Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2025 年第 4 季 13F 持有人
Spyre Therapeutics, Inc. 在 2025/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 153
- 較 2025 年第 3 季 +16 家
- 持有股數
- 8,098 萬
- 較 2025 年第 3 季 +1,668 萬 (+25.9%)
- 總市值
- $26.5 億
- 較 2025 年第 3 季 +$15.7 億 (+146.2%)
- 新進機構
- 30
- 另有 76 家加碼
- 清倉機構
- 14
- 另有 27 家減碼
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2025 年第 4 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | 不變 |
| SBI Securities Co., Ltd. | 5 | $164 | 0.00% | −118−95.9% | 減碼 |
| Comerica Bank | 5 | $164 | 0.00% | 00.0% | 不變 |
| US Bancorp | 10 | $328 | 0.00% | 00.0% | 不變 |
| IFP Advisors, Inc | 24 | $786 | 0.00% | 00.0% | 不變 |
| Parkside Financial Bank & Trust | 35 | $1,147 | 0.00% | 00.0% | 不變 |
| Farther Finance Advisors, LLC | 37 | $1,212 | 0.00% | +27+270.0% | 加碼 |
| Allworth Financial LP | 58 | $1,901 | 0.00% | +26+81.3% | 加碼 |
| EverSource Wealth Advisors, LLC | 65 | $2,129 | 0.00% | 00.0% | 不變 |
| Signaturefd, LLC | 70 | $2,293 | 0.00% | 00.0% | 不變 |
| Rothschild Investment LLC | 82 | $2,686 | 0.00% | +2+2.5% | 加碼 |
| The PNC Financial Services Group, Inc. | 86 | $2,818 | 0.00% | 00.0% | 不變 |
| Larson Financial Group LLC | 144 | $4,717 | 0.00% | +132+1,100.0% | 加碼 |
| Meeder Asset Management Inc | 181 | $5,930 | 0.00% | −35−16.2% | 減碼 |
| Optiver Holding B.V. | 240 | $7,862 | 0.00% | −260−52.0% | 減碼 |
| Daiwa Securities Group Inc. | 258 | $8,000 | 0.00% | +52+25.2% | 加碼 |
| GAMMA Investing LLC | 330 | $1.08 萬 | 0.00% | +122+58.7% | 加碼 |
| Advisor Group Holdings, Inc. | 367 | $1.20 萬 | 0.00% | +53+16.9% | 加碼 |
| Group One Trading, L.P. | 400 | $1.31 萬 | 0.00% | +400 | 新進 |
| Tower Research Capital LLC (TRC) | 425 | $1.39 萬 | 0.00% | −4,171−90.8% | 減碼 |
| Rockefeller Capital Management L.P. | 549 | $1.80 萬 | 0.00% | +148+36.9% | 加碼 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 656 | $2.10 萬 | 0.00% | +321+95.8% | 加碼 |
| Nisa Investment Advisors, LLC | 705 | $2.31 萬 | 0.00% | 00.0% | 不變 |
| GF Fund Management Co. Ltd. | 1,523 | $4.99 萬 | 0.00% | +224+17.2% | 加碼 |
| Public Employees Retirement Association of Colorado | 1,589 | $5.20 萬 | 0.00% | 00.0% | 不變 |
| Sterling Capital Management LLC | 1,610 | $5.27 萬 | 0.00% | +396+32.6% | 加碼 |
| Royal Bank of Canada | 1,988 | $6.50 萬 | 0.00% | −5,895−74.8% | 減碼 |
| CWM, LLC | 1,970 | $6.50 萬 | 0.00% | +10+0.5% | 加碼 |
| Amalgamated Bank | 2,165 | $7.10 萬 | 0.00% | +786+57.0% | 加碼 |
| Persistent Asset Partners Ltd | 2,246 | $7.36 萬 | 0.04% | +2,246 | 新進 |
| Quest Partners LLC | 3,538 | $11.6 萬 | 0.01% | −62,625−94.7% | 減碼 |
| Mirae Asset Global Investments Co., Ltd. | 3,770 | $12.4 萬 | 0.00% | +1,435+61.5% | 加碼 |
| Russell Investments Group, Ltd. | 5,554 | $18.2 萬 | 0.00% | +1,320+31.2% | 加碼 |
| Ameritas Investment Partners, Inc. | 5,593 | $18.3 萬 | 0.01% | +1,427+34.3% | 加碼 |
| Susquehanna International Group, LLP | 6,111 | $20.0 萬 | 0.00% | +6,111 | 新進 |
| SEI Investments Co | 6,117 | $20.0 萬 | 0.00% | +6,117 | 新進 |
| Brevan Howard Capital Management LP | 6,198 | $20.3 萬 | 0.00% | +6,198 | 新進 |
| Martingale Asset Management L P | 6,930 | $22.7 萬 | 0.01% | +6,930 | 新進 |
| Teacher Retirement System of Texas | 7,173 | $23.5 萬 | 0.00% | +7,173 | 新進 |
| Virtus Investment Advisers, Inc. | 7,913 | $25.9 萬 | 0.07% | +1,488+23.2% | 加碼 |
| VARCOV Co. | 8,008 | $26.2 萬 | 0.10% | +8,008 | 新進 |
| Caxton Corp | 8,919 | $29.2 萬 | 6.83% | +8,919 | 新進 |
| State Board of Administration of Florida Retirement System | 9,030 | $29.6 萬 | 0.00% | +9,030 | 新進 |
| Los Angeles Capital Management LLC | 12,882 | $31.3 萬 | 0.00% | −5,290−29.1% | 減碼 |
| Carlyle Group Inc. | 9,620 | $31.5 萬 | 0.00% | +9,620 | 新進 |
| Tudor Investment Corp Et Al | 10,127 | $33.2 萬 | 0.00% | +10,127 | 新進 |
| KLP Kapitalforvaltning AS | 10,400 | $34.1 萬 | 0.00% | +2,600+33.3% | 加碼 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,164 | $36.6 萬 | 0.00% | +290+2.7% | 加碼 |
| BNP Paribas Arbitrage, SA | 11,844 | $38.8 萬 | 0.00% | −304,065−96.3% | 減碼 |
| China Universal Asset Management Co., Ltd. | 12,644 | $41.4 萬 | 0.03% | +2,057+19.4% | 加碼 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 13,724 | $45.0 萬 | 0.07% | +13,724 | 新進 |
| Arizona State Retirement System | 13,797 | $45.2 萬 | 0.00% | +3,104+29.0% | 加碼 |
| PSP Research LLC | 15,840 | $51.9 萬 | 0.45% | +15,840 | 新進 |
| ProShare Advisors LLC | 15,989 | $52.4 萬 | 0.00% | +5,311+49.7% | 加碼 |
| State of New Jersey Common Pension Fund D | 16,698 | $54.7 萬 | 0.00% | +16,698 | 新進 |
| AQR Capital Management LLC | 17,820 | $58.4 萬 | 0.00% | +773+4.5% | 加碼 |
| Global Endowment Management, LP | 18,184 | $59.6 萬 | 0.07% | 00.0% | 不變 |
| Neo Ivy Capital Management | 18,261 | $59.8 萬 | 0.09% | +18,261 | 新進 |
| Intech Investment Management LLC | 18,274 | $59.9 萬 | 0.01% | −2,086−10.2% | 減碼 |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $60.1 萬 | 0.01% | +4,551+33.0% | 加碼 |
| New York State Common Retirement Fund | 19,165 | $62.8 萬 | 0.00% | +2,600+15.7% | 加碼 |
| Profund Advisors LLC | 20,593 | $67.5 萬 | 0.02% | +7,370+55.7% | 加碼 |
| Assenagon Asset Management S.A. | 22,136 | $72.5 萬 | 0.00% | 00.0% | 不變 |
| SG Americas Securities, LLC | 23,343 | $76.5 萬 | 0.00% | +23,343 | 新進 |
| Virginia Retirement Systems Et Al | 24,950 | $81.7 萬 | 0.00% | +6,450+34.9% | 加碼 |
| Optimize Financial Inc | 25,331 | $83.0 萬 | 0.42% | +364+1.5% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $84.5 萬 | 0.01% | 00.0% | 不變 |
| Warren Averett Asset Management, LLC | 25,954 | $85.0 萬 | 0.01% | +10.0% | 加碼 |
| State of Wisconsin Investment Board | 27,252 | $89.3 萬 | 0.00% | −6,294−18.8% | 減碼 |
| Voya Investment Management LLC | 27,277 | $89.4 萬 | 0.00% | +27,277 | 新進 |
| StemPoint Capital LP | 32,377 | $106.1 萬 | 0.18% | +32,377 | 新進 |
| ADAR1 Capital Management, LLC | 34,051 | $111.6 萬 | 0.08% | 00.0% | 不變 |
| Mirae Asset Global ETFs Holdings Ltd. | 35,144 | $114.9 萬 | 0.00% | +8,696+32.9% | 加碼 |
| Cinctive Capital Management LP | 35,935 | $117.7 萬 | 0.07% | +35,935 | 新進 |
| ExodusPoint Capital Management, LP | 37,871 | $124.1 萬 | 0.01% | −30,692−44.8% | 減碼 |
| MetLife Investment Management | 38,011 | $124.5 萬 | 0.01% | +8,093+27.1% | 加碼 |
| Ameriprise Financial Inc | 38,256 | $125.3 萬 | 0.00% | +38,256 | 新進 |
| California State Teachers Retirement System | 48,038 | $157.4 萬 | 0.00% | +14,835+44.7% | 加碼 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $174.0 萬 | 0.03% | +31,362+144.3% | 加碼 |
| Rafferty Asset Management, LLC | 53,410 | $175.0 萬 | 0.01% | −6,257−10.5% | 減碼 |
| Legal & General Group Plc | 56,448 | $184.9 萬 | 0.00% | +9,607+20.5% | 加碼 |
| Schroder Investment Management Group | 61,574 | $196.3 萬 | 0.00% | −46,164−42.8% | 減碼 |
| UBS Asset Management Americas Inc | 62,216 | $203.8 萬 | 0.00% | +22,718+57.5% | 加碼 |
| JPMorgan Chase & Co | 62,951 | $206.2 萬 | 0.00% | −213,033−77.2% | 減碼 |
| Alps Advisors Inc | 63,708 | $208.7 萬 | 0.01% | +63,708 | 新進 |
| Citadel Advisors LLC | 63,904 | $209.3 萬 | 0.00% | +63,904 | 新進 |
| Alliancebernstein L.P. | 67,500 | $221.1 萬 | 0.00% | +31,270+86.3% | 加碼 |
| Balyasny Asset Management LLC | 73,465 | $240.7 萬 | 0.00% | +73,465 | 新進 |
| Millennium Management LLC | 76,194 | $249.6 萬 | 0.00% | −332,005−81.3% | 減碼 |
| Dimensional Fund Advisors LP | 77,290 | $253.2 萬 | 0.00% | −6,926−8.2% | 減碼 |
| Wells Fargo & Company | 82,416 | $270.0 萬 | 0.00% | +43,097+109.6% | 加碼 |
| Rhumbline Advisers | 82,956 | $271.8 萬 | 0.00% | +12,042+17.0% | 加碼 |
| Swiss National Bank | 96,500 | $316.1 萬 | 0.00% | +26,300+37.5% | 加碼 |
| B Group, Inc. | 100,000 | $327.6 萬 | 2.43% | 00.0% | 不變 |
| Seven Grand Managers, LLC | 100,000 | $327.6 萬 | 0.25% | +100,000 | 新進 |
| Citigroup Inc | 100,058 | $327.8 萬 | 0.00% | +67,162+204.2% | 加碼 |
| F/M Investments LLC | 103,718 | $339.8 萬 | 0.13% | +48,825+88.9% | 加碼 |
| Mercer Global Advisors Inc | 106,316 | $348.3 萬 | 0.01% | −348−0.3% | 減碼 |
| Deutsche Bank AG | 121,941 | $399.5 萬 | 0.00% | +83,398+216.4% | 加碼 |
| Parkman Healthcare Partners LLC | 124,485 | $407.8 萬 | 0.39% | −76,268−38.0% | 減碼 |