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Spyre Therapeutics, Inc.

SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001636282

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

Q3 2022 vs. Q2 2022

How the institutions holding Spyre Therapeutics, Inc. changed between Q2 2022 and Q3 2022.

All holders in Q3 2022All holders in Q2 2022

13F holders of SYRE: Q2 2022 compared with Q3 2022
MeasureQ2 2022Q3 2022Change
Holders6755−12
Shares49.4M44.7M−4.69M (−9.5%)
Value$24.8M$23.5M−$1.30M (−5.2%)

New holders (3)

Institutions that held Spyre Therapeutics, Inc. at the end of Q3 2022 but not at the end of Q2 2022.

Institutions new to SYRE in Q3 2022
InstitutionSharesValue% of portfolio
Two Sigma Securities, LLC31,043$16.0K0.00%
Ra Capital Management, L.P.10,439$5.00K0.00%
China Universal Asset Management Co., Ltd.573$00.00%

Sold out (15)

Institutions that held Spyre Therapeutics, Inc. at the end of Q2 2022 and filed for Q3 2022 without it.

Institutions that sold out of SYRE in Q3 2022
InstitutionShares, Q2 2022Value, Q2 2022
Dimensional Fund Advisors LP506,326$255.0K
D. E. Shaw & Co., Inc.476,404$241.0K
Ergoteles LLC147,200$74.0K
UBS Group AG76,806$39.0K
Susquehanna International Group, LLP65,195$33.0K
Bridgeway Capital Management, LLC48,643$25.0K
Virtu Financial LLC31,151$16.0K
SG Americas Securities, LLC17,822$9.00K
Schonfeld Strategic Advisors LLC10,100$5.00K
Legal & General Group Plc3,264$2.00K
FMR LLC1,494$1.00K
New York State Common Retirement Fund341$0
Credit Suisse AG21$0
Advisor Group Holdings, Inc.470$0
Lion Point Capital, LP300,000–