Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 55
- −12 vs. Q2 2022
- Shares held
- 44.7M
- −4.69M (−9.5%) vs. Q2 2022
- Total value
- $23.5M
- −$1.30M (−5.2%) vs. Q2 2022
- New holders
- 3
- 11 more added
- Sold out
- 15
- 14 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Citigroup Inc | 633 | $0 | 0.00% | −4,543−87.8% | Reduced |
| Barclays PLC | 99 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 573 | $0 | 0.00% | +573 | New |
| BNP Paribas Arbitrage, SA | 1,575 | $828 | 0.00% | −3,694−70.1% | Reduced |
| Wells Fargo & Company | 2,530 | $1.00K | 0.00% | +87+3.6% | Added |
| Federated Hermes, Inc. | 1,930 | $1.00K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,401 | $1.00K | 0.00% | +727+107.9% | Added |
| Group One Trading, L.P. | 3,100 | $2.00K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 3,646 | $2.00K | 0.00% | +1,324+57.0% | Added |
| Ra Capital Management, L.P. | 10,439 | $5.00K | 0.00% | +10,439 | New |
| Bank of America Corp | 11,676 | $6.00K | 0.00% | +4,375+59.9% | Added |
| Simplex Trading, LLC | 13,121 | $6.00K | 0.00% | +13,108+100,830.8% | Added |
| LMR Partners LLP | 19,220 | $10.0K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 23,233 | $12.0K | 0.00% | −1,903−7.6% | Reduced |
| BIT Capital GmbH | 25,000 | $13.2K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 26,886 | $14.0K | 0.00% | +11,197+71.4% | Added |
| Franklin Resources Inc | 31,364 | $16.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Securities, LLC | 31,043 | $16.0K | 0.00% | +31,043 | New |
| Man Group plc | 34,478 | $18.0K | 0.00% | – | – |
| Qube Research & Technologies Ltd | 36,475 | $19.0K | 0.00% | −4,486−11.0% | Reduced |
| Citadel Advisors LLC | 60,775 | $32.0K | 0.00% | −166,420−73.2% | Reduced |
| Northern Trust Corp | 69,209 | $36.0K | 0.00% | 00.0% | Unchanged |
| Blair William & Co | 76,594 | $40.0K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $40.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 103,589 | $54.0K | 0.00% | −212,251−67.2% | Reduced |
| Franklin Street Advisors Inc | 105,800 | $56.0K | 0.01% | 00.0% | Unchanged |
| Fan Yu | 112,044 | $59.0K | 0.80% | 00.0% | Unchanged |
| State Street Corp | 158,989 | $84.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 168,258 | $88.0K | 0.00% | −125,576−42.7% | Reduced |
| Abingworth LLP | 240,500 | $127.0K | 0.04% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $129.0K | 0.05% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 249,800 | $131.0K | 0.00% | −332,644−57.1% | Reduced |
| Assenagon Asset Management S.A. | 318,451 | $168.0K | 0.00% | −324,384−50.5% | Reduced |
| Geode Capital Management, LLC | 394,020 | $207.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 409,900 | $216.0K | 0.00% | +178,200+76.9% | Added |
| Acadian Asset Management LLC | 468,558 | $245.0K | 0.00% | +55,171+13.3% | Added |
| Millennium Management LLC | 814,672 | $429.0K | 0.00% | +292,757+56.1% | Added |
| Samsara BioCapital, LLC | 883,720 | $465.0K | 0.11% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 915,695 | $482.0K | 0.00% | −271,598−22.9% | Reduced |
| Ghost Tree Capital, LLC | 1,000,000 | $526.0K | 0.21% | +75,000+8.1% | Added |
| BlackRock Inc. | 1,032,665 | $542.0K | 0.00% | −36,937−3.5% | Reduced |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $789.0K | 0.00% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,691,151 | $890.0K | 0.59% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 1,797,221 | $945.0K | 0.02% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,887,396 | $993.0K | 0.00% | −60,613−3.1% | Reduced |
| Great Point Partners LLC | 2,500,000 | $1.31M | 0.32% | 00.0% | Unchanged |
| Pictet Asset Management SA | 2,542,925 | $1.34M | 0.00% | −2,347,577−48.0% | Reduced |
| Baker Bros. Advisors LP | 3,410,106 | $1.79M | 0.01% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 3,413,906 | $1.80M | 0.05% | +341,872+11.1% | Added |
| Nantahala Capital Management, LLC | 3,710,778 | $1.95M | 0.19% | −166,533−4.3% | Reduced |
| Suvretta Capital Management, LLC | 4,059,894 | $2.14M | 0.09% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 4,668,536 | $2.46M | 1.05% | 00.0% | Unchanged |
| Bain Capital Life Sciences Investors, LLC | 5,347,689 | $2.81M | 0.34% | 00.0% | Unchanged |
| IFP Advisors, Inc | 2,860 | – | – | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −506,326−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −476,404−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −147,200−100.0% | Sold out |
| UBS Group AG | 0 | $0 | 0.00% | −76,806−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −65,195−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −48,643−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −31,151−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −17,822−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −10,100−100.0% | Sold out |
| Legal & General Group Plc | 0 | $0 | 0.00% | −3,264−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −1,494−100.0% | Sold out |
| New York State Common Retirement Fund | 0 | $0 | 0.00% | −341−100.0% | Sold out |
| Credit Suisse AG | 0 | $0 | 0.00% | −21−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −470−100.0% | Sold out |
| Lion Point Capital, LP | 0 | $0 | 0.00% | −300,000−100.0% | Sold out |