Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2025 年第 4 季 13F 持有人
Spyre Therapeutics, Inc. 在 2025/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 153
- 較 2025 年第 3 季 +16 家
- 持有股數
- 8,098 萬
- 較 2025 年第 3 季 +1,668 萬 (+25.9%)
- 總市值
- $26.5 億
- 較 2025 年第 3 季 +$15.7 億 (+146.2%)
- 新進機構
- 30
- 另有 76 家加碼
- 清倉機構
- 14
- 另有 27 家減碼
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2025 年第 4 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 11,638,819 | $3.81 億 | 0.02% | +2,578,675+28.5% | 加碼 |
| BlackRock, Inc. | 5,522,101 | $1.81 億 | 0.00% | +1,539,357+38.7% | 加碼 |
| RTW Investments, LP | 4,171,996 | $1.37 億 | 1.37% | +550,000+15.2% | 加碼 |
| Vanguard Group Inc | 4,035,074 | $1.32 億 | 0.00% | +984,344+32.3% | 加碼 |
| Fairmount Funds Management LLC | 4,018,101 | $1.32 億 | 10.02% | 00.0% | 不變 |
| VR Adviser, LLC | 3,685,448 | $1.21 億 | 5.96% | +1,000,000+37.2% | 加碼 |
| Capital International Investors | 3,492,541 | $1.14 億 | 0.02% | +1,100,000+46.0% | 加碼 |
| Perceptive Advisors LLC | 3,069,225 | $1.01 億 | 1.84% | +1,839,780+149.6% | 加碼 |
| Driehaus Capital Management LLC | 2,882,420 | $9,443 萬 | 0.64% | +822,045+39.9% | 加碼 |
| Commodore Capital LP | 2,388,245 | $7,824 萬 | 5.21% | +400,161+20.1% | 加碼 |
| State Street Corp | 2,262,839 | $7,413 萬 | 0.00% | +477,633+26.8% | 加碼 |
| TCG Crossover Management, LLC | 1,900,582 | $6,226 萬 | 2.06% | +800,000+72.7% | 加碼 |
| Tang Capital Management LLC | 1,892,200 | $6,199 萬 | 3.06% | −1,307,800−40.9% | 減碼 |
| Janus Henderson Group PLC | 1,829,009 | $5,992 萬 | 0.03% | +1,816,009+13,969.3% | 加碼 |
| Geode Capital Management, LLC | 1,659,140 | $5,436 萬 | 0.00% | +433,987+35.4% | 加碼 |
| Braidwell LP | 1,634,615 | $5,355 萬 | 1.71% | −943,789−36.6% | 減碼 |
| Ra Capital Management, L.P. | 1,621,620 | $5,312 萬 | 0.54% | +1,621,620 | 新進 |
| Price T Rowe Associates Inc | 1,601,882 | $5,248 萬 | 0.01% | +981,262+158.1% | 加碼 |
| Wellington Management Group LLP | 1,549,284 | $5,075 萬 | 0.01% | −91,028−5.5% | 減碼 |
| Paradigm Biocapital Advisors LP | 1,467,266 | $4,807 萬 | 1.29% | 00.0% | 不變 |
| Remedium Capital Partners, LLC | 1,456,231 | $4,771 萬 | 28.03% | +1,456,231 | 新進 |
| Affinity Asset Advisors, LLC | 1,432,591 | $4,693 萬 | 3.37% | +13,292+0.9% | 加碼 |
| Franklin Resources Inc | 1,109,274 | $3,634 萬 | 0.01% | +313,999+39.5% | 加碼 |
| Baker Bros. Advisors LP | 1,000,000 | $3,276 萬 | 0.19% | 00.0% | 不變 |
| Pictet Asset Management Holding SA | 913,960 | $2,994 萬 | 0.03% | −122,258−11.8% | 減碼 |
| Siren, L.L.C. | 818,598 | $2,682 萬 | 0.80% | +450,000+122.1% | 加碼 |
| Polar Capital Holdings Plc | 740,326 | $2,425 萬 | 0.11% | −48,462−6.1% | 減碼 |
| Deerfield Management Company, L.P. (Series C) | 710,626 | $2,328 萬 | 0.30% | +96,961+15.8% | 加碼 |
| UBS Group AG | 680,566 | $2,230 萬 | 0.00% | +294,977+76.5% | 加碼 |
| Point72 Asset Management, L.P. | 662,351 | $2,170 萬 | 0.03% | +662,351 | 新進 |
| Emerald Advisers, LLC | 636,109 | $2,084 萬 | 0.64% | +87,397+15.9% | 加碼 |
| Charles Schwab Investment Management Inc | 574,622 | $1,882 萬 | 0.00% | +149,277+35.1% | 加碼 |
| Northern Trust Corp | 561,023 | $1,838 萬 | 0.00% | +118,987+26.9% | 加碼 |
| Blackstone Group Inc. | 500,998 | $1,641 萬 | 0.07% | 00.0% | 不變 |
| Candriam Luxembourg S.C.A. | 425,534 | $1,394 萬 | 0.07% | +21,172+5.2% | 加碼 |
| Bank of America Corp | 419,727 | $1,375 萬 | 0.00% | +74,924+21.7% | 加碼 |
| Emerald Mutual Fund Advisers Trust | 412,371 | $1,351 萬 | 0.66% | +104,159+33.8% | 加碼 |
| Goldman Sachs Group Inc | 275,065 | $901.1 萬 | 0.00% | −54,468−16.5% | 減碼 |
| Woodline Partners LP | 265,892 | $871.1 萬 | 0.03% | +134,016+101.6% | 加碼 |
| Capital World Investors | 200,172 | $655.8 萬 | 0.00% | 00.0% | 不變 |
| Armistice Capital, LLC | 196,426 | $643.5 萬 | 0.16% | +40,426+25.9% | 加碼 |
| Bank of New York Mellon Corp | 192,830 | $631.7 萬 | 0.00% | +56,870+41.8% | 加碼 |
| HighVista Strategies LLC | 188,206 | $616.6 萬 | 1.59% | −27,540−12.8% | 減碼 |
| Silverarc Capital Management, LLC | 187,737 | $615.0 萬 | 0.89% | +187,737 | 新進 |
| Morgan Stanley | 182,734 | $598.6 萬 | 0.00% | −151,988−45.4% | 減碼 |
| Barclays PLC | 182,524 | $597.9 萬 | 0.00% | +14,194+8.4% | 加碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | $560.9 萬 | 0.01% | +60,755+55.0% | 加碼 |
| Nuveen, LLC | 150,980 | $494.6 萬 | 0.00% | +54,808+57.0% | 加碼 |
| Invesco Ltd. | 150,934 | $494.5 萬 | 0.00% | +100,232+197.7% | 加碼 |
| Patient Square Capital LP | 150,000 | $491.4 萬 | 1.05% | +150,000 | 新進 |
| TD Asset Management Inc | 149,822 | $490.8 萬 | 0.00% | +77,454+107.0% | 加碼 |
| Victory Capital Management Inc | 146,079 | $478.6 萬 | 0.00% | −180,002−55.2% | 減碼 |
| Manufacturers Life Insurance Company, The | 129,013 | $414.4 萬 | 0.00% | +57,065+79.3% | 加碼 |
| Parkman Healthcare Partners LLC | 124,485 | $407.8 萬 | 0.39% | −76,268−38.0% | 減碼 |
| Deutsche Bank AG | 121,941 | $399.5 萬 | 0.00% | +83,398+216.4% | 加碼 |
| Mercer Global Advisors Inc | 106,316 | $348.3 萬 | 0.01% | −348−0.3% | 減碼 |
| F/M Investments LLC | 103,718 | $339.8 萬 | 0.13% | +48,825+88.9% | 加碼 |
| Citigroup Inc | 100,058 | $327.8 萬 | 0.00% | +67,162+204.2% | 加碼 |
| B Group, Inc. | 100,000 | $327.6 萬 | 2.43% | 00.0% | 不變 |
| Seven Grand Managers, LLC | 100,000 | $327.6 萬 | 0.25% | +100,000 | 新進 |
| Swiss National Bank | 96,500 | $316.1 萬 | 0.00% | +26,300+37.5% | 加碼 |
| Rhumbline Advisers | 82,956 | $271.8 萬 | 0.00% | +12,042+17.0% | 加碼 |
| Wells Fargo & Company | 82,416 | $270.0 萬 | 0.00% | +43,097+109.6% | 加碼 |
| Dimensional Fund Advisors LP | 77,290 | $253.2 萬 | 0.00% | −6,926−8.2% | 減碼 |
| Millennium Management LLC | 76,194 | $249.6 萬 | 0.00% | −332,005−81.3% | 減碼 |
| Balyasny Asset Management LLC | 73,465 | $240.7 萬 | 0.00% | +73,465 | 新進 |
| Alliancebernstein L.P. | 67,500 | $221.1 萬 | 0.00% | +31,270+86.3% | 加碼 |
| Citadel Advisors LLC | 63,904 | $209.3 萬 | 0.00% | +63,904 | 新進 |
| Alps Advisors Inc | 63,708 | $208.7 萬 | 0.01% | +63,708 | 新進 |
| JPMorgan Chase & Co | 62,951 | $206.2 萬 | 0.00% | −213,033−77.2% | 減碼 |
| UBS Asset Management Americas Inc | 62,216 | $203.8 萬 | 0.00% | +22,718+57.5% | 加碼 |
| Schroder Investment Management Group | 61,574 | $196.3 萬 | 0.00% | −46,164−42.8% | 減碼 |
| Legal & General Group Plc | 56,448 | $184.9 萬 | 0.00% | +9,607+20.5% | 加碼 |
| Rafferty Asset Management, LLC | 53,410 | $175.0 萬 | 0.01% | −6,257−10.5% | 減碼 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $174.0 萬 | 0.03% | +31,362+144.3% | 加碼 |
| California State Teachers Retirement System | 48,038 | $157.4 萬 | 0.00% | +14,835+44.7% | 加碼 |
| Ameriprise Financial Inc | 38,256 | $125.3 萬 | 0.00% | +38,256 | 新進 |
| MetLife Investment Management | 38,011 | $124.5 萬 | 0.01% | +8,093+27.1% | 加碼 |
| ExodusPoint Capital Management, LP | 37,871 | $124.1 萬 | 0.01% | −30,692−44.8% | 減碼 |
| Cinctive Capital Management LP | 35,935 | $117.7 萬 | 0.07% | +35,935 | 新進 |
| Mirae Asset Global ETFs Holdings Ltd. | 35,144 | $114.9 萬 | 0.00% | +8,696+32.9% | 加碼 |
| ADAR1 Capital Management, LLC | 34,051 | $111.6 萬 | 0.08% | 00.0% | 不變 |
| StemPoint Capital LP | 32,377 | $106.1 萬 | 0.18% | +32,377 | 新進 |
| Voya Investment Management LLC | 27,277 | $89.4 萬 | 0.00% | +27,277 | 新進 |
| State of Wisconsin Investment Board | 27,252 | $89.3 萬 | 0.00% | −6,294−18.8% | 減碼 |
| Warren Averett Asset Management, LLC | 25,954 | $85.0 萬 | 0.01% | +10.0% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $84.5 萬 | 0.01% | 00.0% | 不變 |
| Optimize Financial Inc | 25,331 | $83.0 萬 | 0.42% | +364+1.5% | 加碼 |
| Virginia Retirement Systems Et Al | 24,950 | $81.7 萬 | 0.00% | +6,450+34.9% | 加碼 |
| SG Americas Securities, LLC | 23,343 | $76.5 萬 | 0.00% | +23,343 | 新進 |
| Assenagon Asset Management S.A. | 22,136 | $72.5 萬 | 0.00% | 00.0% | 不變 |
| Profund Advisors LLC | 20,593 | $67.5 萬 | 0.02% | +7,370+55.7% | 加碼 |
| New York State Common Retirement Fund | 19,165 | $62.8 萬 | 0.00% | +2,600+15.7% | 加碼 |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $60.1 萬 | 0.01% | +4,551+33.0% | 加碼 |
| Intech Investment Management LLC | 18,274 | $59.9 萬 | 0.01% | −2,086−10.2% | 減碼 |
| Neo Ivy Capital Management | 18,261 | $59.8 萬 | 0.09% | +18,261 | 新進 |
| Global Endowment Management, LP | 18,184 | $59.6 萬 | 0.07% | 00.0% | 不變 |
| AQR Capital Management LLC | 17,820 | $58.4 萬 | 0.00% | +773+4.5% | 加碼 |
| State of New Jersey Common Pension Fund D | 16,698 | $54.7 萬 | 0.00% | +16,698 | 新進 |
| ProShare Advisors LLC | 15,989 | $52.4 萬 | 0.00% | +5,311+49.7% | 加碼 |