Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 86
- +10 vs. Q3 2021
- Shares held
- 39.9M
- −661.2K (−1.6%) vs. Q3 2021
- Total value
- $189.4M
- −$133.1M (−41.3%) vs. Q3 2021
- New holders
- 19
- 26 more added
- Sold out
- 9
- 22 more reduced
1 institution that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| Toronto Dominion Bank | 5 | $0 | 0.00% | +5 | New |
| Captrust Financial Advisors | 171 | $1.00K | 0.00% | +171 | New |
| Point72 Hong Kong Ltd | 153 | $1.00K | 0.00% | +153 | New |
| Quadrant Capital Group LLC | 1,137 | $5.00K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 1,334 | $6.00K | 0.00% | +1,334 | New |
| IFP Advisors, Inc | 2,980 | $14.0K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 3,008 | $14.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 3,264 | $16.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 3,710 | $18.0K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 3,893 | $18.0K | 0.00% | +3,893 | New |
| Tower Research Capital LLC (TRC) | 4,952 | $24.0K | 0.00% | +1,702+52.4% | Added |
| Group One Trading, L.P. | 5,300 | $25.0K | 0.00% | +5,300 | New |
| Royal Bank of Canada | 8,160 | $39.0K | 0.00% | +2,692+49.2% | Added |
| Pinnacle Wealth Planning Services, Inc. | 10,130 | $48.0K | 0.01% | +10,130 | New |
| SG Americas Securities, LLC | 11,033 | $52.0K | 0.00% | −17,545−61.4% | Reduced |
| BNP Paribas Arbitrage, SA | 11,159 | $53.0K | 0.00% | +403+3.7% | Added |
| Citigroup Inc | 11,894 | $56.0K | 0.00% | +4,761+66.7% | Added |
| Nisa Investment Advisors, LLC | 13,192 | $57.0K | 0.00% | +13,192 | New |
| Invesco Ltd. | 12,212 | $58.0K | 0.00% | −2,514−17.1% | Reduced |
| Delphia (USA) Inc. | 12,944 | $61.0K | 0.06% | +12,944 | New |
| Engineers Gate Manager LP | 15,000 | $71.0K | 0.00% | +15,000 | New |
| Voya Investment Management LLC | 15,466 | $73.0K | 0.00% | −4,412−22.2% | Reduced |
| ProShare Advisors LLC | 15,771 | $75.0K | 0.00% | +113+0.7% | Added |
| New York State Common Retirement Fund | 17,041 | $81.0K | 0.00% | −38−0.2% | Reduced |
| Manufacturers Life Insurance Company, The | 20,139 | $96.0K | 0.00% | −5,184−20.5% | Reduced |
| JPMorgan Chase & Co | 20,878 | $99.0K | 0.00% | +1,691+8.8% | Added |
| California State Teachers Retirement System | 21,314 | $101.0K | 0.00% | −384−1.8% | Reduced |
| Wells Fargo & Company | 21,332 | $101.0K | 0.00% | +19,120+864.4% | Added |
| American International Group, Inc. | 21,476 | $102.0K | 0.00% | −644−2.9% | Reduced |
| Deutsche Bank AG | 24,535 | $117.0K | 0.00% | +1,292+5.6% | Added |
| BIT Capital GmbH | 25,000 | $118.8K | 0.01% | +25,000 | New |
| Alliancebernstein L.P. | 25,600 | $122.0K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 31,067 | $147.0K | 0.00% | +5,428+21.2% | Added |
| Algert Global LLC | 32,424 | $154.0K | 0.02% | −4,380−11.9% | Reduced |
| Aristides Capital LLC | 35,763 | $170.0K | 0.10% | +35,763 | New |
| Two Sigma Advisers, LP | 38,200 | $181.0K | 0.00% | +38,200 | New |
| Marshall Wace, LLP | 41,624 | $197.0K | 0.00% | −274,199−86.8% | Reduced |
| Parametric Portfolio Associates LLC | 41,983 | $199.0K | 0.00% | −3,123−6.9% | Reduced |
| Barclays PLC | 49,153 | $233.0K | 0.00% | +32,629+197.5% | Added |
| Rhumbline Advisers | 53,918 | $256.0K | 0.00% | −225−0.4% | Reduced |
| Cubist Systematic Strategies, LLC | 55,945 | $266.0K | 0.00% | +55,945 | New |
| Alps Advisors Inc | 57,080 | $271.0K | 0.00% | +57,080 | New |
| Two Sigma Investments, LP | 64,511 | $306.0K | 0.00% | +64,511 | New |
| Ritholtz Wealth Management | 76,490 | $363.0K | 0.02% | 00.0% | Unchanged |
| Blair William & Co | 76,594 | $364.0K | 0.00% | +24,390+46.7% | Added |
| Charles Schwab Investment Management Inc | 99,477 | $473.0K | 0.00% | 00.0% | Unchanged |
| Franklin Street Advisors Inc | 105,800 | $503.0K | 0.04% | +2,200+2.1% | Added |
| Fan Yu | 112,044 | $532.0K | 6.17% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 130,835 | $620.0K | 0.00% | +130,835 | New |
| UBS Group AG | 136,636 | $649.0K | 0.00% | +82,416+152.0% | Added |
| Nuveen Asset Management, LLC | 168,822 | $653.0K | 0.00% | −10,820−6.0% | Reduced |
| Jacobs Levy Equity Management, Inc | 144,093 | $684.0K | 0.00% | +144,093 | New |
| Bank of New York Mellon Corp | 159,274 | $757.0K | 0.00% | −214−0.1% | Reduced |
| ClariVest Asset Management LLC | 174,919 | $832.0K | 0.03% | +174,919 | New |
| Millennium Management LLC | 190,482 | $905.0K | 0.00% | −344,740−64.4% | Reduced |
| Morgan Stanley | 196,218 | $932.0K | 0.00% | +1,993+1.0% | Added |
| D. E. Shaw & Co., Inc. | 227,508 | $1.08M | 0.00% | +199,005+698.2% | Added |
| Abingworth LLP | 240,500 | $1.14M | 0.28% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $1.17M | 0.53% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 248,200 | $1.18M | 0.00% | +147,900+147.5% | Added |
| Altium Capital Management LP | 293,764 | $1.40M | 0.39% | −315,925−51.8% | Reduced |
| Lion Point Capital, LP | 300,000 | $1.43M | 0.47% | 00.0% | Unchanged |
| Northern Trust Corp | 349,688 | $1.66M | 0.00% | −16,015−4.4% | Reduced |
| Assenagon Asset Management S.A. | 416,174 | $1.98M | 0.01% | +149,108+55.8% | Added |
| AXA S.A. | 444,931 | $2.11M | 0.01% | +5,264+1.2% | Added |
| Sio Capital Management, LLC | 498,500 | $2.37M | 0.72% | +52,500+11.8% | Added |
| Geode Capital Management, LLC | 685,745 | $3.26M | 0.00% | −4,252−0.6% | Reduced |
| Dimensional Fund Advisors LP | 690,573 | $3.28M | 0.00% | +57,740+9.1% | Added |
| State Street Corp | 758,041 | $3.60M | 0.00% | −8,900−1.2% | Reduced |
| Samsara BioCapital, LLC | 883,720 | $4.20M | 0.84% | 00.0% | Unchanged |
| Great Point Partners LLC | 910,251 | $4.32M | 0.97% | +10,251+1.1% | Added |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $4.75M | 0.01% | −2,500,000−71.4% | Reduced |
| Artal Group S.A. | 1,045,000 | $4.96M | 0.15% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,134,351 | $5.39M | 0.00% | −1,699−0.1% | Reduced |
| Laurion Capital Management LP | 1,450,638 | $6.89M | 0.12% | +844,000+139.1% | Added |
| Rock Springs Capital Management LP | 1,577,296 | $7.49M | 0.17% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,691,151 | $8.03M | 2.83% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,120,625 | $10.1M | 0.00% | +11,865+0.6% | Added |
| Pictet Asset Management SA | 2,468,129 | $11.7M | 0.01% | −64,670−2.6% | Reduced |
| Suvretta Capital Management, LLC | 2,571,000 | $12.2M | 0.24% | +413,273+19.2% | Added |
| Nantahala Capital Management, LLC | 2,813,560 | $13.4M | 0.83% | +1,296,605+85.5% | Added |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $13.5M | 1.07% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 2,956,124 | $14.0M | 0.18% | −1,059,400−26.4% | Reduced |
| BlackRock Inc. | 2,998,479 | $14.2M | 0.00% | +14,584+0.5% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $16.2M | 0.08% | 00.0% | Unchanged |
| AlphaCentric Advisors LLC | 0 | $0 | 0.00% | −110,000−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −15,353−100.0% | Sold out |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −13,137−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −11,616−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −11,242−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −11,192−100.0% | Sold out |
| Personal Cfo Solutions, LLC | 0 | $0 | 0.00% | −10,888−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −8,801−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −1,120−100.0% | Sold out |
| Berman Capital Advisors, LLC | – | – | – | – | Not filed |