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Spyre Therapeutics, Inc.

SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001636282

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

13F holders, Q1 2023

Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
45
−5 vs. Q4 2022
Shares held
41.3M
−1.10M (−2.6%) vs. Q4 2022
Total value
$12.0M
−$7.10M (−37.2%) vs. Q4 2022
New holders
3
9 more added
Sold out
8
9 more reduced

1 institution that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2023: 45 institutions
Q1 2021: 84 institutionsQ2 2021: 78 institutionsQ3 2021: 77 institutionsQ4 2021: 86 institutionsQ1 2022: 84 institutionsQ2 2022: 67 institutionsQ3 2022: 55 institutionsQ4 2022: 51 institutionsQ1 2023: 45 institutionsQ2 2023: 44 institutionsQ3 2023: 29 institutionsQ4 2023: 54 institutionsQ1 2024: 103 institutionsQ2 2024: 107 institutionsQ3 2024: 119 institutionsQ4 2024: 131 institutionsQ1 2025: 129 institutionsQ2 2025: 129 institutionsQ3 2025: 137 institutionsQ4 2025: 153 institutionsQ1 2026: 198 institutionsQ2 2026: 265 institutions
Value heldQ1 2023: $12.0M
Q1 2021: $328.7MQ2 2021: $285.8MQ3 2021: $322.5MQ4 2021: $189.4MQ1 2022: $95.4MQ2 2022: $24.8MQ3 2022: $23.5MQ4 2022: $19.2MQ1 2023: $12.0MQ2 2023: $31.9MQ3 2023: $43.9MQ4 2023: $601.0MQ1 2024: $1.21BQ2 2024: $1.18BQ3 2024: $1.51BQ4 2024: $1.39BQ1 2025: $1.00BQ2 2025: $952.6MQ3 2025: $1.08BQ4 2025: $2.65BQ1 2026: $4.16BQ2 2026: $8.52B
Institutions holding SYRE and their total value by quarter
QuarterHoldersValue
Q2 2026265$8.52B
Q1 2026198$4.16B
Q4 2025153$2.65B
Q3 2025137$1.08B
Q2 2025129$952.6M
Q1 2025129$1.00B
Q4 2024131$1.39B
Q3 2024119$1.51B
Q2 2024107$1.18B
Q1 2024103$1.21B
Q4 202354$601.0M
Q3 202329$43.9M
Q2 202344$31.9M
Q1 202345$12.0M
Q4 202251$19.2M
Q3 202255$23.5M
Q2 202267$24.8M
Q1 202284$95.4M
Q4 202186$189.4M
Q3 202177$322.5M
Q2 202178$285.8M
Q1 202184$328.7M

Institutions, Q1 2023

Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2022.

Institutions holding SYRE in Q1 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Bain Capital Life Sciences Investors, LLC5,347,689$1.55M0.19%00.0%Unchanged
Nantahala Capital Management, LLC4,558,012$1.32M0.13%−53,290−1.2%Reduced
Suvretta Capital Management, LLC4,059,894$1.18M0.06%00.0%Unchanged
Millennium Management LLC3,736,483$1.08M0.00%+605,004+19.3%Added
Rock Springs Capital Management LP3,413,906$990.0K0.02%00.0%Unchanged
Baker Bros. Advisors LP3,410,106$988.9K0.01%00.0%Unchanged
Sio Capital Management, LLC3,004,959$871.4K0.43%00.0%Unchanged
Vanguard Group Inc1,997,597$579.3K0.00%00.0%Unchanged
OrbiMed Advisors LLC1,797,221$521.2K0.01%00.0%Unchanged
Aisling Capital Management LP1,691,151$490.4K0.24%00.0%Unchanged
Adage Capital Partners GP, L.L.C.1,500,000$435.0K0.00%00.0%Unchanged
Acadian Asset Management LLC1,391,381$402.0K0.00%00.0%Unchanged
Samsara BioCapital, LLC883,720$256.3K0.05%00.0%Unchanged
BlackRock Inc.648,648$188.1K0.00%+2,694+0.4%Added
Sphera Funds Management Ltd.646,478$187.5K0.04%+205,641+46.6%Added
Geode Capital Management, LLC600,455$174.1K0.00%00.0%Unchanged
Two Sigma Investments, LP320,498$92.9K0.00%−73,140−18.6%Reduced
Assenagon Asset Management S.A.318,451$92.4K0.00%00.0%Unchanged
University of Texas/Texas Am Investment Managment Co245,678$71.0K0.03%00.0%Unchanged
Carlyle Group Inc.240,500$69.0K0.00%+240,500New
State Street Corp214,989$62.3K0.00%00.0%Unchanged
Two Sigma Advisers, LP210,800$61.1K0.00%−62,000−22.7%Reduced
Renaissance Technologies LLC181,100$53.0K0.00%+30,000+19.9%Added
Bridgeway Capital Management, LLC150,000$43.5K0.00%00.0%Unchanged
ExodusPoint Capital Management, LP117,479$34.0K0.00%+12,217+11.6%Added
Fan Yu112,044$32.5K1.79%00.0%Unchanged
Franklin Street Advisors Inc105,800$31.0K0.00%00.0%Unchanged
Northern Trust Corp97,927$28.4K0.00%+11,502+13.3%Added
Blair William & Co60,302$17.5K0.00%−16,292−21.3%Reduced
Jane Street Group, LLC42,763$12.4K0.00%+42,763New
Ritholtz Wealth Management41,774$12.1K0.00%−34,716−45.4%Reduced
Tower Research Capital LLC (TRC)37,381$11.0K0.00%+19,537+109.5%Added
Bank of America Corp35,230$10.2K0.00%+19,460+123.4%Added
Franklin Resources Inc31,364$9.10K0.00%00.0%Unchanged
Bank of New York Mellon Corp23,233$6.74K0.00%00.0%Unchanged
Virtu Financial LLC19,295$6.00K0.00%+19,295New
Morgan Stanley13,656$3.96K0.00%−66,805−83.0%Reduced
Wells Fargo & Company8,224$2.38K0.00%+5,681+223.4%Added
Group One Trading, L.P.2,882$8360.00%−300−9.4%Reduced
BNP Paribas Arbitrage, SA396$1150.00%−2,572−86.7%Reduced
Barclays PLC99$290.00%00.0%Unchanged
UBS Group AG7$20.00%−1−12.5%Reduced
JPMorgan Chase & Co1,068$00.00%00.0%Unchanged
Simplex Trading, LLC56$00.00%00.0%Unchanged
IFP Advisors, Inc2,860––00.0%Unchanged
Pura Vida Investments, LLC0$00.00%−1,048,697−100.0%Sold out
Ghost Tree Capital, LLC0$00.00%−800,000−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−50,943−100.0%Sold out
HRT Financial LP0$00.00%−49,978−100.0%Sold out
Prudential Financial Inc0$00.00%−17,200−100.0%Sold out
Citadel Advisors LLC0$00.00%−15,472−100.0%Sold out
Ergoteles LLC0$00.00%−14,722−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−11,272−100.0%Sold out
Abingworth LLP––––Not filed