.88M | 1.44% | −10,100−3.6% | Reduced |
| Assenagon Asset Management S.A. | 282,068 | $1.96M | 0.01% | +134,278+90.9% | Added |
| Lion Point Capital, LP | 300,000 | $2.09M | 0.49% | 00.0% | Unchanged |
| Northern Trust Corp | 368,340 | $2.56M | 0.00% | −82,980−18.4% | Reduced |
| Sio Capital Management, LLC | 402,653 | $2.80M | 0.76% | 00.0% | Unchanged |
| AXA S.A. | 424,352 | $2.95M | 0.01% | +432+0.1% | Added |
| Point72 Asset Management, L.P. | 469,765 | $3.27M | 0.02% | −1,030,235−68.7% | Reduced |
| Millennium Management LLC | 543,185 | $3.78M | 0.00% | +172,049+46.4% | Added |
| Boxer Capital, LLC | 550,000 | $3.83M | 0.14% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 604,112 | $4.21M | 0.00% | +10,695+1.8% | Added |
| Altium Capital Management LP | 609,689 | $4.24M | 0.98% | +341,936+127.7% | Added |
| Marshall Wace, LLP | 651,403 | $4.53M | 0.02% | −539,836−45.3% | Reduced |
| Geode Capital Management, LLC | 677,726 | $4.72M | 0.00% | +19,856+3.0% | Added |
| State Street Corp | 757,500 | $5.27M | 0.00% | +39,025+5.4% | Added |
| Samsara BioCapital, LLC | 883,720 | $6.15M | 0.81% | 00.0% | Unchanged |
| Great Point Partners LLC | 900,000 | $6.26M | 1.40% | +397,100+79.0% | Added |
| Artal Group S.A. | 1,045,000 | $7.27M | 0.17% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,131,059 | $7.87M | 0.00% | −5,614−0.5% | Reduced |
| Rock Springs Capital Management LP | 1,577,296 | $11.0M | 0.22% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 1,677,036 | $11.7M | 0.64% | −35,052−2.0% | Reduced |
| Aisling Capital Management LP | 1,691,151 | $11.8M | 1.88% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 2,094,100 | $14.6M | 0.22% | +727,027+53.2% | Added |
| Vanguard Group Inc | 2,097,166 | $14.6M | 0.00% | −76,896−3.5% | Reduced |
| Pictet Asset Management Ltd | 2,532,799 | $17.6M | 0.02% | +13,465+0.5% | Added |
| Bain Capital Life Sciences Investors, LLC | 2,700,000 | $18.8M | 1.23% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 3,049,581 | $21.2M | 0.04% | +101,440+3.4% | Added |
| BlackRock Inc. | 3,103,879 | $21.6M | 0.00% | −246,433−7.4% | Reduced |
| Baker Bros. Advisors LP | 3,410,106 | $23.7M | 0.10% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 4,015,524 | $27.9M | 0.29% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 0 | $0 | 0.00% | −175,000−100.0% | Sold out |
| State of Wisconsin Investment Board | 0 | $0 | 0.00% | −60,300−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −33,800−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −20,285−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −18,332−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −12,039−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −10,800−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −3,727−100.0% | Sold out |
| FNY Investment Advisers, LLC | 0 | $0 | 0.00% | −1,500−100.0% | Sold out |