Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2024 年第 4 季 13F 持有人
Spyre Therapeutics, Inc. 在 2024/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 131
- 較 2024 年第 3 季 +13 家
- 持有股數
- 5,988 萬
- 較 2024 年第 3 季 +856.9 萬 (+16.7%)
- 總市值
- $13.9 億
- 較 2024 年第 3 季 −$1.16 億 (−7.7%)
- 新進機構
- 34
- 另有 63 家加碼
- 清倉機構
- 21
- 另有 20 家減碼
另有 1 家機構在 2024 年第 3 季持有、還沒有申報 2024 年第 4 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2024 年第 4 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2024 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 8,801,266 | $2.05 億 | 0.01% | +1,177,385+15.4% | 加碼 |
| Fairmount Funds Management LLC | 4,018,101 | $9,354 萬 | 9.30% | 00.0% | 不變 |
| RTW Investments, LP | 3,621,996 | $8,432 萬 | 1.28% | +363,636+11.2% | 加碼 |
| BlackRock, Inc. | 3,399,591 | $7,914 萬 | 0.00% | +736,444+27.7% | 加碼 |
| Vanguard Group Inc | 2,846,473 | $6,627 萬 | 0.00% | +330,553+13.1% | 加碼 |
| Driehaus Capital Management LLC | 2,803,655 | $6,527 萬 | 0.54% | +2,116,575+308.1% | 加碼 |
| VR Adviser, LLC | 2,685,448 | $6,252 萬 | 4.29% | 00.0% | 不變 |
| Braidwell LP | 2,578,404 | $6,003 萬 | 1.78% | +388,568+17.7% | 加碼 |
| Perceptive Advisors LLC | 2,574,723 | $5,994 萬 | 1.67% | −297,824−10.4% | 減碼 |
| Commodore Capital LP | 1,988,084 | $4,628 萬 | 3.39% | 00.0% | 不變 |
| State Street Corp | 1,680,936 | $3,913 萬 | 0.00% | +139,381+9.0% | 加碼 |
| Wellington Management Group LLP | 1,604,508 | $3,735 萬 | 0.01% | +97,308+6.5% | 加碼 |
| Paradigm Biocapital Advisors LP | 1,527,205 | $3,555 萬 | 1.24% | +259,624+20.5% | 加碼 |
| Janus Henderson Group PLC | 1,456,740 | $3,393 萬 | 0.02% | +336,209+30.0% | 加碼 |
| Jefferies Financial Group Inc. | 1,216,954 | $2,833 萬 | 0.32% | +762,147+167.6% | 加碼 |
| Pictet Asset Management Holding SA | 1,092,124 | $2,542 萬 | 0.03% | +266,418+32.3% | 加碼 |
| Citadel Advisors LLC | 1,079,307 | $2,513 萬 | 0.02% | +371,721+52.5% | 加碼 |
| Adage Capital Partners GP, L.L.C. | 1,030,000 | $2,398 萬 | 0.04% | −25,000−2.4% | 減碼 |
| Geode Capital Management, LLC | 966,129 | $2,250 萬 | 0.00% | +75,081+8.4% | 加碼 |
| Affinity Asset Advisors, LLC | 824,328 | $1,919 萬 | 3.00% | +325,908+65.4% | 加碼 |
| Franklin Resources Inc | 760,642 | $1,771 萬 | 0.00% | −240.0% | 減碼 |
| Polar Capital Holdings Plc | 750,000 | $1,746 萬 | 0.10% | +250,000+50.0% | 加碼 |
| Goldman Sachs Group Inc | 747,552 | $1,740 萬 | 0.00% | +578,238+341.5% | 加碼 |
| Emerald Advisers, LLC | 546,791 | $1,273 萬 | 0.49% | +254,222+86.9% | 加碼 |
| Price T Rowe Associates Inc | 506,450 | $1,179 萬 | 0.00% | +77,323+18.0% | 加碼 |
| Logos Global Management LP | 500,000 | $1,164 萬 | 1.36% | +300,000+150.0% | 加碼 |
| Boxer Capital Management, LLC | 466,680 | $1,086 萬 | 0.93% | +466,680 | 新進 |
| Deerfield Management Company, L.P. (Series C) | 450,000 | $1,048 萬 | 0.20% | +450,000 | 新進 |
| Blackstone Group Inc. | 449,201 | $1,046 萬 | 0.05% | +156,206+53.3% | 加碼 |
| UBS Group AG | 392,197 | $913.0 萬 | 0.00% | +334,359+578.1% | 加碼 |
| Emerald Mutual Fund Advisers Trust | 386,384 | $899.5 萬 | 0.55% | +132,834+52.4% | 加碼 |
| Charles Schwab Investment Management Inc | 379,650 | $883.8 萬 | 0.00% | +46,375+13.9% | 加碼 |
| Capital World Investors | 378,573 | $881.3 萬 | 0.00% | +378,573 | 新進 |
| Siren, L.L.C. | 374,000 | $870.7 萬 | 0.38% | +374,000 | 新進 |
| Woodline Partners LP | 352,680 | $821.0 萬 | 0.06% | +88,424+33.5% | 加碼 |
| Northern Trust Corp | 348,983 | $812.4 萬 | 0.00% | +34,693+11.0% | 加碼 |
| Ikarian Capital, LLC | 282,159 | $656.9 萬 | 1.88% | −20,088−6.6% | 減碼 |
| Victory Capital Management Inc | 268,076 | $624.1 萬 | 0.01% | +268,076 | 新進 |
| Morgan Stanley | 255,256 | $594.2 萬 | 0.00% | +11,514+4.7% | 加碼 |
| Soros Fund Management LLC大師索羅斯基金管理 | 250,000 | $582.0 萬 | 0.10% | +105,000+72.4% | 加碼 |
| Candriam Luxembourg S.C.A. | 247,591 | $576.4 萬 | 0.03% | +142,591+135.8% | 加碼 |
| Deep Track Capital, LP | 219,015 | $509.9 萬 | 0.19% | −780,985−78.1% | 減碼 |
| Armistice Capital, LLC | 200,000 | $465.6 萬 | 0.11% | +64,000+47.1% | 加碼 |
| Millennium Management LLC | 167,804 | $390.6 萬 | 0.00% | +167,804 | 新進 |
| Nuveen Asset Management, LLC | 125,668 | $292.6 萬 | 0.00% | +378+0.3% | 加碼 |
| Barclays PLC | 123,071 | $286.5 萬 | 0.00% | +17,604+16.7% | 加碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 122,153 | $284.4 萬 | 0.01% | +122,153 | 新進 |
| Voloridge Investment Management, LLC | 115,470 | $268.8 萬 | 0.01% | −41,011−26.2% | 減碼 |
| Schroder Investment Management Group | 113,620 | $256.1 萬 | 0.00% | +113,620 | 新進 |
| Bank of New York Mellon Corp | 103,688 | $241.4 萬 | 0.00% | −1,118−1.1% | 減碼 |
| HighVista Strategies LLC | 95,159 | $221.5 萬 | 0.82% | −10,192−9.7% | 減碼 |
| Boothbay Fund Management, LLC | 85,618 | $199.3 萬 | 0.06% | −6,157−6.7% | 減碼 |
| EFG Asset Management (North America) Corp. | 82,818 | $192.9 萬 | 0.26% | +30,608+58.6% | 加碼 |
| Ensign Peak Advisors, Inc | 82,475 | $192.0 萬 | 0.00% | 00.0% | 不變 |
| Prosight Management, LP | 80,000 | $186.2 萬 | 0.52% | +80,000 | 新進 |
| Rafferty Asset Management, LLC | 76,740 | $178.7 萬 | 0.01% | +6,154+8.7% | 加碼 |
| Citigroup Inc | 73,752 | $171.7 萬 | 0.00% | +48,561+192.8% | 加碼 |
| Swiss National Bank | 68,600 | $159.7 萬 | 0.00% | +19,000+38.3% | 加碼 |
| TD Asset Management Inc | 64,968 | $151.2 萬 | 0.00% | +12,200+23.1% | 加碼 |
| Rhumbline Advisers | 57,657 | $134.2 萬 | 0.00% | +3,722+6.9% | 加碼 |
| Manufacturers Life Insurance Company, The | 52,762 | $122.8 萬 | 0.00% | +9,302+21.4% | 加碼 |
| B Group, Inc. | 50,000 | $116.4 萬 | 0.71% | +50,000 | 新進 |
| UBS Asset Management Americas Inc | 48,981 | $114.0 萬 | 0.00% | +22,540+85.2% | 加碼 |
| F/M Investments LLC | 48,806 | $113.6 萬 | 0.04% | +48,806 | 新進 |
| Legal & General Group Plc | 37,490 | $87.3 萬 | 0.00% | +8,335+28.6% | 加碼 |
| Alliancebernstein L.P. | 36,230 | $84.3 萬 | 0.00% | 00.0% | 不變 |
| JPMorgan Chase & Co | 35,248 | $82.1 萬 | 0.00% | +5,775+19.6% | 加碼 |
| California State Teachers Retirement System | 32,598 | $75.9 萬 | 0.00% | +7,923+32.1% | 加碼 |
| State of Wisconsin Investment Board | 31,484 | $73.3 萬 | 0.00% | +13,169+71.9% | 加碼 |
| Deutsche Bank AG | 31,418 | $73.1 萬 | 0.00% | +9,910+46.1% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $60.1 萬 | 0.01% | +4,645+22.0% | 加碼 |
| Wells Fargo & Company | 24,718 | $57.5 萬 | 0.00% | +6,908+38.8% | 加碼 |
| First Trust Advisors LP | 23,550 | $54.8 萬 | 0.00% | +23,550 | 新進 |
| Susquehanna International Group, LLP | 23,089 | $53.8 萬 | 0.00% | +9,891+74.9% | 加碼 |
| Assenagon Asset Management S.A. | 22,652 | $52.7 萬 | 0.00% | −1,120,116−98.0% | 減碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 22,741 | $52.7 萬 | 0.00% | +916+4.2% | 加碼 |
| MetLife Investment Management | 21,382 | $49.8 萬 | 0.00% | +1,250+6.2% | 加碼 |
| Invesco Ltd. | 19,663 | $45.8 萬 | 0.00% | −118,195−85.7% | 減碼 |
| Cinctive Capital Management LP | 19,567 | $45.6 萬 | 0.02% | −41,689−68.1% | 減碼 |
| NBW Capital LLC | 19,430 | $45.2 萬 | 0.08% | −7,500−27.8% | 減碼 |
| BNP Paribas Arbitrage, SA | 18,784 | $43.7 萬 | 0.00% | +18,784 | 新進 |
| Global Endowment Management, LP | 18,184 | $42.3 萬 | 0.05% | 00.0% | 不變 |
| Natixis Advisors, L.P. | 17,300 | $40.3 萬 | 0.00% | +17,300 | 新進 |
| Corebridge Financial, Inc. | 17,213 | $40.1 萬 | 0.00% | −1,299−7.0% | 減碼 |
| Brevan Howard Capital Management LP | 16,899 | $39.3 萬 | 0.01% | +16,899 | 新進 |
| ExodusPoint Capital Management, LP | 16,691 | $38.9 萬 | 0.00% | +6,958+71.5% | 加碼 |
| Squarepoint Ops LLC | 15,231 | $35.5 萬 | 0.00% | +6,754+79.7% | 加碼 |
| Profund Advisors LLC | 14,862 | $34.6 萬 | 0.01% | +787+5.6% | 加碼 |
| Intech Investment Management LLC | 14,043 | $32.7 萬 | 0.00% | +5,672+67.8% | 加碼 |
| ProShare Advisors LLC | 12,531 | $29.2 萬 | 0.00% | +12,531 | 新進 |
| China Universal Asset Management Co., Ltd. | 12,440 | $29.0 萬 | 0.03% | +12,440 | 新進 |
| Aquatic Capital Management LLC | 11,767 | $27.4 萬 | 0.01% | +11,767 | 新進 |
| Voya Investment Management LLC | 10,495 | $24.4 萬 | 0.00% | −856−7.5% | 減碼 |
| Teacher Retirement System of Texas | 10,383 | $24.2 萬 | 0.00% | +10,383 | 新進 |
| New York State Common Retirement Fund | 10,265 | $23.9 萬 | 0.00% | 00.0% | 不變 |
| Arizona State Retirement System | 10,115 | $23.5 萬 | 0.00% | +2,805+38.4% | 加碼 |
| Two Sigma Investments, LP | 9,638 | $22.4 萬 | 0.00% | −165−1.7% | 減碼 |
| Carlyle Group Inc. | 9,620 | $22.4 萬 | 0.01% | 00.0% | 不變 |
| State Board of Administration of Florida Retirement System | 9,030 | $21.0 萬 | 0.00% | 00.0% | 不變 |
| Tower Research Capital LLC (TRC) | 8,574 | $20.0 萬 | 0.00% | +8,054+1,548.8% | 加碼 |