Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 131
- +13 vs. Q3 2024
- Shares held
- 59.9M
- +8.57M (+16.7%) vs. Q3 2024
- Total value
- $1.39B
- −$116.0M (−7.7%) vs. Q3 2024
- New holders
- 34
- 63 more added
- Sold out
- 21
- 20 more reduced
1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,801,266 | $204.9M | 0.01% | +1,177,385+15.4% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $93.5M | 9.30% | 00.0% | Unchanged |
| RTW Investments, LP | 3,621,996 | $84.3M | 1.28% | +363,636+11.2% | Added |
| BlackRock, Inc. | 3,399,591 | $79.1M | 0.00% | +736,444+27.7% | Added |
| Vanguard Group Inc | 2,846,473 | $66.3M | 0.00% | +330,553+13.1% | Added |
| Driehaus Capital Management LLC | 2,803,655 | $65.3M | 0.54% | +2,116,575+308.1% | Added |
| VR Adviser, LLC | 2,685,448 | $62.5M | 4.29% | 00.0% | Unchanged |
| Braidwell LP | 2,578,404 | $60.0M | 1.78% | +388,568+17.7% | Added |
| Perceptive Advisors LLC | 2,574,723 | $59.9M | 1.67% | −297,824−10.4% | Reduced |
| Commodore Capital LP | 1,988,084 | $46.3M | 3.39% | 00.0% | Unchanged |
| State Street Corp | 1,680,936 | $39.1M | 0.00% | +139,381+9.0% | Added |
| Wellington Management Group LLP | 1,604,508 | $37.4M | 0.01% | +97,308+6.5% | Added |
| Paradigm Biocapital Advisors LP | 1,527,205 | $35.6M | 1.24% | +259,624+20.5% | Added |
| Janus Henderson Group PLC | 1,456,740 | $33.9M | 0.02% | +336,209+30.0% | Added |
| Jefferies Financial Group Inc. | 1,216,954 | $28.3M | 0.32% | +762,147+167.6% | Added |
| Pictet Asset Management Holding SA | 1,092,124 | $25.4M | 0.03% | +266,418+32.3% | Added |
| Citadel Advisors LLC | 1,079,307 | $25.1M | 0.02% | +371,721+52.5% | Added |
| Adage Capital Partners GP, L.L.C. | 1,030,000 | $24.0M | 0.04% | −25,000−2.4% | Reduced |
| Geode Capital Management, LLC | 966,129 | $22.5M | 0.00% | +75,081+8.4% | Added |
| Affinity Asset Advisors, LLC | 824,328 | $19.2M | 3.00% | +325,908+65.4% | Added |
| Franklin Resources Inc | 760,642 | $17.7M | 0.00% | −240.0% | Reduced |
| Polar Capital Holdings Plc | 750,000 | $17.5M | 0.10% | +250,000+50.0% | Added |
| Goldman Sachs Group Inc | 747,552 | $17.4M | 0.00% | +578,238+341.5% | Added |
| Emerald Advisers, LLC | 546,791 | $12.7M | 0.49% | +254,222+86.9% | Added |
| Price T Rowe Associates Inc | 506,450 | $11.8M | 0.00% | +77,323+18.0% | Added |
| Logos Global Management LP | 500,000 | $11.6M | 1.36% | +300,000+150.0% | Added |
| Boxer Capital Management, LLC | 466,680 | $10.9M | 0.93% | +466,680 | New |
| Deerfield Management Company, L.P. (Series C) | 450,000 | $10.5M | 0.20% | +450,000 | New |
| Blackstone Group Inc. | 449,201 | $10.5M | 0.05% | +156,206+53.3% | Added |
| UBS Group AG | 392,197 | $9.13M | 0.00% | +334,359+578.1% | Added |
| Emerald Mutual Fund Advisers Trust | 386,384 | $9.00M | 0.55% | +132,834+52.4% | Added |
| Charles Schwab Investment Management Inc | 379,650 | $8.84M | 0.00% | +46,375+13.9% | Added |
| Capital World Investors | 378,573 | $8.81M | 0.00% | +378,573 | New |
| Siren, L.L.C. | 374,000 | $8.71M | 0.38% | +374,000 | New |
| Woodline Partners LP | 352,680 | $8.21M | 0.06% | +88,424+33.5% | Added |
| Northern Trust Corp | 348,983 | $8.12M | 0.00% | +34,693+11.0% | Added |
| Ikarian Capital, LLC | 282,159 | $6.57M | 1.88% | −20,088−6.6% | Reduced |
| Victory Capital Management Inc | 268,076 | $6.24M | 0.01% | +268,076 | New |
| Morgan Stanley | 255,256 | $5.94M | 0.00% | +11,514+4.7% | Added |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 250,000 | $5.82M | 0.10% | +105,000+72.4% | Added |
| Candriam Luxembourg S.C.A. | 247,591 | $5.76M | 0.03% | +142,591+135.8% | Added |
| Deep Track Capital, LP | 219,015 | $5.10M | 0.19% | −780,985−78.1% | Reduced |
| Armistice Capital, LLC | 200,000 | $4.66M | 0.11% | +64,000+47.1% | Added |
| Millennium Management LLC | 167,804 | $3.91M | 0.00% | +167,804 | New |
| Nuveen Asset Management, LLC | 125,668 | $2.93M | 0.00% | +378+0.3% | Added |
| Barclays PLC | 123,071 | $2.87M | 0.00% | +17,604+16.7% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 122,153 | $2.84M | 0.01% | +122,153 | New |
| Voloridge Investment Management, LLC | 115,470 | $2.69M | 0.01% | −41,011−26.2% | Reduced |
| Schroder Investment Management Group | 113,620 | $2.56M | 0.00% | +113,620 | New |
| Bank of New York Mellon Corp | 103,688 | $2.41M | 0.00% | −1,118−1.1% | Reduced |
| HighVista Strategies LLC | 95,159 | $2.22M | 0.82% | −10,192−9.7% | Reduced |
| Boothbay Fund Management, LLC | 85,618 | $1.99M | 0.06% | −6,157−6.7% | Reduced |
| EFG Asset Management (North America) Corp. | 82,818 | $1.93M | 0.26% | +30,608+58.6% | Added |
| Ensign Peak Advisors, Inc | 82,475 | $1.92M | 0.00% | 00.0% | Unchanged |
| Prosight Management, LP | 80,000 | $1.86M | 0.52% | +80,000 | New |
| Rafferty Asset Management, LLC | 76,740 | $1.79M | 0.01% | +6,154+8.7% | Added |
| Citigroup Inc | 73,752 | $1.72M | 0.00% | +48,561+192.8% | Added |
| Swiss National Bank | 68,600 | $1.60M | 0.00% | +19,000+38.3% | Added |
| TD Asset Management Inc | 64,968 | $1.51M | 0.00% | +12,200+23.1% | Added |
| Rhumbline Advisers | 57,657 | $1.34M | 0.00% | +3,722+6.9% | Added |
| Manufacturers Life Insurance Company, The | 52,762 | $1.23M | 0.00% | +9,302+21.4% | Added |
| B Group, Inc. | 50,000 | $1.16M | 0.71% | +50,000 | New |
| UBS Asset Management Americas Inc | 48,981 | $1.14M | 0.00% | +22,540+85.2% | Added |
| F/M Investments LLC | 48,806 | $1.14M | 0.04% | +48,806 | New |
| Legal & General Group Plc | 37,490 | $872.8K | 0.00% | +8,335+28.6% | Added |
| Alliancebernstein L.P. | 36,230 | $843.4K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 35,248 | $820.6K | 0.00% | +5,775+19.6% | Added |
| California State Teachers Retirement System | 32,598 | $758.9K | 0.00% | +7,923+32.1% | Added |
| State of Wisconsin Investment Board | 31,484 | $732.9K | 0.00% | +13,169+71.9% | Added |
| Deutsche Bank AG | 31,418 | $731.4K | 0.00% | +9,910+46.1% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $601.0K | 0.01% | +4,645+22.0% | Added |
| Wells Fargo & Company | 24,718 | $575.4K | 0.00% | +6,908+38.8% | Added |
| First Trust Advisors LP | 23,550 | $548.2K | 0.00% | +23,550 | New |
| Susquehanna International Group, LLP | 23,089 | $537.5K | 0.00% | +9,891+74.9% | Added |
| Assenagon Asset Management S.A. | 22,652 | $527.3K | 0.00% | −1,120,116−98.0% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 22,741 | $527.2K | 0.00% | +916+4.2% | Added |
| MetLife Investment Management | 21,382 | $497.8K | 0.00% | +1,250+6.2% | Added |
| Invesco Ltd. | 19,663 | $457.8K | 0.00% | −118,195−85.7% | Reduced |
| Cinctive Capital Management LP | 19,567 | $455.5K | 0.02% | −41,689−68.1% | Reduced |
| NBW Capital LLC | 19,430 | $452.3K | 0.08% | −7,500−27.8% | Reduced |
| BNP Paribas Arbitrage, SA | 18,784 | $437.3K | 0.00% | +18,784 | New |
| Global Endowment Management, LP | 18,184 | $423.3K | 0.05% | 00.0% | Unchanged |
| Natixis Advisors, L.P. | 17,300 | $403.0K | 0.00% | +17,300 | New |
| Corebridge Financial, Inc. | 17,213 | $400.7K | 0.00% | −1,299−7.0% | Reduced |
| Brevan Howard Capital Management LP | 16,899 | $393.4K | 0.01% | +16,899 | New |
| ExodusPoint Capital Management, LP | 16,691 | $389.0K | 0.00% | +6,958+71.5% | Added |
| Squarepoint Ops LLC | 15,231 | $354.6K | 0.00% | +6,754+79.7% | Added |
| Profund Advisors LLC | 14,862 | $346.0K | 0.01% | +787+5.6% | Added |
| Intech Investment Management LLC | 14,043 | $326.9K | 0.00% | +5,672+67.8% | Added |
| ProShare Advisors LLC | 12,531 | $291.7K | 0.00% | +12,531 | New |
| China Universal Asset Management Co., Ltd. | 12,440 | $289.6K | 0.03% | +12,440 | New |
| Aquatic Capital Management LLC | 11,767 | $273.9K | 0.01% | +11,767 | New |
| Voya Investment Management LLC | 10,495 | $244.3K | 0.00% | −856−7.5% | Reduced |
| Teacher Retirement System of Texas | 10,383 | $242.0K | 0.00% | +10,383 | New |
| New York State Common Retirement Fund | 10,265 | $239.0K | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 10,115 | $235.5K | 0.00% | +2,805+38.4% | Added |
| Two Sigma Investments, LP | 9,638 | $224.4K | 0.00% | −165−1.7% | Reduced |
| Carlyle Group Inc. | 9,620 | $223.8K | 0.01% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 9,030 | $210.2K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 8,574 | $199.6K | 0.00% | +8,054+1,548.8% | Added |