Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +9 vs. Q2 2025
- Shares held
- 64.3M
- +693.4K (+1.1%) vs. Q2 2025
- Total value
- $1.08B
- +$125.3M (+13.2%) vs. Q2 2025
- New holders
- 22
- 44 more added
- Sold out
- 13
- 43 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | Unchanged |
| Comerica Bank | 5 | $84 | 0.00% | +5 | New |
| US Bancorp | 10 | $168 | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 10 | $168 | 0.00% | +10 | New |
| Larson Financial Group LLC | 12 | $201 | 0.00% | +6+100.0% | Added |
| IFP Advisors, Inc | 24 | $402 | 0.00% | +1+4.3% | Added |
| Allworth Financial LP | 32 | $537 | 0.00% | +2+6.7% | Added |
| Parkside Financial Bank & Trust | 35 | $587 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 65 | $1.09K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 70 | $1.17K | 0.00% | −95−57.6% | Reduced |
| Rothschild Investment LLC | 80 | $1.34K | 0.00% | −60−42.9% | Reduced |
| The PNC Financial Services Group, Inc. | 86 | $1.44K | 0.00% | +86 | New |
| SRS Capital Advisors, Inc. | 121 | $2.03K | 0.00% | +121 | New |
| Daiwa Securities Group Inc. | 206 | $3.00K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 208 | $3.49K | 0.00% | +34+19.5% | Added |
| Meeder Asset Management Inc | 216 | $3.62K | 0.00% | +46+27.1% | Added |
| Advisor Group Holdings, Inc. | 314 | $5.17K | 0.00% | +14+4.7% | Added |
| SBI Securities Co., Ltd. | 123 | $5.88K | 0.00% | +112+1,018.2% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 335 | $6.00K | 0.00% | −42−11.1% | Reduced |
| Rockefeller Capital Management L.P. | 401 | $6.72K | 0.00% | +401 | New |
| Optiver Holding B.V. | 500 | $8.38K | 0.00% | +500 | New |
| Nisa Investment Advisors, LLC | 705 | $11.8K | 0.00% | +159+29.1% | Added |
| Sterling Capital Management LLC | 1,214 | $20.3K | 0.00% | +690+131.7% | Added |
| GF Fund Management Co. Ltd. | 1,299 | $21.8K | 0.00% | −203−13.5% | Reduced |
| Amalgamated Bank | 1,379 | $23.0K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1,470 | $24.6K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 1,589 | $27.0K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 1,960 | $33.0K | 0.00% | +248+14.5% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,335 | $39.1K | 0.00% | +4+0.2% | Added |
| Ameritas Investment Partners, Inc. | 4,166 | $69.8K | 0.00% | −925−18.2% | Reduced |
| Russell Investments Group, Ltd. | 4,234 | $71.0K | 0.00% | +4,092+2,881.7% | Added |
| Tower Research Capital LLC (TRC) | 4,596 | $77.0K | 0.00% | −1,173−20.3% | Reduced |
| Virtus Investment Advisers, Inc. | 6,425 | $107.7K | 0.03% | +1,115+21.0% | Added |
| KLP Kapitalforvaltning AS | 7,800 | $130.7K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 7,883 | $132.0K | 0.00% | −591−7.0% | Reduced |
| China Universal Asset Management Co., Ltd. | 10,587 | $177.4K | 0.01% | −1,535−12.7% | Reduced |
| ProShare Advisors LLC | 10,678 | $179.0K | 0.00% | −1,801−14.4% | Reduced |
| Arizona State Retirement System | 10,693 | $179.2K | 0.00% | +181+1.7% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,874 | $182.2K | 0.00% | −1,999−15.5% | Reduced |
| DRW Securities, LLC | 11,475 | $190.2K | 0.01% | +11,475 | New |
| Janus Henderson Group PLC | 13,000 | $217.9K | 0.00% | 00.0% | Unchanged |
| Profund Advisors LLC | 13,223 | $221.6K | 0.01% | +2,180+19.7% | Added |
| Police & Firemen's Retirement System of New Jersey | 13,809 | $231.4K | 0.00% | +2,284+19.8% | Added |
| Dark Forest Capital Management LP | 14,733 | $246.9K | 0.01% | +14,733 | New |
| New York State Common Retirement Fund | 16,565 | $277.6K | 0.00% | 00.0% | Unchanged |
| AQR Capital Management LLC | 17,047 | $285.7K | 0.00% | −926−5.2% | Reduced |
| Los Angeles Capital Management LLC | 18,172 | $304.6K | 0.00% | +18,172 | New |
| Global Endowment Management, LP | 18,184 | $304.8K | 0.04% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 18,500 | $310.1K | 0.00% | +18,500 | New |
| Quadrature Capital Ltd | 19,366 | $324.8K | 0.00% | +19,366 | New |
| Squarepoint Ops LLC | 20,232 | $339.1K | 0.00% | −9,814−32.7% | Reduced |
| Intech Investment Management LLC | 20,360 | $341.2K | 0.00% | −4,585−18.4% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 21,739 | $364.3K | 0.01% | +21,739 | New |
| Assenagon Asset Management S.A. | 22,136 | $371.0K | 0.00% | 00.0% | Unchanged |
| Optimize Financial Inc | 24,967 | $418.4K | 0.22% | +24,967 | New |
| Teachers Retirement System of the State of Kentucky | 25,799 | $432.0K | 0.00% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 25,953 | $435.0K | 0.00% | +6,500+33.4% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 26,448 | $442.0K | 0.00% | −3,364−11.3% | Reduced |
| Jump Financial, LLC | 27,100 | $454.2K | 0.01% | +27,100 | New |
| MetLife Investment Management | 29,918 | $501.4K | 0.00% | 00.0% | Unchanged |
| DLD Asset Management, LP | 30,000 | $502.8K | 0.06% | +30,000 | New |
| Citigroup Inc | 32,896 | $551.3K | 0.00% | +3,635+12.4% | Added |
| California State Teachers Retirement System | 33,203 | $556.5K | 0.00% | +20.0% | Added |
| State of Wisconsin Investment Board | 33,546 | $562.2K | 0.00% | −1,500−4.3% | Reduced |
| ADAR1 Capital Management, LLC | 34,051 | $570.7K | 0.06% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 36,230 | $607.2K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 38,543 | $646.0K | 0.00% | +4,605+13.6% | Added |
| Wells Fargo & Company | 39,319 | $659.0K | 0.00% | +4,910+14.3% | Added |
| UBS Asset Management Americas Inc | 39,498 | $662.0K | 0.00% | −46,204−53.9% | Reduced |
| Legal & General Group Plc | 46,841 | $785.1K | 0.00% | +11,872+34.0% | Added |
| Verition Fund Management LLC | 48,496 | $812.8K | 0.00% | −16,546−25.4% | Reduced |
| Invesco Ltd. | 50,702 | $849.8K | 0.00% | +16,022+46.2% | Added |
| F/M Investments LLC | 54,893 | $920.0K | 0.04% | +2,347+4.5% | Added |
| Rafferty Asset Management, LLC | 59,667 | $1.00M | 0.00% | +8,710+17.1% | Added |
| Opaleye Management Inc. | 65,000 | $1.09M | 0.15% | +65,000 | New |
| Quest Partners LLC | 66,163 | $1.11M | 0.07% | +61,989+1,485.1% | Added |
| ExodusPoint Capital Management, LP | 68,563 | $1.15M | 0.02% | −14,414−17.4% | Reduced |
| Swiss National Bank | 70,200 | $1.18M | 0.00% | +1,600+2.3% | Added |
| Rhumbline Advisers | 70,914 | $1.19M | 0.00% | −2,254−3.1% | Reduced |
| Manufacturers Life Insurance Company, The | 71,948 | $1.21M | 0.00% | −7,948−9.9% | Reduced |
| TD Asset Management Inc | 72,368 | $1.21M | 0.00% | −41,600−36.5% | Reduced |
| Schonfeld Strategic Advisors LLC | 81,474 | $1.37M | 0.01% | +81,474 | New |
| Dimensional Fund Advisors LP | 84,216 | $1.41M | 0.00% | +84,216 | New |
| Jane Street Group, LLC | 96,057 | $1.61M | 0.00% | +96,057 | New |
| Nuveen, LLC | 96,172 | $1.61M | 0.00% | −38,896−28.8% | Reduced |
| B Group, Inc. | 100,000 | $1.68M | 1.60% | +20,000+25.0% | Added |
| Schroder Investment Management Group | 107,738 | $1.76M | 0.00% | −21,820−16.8% | Reduced |
| Mercer Global Advisors Inc | 106,664 | $1.79M | 0.00% | +522+0.5% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,456 | $1.85M | 0.00% | +1,172+1.1% | Added |
| Woodline Partners LP | 131,876 | $2.21M | 0.01% | −333,276−71.6% | Reduced |
| Bank of New York Mellon Corp | 135,960 | $2.28M | 0.00% | +3,810+2.9% | Added |
| Armistice Capital, LLC | 156,000 | $2.61M | 0.08% | −16,000−9.3% | Reduced |
| Barclays PLC | 168,330 | $2.82M | 0.00% | −48,316−22.3% | Reduced |
| Capital World Investors | 200,172 | $3.35M | 0.00% | −150,602−42.9% | Reduced |
| Parkman Healthcare Partners LLC | 200,753 | $3.36M | 0.37% | +200,753 | New |
| HighVista Strategies LLC | 215,746 | $3.62M | 0.89% | +102,941+91.3% | Added |
| Voloridge Investment Management, LLC | 264,317 | $4.43M | 0.01% | −14,603−5.2% | Reduced |
| JPMorgan Chase & Co | 275,984 | $4.63M | 0.00% | +228,705+483.7% | Added |
| Emerald Mutual Fund Advisers Trust | 308,212 | $5.17M | 0.27% | −21,218−6.4% | Reduced |
| BNP Paribas Arbitrage, SA | 315,909 | $5.29M | 0.00% | +92,589+41.5% | Added |