Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 55
- −12 vs. Q2 2022
- Shares held
- 44.7M
- −4.69M (−9.5%) vs. Q2 2022
- Total value
- $23.5M
- −$1.30M (−5.2%) vs. Q2 2022
- New holders
- 3
- 11 more added
- Sold out
- 15
- 14 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 5,347,689 | $2.81M | 0.34% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 4,668,536 | $2.46M | 1.05% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 4,059,894 | $2.14M | 0.09% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 3,710,778 | $1.95M | 0.19% | −166,533−4.3% | Reduced |
| Rock Springs Capital Management LP | 3,413,906 | $1.80M | 0.05% | +341,872+11.1% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $1.79M | 0.01% | 00.0% | Unchanged |
| Pictet Asset Management SA | 2,542,925 | $1.34M | 0.00% | −2,347,577−48.0% | Reduced |
| Great Point Partners LLC | 2,500,000 | $1.31M | 0.32% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,887,396 | $993.0K | 0.00% | −60,613−3.1% | Reduced |
| OrbiMed Advisors LLC | 1,797,221 | $945.0K | 0.02% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,691,151 | $890.0K | 0.59% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $789.0K | 0.00% | 00.0% | Unchanged |
| BlackRock Inc. | 1,032,665 | $542.0K | 0.00% | −36,937−3.5% | Reduced |
| Ghost Tree Capital, LLC | 1,000,000 | $526.0K | 0.21% | +75,000+8.1% | Added |
| Goldman Sachs Group Inc | 915,695 | $482.0K | 0.00% | −271,598−22.9% | Reduced |
| Samsara BioCapital, LLC | 883,720 | $465.0K | 0.11% | 00.0% | Unchanged |
| Millennium Management LLC | 814,672 | $429.0K | 0.00% | +292,757+56.1% | Added |
| Acadian Asset Management LLC | 468,558 | $245.0K | 0.00% | +55,171+13.3% | Added |
| Two Sigma Advisers, LP | 409,900 | $216.0K | 0.00% | +178,200+76.9% | Added |
| Geode Capital Management, LLC | 394,020 | $207.0K | 0.00% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 318,451 | $168.0K | 0.00% | −324,384−50.5% | Reduced |
| Renaissance Technologies LLC | 249,800 | $131.0K | 0.00% | −332,644−57.1% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $129.0K | 0.05% | 00.0% | Unchanged |
| Abingworth LLP | 240,500 | $127.0K | 0.04% | 00.0% | Unchanged |
| Morgan Stanley | 168,258 | $88.0K | 0.00% | −125,576−42.7% | Reduced |
| State Street Corp | 158,989 | $84.0K | 0.00% | 00.0% | Unchanged |
| Fan Yu | 112,044 | $59.0K | 0.80% | 00.0% | Unchanged |
| Franklin Street Advisors Inc | 105,800 | $56.0K | 0.01% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 103,589 | $54.0K | 0.00% | −212,251−67.2% | Reduced |
| Blair William & Co | 76,594 | $40.0K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $40.0K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 69,209 | $36.0K | 0.00% | 00.0% | Unchanged |
| Citadel Advisors LLC | 60,775 | $32.0K | 0.00% | −166,420−73.2% | Reduced |
| Qube Research & Technologies Ltd | 36,475 | $19.0K | 0.00% | −4,486−11.0% | Reduced |
| Man Group plc | 34,478 | $18.0K | 0.00% | – | – |
| Franklin Resources Inc | 31,364 | $16.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Securities, LLC | 31,043 | $16.0K | 0.00% | +31,043 | New |
| Tower Research Capital LLC (TRC) | 26,886 | $14.0K | 0.00% | +11,197+71.4% | Added |
| BIT Capital GmbH | 25,000 | $13.2K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 23,233 | $12.0K | 0.00% | −1,903−7.6% | Reduced |
| LMR Partners LLP | 19,220 | $10.0K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 11,676 | $6.00K | 0.00% | +4,375+59.9% | Added |
| Simplex Trading, LLC | 13,121 | $6.00K | 0.00% | +13,108+100,830.8% | Added |
| Ra Capital Management, L.P. | 10,439 | $5.00K | 0.00% | +10,439 | New |
| Group One Trading, L.P. | 3,100 | $2.00K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 3,646 | $2.00K | 0.00% | +1,324+57.0% | Added |
| Wells Fargo & Company | 2,530 | $1.00K | 0.00% | +87+3.6% | Added |
| Federated Hermes, Inc. | 1,930 | $1.00K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,401 | $1.00K | 0.00% | +727+107.9% | Added |
| BNP Paribas Arbitrage, SA | 1,575 | $828 | 0.00% | −3,694−70.1% | Reduced |
| Citigroup Inc | 633 | $0 | 0.00% | −4,543−87.8% | Reduced |
| Barclays PLC | 99 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 573 | $0 | 0.00% | +573 | New |
| IFP Advisors, Inc | 2,860 | – | – | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −506,326−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −476,404−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −147,200−100.0% | Sold out |
| UBS Group AG | 0 | $0 | 0.00% | −76,806−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −65,195−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −48,643−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −31,151−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −17,822−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −10,100−100.0% | Sold out |
| Legal & General Group Plc | 0 | $0 | 0.00% | −3,264−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −1,494−100.0% | Sold out |
| New York State Common Retirement Fund | 0 | $0 | 0.00% | −341−100.0% | Sold out |
| Credit Suisse AG | 0 | $0 | 0.00% | −21−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −470−100.0% | Sold out |
| Lion Point Capital, LP | 0 | $0 | 0.00% | −300,000−100.0% | Sold out |