Spyre Therapeutics, Inc.

SYRE

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001636282

SEC filings (opens in a new tab)

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

Q4 2024 vs. Q3 2024

How the institutions holding Spyre Therapeutics, Inc. changed between Q3 2024 and Q4 2024.

All holders in Q4 2024 All holders in Q3 2024

13F holders of SYRE: Q3 2024 compared with Q4 2024
Measure	Q3 2024	Of which not filed for Q4 2024	Q4 2024	Change
Holders	119	1	131	+13
Shares	51.4M	60.0K	59.9M	+8.57M (+16.7%)
Value	$1.51B	$1.76M	$1.39B	−$116.0M (−7.7%)

1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so the changes leave them out.

New holders (34)

Institutions that held Spyre Therapeutics, Inc. at the end of Q4 2024 but not at the end of Q3 2024.

Institutions new to SYRE in Q4 2024
Institution	Shares	Value	% of portfolio
Boxer Capital Management, LLC	466,680	$10.9M	0.93%
Deerfield Management Company, L.P. (Series C)	450,000	$10.5M	0.20%
Capital World Investors	378,573	$8.81M	0.00%
Siren, L.L.C.	374,000	$8.71M	0.38%
Victory Capital Management Inc	268,076	$6.24M	0.01%
Millennium Management LLC	167,804	$3.91M	0.00%
Universal- Beteiligungs- und Servicegesellschaft mbH	122,153	$2.84M	0.01%
Schroder Investment Management Group	113,620	$2.56M	0.00%
Prosight Management, LP	80,000	$1.86M	0.52%
B Group, Inc.	50,000	$1.16M	0.71%
F/M Investments LLC	48,806	$1.14M	0.04%
First Trust Advisors LP	23,550	$548.2K	0.00%
BNP Paribas Arbitrage, SA	18,784	$437.3K	0.00%
Natixis Advisors, L.P.	17,300	$403.0K	0.00%
Brevan Howard Capital Management LP	16,899	$393.4K	0.01%
ProShare Advisors LLC	12,531	$291.7K	0.00%
China Universal Asset Management Co., Ltd.	12,440	$289.6K	0.03%
Aquatic Capital Management LLC	11,767	$273.9K	0.01%
Teacher Retirement System of Texas	10,383	$242.0K	0.00%
KLP Kapitalforvaltning AS	7,800	$181.6K	0.00%
Police & Firemen's Retirement System of New Jersey	7,378	$171.8K	0.00%
Mirae Asset Global Investments Co., Ltd.	1,955	$46.3K	0.00%
Huntington National Bank	1,470	$34.2K	0.00%
GF Fund Management Co. Ltd.	1,232	$28.7K	0.00%
R Squared Ltd	710	$16.5K	0.02%
Venturi Wealth Management, LLC	231	$5.38K	0.00%
Sugar Maple Asset Management, LLC	180	$4.19K	0.00%
Skopos Labs, Inc.	120	$2.79K	0.00%
Signaturefd, LLC	68	$1.58K	0.00%
Simplex Trading, LLC	55	$1.00K	0.00%
Amundi	32	$769	0.00%
Caitong International Asset Management Co., Ltd	14	$326	0.00%
EverSource Wealth Advisors, LLC	8	$186	0.00%
SBI Securities Co., Ltd.	5	$116	0.00%

Sold out (21)

Institutions that held Spyre Therapeutics, Inc. at the end of Q3 2024 and filed for Q4 2024 without it.

Institutions that sold out of SYRE in Q4 2024
Institution	Shares, Q3 2024	Value, Q3 2024
Boxer Capital, LLC	696,480	$20.5M
Avoro Capital Advisors LLC	598,600	$17.6M
Walleye Capital LLC	243,372	$7.16M
Balyasny Asset Management LLC	227,950	$6.70M
Schonfeld Strategic Advisors LLC	46,072	$1.35M
Superstring Capital Management LP	37,287	$1.10M
AQR Capital Management LLC	35,003	$1.03M
Tudor Investment Corp Et Al	31,138	$915.8K
Jane Street Group, LLC	20,641	$607.1K
SG Americas Securities, LLC	12,589	$370.0K
ADAR1 Capital Management, LLC	12,560	$369.4K
Acadian Asset Management LLC	814	$23.0K
nVerses Capital, LLC	500	$14.7K
Russell Investments Group, Ltd.	129	$3.79K
Capital Performance Advisors LLP	46	$1.35K
Bessemer Group Inc	45	$1.00K
Lindbrook Capital, LLC	19	$559
True Wealth Design, LLC	16	$471
US Bancorp	9	$265
GAMMA Investing LLC	5	$147
National Bank of Canada	1	$29

Not filed for Q4 2024 yet (1)

Institutions that held Spyre Therapeutics, Inc. at the end of Q3 2024 and haven't filed a 13F for Q4 2024. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding SYRE in Q3 2024 that haven't filed for Q4 2024
Institution	Shares, Q3 2024	Value, Q3 2024
Ghost Tree Capital, LLC	60,000	$1.76M