Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 86
- +10 vs. Q3 2021
- Shares held
- 39.9M
- −661.2K (−1.6%) vs. Q3 2021
- Total value
- $189.4M
- −$133.1M (−41.3%) vs. Q3 2021
- New holders
- 19
- 26 more added
- Sold out
- 9
- 22 more reduced
1 institution that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Baker Bros. Advisors LP | 3,410,106 | $16.2M | 0.08% | 00.0% | Unchanged |
| BlackRock Inc. | 2,998,479 | $14.2M | 0.00% | +14,584+0.5% | Added |
| OrbiMed Advisors LLC | 2,956,124 | $14.0M | 0.18% | −1,059,400−26.4% | Reduced |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $13.5M | 1.07% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 2,813,560 | $13.4M | 0.83% | +1,296,605+85.5% | Added |
| Suvretta Capital Management, LLC | 2,571,000 | $12.2M | 0.24% | +413,273+19.2% | Added |
| Pictet Asset Management SA | 2,468,129 | $11.7M | 0.01% | −64,670−2.6% | Reduced |
| Vanguard Group Inc | 2,120,625 | $10.1M | 0.00% | +11,865+0.6% | Added |
| Aisling Capital Management LP | 1,691,151 | $8.03M | 2.83% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 1,577,296 | $7.49M | 0.17% | 00.0% | Unchanged |
| Laurion Capital Management LP | 1,450,638 | $6.89M | 0.12% | +844,000+139.1% | Added |
| Goldman Sachs Group Inc | 1,134,351 | $5.39M | 0.00% | −1,699−0.1% | Reduced |
| Artal Group S.A. | 1,045,000 | $4.96M | 0.15% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $4.75M | 0.01% | −2,500,000−71.4% | Reduced |
| Great Point Partners LLC | 910,251 | $4.32M | 0.97% | +10,251+1.1% | Added |
| Samsara BioCapital, LLC | 883,720 | $4.20M | 0.84% | 00.0% | Unchanged |
| State Street Corp | 758,041 | $3.60M | 0.00% | −8,900−1.2% | Reduced |
| Dimensional Fund Advisors LP | 690,573 | $3.28M | 0.00% | +57,740+9.1% | Added |
| Geode Capital Management, LLC | 685,745 | $3.26M | 0.00% | −4,252−0.6% | Reduced |
| Sio Capital Management, LLC | 498,500 | $2.37M | 0.72% | +52,500+11.8% | Added |
| AXA S.A. | 444,931 | $2.11M | 0.01% | +5,264+1.2% | Added |
| Assenagon Asset Management S.A. | 416,174 | $1.98M | 0.01% | +149,108+55.8% | Added |
| Northern Trust Corp | 349,688 | $1.66M | 0.00% | −16,015−4.4% | Reduced |
| Lion Point Capital, LP | 300,000 | $1.43M | 0.47% | 00.0% | Unchanged |
| Altium Capital Management LP | 293,764 | $1.40M | 0.39% | −315,925−51.8% | Reduced |
| Renaissance Technologies LLC | 248,200 | $1.18M | 0.00% | +147,900+147.5% | Added |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $1.17M | 0.53% | 00.0% | Unchanged |
| Abingworth LLP | 240,500 | $1.14M | 0.28% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 227,508 | $1.08M | 0.00% | +199,005+698.2% | Added |
| Morgan Stanley | 196,218 | $932.0K | 0.00% | +1,993+1.0% | Added |
| Millennium Management LLC | 190,482 | $905.0K | 0.00% | −344,740−64.4% | Reduced |
| ClariVest Asset Management LLC | 174,919 | $832.0K | 0.03% | +174,919 | New |
| Bank of New York Mellon Corp | 159,274 | $757.0K | 0.00% | −214−0.1% | Reduced |
| Jacobs Levy Equity Management, Inc | 144,093 | $684.0K | 0.00% | +144,093 | New |
| Nuveen Asset Management, LLC | 168,822 | $653.0K | 0.00% | −10,820−6.0% | Reduced |
| UBS Group AG | 136,636 | $649.0K | 0.00% | +82,416+152.0% | Added |
| Acadian Asset Management LLC | 130,835 | $620.0K | 0.00% | +130,835 | New |
| Fan Yu | 112,044 | $532.0K | 6.17% | 00.0% | Unchanged |
| Franklin Street Advisors Inc | 105,800 | $503.0K | 0.04% | +2,200+2.1% | Added |
| Charles Schwab Investment Management Inc | 99,477 | $473.0K | 0.00% | 00.0% | Unchanged |
| Blair William & Co | 76,594 | $364.0K | 0.00% | +24,390+46.7% | Added |
| Ritholtz Wealth Management | 76,490 | $363.0K | 0.02% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 64,511 | $306.0K | 0.00% | +64,511 | New |
| Alps Advisors Inc | 57,080 | $271.0K | 0.00% | +57,080 | New |
| Cubist Systematic Strategies, LLC | 55,945 | $266.0K | 0.00% | +55,945 | New |
| Rhumbline Advisers | 53,918 | $256.0K | 0.00% | −225−0.4% | Reduced |
| Barclays PLC | 49,153 | $233.0K | 0.00% | +32,629+197.5% | Added |
| Parametric Portfolio Associates LLC | 41,983 | $199.0K | 0.00% | −3,123−6.9% | Reduced |
| Marshall Wace, LLP | 41,624 | $197.0K | 0.00% | −274,199−86.8% | Reduced |
| Two Sigma Advisers, LP | 38,200 | $181.0K | 0.00% | +38,200 | New |
| Aristides Capital LLC | 35,763 | $170.0K | 0.10% | +35,763 | New |
| Algert Global LLC | 32,424 | $154.0K | 0.02% | −4,380−11.9% | Reduced |
| Bank of America Corp | 31,067 | $147.0K | 0.00% | +5,428+21.2% | Added |
| Alliancebernstein L.P. | 25,600 | $122.0K | 0.00% | 00.0% | Unchanged |
| BIT Capital GmbH | 25,000 | $118.8K | 0.01% | +25,000 | New |
| Deutsche Bank AG | 24,535 | $117.0K | 0.00% | +1,292+5.6% | Added |
| American International Group, Inc. | 21,476 | $102.0K | 0.00% | −644−2.9% | Reduced |
| California State Teachers Retirement System | 21,314 | $101.0K | 0.00% | −384−1.8% | Reduced |
| Wells Fargo & Company | 21,332 | $101.0K | 0.00% | +19,120+864.4% | Added |
| JPMorgan Chase & Co | 20,878 | $99.0K | 0.00% | +1,691+8.8% | Added |
| Manufacturers Life Insurance Company, The | 20,139 | $96.0K | 0.00% | −5,184−20.5% | Reduced |
| New York State Common Retirement Fund | 17,041 | $81.0K | 0.00% | −38−0.2% | Reduced |
| ProShare Advisors LLC | 15,771 | $75.0K | 0.00% | +113+0.7% | Added |
| Voya Investment Management LLC | 15,466 | $73.0K | 0.00% | −4,412−22.2% | Reduced |
| Engineers Gate Manager LP | 15,000 | $71.0K | 0.00% | +15,000 | New |
| Delphia (USA) Inc. | 12,944 | $61.0K | 0.06% | +12,944 | New |
| Invesco Ltd. | 12,212 | $58.0K | 0.00% | −2,514−17.1% | Reduced |
| Nisa Investment Advisors, LLC | 13,192 | $57.0K | 0.00% | +13,192 | New |
| Citigroup Inc | 11,894 | $56.0K | 0.00% | +4,761+66.7% | Added |
| BNP Paribas Arbitrage, SA | 11,159 | $53.0K | 0.00% | +403+3.7% | Added |
| SG Americas Securities, LLC | 11,033 | $52.0K | 0.00% | −17,545−61.4% | Reduced |
| Pinnacle Wealth Planning Services, Inc. | 10,130 | $48.0K | 0.01% | +10,130 | New |
| Royal Bank of Canada | 8,160 | $39.0K | 0.00% | +2,692+49.2% | Added |
| Group One Trading, L.P. | 5,300 | $25.0K | 0.00% | +5,300 | New |
| Tower Research Capital LLC (TRC) | 4,952 | $24.0K | 0.00% | +1,702+52.4% | Added |
| Ameritas Investment Partners, Inc. | 3,710 | $18.0K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 3,893 | $18.0K | 0.00% | +3,893 | New |
| Legal & General Group Plc | 3,264 | $16.0K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 2,980 | $14.0K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 3,008 | $14.0K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 1,334 | $6.00K | 0.00% | +1,334 | New |
| Quadrant Capital Group LLC | 1,137 | $5.00K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 171 | $1.00K | 0.00% | +171 | New |
| Point72 Hong Kong Ltd | 153 | $1.00K | 0.00% | +153 | New |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| Toronto Dominion Bank | 5 | $0 | 0.00% | +5 | New |
| AlphaCentric Advisors LLC | 0 | $0 | 0.00% | −110,000−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −15,353−100.0% | Sold out |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −13,137−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −11,616−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −11,242−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −11,192−100.0% | Sold out |
| Personal Cfo Solutions, LLC | 0 | $0 | 0.00% | −10,888−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −8,801−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −1,120−100.0% | Sold out |
| Berman Capital Advisors, LLC | – | – | – | – | Not filed |