Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +9 vs. Q2 2025
- Shares held
- 64.3M
- +693.4K (+1.1%) vs. Q2 2025
- Total value
- $1.08B
- +$125.3M (+13.2%) vs. Q2 2025
- New holders
- 22
- 44 more added
- Sold out
- 13
- 43 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 9,060,144 | $151.8M | 0.01% | +7,110+0.1% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $67.3M | 6.06% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,982,744 | $66.8M | 0.00% | −24,552−0.6% | Reduced |
| RTW Investments, LP | 3,621,996 | $60.7M | 0.75% | 00.0% | Unchanged |
| Tang Capital Management LLC | 3,200,000 | $53.6M | 2.06% | 00.0% | Unchanged |
| Vanguard Group Inc | 3,050,730 | $51.1M | 0.00% | −15,856−0.5% | Reduced |
| VR Adviser, LLC | 2,685,448 | $45.0M | 2.53% | 00.0% | Unchanged |
| Braidwell LP | 2,578,404 | $43.2M | 1.28% | 00.0% | Unchanged |
| Capital International Investors | 2,392,541 | $40.1M | 0.01% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 2,060,375 | $34.5M | 0.25% | −25,215−1.2% | Reduced |
| Commodore Capital LP | 1,988,084 | $33.3M | 1.63% | 00.0% | Unchanged |
| State Street Corp | 1,785,206 | $29.9M | 0.00% | +189,915+11.9% | Added |
| Wellington Management Group LLP | 1,640,312 | $27.5M | 0.00% | +126,834+8.4% | Added |
| Paradigm Biocapital Advisors LP | 1,467,266 | $24.6M | 0.73% | −403,179−21.6% | Reduced |
| Affinity Asset Advisors, LLC | 1,419,299 | $23.8M | 2.21% | +812,621+133.9% | Added |
| Jefferies Financial Group Inc. | 1,388,854 | $23.3M | 0.21% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 1,229,445 | $20.6M | 0.60% | −300,000−19.6% | Reduced |
| Geode Capital Management, LLC | 1,225,153 | $20.5M | 0.00% | −2,079−0.2% | Reduced |
| TCG Crossover Management, LLC | 1,100,582 | $18.4M | 0.91% | +1,100,582 | New |
| Pictet Asset Management Holding SA | 1,036,218 | $17.4M | 0.02% | −43,225−4.0% | Reduced |
| Baker Bros. Advisors LP | 1,000,000 | $16.8M | 0.12% | +373,297+59.6% | Added |
| Franklin Resources Inc | 795,275 | $13.3M | 0.00% | 00.0% | Unchanged |
| Polar Capital Holdings Plc | 788,788 | $13.2M | 0.06% | +43,788+5.9% | Added |
| Price T Rowe Associates Inc | 620,620 | $10.4M | 0.00% | −309,861−33.3% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 613,665 | $10.3M | 0.16% | 00.0% | Unchanged |
| Emerald Advisers, LLC | 548,712 | $9.20M | 0.29% | −17,151−3.0% | Reduced |
| Blackstone Group Inc. | 500,998 | $8.40M | 0.04% | +11,750+2.4% | Added |
| Northern Trust Corp | 442,036 | $7.41M | 0.00% | +5,089+1.2% | Added |
| Charles Schwab Investment Management Inc | 425,345 | $7.13M | 0.00% | +6,842+1.6% | Added |
| Millennium Management LLC | 408,199 | $6.84M | 0.01% | +408,199 | New |
| Candriam Luxembourg S.C.A. | 404,362 | $6.78M | 0.04% | +158,332+64.4% | Added |
| UBS Group AG | 385,589 | $6.46M | 0.00% | −77,274−16.7% | Reduced |
| Siren, L.L.C. | 368,598 | $6.18M | 0.24% | 00.0% | Unchanged |
| Bank of America Corp | 344,803 | $5.78M | 0.00% | −51,548−13.0% | Reduced |
| Morgan Stanley | 334,722 | $5.61M | 0.00% | −336,322−50.1% | Reduced |
| Goldman Sachs Group Inc | 329,533 | $5.52M | 0.00% | −193,883−37.0% | Reduced |
| Victory Capital Management Inc | 326,081 | $5.47M | 0.00% | −28,035−7.9% | Reduced |
| BNP Paribas Arbitrage, SA | 315,909 | $5.29M | 0.00% | +92,589+41.5% | Added |
| Emerald Mutual Fund Advisers Trust | 308,212 | $5.17M | 0.27% | −21,218−6.4% | Reduced |
| JPMorgan Chase & Co | 275,984 | $4.63M | 0.00% | +228,705+483.7% | Added |
| Voloridge Investment Management, LLC | 264,317 | $4.43M | 0.01% | −14,603−5.2% | Reduced |
| HighVista Strategies LLC | 215,746 | $3.62M | 0.89% | +102,941+91.3% | Added |
| Parkman Healthcare Partners LLC | 200,753 | $3.36M | 0.37% | +200,753 | New |
| Capital World Investors | 200,172 | $3.35M | 0.00% | −150,602−42.9% | Reduced |
| Barclays PLC | 168,330 | $2.82M | 0.00% | −48,316−22.3% | Reduced |
| Armistice Capital, LLC | 156,000 | $2.61M | 0.08% | −16,000−9.3% | Reduced |
| Bank of New York Mellon Corp | 135,960 | $2.28M | 0.00% | +3,810+2.9% | Added |
| Woodline Partners LP | 131,876 | $2.21M | 0.01% | −333,276−71.6% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,456 | $1.85M | 0.00% | +1,172+1.1% | Added |
| Mercer Global Advisors Inc | 106,664 | $1.79M | 0.00% | +522+0.5% | Added |
| Schroder Investment Management Group | 107,738 | $1.76M | 0.00% | −21,820−16.8% | Reduced |
| B Group, Inc. | 100,000 | $1.68M | 1.60% | +20,000+25.0% | Added |
| Nuveen, LLC | 96,172 | $1.61M | 0.00% | −38,896−28.8% | Reduced |
| Jane Street Group, LLC | 96,057 | $1.61M | 0.00% | +96,057 | New |
| Dimensional Fund Advisors LP | 84,216 | $1.41M | 0.00% | +84,216 | New |
| Schonfeld Strategic Advisors LLC | 81,474 | $1.37M | 0.01% | +81,474 | New |
| TD Asset Management Inc | 72,368 | $1.21M | 0.00% | −41,600−36.5% | Reduced |
| Manufacturers Life Insurance Company, The | 71,948 | $1.21M | 0.00% | −7,948−9.9% | Reduced |
| Rhumbline Advisers | 70,914 | $1.19M | 0.00% | −2,254−3.1% | Reduced |
| Swiss National Bank | 70,200 | $1.18M | 0.00% | +1,600+2.3% | Added |
| ExodusPoint Capital Management, LP | 68,563 | $1.15M | 0.02% | −14,414−17.4% | Reduced |
| Quest Partners LLC | 66,163 | $1.11M | 0.07% | +61,989+1,485.1% | Added |
| Opaleye Management Inc. | 65,000 | $1.09M | 0.15% | +65,000 | New |
| Rafferty Asset Management, LLC | 59,667 | $1.00M | 0.00% | +8,710+17.1% | Added |
| F/M Investments LLC | 54,893 | $920.0K | 0.04% | +2,347+4.5% | Added |
| Invesco Ltd. | 50,702 | $849.8K | 0.00% | +16,022+46.2% | Added |
| Verition Fund Management LLC | 48,496 | $812.8K | 0.00% | −16,546−25.4% | Reduced |
| Legal & General Group Plc | 46,841 | $785.1K | 0.00% | +11,872+34.0% | Added |
| UBS Asset Management Americas Inc | 39,498 | $662.0K | 0.00% | −46,204−53.9% | Reduced |
| Wells Fargo & Company | 39,319 | $659.0K | 0.00% | +4,910+14.3% | Added |
| Deutsche Bank AG | 38,543 | $646.0K | 0.00% | +4,605+13.6% | Added |
| Alliancebernstein L.P. | 36,230 | $607.2K | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 34,051 | $570.7K | 0.06% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 33,546 | $562.2K | 0.00% | −1,500−4.3% | Reduced |
| California State Teachers Retirement System | 33,203 | $556.5K | 0.00% | +20.0% | Added |
| Citigroup Inc | 32,896 | $551.3K | 0.00% | +3,635+12.4% | Added |
| DLD Asset Management, LP | 30,000 | $502.8K | 0.06% | +30,000 | New |
| MetLife Investment Management | 29,918 | $501.4K | 0.00% | 00.0% | Unchanged |
| Jump Financial, LLC | 27,100 | $454.2K | 0.01% | +27,100 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 26,448 | $442.0K | 0.00% | −3,364−11.3% | Reduced |
| Warren Averett Asset Management, LLC | 25,953 | $435.0K | 0.00% | +6,500+33.4% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $432.0K | 0.00% | 00.0% | Unchanged |
| Optimize Financial Inc | 24,967 | $418.4K | 0.22% | +24,967 | New |
| Assenagon Asset Management S.A. | 22,136 | $371.0K | 0.00% | 00.0% | Unchanged |
| Susquehanna Portfolio Strategies, LLC | 21,739 | $364.3K | 0.01% | +21,739 | New |
| Intech Investment Management LLC | 20,360 | $341.2K | 0.00% | −4,585−18.4% | Reduced |
| Squarepoint Ops LLC | 20,232 | $339.1K | 0.00% | −9,814−32.7% | Reduced |
| Quadrature Capital Ltd | 19,366 | $324.8K | 0.00% | +19,366 | New |
| Virginia Retirement Systems Et Al | 18,500 | $310.1K | 0.00% | +18,500 | New |
| Global Endowment Management, LP | 18,184 | $304.8K | 0.04% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 18,172 | $304.6K | 0.00% | +18,172 | New |
| AQR Capital Management LLC | 17,047 | $285.7K | 0.00% | −926−5.2% | Reduced |
| New York State Common Retirement Fund | 16,565 | $277.6K | 0.00% | 00.0% | Unchanged |
| Dark Forest Capital Management LP | 14,733 | $246.9K | 0.01% | +14,733 | New |
| Police & Firemen's Retirement System of New Jersey | 13,809 | $231.4K | 0.00% | +2,284+19.8% | Added |
| Profund Advisors LLC | 13,223 | $221.6K | 0.01% | +2,180+19.7% | Added |
| Janus Henderson Group PLC | 13,000 | $217.9K | 0.00% | 00.0% | Unchanged |
| DRW Securities, LLC | 11,475 | $190.2K | 0.01% | +11,475 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,874 | $182.2K | 0.00% | −1,999−15.5% | Reduced |
| Arizona State Retirement System | 10,693 | $179.2K | 0.00% | +181+1.7% | Added |