Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2022
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 67
- −15 vs. Q1 2022
- Shares held
- 49.4M
- +8.13M (+19.7%) vs. Q1 2022
- Total value
- $24.8M
- −$70.1M (−73.9%) vs. Q1 2022
- New holders
- 14
- 21 more added
- Sold out
- 29
- 18 more reduced
2 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 5,347,689 | $2.70M | 0.32% | +2,500,000+87.8% | Added |
| Pictet Asset Management SA | 4,890,502 | $2.47M | 0.00% | +2,338,068+91.6% | Added |
| Sio Capital Management, LLC | 4,668,536 | $2.36M | 0.93% | +3,797,435+435.9% | Added |
| Suvretta Capital Management, LLC | 4,059,894 | $2.05M | 0.08% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 3,877,311 | $1.96M | 0.17% | +676,718+21.1% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $1.72M | 0.01% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 3,072,034 | $1.55M | 0.05% | +1,260,609+69.6% | Added |
| Great Point Partners LLC | 2,500,000 | $1.26M | 0.33% | +2,500,000 | New |
| Vanguard Group Inc | 1,948,009 | $984.0K | 0.00% | −169,314−8.0% | Reduced |
| OrbiMed Advisors LLC | 1,797,221 | $908.0K | 0.02% | −1,158,903−39.2% | Reduced |
| Aisling Capital Management LP | 1,691,151 | $854.0K | 0.61% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $758.0K | 0.00% | +1,500,000 | New |
| Goldman Sachs Group Inc | 1,187,293 | $600.0K | 0.00% | +62,504+5.6% | Added |
| BlackRock Inc. | 1,069,602 | $540.0K | 0.00% | −1,852,208−63.4% | Reduced |
| Ghost Tree Capital, LLC | 925,000 | $467.0K | 0.32% | +238,401+34.7% | Added |
| Samsara BioCapital, LLC | 883,720 | $446.0K | 0.12% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 642,835 | $325.0K | 0.00% | +119,693+22.9% | Added |
| Renaissance Technologies LLC | 582,444 | $294.0K | 0.00% | +430,576+283.5% | Added |
| Millennium Management LLC | 521,915 | $264.0K | 0.00% | +98,001+23.1% | Added |
| Dimensional Fund Advisors LP | 506,326 | $255.0K | 0.00% | −174,638−25.6% | Reduced |
| D. E. Shaw & Co., Inc. | 476,404 | $241.0K | 0.00% | +22,311+4.9% | Added |
| Acadian Asset Management LLC | 413,387 | $208.0K | 0.00% | +263,988+176.7% | Added |
| Geode Capital Management, LLC | 394,020 | $199.0K | 0.00% | −298,201−43.1% | Reduced |
| Two Sigma Investments, LP | 315,840 | $160.0K | 0.00% | +99,239+45.8% | Added |
| Morgan Stanley | 293,834 | $148.0K | 0.00% | +112,133+61.7% | Added |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $124.0K | 0.05% | 00.0% | Unchanged |
| Abingworth LLP | 240,500 | $121.0K | 0.04% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 231,700 | $117.0K | 0.00% | +70,400+43.6% | Added |
| Citadel Advisors LLC | 227,195 | $115.0K | 0.00% | +153,781+209.5% | Added |
| State Street Corp | 158,989 | $80.0K | 0.00% | −628,059−79.8% | Reduced |
| Ergoteles LLC | 147,200 | $74.0K | 0.00% | +147,200 | New |
| Fan Yu | 112,044 | $57.0K | 0.88% | 00.0% | Unchanged |
| Franklin Street Advisors Inc | 105,800 | $53.0K | 0.01% | 00.0% | Unchanged |
| Blair William & Co | 76,594 | $39.0K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $39.0K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 76,806 | $39.0K | 0.00% | +11,530+17.7% | Added |
| Northern Trust Corp | 69,209 | $35.0K | 0.00% | −264,532−79.3% | Reduced |
| Susquehanna International Group, LLP | 65,195 | $33.0K | 0.00% | +65,195 | New |
| Bridgeway Capital Management, LLC | 48,643 | $25.0K | 0.00% | −74,357−60.5% | Reduced |
| Qube Research & Technologies Ltd | 40,961 | $21.0K | 0.00% | +40,961 | New |
| Franklin Resources Inc | 31,364 | $16.0K | 0.00% | −14,936−32.3% | Reduced |
| Virtu Financial LLC | 31,151 | $16.0K | 0.00% | +31,151 | New |
| Bank of New York Mellon Corp | 25,136 | $13.0K | 0.00% | −132,521−84.1% | Reduced |
| BIT Capital GmbH | 25,000 | $12.6K | 0.00% | 00.0% | Unchanged |
| LMR Partners LLP | 19,220 | $10.0K | 0.00% | +19,220 | New |
| SG Americas Securities, LLC | 17,822 | $9.00K | 0.00% | +17,822 | New |
| Tower Research Capital LLC (TRC) | 15,689 | $8.00K | 0.00% | −6,390−28.9% | Reduced |
| Man Group plc | – | $8.00K | 0.00% | – | New |
| Schonfeld Strategic Advisors LLC | 10,100 | $5.00K | 0.00% | +10,100 | New |
| Bank of America Corp | 7,301 | $4.00K | 0.00% | −10,704−59.5% | Reduced |
| Citigroup Inc | 5,176 | $3.00K | 0.00% | +857+19.8% | Added |
| BNP Paribas Arbitrage, SA | 5,269 | $2.66K | 0.00% | +1,689+47.2% | Added |
| Legal & General Group Plc | 3,264 | $2.00K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 3,100 | $2.00K | 0.00% | +100+3.3% | Added |
| JPMorgan Chase & Co | 2,322 | $1.00K | 0.00% | −22,601−90.7% | Reduced |
| Wells Fargo & Company | 2,443 | $1.00K | 0.00% | −4,582−65.2% | Reduced |
| FMR LLC | 1,494 | $1.00K | 0.00% | +1,373+1,134.7% | Added |
| Federated Hermes, Inc. | 1,930 | $1.00K | 0.00% | +1,930 | New |
| New York State Common Retirement Fund | 341 | $0 | 0.00% | −16,700−98.0% | Reduced |
| Barclays PLC | 99 | $0 | 0.00% | −6,561−98.5% | Reduced |
| Royal Bank of Canada | 674 | $0 | 0.00% | −1,809−72.9% | Reduced |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| Credit Suisse AG | 21 | $0 | 0.00% | +21 | New |
| Simplex Trading, LLC | 13 | $0 | 0.00% | +13 | New |
| Advisor Group Holdings, Inc. | 470 | $0 | 0.00% | +470 | New |
| Lion Point Capital, LP | 300,000 | – | – | 00.0% | Unchanged |
| IFP Advisors, Inc | 2,860 | – | – | −2,980−51.0% | Reduced |
| Laurion Capital Management LP | 0 | $0 | 0.00% | −1,575,638−100.0% | Sold out |
| Deutsche Bank AG | 0 | $0 | 0.00% | −515,133−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −436,183−100.0% | Sold out |
| Nuveen Asset Management, LLC | 0 | $0 | 0.00% | −169,120−100.0% | Sold out |
| ClariVest Asset Management LLC | 0 | $0 | 0.00% | −184,119−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −154,175−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −135,611−100.0% | Sold out |
| Charles Schwab Investment Management Inc | 0 | $0 | 0.00% | −106,810−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −56,944−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −50,735−100.0% | Sold out |
| Rhumbline Advisers | 0 | $0 | 0.00% | −48,918−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −36,787−100.0% | Sold out |
| Alliancebernstein L.P. | 0 | $0 | 0.00% | −21,600−100.0% | Sold out |
| American International Group, Inc. | 0 | $0 | 0.00% | −20,064−100.0% | Sold out |
| California State Teachers Retirement System | 0 | $0 | 0.00% | −17,202−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −15,466−100.0% | Sold out |
| Invesco Ltd. | 0 | $0 | 0.00% | −12,350−100.0% | Sold out |
| ProShare Advisors LLC | 0 | $0 | 0.00% | −12,680−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −12,096−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −11,679−100.0% | Sold out |
| Public Employees Retirement System of Ohio | 0 | $0 | 0.00% | −8,189−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −4,887−100.0% | Sold out |
| Ameritas Investment Partners, Inc. | 0 | $0 | 0.00% | −3,710−100.0% | Sold out |
| Point72 Hong Kong Ltd | 0 | $0 | 0.00% | −3,921−100.0% | Sold out |
| Russell Investments Group, Ltd. | 0 | $0 | 0.00% | −3,008−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −1,084−100.0% | Sold out |
| Allspring Global Investments Holdings, LLC | 0 | $0 | 0.00% | −1,151−100.0% | Sold out |
| Toronto Dominion Bank | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Glassman Wealth Services | 0 | $0 | 0.00% | −88−100.0% | Sold out |
| Parametric Portfolio Associates LLC | – | – | – | – | Not filed |
| Amalgamated Financial Corp. | – | – | – | – | Not filed |