Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 131
- +13 vs. Q3 2024
- Shares held
- 59.9M
- +8.57M (+16.7%) vs. Q3 2024
- Total value
- $1.39B
- −$116.0M (−7.7%) vs. Q3 2024
- New holders
- 34
- 63 more added
- Sold out
- 21
- 20 more reduced
1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CWM, LLC | 8 | $0 | 0.00% | −219−96.5% | Reduced |
| Covestor Ltd | 4 | $0 | 0.00% | +1+33.3% | Added |
| SBI Securities Co., Ltd. | 5 | $116 | 0.00% | +5 | New |
| Pacific Capital Wealth Advisors, Inc | 8 | $186 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 8 | $186 | 0.00% | +8 | New |
| Allworth Financial LP | 9 | $197 | 0.00% | +2+28.6% | Added |
| Caitong International Asset Management Co., Ltd | 14 | $326 | 0.00% | +14 | New |
| Amundi | 32 | $769 | 0.00% | +32 | New |
| Rothschild Investment LLC | 40 | $931 | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 55 | $1.00K | 0.00% | +55 | New |
| Signaturefd, LLC | 68 | $1.58K | 0.00% | +68 | New |
| Advisor Group Holdings, Inc. | 105 | $2.44K | 0.00% | +22+26.5% | Added |
| IFP Advisors, Inc | 109 | $2.77K | 0.00% | −5−4.4% | Reduced |
| Nisa Investment Advisors, LLC | 120 | $2.79K | 0.00% | +9+8.1% | Added |
| Skopos Labs, Inc. | 120 | $2.79K | 0.00% | +120 | New |
| Sugar Maple Asset Management, LLC | 180 | $4.19K | 0.00% | +180 | New |
| Venturi Wealth Management, LLC | 231 | $5.38K | 0.00% | +231 | New |
| R Squared Ltd | 710 | $16.5K | 0.02% | +710 | New |
| Sterling Capital Management LLC | 1,009 | $23.5K | 0.00% | +894+777.4% | Added |
| Amalgamated Bank | 1,198 | $28.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,232 | $28.7K | 0.00% | +1,232 | New |
| Huntington National Bank | 1,470 | $34.2K | 0.00% | +1,470 | New |
| Public Employees Retirement Association of Colorado | 1,589 | $37.0K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 1,955 | $46.3K | 0.00% | +1,955 | New |
| Quest Partners LLC | 2,198 | $51.2K | 0.01% | −3,456−61.1% | Reduced |
| Virtus ETF Advisers LLC | 2,972 | $69.2K | 0.03% | +124+4.4% | Added |
| Ameritas Investment Partners, Inc. | 3,392 | $79.0K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 4,022 | $94.0K | 0.00% | +236+6.2% | Added |
| Bank of America Corp | 7,142 | $166.3K | 0.00% | −250,655−97.2% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 7,378 | $171.8K | 0.00% | +7,378 | New |
| KLP Kapitalforvaltning AS | 7,800 | $181.6K | 0.00% | +7,800 | New |
| Tower Research Capital LLC (TRC) | 8,574 | $199.6K | 0.00% | +8,054+1,548.8% | Added |
| State Board of Administration of Florida Retirement System | 9,030 | $210.2K | 0.00% | 00.0% | Unchanged |
| Carlyle Group Inc. | 9,620 | $223.8K | 0.01% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 9,638 | $224.4K | 0.00% | −165−1.7% | Reduced |
| Arizona State Retirement System | 10,115 | $235.5K | 0.00% | +2,805+38.4% | Added |
| New York State Common Retirement Fund | 10,265 | $239.0K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 10,383 | $242.0K | 0.00% | +10,383 | New |
| Voya Investment Management LLC | 10,495 | $244.3K | 0.00% | −856−7.5% | Reduced |
| Aquatic Capital Management LLC | 11,767 | $273.9K | 0.01% | +11,767 | New |
| China Universal Asset Management Co., Ltd. | 12,440 | $289.6K | 0.03% | +12,440 | New |
| ProShare Advisors LLC | 12,531 | $291.7K | 0.00% | +12,531 | New |
| Intech Investment Management LLC | 14,043 | $326.9K | 0.00% | +5,672+67.8% | Added |
| Profund Advisors LLC | 14,862 | $346.0K | 0.01% | +787+5.6% | Added |
| Squarepoint Ops LLC | 15,231 | $354.6K | 0.00% | +6,754+79.7% | Added |
| ExodusPoint Capital Management, LP | 16,691 | $389.0K | 0.00% | +6,958+71.5% | Added |
| Brevan Howard Capital Management LP | 16,899 | $393.4K | 0.01% | +16,899 | New |
| Corebridge Financial, Inc. | 17,213 | $400.7K | 0.00% | −1,299−7.0% | Reduced |
| Natixis Advisors, L.P. | 17,300 | $403.0K | 0.00% | +17,300 | New |
| Global Endowment Management, LP | 18,184 | $423.3K | 0.05% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 18,784 | $437.3K | 0.00% | +18,784 | New |
| NBW Capital LLC | 19,430 | $452.3K | 0.08% | −7,500−27.8% | Reduced |
| Cinctive Capital Management LP | 19,567 | $455.5K | 0.02% | −41,689−68.1% | Reduced |
| Invesco Ltd. | 19,663 | $457.8K | 0.00% | −118,195−85.7% | Reduced |
| MetLife Investment Management | 21,382 | $497.8K | 0.00% | +1,250+6.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 22,741 | $527.2K | 0.00% | +916+4.2% | Added |
| Assenagon Asset Management S.A. | 22,652 | $527.3K | 0.00% | −1,120,116−98.0% | Reduced |
| Susquehanna International Group, LLP | 23,089 | $537.5K | 0.00% | +9,891+74.9% | Added |
| First Trust Advisors LP | 23,550 | $548.2K | 0.00% | +23,550 | New |
| Wells Fargo & Company | 24,718 | $575.4K | 0.00% | +6,908+38.8% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $601.0K | 0.01% | +4,645+22.0% | Added |
| Deutsche Bank AG | 31,418 | $731.4K | 0.00% | +9,910+46.1% | Added |
| State of Wisconsin Investment Board | 31,484 | $732.9K | 0.00% | +13,169+71.9% | Added |
| California State Teachers Retirement System | 32,598 | $758.9K | 0.00% | +7,923+32.1% | Added |
| JPMorgan Chase & Co | 35,248 | $820.6K | 0.00% | +5,775+19.6% | Added |
| Alliancebernstein L.P. | 36,230 | $843.4K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 37,490 | $872.8K | 0.00% | +8,335+28.6% | Added |
| F/M Investments LLC | 48,806 | $1.14M | 0.04% | +48,806 | New |
| UBS Asset Management Americas Inc | 48,981 | $1.14M | 0.00% | +22,540+85.2% | Added |
| B Group, Inc. | 50,000 | $1.16M | 0.71% | +50,000 | New |
| Manufacturers Life Insurance Company, The | 52,762 | $1.23M | 0.00% | +9,302+21.4% | Added |
| Rhumbline Advisers | 57,657 | $1.34M | 0.00% | +3,722+6.9% | Added |
| TD Asset Management Inc | 64,968 | $1.51M | 0.00% | +12,200+23.1% | Added |
| Swiss National Bank | 68,600 | $1.60M | 0.00% | +19,000+38.3% | Added |
| Citigroup Inc | 73,752 | $1.72M | 0.00% | +48,561+192.8% | Added |
| Rafferty Asset Management, LLC | 76,740 | $1.79M | 0.01% | +6,154+8.7% | Added |
| Prosight Management, LP | 80,000 | $1.86M | 0.52% | +80,000 | New |
| Ensign Peak Advisors, Inc | 82,475 | $1.92M | 0.00% | 00.0% | Unchanged |
| EFG Asset Management (North America) Corp. | 82,818 | $1.93M | 0.26% | +30,608+58.6% | Added |
| Boothbay Fund Management, LLC | 85,618 | $1.99M | 0.06% | −6,157−6.7% | Reduced |
| HighVista Strategies LLC | 95,159 | $2.22M | 0.82% | −10,192−9.7% | Reduced |
| Bank of New York Mellon Corp | 103,688 | $2.41M | 0.00% | −1,118−1.1% | Reduced |
| Schroder Investment Management Group | 113,620 | $2.56M | 0.00% | +113,620 | New |
| Voloridge Investment Management, LLC | 115,470 | $2.69M | 0.01% | −41,011−26.2% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 122,153 | $2.84M | 0.01% | +122,153 | New |
| Barclays PLC | 123,071 | $2.87M | 0.00% | +17,604+16.7% | Added |
| Nuveen Asset Management, LLC | 125,668 | $2.93M | 0.00% | +378+0.3% | Added |
| Millennium Management LLC | 167,804 | $3.91M | 0.00% | +167,804 | New |
| Armistice Capital, LLC | 200,000 | $4.66M | 0.11% | +64,000+47.1% | Added |
| Deep Track Capital, LP | 219,015 | $5.10M | 0.19% | −780,985−78.1% | Reduced |
| Candriam Luxembourg S.C.A. | 247,591 | $5.76M | 0.03% | +142,591+135.8% | Added |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 250,000 | $5.82M | 0.10% | +105,000+72.4% | Added |
| Morgan Stanley | 255,256 | $5.94M | 0.00% | +11,514+4.7% | Added |
| Victory Capital Management Inc | 268,076 | $6.24M | 0.01% | +268,076 | New |
| Ikarian Capital, LLC | 282,159 | $6.57M | 1.88% | −20,088−6.6% | Reduced |
| Northern Trust Corp | 348,983 | $8.12M | 0.00% | +34,693+11.0% | Added |
| Woodline Partners LP | 352,680 | $8.21M | 0.06% | +88,424+33.5% | Added |
| Siren, L.L.C. | 374,000 | $8.71M | 0.38% | +374,000 | New |
| Capital World Investors | 378,573 | $8.81M | 0.00% | +378,573 | New |
| Charles Schwab Investment Management Inc | 379,650 | $8.84M | 0.00% | +46,375+13.9% | Added |