Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2025 年第 3 季 13F 持有人
Spyre Therapeutics, Inc. 在 2025/9/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 137
- 較 2025 年第 2 季 +9 家
- 持有股數
- 6,430 萬
- 較 2025 年第 2 季 +69.3 萬 (+1.1%)
- 總市值
- $10.8 億
- 較 2025 年第 2 季 +$1.25 億 (+13.2%)
- 新進機構
- 22
- 另有 44 家加碼
- 清倉機構
- 13
- 另有 43 家減碼
另有 1 家機構在 2025 年第 2 季持有、還沒有申報 2025 年第 3 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2025 年第 3 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 2 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 9,060,144 | $1.52 億 | 0.01% | +7,110+0.1% | 加碼 |
| Fairmount Funds Management LLC | 4,018,101 | $6,734 萬 | 6.06% | 00.0% | 不變 |
| BlackRock, Inc. | 3,982,744 | $6,675 萬 | 0.00% | −24,552−0.6% | 減碼 |
| RTW Investments, LP | 3,621,996 | $6,070 萬 | 0.75% | 00.0% | 不變 |
| Tang Capital Management LLC | 3,200,000 | $5,363 萬 | 2.06% | 00.0% | 不變 |
| Vanguard Group Inc | 3,050,730 | $5,113 萬 | 0.00% | −15,856−0.5% | 減碼 |
| VR Adviser, LLC | 2,685,448 | $4,501 萬 | 2.53% | 00.0% | 不變 |
| Braidwell LP | 2,578,404 | $4,321 萬 | 1.28% | 00.0% | 不變 |
| Capital International Investors | 2,392,541 | $4,010 萬 | 0.01% | 00.0% | 不變 |
| Driehaus Capital Management LLC | 2,060,375 | $3,453 萬 | 0.25% | −25,215−1.2% | 減碼 |
| Commodore Capital LP | 1,988,084 | $3,332 萬 | 1.63% | 00.0% | 不變 |
| State Street Corp | 1,785,206 | $2,992 萬 | 0.00% | +189,915+11.9% | 加碼 |
| Wellington Management Group LLP | 1,640,312 | $2,749 萬 | 0.00% | +126,834+8.4% | 加碼 |
| Paradigm Biocapital Advisors LP | 1,467,266 | $2,459 萬 | 0.73% | −403,179−21.6% | 減碼 |
| Affinity Asset Advisors, LLC | 1,419,299 | $2,379 萬 | 2.21% | +812,621+133.9% | 加碼 |
| Jefferies Financial Group Inc. | 1,388,854 | $2,328 萬 | 0.21% | 00.0% | 不變 |
| Perceptive Advisors LLC | 1,229,445 | $2,061 萬 | 0.60% | −300,000−19.6% | 減碼 |
| Geode Capital Management, LLC | 1,225,153 | $2,054 萬 | 0.00% | −2,079−0.2% | 減碼 |
| TCG Crossover Management, LLC | 1,100,582 | $1,845 萬 | 0.91% | +1,100,582 | 新進 |
| Pictet Asset Management Holding SA | 1,036,218 | $1,737 萬 | 0.02% | −43,225−4.0% | 減碼 |
| Baker Bros. Advisors LP | 1,000,000 | $1,676 萬 | 0.12% | +373,297+59.6% | 加碼 |
| Franklin Resources Inc | 795,275 | $1,333 萬 | 0.00% | 00.0% | 不變 |
| Polar Capital Holdings Plc | 788,788 | $1,322 萬 | 0.06% | +43,788+5.9% | 加碼 |
| Price T Rowe Associates Inc | 620,620 | $1,040 萬 | 0.00% | −309,861−33.3% | 減碼 |
| Deerfield Management Company, L.P. (Series C) | 613,665 | $1,029 萬 | 0.16% | 00.0% | 不變 |
| Emerald Advisers, LLC | 548,712 | $919.6 萬 | 0.29% | −17,151−3.0% | 減碼 |
| Blackstone Group Inc. | 500,998 | $839.7 萬 | 0.04% | +11,750+2.4% | 加碼 |
| Northern Trust Corp | 442,036 | $740.9 萬 | 0.00% | +5,089+1.2% | 加碼 |
| Charles Schwab Investment Management Inc | 425,345 | $712.9 萬 | 0.00% | +6,842+1.6% | 加碼 |
| Millennium Management LLC | 408,199 | $684.1 萬 | 0.01% | +408,199 | 新進 |
| Candriam Luxembourg S.C.A. | 404,362 | $677.7 萬 | 0.04% | +158,332+64.4% | 加碼 |
| UBS Group AG | 385,589 | $646.2 萬 | 0.00% | −77,274−16.7% | 減碼 |
| Siren, L.L.C. | 368,598 | $617.8 萬 | 0.24% | 00.0% | 不變 |
| Bank of America Corp | 344,803 | $577.9 萬 | 0.00% | −51,548−13.0% | 減碼 |
| Morgan Stanley | 334,722 | $561.0 萬 | 0.00% | −336,322−50.1% | 減碼 |
| Goldman Sachs Group Inc | 329,533 | $552.3 萬 | 0.00% | −193,883−37.0% | 減碼 |
| Victory Capital Management Inc | 326,081 | $546.5 萬 | 0.00% | −28,035−7.9% | 減碼 |
| BNP Paribas Arbitrage, SA | 315,909 | $529.5 萬 | 0.00% | +92,589+41.5% | 加碼 |
| Emerald Mutual Fund Advisers Trust | 308,212 | $516.6 萬 | 0.27% | −21,218−6.4% | 減碼 |
| JPMorgan Chase & Co | 275,984 | $462.5 萬 | 0.00% | +228,705+483.7% | 加碼 |
| Voloridge Investment Management, LLC | 264,317 | $443.0 萬 | 0.01% | −14,603−5.2% | 減碼 |
| HighVista Strategies LLC | 215,746 | $361.6 萬 | 0.89% | +102,941+91.3% | 加碼 |
| Parkman Healthcare Partners LLC | 200,753 | $336.5 萬 | 0.37% | +200,753 | 新進 |
| Capital World Investors | 200,172 | $335.5 萬 | 0.00% | −150,602−42.9% | 減碼 |
| Barclays PLC | 168,330 | $282.1 萬 | 0.00% | −48,316−22.3% | 減碼 |
| Armistice Capital, LLC | 156,000 | $261.5 萬 | 0.08% | −16,000−9.3% | 減碼 |
| Bank of New York Mellon Corp | 135,960 | $227.9 萬 | 0.00% | +3,810+2.9% | 加碼 |
| Woodline Partners LP | 131,876 | $221.0 萬 | 0.01% | −333,276−71.6% | 減碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,456 | $185.1 萬 | 0.00% | +1,172+1.1% | 加碼 |
| Mercer Global Advisors Inc | 106,664 | $178.8 萬 | 0.00% | +522+0.5% | 加碼 |
| Schroder Investment Management Group | 107,738 | $176.3 萬 | 0.00% | −21,820−16.8% | 減碼 |
| B Group, Inc. | 100,000 | $167.6 萬 | 1.60% | +20,000+25.0% | 加碼 |
| Nuveen, LLC | 96,172 | $161.2 萬 | 0.00% | −38,896−28.8% | 減碼 |
| Jane Street Group, LLC | 96,057 | $161.0 萬 | 0.00% | +96,057 | 新進 |
| Dimensional Fund Advisors LP | 84,216 | $141.1 萬 | 0.00% | +84,216 | 新進 |
| Schonfeld Strategic Advisors LLC | 81,474 | $136.6 萬 | 0.01% | +81,474 | 新進 |
| TD Asset Management Inc | 72,368 | $121.3 萬 | 0.00% | −41,600−36.5% | 減碼 |
| Manufacturers Life Insurance Company, The | 71,948 | $120.6 萬 | 0.00% | −7,948−9.9% | 減碼 |
| Rhumbline Advisers | 70,914 | $118.9 萬 | 0.00% | −2,254−3.1% | 減碼 |
| Swiss National Bank | 70,200 | $117.7 萬 | 0.00% | +1,600+2.3% | 加碼 |
| ExodusPoint Capital Management, LP | 68,563 | $114.9 萬 | 0.02% | −14,414−17.4% | 減碼 |
| Quest Partners LLC | 66,163 | $110.9 萬 | 0.07% | +61,989+1,485.1% | 加碼 |
| Opaleye Management Inc. | 65,000 | $108.9 萬 | 0.15% | +65,000 | 新進 |
| Rafferty Asset Management, LLC | 59,667 | $100.0 萬 | 0.00% | +8,710+17.1% | 加碼 |
| F/M Investments LLC | 54,893 | $92.0 萬 | 0.04% | +2,347+4.5% | 加碼 |
| Invesco Ltd. | 50,702 | $85.0 萬 | 0.00% | +16,022+46.2% | 加碼 |
| Verition Fund Management LLC | 48,496 | $81.3 萬 | 0.00% | −16,546−25.4% | 減碼 |
| Legal & General Group Plc | 46,841 | $78.5 萬 | 0.00% | +11,872+34.0% | 加碼 |
| UBS Asset Management Americas Inc | 39,498 | $66.2 萬 | 0.00% | −46,204−53.9% | 減碼 |
| Wells Fargo & Company | 39,319 | $65.9 萬 | 0.00% | +4,910+14.3% | 加碼 |
| Deutsche Bank AG | 38,543 | $64.6 萬 | 0.00% | +4,605+13.6% | 加碼 |
| Alliancebernstein L.P. | 36,230 | $60.7 萬 | 0.00% | 00.0% | 不變 |
| ADAR1 Capital Management, LLC | 34,051 | $57.1 萬 | 0.06% | 00.0% | 不變 |
| State of Wisconsin Investment Board | 33,546 | $56.2 萬 | 0.00% | −1,500−4.3% | 減碼 |
| California State Teachers Retirement System | 33,203 | $55.6 萬 | 0.00% | +20.0% | 加碼 |
| Citigroup Inc | 32,896 | $55.1 萬 | 0.00% | +3,635+12.4% | 加碼 |
| DLD Asset Management, LP | 30,000 | $50.3 萬 | 0.06% | +30,000 | 新進 |
| MetLife Investment Management | 29,918 | $50.1 萬 | 0.00% | 00.0% | 不變 |
| Jump Financial, LLC | 27,100 | $45.4 萬 | 0.01% | +27,100 | 新進 |
| Mirae Asset Global ETFs Holdings Ltd. | 26,448 | $44.2 萬 | 0.00% | −3,364−11.3% | 減碼 |
| Warren Averett Asset Management, LLC | 25,953 | $43.5 萬 | 0.00% | +6,500+33.4% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $43.2 萬 | 0.00% | 00.0% | 不變 |
| Optimize Financial Inc | 24,967 | $41.8 萬 | 0.22% | +24,967 | 新進 |
| Assenagon Asset Management S.A. | 22,136 | $37.1 萬 | 0.00% | 00.0% | 不變 |
| Susquehanna Portfolio Strategies, LLC | 21,739 | $36.4 萬 | 0.01% | +21,739 | 新進 |
| Intech Investment Management LLC | 20,360 | $34.1 萬 | 0.00% | −4,585−18.4% | 減碼 |
| Squarepoint Ops LLC | 20,232 | $33.9 萬 | 0.00% | −9,814−32.7% | 減碼 |
| Quadrature Capital Ltd | 19,366 | $32.5 萬 | 0.00% | +19,366 | 新進 |
| Virginia Retirement Systems Et Al | 18,500 | $31.0 萬 | 0.00% | +18,500 | 新進 |
| Global Endowment Management, LP | 18,184 | $30.5 萬 | 0.04% | 00.0% | 不變 |
| Los Angeles Capital Management LLC | 18,172 | $30.5 萬 | 0.00% | +18,172 | 新進 |
| AQR Capital Management LLC | 17,047 | $28.6 萬 | 0.00% | −926−5.2% | 減碼 |
| New York State Common Retirement Fund | 16,565 | $27.8 萬 | 0.00% | 00.0% | 不變 |
| Dark Forest Capital Management LP | 14,733 | $24.7 萬 | 0.01% | +14,733 | 新進 |
| Police & Firemen's Retirement System of New Jersey | 13,809 | $23.1 萬 | 0.00% | +2,284+19.8% | 加碼 |
| Profund Advisors LLC | 13,223 | $22.2 萬 | 0.01% | +2,180+19.7% | 加碼 |
| Janus Henderson Group PLC | 13,000 | $21.8 萬 | 0.00% | 00.0% | 不變 |
| DRW Securities, LLC | 11,475 | $19.0 萬 | 0.01% | +11,475 | 新進 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,874 | $18.2 萬 | 0.00% | −1,999−15.5% | 減碼 |
| Arizona State Retirement System | 10,693 | $17.9 萬 | 0.00% | +181+1.7% | 加碼 |