Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2025 年第 1 季 13F 持有人
Spyre Therapeutics, Inc. 在 2025/3/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 129
- 較 2024 年第 4 季 −1 家
- 持有股數
- 6,211 萬
- 較 2024 年第 4 季 +235.0 萬 (+3.9%)
- 總市值
- $10.0 億
- 較 2024 年第 4 季 −$3.87 億 (−27.8%)
- 新進機構
- 20
- 另有 52 家加碼
- 清倉機構
- 21
- 另有 35 家減碼
另有 1 家機構在 2024 年第 4 季持有、還沒有申報 2025 年第 1 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2025 年第 1 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2024 年第 4 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 9,038,553 | $1.46 億 | 0.01% | +237,287+2.7% | 加碼 |
| Fairmount Funds Management LLC | 4,018,101 | $6,483 萬 | 10.06% | 00.0% | 不變 |
| RTW Investments, LP | 3,621,996 | $5,844 萬 | 0.89% | 00.0% | 不變 |
| BlackRock, Inc. | 3,572,674 | $5,765 萬 | 0.00% | +173,083+5.1% | 加碼 |
| Vanguard Group Inc | 2,898,267 | $4,676 萬 | 0.00% | +51,794+1.8% | 加碼 |
| Driehaus Capital Management LLC | 2,717,312 | $4,384 萬 | 0.42% | −86,343−3.1% | 減碼 |
| VR Adviser, LLC | 2,685,448 | $4,333 萬 | 3.69% | 00.0% | 不變 |
| Braidwell LP | 2,578,404 | $4,160 萬 | 1.46% | 00.0% | 不變 |
| Capital International Investors | 2,392,541 | $3,860 萬 | 0.01% | +2,392,541 | 新進 |
| Perceptive Advisors LLC | 2,313,272 | $3,732 萬 | 1.32% | −261,451−10.2% | 減碼 |
| Paradigm Biocapital Advisors LP | 2,127,205 | $3,432 萬 | 1.58% | +600,000+39.3% | 加碼 |
| Tang Capital Management LLC | 2,050,000 | $3,308 萬 | 1.83% | +2,050,000 | 新進 |
| Commodore Capital LP | 1,988,084 | $3,208 萬 | 2.36% | 00.0% | 不變 |
| State Street Corp | 1,697,115 | $2,738 萬 | 0.00% | +16,179+1.0% | 加碼 |
| Wellington Management Group LLP | 1,593,678 | $2,571 萬 | 0.00% | −10,830−0.7% | 減碼 |
| Jefferies Financial Group Inc. | 1,248,854 | $2,015 萬 | 0.35% | +31,900+2.6% | 加碼 |
| Janus Henderson Group PLC | 1,041,410 | $1,868 萬 | 0.01% | −415,330−28.5% | 減碼 |
| Pictet Asset Management Holding SA | 1,068,892 | $1,725 萬 | 0.02% | −23,232−2.1% | 減碼 |
| Geode Capital Management, LLC | 1,059,563 | $1,710 萬 | 0.00% | +93,434+9.7% | 加碼 |
| Polar Capital Holdings Plc | 825,000 | $1,331 萬 | 0.08% | +75,000+10.0% | 加碼 |
| Adage Capital Partners GP, L.L.C. | 803,200 | $1,296 萬 | 0.02% | −226,800−22.0% | 減碼 |
| Franklin Resources Inc | 760,628 | $1,227 萬 | 0.00% | −140.0% | 減碼 |
| UBS Group AG | 552,243 | $891.0 萬 | 0.00% | +160,046+40.8% | 加碼 |
| Emerald Advisers, LLC | 547,827 | $883.9 萬 | 0.40% | +1,036+0.2% | 加碼 |
| Blackstone Group Inc. | 489,248 | $789.4 萬 | 0.03% | +40,047+8.9% | 加碼 |
| Affinity Asset Advisors, LLC | 481,678 | $777.2 萬 | 1.22% | −342,650−41.6% | 減碼 |
| Woodline Partners LP | 464,808 | $750.0 萬 | 0.05% | +112,128+31.8% | 加碼 |
| Deerfield Management Company, L.P. (Series C) | 450,000 | $726.1 萬 | 0.14% | 00.0% | 不變 |
| Bank of America Corp | 427,075 | $689.1 萬 | 0.00% | +419,933+5,879.8% | 加碼 |
| Emerald Mutual Fund Advisers Trust | 389,422 | $628.3 萬 | 0.45% | +3,038+0.8% | 加碼 |
| Charles Schwab Investment Management Inc | 382,636 | $617.4 萬 | 0.00% | +2,986+0.8% | 加碼 |
| Northern Trust Corp | 379,875 | $612.9 萬 | 0.00% | +30,892+8.9% | 加碼 |
| Siren, L.L.C. | 368,598 | $594.7 萬 | 0.34% | −5,402−1.4% | 減碼 |
| Capital World Investors | 350,774 | $566.0 萬 | 0.00% | −27,799−7.3% | 減碼 |
| Morgan Stanley | 335,467 | $541.3 萬 | 0.00% | +80,211+31.4% | 加碼 |
| Voloridge Investment Management, LLC | 257,432 | $415.4 萬 | 0.02% | +141,962+122.9% | 加碼 |
| Victory Capital Management Inc | 251,846 | $406.4 萬 | 0.00% | −16,230−6.1% | 減碼 |
| Price T Rowe Associates Inc | 248,542 | $401.1 萬 | 0.00% | −257,908−50.9% | 減碼 |
| Candriam Luxembourg S.C.A. | 246,030 | $397.0 萬 | 0.02% | −1,561−0.6% | 減碼 |
| Deep Track Capital, LP | 219,015 | $353.4 萬 | 0.11% | 00.0% | 不變 |
| Barclays PLC | 214,606 | $346.3 萬 | 0.00% | +91,535+74.4% | 加碼 |
| Armistice Capital, LLC | 200,000 | $322.7 萬 | 0.09% | 00.0% | 不變 |
| Goldman Sachs Group Inc | 197,068 | $318.0 萬 | 0.00% | −550,484−73.6% | 減碼 |
| Nuveen, LLC | 140,129 | $226.1 萬 | 0.00% | +140,129 | 新進 |
| StemPoint Capital LP | 136,139 | $219.7 萬 | 0.70% | +136,139 | 新進 |
| Citadel Advisors LLC | 130,884 | $211.2 萬 | 0.00% | −948,423−87.9% | 減碼 |
| Soros Fund Management LLC大師索羅斯基金管理 | 125,000 | $201.7 萬 | 0.04% | −125,000−50.0% | 減碼 |
| Schroder Investment Management Group | 108,504 | $194.7 萬 | 0.00% | −5,116−4.5% | 減碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 120,321 | $194.1 萬 | 0.00% | −1,832−1.5% | 減碼 |
| Bank of New York Mellon Corp | 114,240 | $184.3 萬 | 0.00% | +10,552+10.2% | 加碼 |
| HighVista Strategies LLC | 95,159 | $153.5 萬 | 0.59% | 00.0% | 不變 |
| Citigroup Inc | 83,464 | $134.7 萬 | 0.00% | +9,712+13.2% | 加碼 |
| EFG Asset Management (North America) Corp. | 82,472 | $133.1 萬 | 0.22% | −346−0.4% | 減碼 |
| Prosight Management, LP | 74,921 | $120.9 萬 | 0.40% | −5,079−6.3% | 減碼 |
| Squarepoint Ops LLC | 72,011 | $116.2 萬 | 0.00% | +56,780+372.8% | 加碼 |
| Rafferty Asset Management, LLC | 70,323 | $113.5 萬 | 0.00% | −6,417−8.4% | 減碼 |
| B Group, Inc. | 70,000 | $112.9 萬 | 0.98% | +20,000+40.0% | 加碼 |
| Swiss National Bank | 68,600 | $110.7 萬 | 0.00% | 00.0% | 不變 |
| Susquehanna International Group, LLP | 58,696 | $94.7 萬 | 0.00% | +35,607+154.2% | 加碼 |
| Rhumbline Advisers | 56,023 | $90.4 萬 | 0.00% | −1,634−2.8% | 減碼 |
| BNP Paribas Arbitrage, SA | 55,833 | $90.1 萬 | 0.00% | +37,049+197.2% | 加碼 |
| Manufacturers Life Insurance Company, The | 53,901 | $87.0 萬 | 0.00% | +1,139+2.2% | 加碼 |
| UBS Asset Management Americas Inc | 52,138 | $84.1 萬 | 0.00% | +3,157+6.4% | 加碼 |
| F/M Investments LLC | 51,844 | $83.7 萬 | 0.03% | +3,038+6.2% | 加碼 |
| JPMorgan Chase & Co | 41,556 | $67.1 萬 | 0.00% | +6,308+17.9% | 加碼 |
| Wexford Capital LP | 38,292 | $61.8 萬 | 0.16% | +38,292 | 新進 |
| Legal & General Group Plc | 37,844 | $61.1 萬 | 0.00% | +354+0.9% | 加碼 |
| Alliancebernstein L.P. | 36,230 | $58.5 萬 | 0.00% | 00.0% | 不變 |
| State of Wisconsin Investment Board | 34,901 | $56.3 萬 | 0.00% | +3,417+10.9% | 加碼 |
| California State Teachers Retirement System | 32,598 | $52.6 萬 | 0.00% | 00.0% | 不變 |
| Wells Fargo & Company | 30,035 | $48.5 萬 | 0.00% | +5,317+21.5% | 加碼 |
| XTX Topco Ltd | 28,499 | $46.0 萬 | 0.02% | +28,499 | 新進 |
| Deutsche Bank AG | 28,483 | $46.0 萬 | 0.00% | −2,935−9.3% | 減碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 27,018 | $44.2 萬 | 0.00% | +4,277+18.8% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $41.6 萬 | 0.00% | 00.0% | 不變 |
| Invesco Ltd. | 25,207 | $40.7 萬 | 0.00% | +5,544+28.2% | 加碼 |
| MetLife Investment Management | 23,733 | $38.3 萬 | 0.00% | +2,351+11.0% | 加碼 |
| Assenagon Asset Management S.A. | 22,726 | $36.7 萬 | 0.00% | +74+0.3% | 加碼 |
| TD Asset Management Inc | 22,368 | $36.1 萬 | 0.00% | −42,600−65.6% | 減碼 |
| Intech Investment Management LLC | 20,428 | $33.0 萬 | 0.00% | +6,385+45.5% | 加碼 |
| Corebridge Financial, Inc. | 19,595 | $31.6 萬 | 0.00% | +2,382+13.8% | 加碼 |
| NBW Capital LLC | 19,430 | $31.4 萬 | 0.07% | 00.0% | 不變 |
| Warren Averett Asset Management, LLC | 19,430 | $31.4 萬 | 0.00% | +19,430 | 新進 |
| Global Endowment Management, LP | 18,184 | $29.3 萬 | 0.04% | 00.0% | 不變 |
| Natixis Advisors, L.P. | 16,401 | $26.5 萬 | 0.00% | −899−5.2% | 減碼 |
| ExodusPoint Capital Management, LP | 15,055 | $24.3 萬 | 0.00% | −1,636−9.8% | 減碼 |
| ADAR1 Capital Management, LLC | 15,033 | $24.3 萬 | 0.05% | +15,033 | 新進 |
| Profund Advisors LLC | 14,662 | $23.7 萬 | 0.01% | −200−1.3% | 減碼 |
| Aquatic Capital Management LLC | 12,903 | $20.8 萬 | 0.01% | +1,136+9.7% | 加碼 |
| China Universal Asset Management Co., Ltd. | 12,087 | $19.5 萬 | 0.02% | −353−2.8% | 減碼 |
| ProShare Advisors LLC | 11,378 | $18.4 萬 | 0.00% | −1,153−9.2% | 減碼 |
| Voya Investment Management LLC | 10,348 | $16.7 萬 | 0.00% | −147−1.4% | 減碼 |
| New York State Common Retirement Fund | 10,265 | $16.6 萬 | 0.00% | 00.0% | 不變 |
| Arizona State Retirement System | 10,017 | $16.2 萬 | 0.00% | −98−1.0% | 減碼 |
| Police & Firemen's Retirement System of New Jersey | 8,767 | $14.1 萬 | 0.00% | +1,389+18.8% | 加碼 |
| KLP Kapitalforvaltning AS | 7,800 | $12.6 萬 | 0.00% | 00.0% | 不變 |
| SG Americas Securities, LLC | 7,122 | $11.5 萬 | 0.00% | +7,122 | 新進 |
| Virtus Investment Advisers, Inc. | 6,861 | $11.1 萬 | 0.03% | +6,861 | 新進 |
| Ameritas Investment Partners, Inc. | 4,046 | $6.53 萬 | 0.00% | +654+19.3% | 加碼 |
| Quest Partners LLC | 3,191 | $5.15 萬 | 0.01% | +993+45.2% | 加碼 |