Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2026 年第 2 季 13F 持有人
Spyre Therapeutics, Inc. 在 2026/6/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 265
- 較 2026 年第 1 季 +69 家
- 持有股數
- 9,583 萬
- 較 2026 年第 1 季 +1,464 萬 (+18.0%)
- 總市值
- $85.2 億
- 較 2026 年第 1 季 +$44.3 億 (+108.3%)
- 新進機構
- 91
- 另有 105 家加碼
- 清倉機構
- 22
- 另有 55 家減碼
另有 2 家機構在 2026 年第 1 季持有、還沒有申報 2026 年第 2 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.7 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $12.0 億 |
| 2024 年第 1 季 | 102 | $12.0 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 27 | $3,991 萬 |
| 2023 年第 2 季 | 0 | $0 |
| 2023 年第 1 季 | 0 | $0 |
| 2022 年第 4 季 | 0 | $0 |
| 2022 年第 3 季 | 0 | $0 |
| 2022 年第 2 季 | 0 | $0 |
| 2022 年第 1 季 | 0 | $0 |
| 2021 年第 4 季 | 0 | $0 |
| 2021 年第 3 季 | 0 | $0 |
| 2021 年第 2 季 | 0 | $0 |
| 2021 年第 1 季 | 0 | $0 |
2026 年第 2 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2026 年第 1 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 13,026,187 | $11.6 億 | 0.05% | +1,245,163+10.6% | 加碼 |
| BlackRock, Inc. | 6,506,605 | $5.78 億 | 0.01% | +985,384+17.8% | 加碼 |
| Perceptive Advisors LLC | 4,319,496 | $3.83 億 | 5.95% | +536,271+14.2% | 加碼 |
| RTW Investments, LP | 4,251,996 | $3.77 億 | 3.22% | +80,000+1.9% | 加碼 |
| Paradigm Biocapital Advisors LP | 3,840,778 | $3.41 億 | 6.38% | +1,883,512+96.2% | 加碼 |
| Vanguard Capital Management LLC | 3,448,681 | $3.06 億 | 0.01% | +391,280+12.8% | 加碼 |
| State Street Corp | 3,057,416 | $2.71 億 | 0.01% | +450,385+17.3% | 加碼 |
| VR Adviser, LLC | 2,985,448 | $2.65 億 | 8.04% | −700,000−19.0% | 減碼 |
| Price T Rowe Associates Inc | 2,960,855 | $2.63 億 | 0.03% | +1,362,125+85.2% | 加碼 |
| Driehaus Capital Management LLC | 2,799,166 | $2.49 億 | 1.44% | +8,381+0.3% | 加碼 |
| Geode Capital Management, LLC | 2,562,265 | $2.39 億 | 0.01% | +841,353+48.9% | 加碼 |
| Vanguard Portfolio Management LLC | 2,330,098 | $2.07 億 | 0.01% | +1,744,968+298.2% | 加碼 |
| Capital World Investors | 2,315,553 | $2.06 億 | 0.02% | +1,648,989+247.4% | 加碼 |
| Jupiter Topco LLC | 2,206,936 | $1.96 億 | 0.08% | +2,206,936 | 新進 |
| TCG Crossover Management, LLC | 1,900,582 | $1.69 億 | 4.06% | 00.0% | 不變 |
| Tang Capital Management LLC | 1,892,200 | $1.68 億 | 7.63% | 00.0% | 不變 |
| Bank of America Corp | 1,777,854 | $1.58 億 | 0.01% | +549,761+44.8% | 加碼 |
| Adage Capital Partners GP, L.L.C. | 1,722,300 | $1.53 億 | 0.21% | +1,722,300 | 新進 |
| Wellington Management Group LLP | 1,581,505 | $1.40 億 | 0.02% | −243,306−13.3% | 減碼 |
| Goldman Sachs Group Inc | 1,478,059 | $1.31 億 | 0.01% | +1,208,121+447.6% | 加碼 |
| Franklin Resources Inc | 1,472,943 | $1.31 億 | 0.03% | +590,110+66.8% | 加碼 |
| Remedium Capital Partners, LLC | 1,464,169 | $1.30 億 | 28.78% | +7,938+0.5% | 加碼 |
| Affinity Asset Advisors, LLC | 1,279,134 | $1.14 億 | 5.55% | 00.0% | 不變 |
| JPMorgan Chase & Co | 1,093,026 | $9,887 萬 | 0.01% | +113,727+11.6% | 加碼 |
| Holocene Advisors, LP | 1,015,170 | $9,013 萬 | 0.21% | +1,015,170 | 新進 |
| Marshall Wace, LLP | 991,693 | $8,804 萬 | 0.07% | +852,434+612.1% | 加碼 |
| Polar Capital Holdings Plc | 988,009 | $8,772 萬 | 0.25% | +195,162+24.6% | 加碼 |
| Siren, L.L.C. | 968,598 | $8,599 萬 | 1.75% | +150,000+18.3% | 加碼 |
| Capital International Investors | 955,196 | $8,480 萬 | 0.02% | −790,933−45.3% | 減碼 |
| Braidwell LP | 879,467 | $7,808 萬 | 2.89% | −53,356−5.7% | 減碼 |
| Commodore Capital LP | 846,786 | $7,518 萬 | 4.48% | −1,065,594−55.7% | 減碼 |
| UBS Group AG | 843,071 | $7,485 萬 | 0.01% | +171,836+25.6% | 加碼 |
| Northern Trust Corp | 674,529 | $5,988 萬 | 0.01% | +95,622+16.5% | 加碼 |
| Charles Schwab Investment Management Inc | 652,958 | $5,797 萬 | 0.01% | +90,305+16.0% | 加碼 |
| Pictet Asset Management Holding SA | 628,138 | $5,577 萬 | 0.05% | +136,489+27.8% | 加碼 |
| Emerald Advisers, LLC | 567,430 | $5,038 萬 | 1.19% | −45,935−7.5% | 減碼 |
| Victory Capital Management Inc | 553,980 | $4,918 萬 | 0.03% | +261,854+89.6% | 加碼 |
| Vanguard Fiduciary Trust Co | 551,389 | $4,895 萬 | 0.01% | +86,738+18.7% | 加碼 |
| Candriam Luxembourg S.C.A. | 546,312 | $4,845 萬 | 0.22% | −63,970−10.5% | 減碼 |
| UBS Asset Management Americas Inc | 522,071 | $4,635 萬 | 0.01% | +314,757+151.8% | 加碼 |
| Morgan Stanley | 499,963 | $4,439 萬 | 0.00% | +253,244+102.6% | 加碼 |
| Voya Investment Management LLC | 431,694 | $3,833 萬 | 0.03% | +377,724+699.9% | 加碼 |
| Emerald Mutual Fund Advisers Trust | 401,271 | $3,562 萬 | 1.25% | −6,842−1.7% | 減碼 |
| Samlyn Capital, LLC | 400,075 | $3,552 萬 | 0.59% | +3,414+0.9% | 加碼 |
| Ameriprise Financial Inc | 356,082 | $3,161 萬 | 0.01% | +196,865+123.6% | 加碼 |
| Integral Health Asset Management, LLC | 325,000 | $2,885 萬 | 1.18% | +325,000 | 新進 |
| Woodline Partners LP | 306,049 | $2,717 萬 | 0.08% | +40,157+15.1% | 加碼 |
| Jennison Associates LLC | 303,180 | $2,692 萬 | 0.02% | +303,180 | 新進 |
| ADAR1 Capital Management, LLC | 283,982 | $2,521 萬 | 1.19% | −54,341−16.1% | 減碼 |
| BNP Paribas Arbitrage, SA | 259,923 | $2,308 萬 | 0.01% | +241,293+1,295.2% | 加碼 |
| Bank of New York Mellon Corp | 245,193 | $2,177 萬 | 0.00% | +53,798+28.1% | 加碼 |
| Bellevue Group AG | 229,931 | $2,041 萬 | 0.43% | +229,931 | 新進 |
| Seven Grand Managers, LLC | 225,000 | $1,998 萬 | 0.80% | +125,000+125.0% | 加碼 |
| Cormorant Asset Management, LP | 225,000 | $1,998 萬 | 1.02% | +225,000 | 新進 |
| Eventide Asset Management, LLC | 201,616 | $1,790 萬 | 0.24% | +201,616 | 新進 |
| Millennium Management LLC | 196,712 | $1,746 萬 | 0.01% | +50,073+34.1% | 加碼 |
| OrbiMed Advisors LLC | 186,145 | $1,653 萬 | 0.31% | +186,145 | 新進 |
| Frontier Capital Management Co LLC | 182,931 | $1,624 萬 | 0.15% | +182,931 | 新進 |
| Nuveen, LLC | 181,105 | $1,608 萬 | 0.00% | +27,206+17.7% | 加碼 |
| Neuberger Berman Group LLC | 180,884 | $1,606 萬 | 0.01% | +180,884 | 新進 |
| Deutsche Bank AG | 174,459 | $1,549 萬 | 0.00% | +45,217+35.0% | 加碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 172,923 | $1,535 萬 | 0.02% | +2,542+1.5% | 加碼 |
| Balyasny Asset Management LLC | 147,042 | $1,305 萬 | 0.02% | +91,565+165.1% | 加碼 |
| Soleus Capital Management, L.P. | 147,000 | $1,305 萬 | 0.45% | +147,000 | 新進 |
| Squarepoint Ops LLC | 139,605 | $1,239 萬 | 0.02% | +139,605 | 新進 |
| Armistice Capital, LLC | 137,588 | $1,222 萬 | 0.34% | +16,657+13.8% | 加碼 |
| Russell Investments Group, Ltd. | 134,757 | $1,196 萬 | 0.01% | +124,826+1,256.9% | 加碼 |
| Ensign Peak Advisors, Inc | 126,620 | $1,124 萬 | 0.02% | −21,917−14.8% | 減碼 |
| Invesco Ltd. | 120,541 | $1,070 萬 | 0.00% | −11,849−9.0% | 減碼 |
| Blackstone Group Inc. | 120,177 | $1,067 萬 | 0.03% | −172,670−59.0% | 減碼 |
| Rhenman & Partners Asset Management AB | 119,300 | $1,059 萬 | 1.00% | +119,300 | 新進 |
| TD Asset Management Inc | 115,990 | $1,030 萬 | 0.01% | −21,400−15.6% | 減碼 |
| Swiss National Bank | 112,500 | $998.8 萬 | 0.01% | +16,000+16.6% | 加碼 |
| StemPoint Capital LP | 106,926 | $949.3 萬 | 1.64% | −228,286−68.1% | 減碼 |
| Manufacturers Life Insurance Company, The | 104,516 | $927.9 萬 | 0.01% | −8,325−7.4% | 減碼 |
| Citadel Advisors LLC | 103,100 | $915.3 萬 | 0.01% | −5,035−4.7% | 減碼 |
| Boxer Capital Management, LLC | 100,000 | $887.8 萬 | 0.67% | +100,000 | 新進 |
| Rhumbline Advisers | 94,763 | $841.3 萬 | 0.01% | +9,642+11.3% | 加碼 |
| Barclays PLC | 94,069 | $835.1 萬 | 0.00% | +48,283+105.5% | 加碼 |
| F/M Investments LLC | 92,618 | $822.3 萬 | 0.42% | −6,842−6.9% | 減碼 |
| Prudential Financial Inc | 87,370 | $775.7 萬 | 0.01% | +27,815+46.7% | 加碼 |
| Federated Hermes, Inc. | 85,950 | $763.1 萬 | 0.01% | +85,950 | 新進 |
| Granahan Investment Management Inc | 82,991 | $736.8 萬 | 0.26% | +82,991 | 新進 |
| Citigroup Inc | 82,593 | $733.3 萬 | 0.00% | +70,587+587.9% | 加碼 |
| Wells Fargo & Company | 82,506 | $732.5 萬 | 0.00% | +49,298+148.5% | 加碼 |
| HighVista Strategies LLC | 77,807 | $690.8 萬 | 1.57% | −68,457−46.8% | 減碼 |
| Mercer Global Advisors Inc | 71,145 | $631.6 萬 | 0.01% | +54+0.1% | 加碼 |
| B Group, Inc. | 70,000 | $621.5 萬 | 3.53% | −30,000−30.0% | 減碼 |
| Trexquant Investment LP | 67,007 | $594.9 萬 | 0.04% | +67,007 | 新進 |
| California State Teachers Retirement System | 64,687 | $574.3 萬 | 0.01% | +5,445+9.2% | 加碼 |
| EAM Investors, LLC | 60,393 | $536.2 萬 | 0.48% | +60,393 | 新進 |
| Silverarc Capital Management, LLC | 59,959 | $532.3 萬 | 0.59% | −126,659−67.9% | 減碼 |
| Principal Financial Group Inc | 59,747 | $530.4 萬 | 0.00% | +55,448+1,289.8% | 加碼 |
| Hudson Bay Capital Management LP | 58,387 | $518.4 萬 | 0.02% | +58,387 | 新進 |
| HealthInvest Partners AB | 57,030 | $506.3 萬 | 1.36% | −5,705−9.1% | 減碼 |
| Raymond James Financial Inc | 53,627 | $476.1 萬 | 0.00% | +33,872+171.5% | 加碼 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $471.4 萬 | 0.08% | 00.0% | 不變 |
| Alliancebernstein L.P. | 92,540 | $466.8 萬 | 0.00% | +21,640+30.5% | 加碼 |
| Royce & Associates LP | 51,789 | $459.8 萬 | 0.04% | +51,789 | 新進 |
| XTX Topco Ltd | 50,483 | $448.2 萬 | 0.06% | +26,048+106.6% | 加碼 |