Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2026 年第 1 季 13F 持有人
Spyre Therapeutics, Inc. 在 2026/3/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 198
- 較 2025 年第 4 季 +47 家
- 持有股數
- 8,268 萬
- 較 2025 年第 4 季 +573.5 萬 (+7.5%)
- 總市值
- $41.6 億
- 較 2025 年第 4 季 +$16.4 億 (+65.2%)
- 新進機構
- 58
- 另有 67 家加碼
- 清倉機構
- 11
- 另有 49 家減碼
另有 2 家機構在 2025 年第 4 季持有、還沒有申報 2026 年第 1 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2026 年第 1 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 4 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 11,781,024 | $5.94 億 | 0.03% | +142,205+1.2% | 加碼 |
| BlackRock, Inc. | 5,521,221 | $2.78 億 | 0.00% | −8800.0% | 減碼 |
| RTW Investments, LP | 4,171,996 | $2.10 億 | 2.09% | 00.0% | 不變 |
| Fairmount Funds Management LLC | 4,018,101 | $2.03 億 | 14.64% | 00.0% | 不變 |
| Perceptive Advisors LLC | 3,783,225 | $1.91 億 | 3.77% | +714,000+23.3% | 加碼 |
| VR Adviser, LLC | 3,685,448 | $1.86 億 | 6.94% | 00.0% | 不變 |
| Vanguard Capital Management LLC | 3,057,401 | $1.54 億 | 0.00% | +3,057,401 | 新進 |
| Driehaus Capital Management LLC | 2,790,785 | $1.41 億 | 1.03% | −91,635−3.2% | 減碼 |
| State Street Corp | 2,607,031 | $1.31 億 | 0.00% | +344,192+15.2% | 加碼 |
| Paradigm Biocapital Advisors LP | 1,957,266 | $9,872 萬 | 2.02% | +490,000+33.4% | 加碼 |
| Commodore Capital LP | 1,912,380 | $9,646 萬 | 5.58% | −475,865−19.9% | 減碼 |
| TCG Crossover Management, LLC | 1,900,582 | $9,587 萬 | 2.74% | 00.0% | 不變 |
| Tang Capital Management LLC | 1,892,200 | $9,544 萬 | 4.85% | 00.0% | 不變 |
| Wellington Management Group LLP | 1,824,811 | $9,204 萬 | 0.02% | +275,527+17.8% | 加碼 |
| Capital International Investors | 1,746,129 | $8,807 萬 | 0.02% | −1,746,412−50.0% | 減碼 |
| Geode Capital Management, LLC | 1,720,912 | $8,682 萬 | 0.01% | +61,772+3.7% | 加碼 |
| Janus Henderson Group PLC | 1,656,164 | $8,359 萬 | 0.04% | −172,845−9.5% | 減碼 |
| Ra Capital Management, L.P. | 1,621,620 | $8,179 萬 | 0.87% | 00.0% | 不變 |
| Price T Rowe Associates Inc | 1,598,730 | $8,064 萬 | 0.01% | −3,152−0.2% | 減碼 |
| Remedium Capital Partners, LLC | 1,456,231 | $7,345 萬 | 26.13% | 00.0% | 不變 |
| Affinity Asset Advisors, LLC | 1,279,134 | $6,452 萬 | 3.78% | −153,457−10.7% | 減碼 |
| Bank of America Corp | 1,228,093 | $6,195 萬 | 0.00% | +808,366+192.6% | 加碼 |
| Baker Bros. Advisors LP | 1,000,000 | $5,044 萬 | 0.29% | 00.0% | 不變 |
| Braidwell LP | 932,823 | $4,705 萬 | 1.57% | −701,792−42.9% | 減碼 |
| Franklin Resources Inc | 882,833 | $4,453 萬 | 0.01% | −226,441−20.4% | 減碼 |
| JPMorgan Chase & Co | 979,299 | $4,448 萬 | 0.00% | +916,348+1,455.7% | 加碼 |
| Caligan Partners LP | 878,127 | $4,429 萬 | 3.13% | +878,127 | 新進 |
| Siren, L.L.C. | 818,598 | $4,129 萬 | 1.14% | 00.0% | 不變 |
| Polar Capital Holdings Plc | 792,847 | $3,999 萬 | 0.17% | +52,521+7.1% | 加碼 |
| UBS Group AG | 671,235 | $3,386 萬 | 0.01% | −9,331−1.4% | 減碼 |
| Capital World Investors | 666,564 | $3,362 萬 | 0.00% | +466,392+233.0% | 加碼 |
| Emerald Advisers, LLC | 613,365 | $3,094 萬 | 0.98% | −22,744−3.6% | 減碼 |
| Candriam Luxembourg S.C.A. | 610,282 | $3,078 萬 | 0.16% | +184,748+43.4% | 加碼 |
| Vanguard Portfolio Management LLC | 585,130 | $2,951 萬 | 0.00% | +585,130 | 新進 |
| Northern Trust Corp | 578,907 | $2,920 萬 | 0.00% | +17,884+3.2% | 加碼 |
| Charles Schwab Investment Management Inc | 562,653 | $2,838 萬 | 0.00% | −11,969−2.1% | 減碼 |
| Pictet Asset Management Holding SA | 491,649 | $2,480 萬 | 0.03% | −422,311−46.2% | 減碼 |
| Vanguard Fiduciary Trust Co | 464,651 | $2,344 萬 | 0.01% | +464,651 | 新進 |
| Emerald Mutual Fund Advisers Trust | 408,113 | $2,059 萬 | 1.00% | −4,258−1.0% | 減碼 |
| Samlyn Capital, LLC | 396,661 | $2,001 萬 | 0.34% | +396,661 | 新進 |
| ADAR1 Capital Management, LLC | 338,323 | $1,707 萬 | 1.03% | +304,272+893.6% | 加碼 |
| Blackstone Group Inc. | 292,847 | $1,477 萬 | 0.06% | −208,151−41.5% | 減碼 |
| Victory Capital Management Inc | 292,126 | $1,473 萬 | 0.01% | +146,047+100.0% | 加碼 |
| Goldman Sachs Group Inc | 269,938 | $1,362 萬 | 0.00% | −5,127−1.9% | 減碼 |
| Woodline Partners LP | 265,892 | $1,341 萬 | 0.05% | 00.0% | 不變 |
| Morgan Stanley | 246,719 | $1,244 萬 | 0.00% | +63,985+35.0% | 加碼 |
| UBS Asset Management Americas Inc | 207,314 | $1,046 萬 | 0.00% | +145,098+233.2% | 加碼 |
| Boothbay Fund Management, LLC | 193,031 | $973.6 萬 | 0.23% | +193,031 | 新進 |
| Bank of New York Mellon Corp | 191,395 | $965.4 萬 | 0.00% | −1,435−0.7% | 減碼 |
| Silverarc Capital Management, LLC | 186,618 | $941.3 萬 | 1.11% | −1,119−0.6% | 減碼 |
| First Trust Advisors LP | 178,389 | $899.8 萬 | 0.01% | +178,389 | 新進 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170,381 | $859.4 萬 | 0.01% | −830−0.5% | 減碼 |
| StemPoint Capital LP | 167,606 | $845.4 萬 | 1.62% | +135,229+417.7% | 加碼 |
| Ameriprise Financial Inc | 159,217 | $803.1 萬 | 0.00% | +120,961+316.2% | 加碼 |
| Nuveen, LLC | 153,899 | $776.3 萬 | 0.00% | +2,919+1.9% | 加碼 |
| Ensign Peak Advisors, Inc | 148,537 | $749.2 萬 | 0.01% | +148,537 | 新進 |
| Millennium Management LLC | 146,639 | $739.6 萬 | 0.01% | +70,445+92.5% | 加碼 |
| HighVista Strategies LLC | 146,264 | $737.8 萬 | 2.04% | −41,942−22.3% | 減碼 |
| Marshall Wace, LLP | 139,259 | $702.4 萬 | 0.01% | +139,259 | 新進 |
| TD Asset Management Inc | 137,390 | $693.0 萬 | 0.01% | −12,432−8.3% | 減碼 |
| Invesco Ltd. | 132,390 | $667.8 萬 | 0.00% | −18,544−12.3% | 減碼 |
| Deutsche Bank AG | 129,242 | $651.9 萬 | 0.00% | +7,301+6.0% | 加碼 |
| Armistice Capital, LLC | 120,931 | $610.0 萬 | 0.20% | −75,495−38.4% | 減碼 |
| Manufacturers Life Insurance Company, The | 112,841 | $569.2 萬 | 0.00% | −16,172−12.5% | 減碼 |
| Citadel Advisors LLC | 108,135 | $545.4 萬 | 0.00% | +44,231+69.2% | 加碼 |
| Seven Grand Managers, LLC | 100,000 | $504.4 萬 | 0.34% | 00.0% | 不變 |
| B Group, Inc. | 100,000 | $504.4 萬 | 3.74% | 00.0% | 不變 |
| F/M Investments LLC | 99,460 | $501.7 萬 | 0.33% | −4,258−4.1% | 減碼 |
| Swiss National Bank | 96,500 | $486.7 萬 | 0.00% | 00.0% | 不變 |
| ExodusPoint Capital Management, LP | 87,065 | $439.2 萬 | 0.04% | +49,194+129.9% | 加碼 |
| Rhumbline Advisers | 85,121 | $429.3 萬 | 0.00% | +2,165+2.6% | 加碼 |
| Mercer Global Advisors Inc | 71,091 | $358.6 萬 | 0.01% | −35,225−33.1% | 減碼 |
| HealthInvest Partners AB | 62,735 | $348.6 萬 | 1.13% | +62,735 | 新進 |
| Rockefeller Capital Management L.P. | 64,002 | $322.8 萬 | 0.01% | +63,453+11,557.9% | 加碼 |
| Alps Advisors Inc | 63,939 | $322.5 萬 | 0.02% | +231+0.4% | 加碼 |
| Prudential Financial Inc | 59,555 | $300.4 萬 | 0.00% | +59,555 | 新進 |
| Fred Alger Management, LLC | 59,453 | $299.9 萬 | 0.01% | +59,453 | 新進 |
| California State Teachers Retirement System | 59,242 | $298.8 萬 | 0.00% | +11,204+23.3% | 加碼 |
| Schroder Investment Management Group | 63,684 | $289.3 萬 | 0.00% | +2,110+3.4% | 加碼 |
| Rafferty Asset Management, LLC | 56,920 | $287.1 萬 | 0.01% | +3,510+6.6% | 加碼 |
| Balyasny Asset Management LLC | 55,477 | $279.8 萬 | 0.01% | −17,988−24.5% | 減碼 |
| Voya Investment Management LLC | 53,970 | $272.2 萬 | 0.00% | +26,693+97.9% | 加碼 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $267.8 萬 | 0.04% | 00.0% | 不變 |
| Dimensional Fund Advisors LP | 47,697 | $240.6 萬 | 0.00% | −29,593−38.3% | 減碼 |
| Alliancebernstein L.P. | 70,900 | $232.3 萬 | 0.00% | +3,400+5.0% | 加碼 |
| Barclays PLC | 45,786 | $230.9 萬 | 0.00% | −136,738−74.9% | 減碼 |
| Legal & General Group Plc | 44,792 | $225.9 萬 | 0.00% | −11,656−20.6% | 減碼 |
| MetLife Investment Management | 38,407 | $193.7 萬 | 0.01% | +396+1.0% | 加碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 36,323 | $181.2 萬 | 0.00% | +1,179+3.4% | 加碼 |
| Vanguard Asset Management, Ltd | 33,232 | $167.6 萬 | 0.00% | +33,232 | 新進 |
| Wells Fargo & Company | 33,208 | $167.5 萬 | 0.00% | −49,208−59.7% | 減碼 |
| Vanguard Global Advisers, LLC | 31,141 | $157.1 萬 | 0.00% | +31,141 | 新進 |
| Susquehanna International Group, LLP | 28,962 | $146.1 萬 | 0.00% | +22,851+373.9% | 加碼 |
| Virginia Retirement Systems Et Al | 27,550 | $139.0 萬 | 0.01% | +2,600+10.4% | 加碼 |
| Cinctive Capital Management LP | 27,430 | $138.4 萬 | 0.09% | −8,505−23.7% | 減碼 |
| State of Wisconsin Investment Board | 26,523 | $133.8 萬 | 0.00% | −729−2.7% | 減碼 |
| Profund Advisors LLC | 26,043 | $131.4 萬 | 0.05% | +5,450+26.5% | 加碼 |
| Warren Averett Asset Management, LLC | 25,966 | $131.0 萬 | 0.01% | +120.0% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $130.1 萬 | 0.01% | 00.0% | 不變 |
| XTX Topco Ltd | 24,435 | $123.3 萬 | 0.02% | +24,435 | 新進 |