Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2022
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 67
- −15 vs. Q1 2022
- Shares held
- 49.4M
- +8.13M (+19.7%) vs. Q1 2022
- Total value
- $24.8M
- −$70.1M (−73.9%) vs. Q1 2022
- New holders
- 14
- 21 more added
- Sold out
- 29
- 18 more reduced
2 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| New York State Common Retirement Fund | 341 | $0 | 0.00% | −16,700−98.0% | Reduced |
| Barclays PLC | 99 | $0 | 0.00% | −6,561−98.5% | Reduced |
| Royal Bank of Canada | 674 | $0 | 0.00% | −1,809−72.9% | Reduced |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| Credit Suisse AG | 21 | $0 | 0.00% | +21 | New |
| Simplex Trading, LLC | 13 | $0 | 0.00% | +13 | New |
| Advisor Group Holdings, Inc. | 470 | $0 | 0.00% | +470 | New |
| JPMorgan Chase & Co | 2,322 | $1.00K | 0.00% | −22,601−90.7% | Reduced |
| Wells Fargo & Company | 2,443 | $1.00K | 0.00% | −4,582−65.2% | Reduced |
| FMR LLC | 1,494 | $1.00K | 0.00% | +1,373+1,134.7% | Added |
| Federated Hermes, Inc. | 1,930 | $1.00K | 0.00% | +1,930 | New |
| Legal & General Group Plc | 3,264 | $2.00K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 3,100 | $2.00K | 0.00% | +100+3.3% | Added |
| BNP Paribas Arbitrage, SA | 5,269 | $2.66K | 0.00% | +1,689+47.2% | Added |
| Citigroup Inc | 5,176 | $3.00K | 0.00% | +857+19.8% | Added |
| Bank of America Corp | 7,301 | $4.00K | 0.00% | −10,704−59.5% | Reduced |
| Schonfeld Strategic Advisors LLC | 10,100 | $5.00K | 0.00% | +10,100 | New |
| Tower Research Capital LLC (TRC) | 15,689 | $8.00K | 0.00% | −6,390−28.9% | Reduced |
| Man Group plc | – | $8.00K | 0.00% | – | New |
| SG Americas Securities, LLC | 17,822 | $9.00K | 0.00% | +17,822 | New |
| LMR Partners LLP | 19,220 | $10.0K | 0.00% | +19,220 | New |
| BIT Capital GmbH | 25,000 | $12.6K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 25,136 | $13.0K | 0.00% | −132,521−84.1% | Reduced |
| Franklin Resources Inc | 31,364 | $16.0K | 0.00% | −14,936−32.3% | Reduced |
| Virtu Financial LLC | 31,151 | $16.0K | 0.00% | +31,151 | New |
| Qube Research & Technologies Ltd | 40,961 | $21.0K | 0.00% | +40,961 | New |
| Bridgeway Capital Management, LLC | 48,643 | $25.0K | 0.00% | −74,357−60.5% | Reduced |
| Susquehanna International Group, LLP | 65,195 | $33.0K | 0.00% | +65,195 | New |
| Northern Trust Corp | 69,209 | $35.0K | 0.00% | −264,532−79.3% | Reduced |
| Blair William & Co | 76,594 | $39.0K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $39.0K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 76,806 | $39.0K | 0.00% | +11,530+17.7% | Added |
| Franklin Street Advisors Inc | 105,800 | $53.0K | 0.01% | 00.0% | Unchanged |
| Fan Yu | 112,044 | $57.0K | 0.88% | 00.0% | Unchanged |
| Ergoteles LLC | 147,200 | $74.0K | 0.00% | +147,200 | New |
| State Street Corp | 158,989 | $80.0K | 0.00% | −628,059−79.8% | Reduced |
| Citadel Advisors LLC | 227,195 | $115.0K | 0.00% | +153,781+209.5% | Added |
| Two Sigma Advisers, LP | 231,700 | $117.0K | 0.00% | +70,400+43.6% | Added |
| Abingworth LLP | 240,500 | $121.0K | 0.04% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $124.0K | 0.05% | 00.0% | Unchanged |
| Morgan Stanley | 293,834 | $148.0K | 0.00% | +112,133+61.7% | Added |
| Two Sigma Investments, LP | 315,840 | $160.0K | 0.00% | +99,239+45.8% | Added |
| Geode Capital Management, LLC | 394,020 | $199.0K | 0.00% | −298,201−43.1% | Reduced |
| Acadian Asset Management LLC | 413,387 | $208.0K | 0.00% | +263,988+176.7% | Added |
| D. E. Shaw & Co., Inc. | 476,404 | $241.0K | 0.00% | +22,311+4.9% | Added |
| Dimensional Fund Advisors LP | 506,326 | $255.0K | 0.00% | −174,638−25.6% | Reduced |
| Millennium Management LLC | 521,915 | $264.0K | 0.00% | +98,001+23.1% | Added |
| Renaissance Technologies LLC | 582,444 | $294.0K | 0.00% | +430,576+283.5% | Added |
| Assenagon Asset Management S.A. | 642,835 | $325.0K | 0.00% | +119,693+22.9% | Added |
| Samsara BioCapital, LLC | 883,720 | $446.0K | 0.12% | 00.0% | Unchanged |
| Ghost Tree Capital, LLC | 925,000 | $467.0K | 0.32% | +238,401+34.7% | Added |
| BlackRock Inc. | 1,069,602 | $540.0K | 0.00% | −1,852,208−63.4% | Reduced |
| Goldman Sachs Group Inc | 1,187,293 | $600.0K | 0.00% | +62,504+5.6% | Added |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $758.0K | 0.00% | +1,500,000 | New |
| Aisling Capital Management LP | 1,691,151 | $854.0K | 0.61% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 1,797,221 | $908.0K | 0.02% | −1,158,903−39.2% | Reduced |
| Vanguard Group Inc | 1,948,009 | $984.0K | 0.00% | −169,314−8.0% | Reduced |
| Great Point Partners LLC | 2,500,000 | $1.26M | 0.33% | +2,500,000 | New |
| Rock Springs Capital Management LP | 3,072,034 | $1.55M | 0.05% | +1,260,609+69.6% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $1.72M | 0.01% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 3,877,311 | $1.96M | 0.17% | +676,718+21.1% | Added |
| Suvretta Capital Management, LLC | 4,059,894 | $2.05M | 0.08% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 4,668,536 | $2.36M | 0.93% | +3,797,435+435.9% | Added |
| Pictet Asset Management SA | 4,890,502 | $2.47M | 0.00% | +2,338,068+91.6% | Added |
| Bain Capital Life Sciences Investors, LLC | 5,347,689 | $2.70M | 0.32% | +2,500,000+87.8% | Added |
| Lion Point Capital, LP | 300,000 | – | – | 00.0% | Unchanged |
| IFP Advisors, Inc | 2,860 | – | – | −2,980−51.0% | Reduced |
| Laurion Capital Management LP | 0 | $0 | 0.00% | −1,575,638−100.0% | Sold out |
| Deutsche Bank AG | 0 | $0 | 0.00% | −515,133−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −436,183−100.0% | Sold out |
| Nuveen Asset Management, LLC | 0 | $0 | 0.00% | −169,120−100.0% | Sold out |
| ClariVest Asset Management LLC | 0 | $0 | 0.00% | −184,119−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −154,175−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −135,611−100.0% | Sold out |
| Charles Schwab Investment Management Inc | 0 | $0 | 0.00% | −106,810−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −56,944−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −50,735−100.0% | Sold out |
| Rhumbline Advisers | 0 | $0 | 0.00% | −48,918−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −36,787−100.0% | Sold out |
| Alliancebernstein L.P. | 0 | $0 | 0.00% | −21,600−100.0% | Sold out |
| American International Group, Inc. | 0 | $0 | 0.00% | −20,064−100.0% | Sold out |
| California State Teachers Retirement System | 0 | $0 | 0.00% | −17,202−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −15,466−100.0% | Sold out |
| Invesco Ltd. | 0 | $0 | 0.00% | −12,350−100.0% | Sold out |
| ProShare Advisors LLC | 0 | $0 | 0.00% | −12,680−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −12,096−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −11,679−100.0% | Sold out |
| Public Employees Retirement System of Ohio | 0 | $0 | 0.00% | −8,189−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −4,887−100.0% | Sold out |
| Ameritas Investment Partners, Inc. | 0 | $0 | 0.00% | −3,710−100.0% | Sold out |
| Point72 Hong Kong Ltd | 0 | $0 | 0.00% | −3,921−100.0% | Sold out |
| Russell Investments Group, Ltd. | 0 | $0 | 0.00% | −3,008−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −1,084−100.0% | Sold out |
| Allspring Global Investments Holdings, LLC | 0 | $0 | 0.00% | −1,151−100.0% | Sold out |
| Toronto Dominion Bank | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Glassman Wealth Services | 0 | $0 | 0.00% | −88−100.0% | Sold out |
| Parametric Portfolio Associates LLC | – | – | – | – | Not filed |
| Amalgamated Financial Corp. | – | – | – | – | Not filed |