Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +9 vs. Q2 2025
- Shares held
- 64.3M
- +693.4K (+1.1%) vs. Q2 2025
- Total value
- $1.08B
- +$125.3M (+13.2%) vs. Q2 2025
- New holders
- 22
- 44 more added
- Sold out
- 13
- 43 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| ProShare Advisors LLC | 10,678 | $179.0K | 0.00% | −1,801−14.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 10,587 | $177.4K | 0.01% | −1,535−12.7% | Reduced |
| Royal Bank of Canada | 7,883 | $132.0K | 0.00% | −591−7.0% | Reduced |
| KLP Kapitalforvaltning AS | 7,800 | $130.7K | 0.00% | 00.0% | Unchanged |
| Virtus Investment Advisers, Inc. | 6,425 | $107.7K | 0.03% | +1,115+21.0% | Added |
| Tower Research Capital LLC (TRC) | 4,596 | $77.0K | 0.00% | −1,173−20.3% | Reduced |
| Russell Investments Group, Ltd. | 4,234 | $71.0K | 0.00% | +4,092+2,881.7% | Added |
| Ameritas Investment Partners, Inc. | 4,166 | $69.8K | 0.00% | −925−18.2% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 2,335 | $39.1K | 0.00% | +4+0.2% | Added |
| CWM, LLC | 1,960 | $33.0K | 0.00% | +248+14.5% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $27.0K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1,470 | $24.6K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 1,379 | $23.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,299 | $21.8K | 0.00% | −203−13.5% | Reduced |
| Sterling Capital Management LLC | 1,214 | $20.3K | 0.00% | +690+131.7% | Added |
| Nisa Investment Advisors, LLC | 705 | $11.8K | 0.00% | +159+29.1% | Added |
| Optiver Holding B.V. | 500 | $8.38K | 0.00% | +500 | New |
| Rockefeller Capital Management L.P. | 401 | $6.72K | 0.00% | +401 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 335 | $6.00K | 0.00% | −42−11.1% | Reduced |
| SBI Securities Co., Ltd. | 123 | $5.88K | 0.00% | +112+1,018.2% | Added |
| Advisor Group Holdings, Inc. | 314 | $5.17K | 0.00% | +14+4.7% | Added |
| Meeder Asset Management Inc | 216 | $3.62K | 0.00% | +46+27.1% | Added |
| GAMMA Investing LLC | 208 | $3.49K | 0.00% | +34+19.5% | Added |
| Daiwa Securities Group Inc. | 206 | $3.00K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 121 | $2.03K | 0.00% | +121 | New |
| The PNC Financial Services Group, Inc. | 86 | $1.44K | 0.00% | +86 | New |
| Rothschild Investment LLC | 80 | $1.34K | 0.00% | −60−42.9% | Reduced |
| Signaturefd, LLC | 70 | $1.17K | 0.00% | −95−57.6% | Reduced |
| EverSource Wealth Advisors, LLC | 65 | $1.09K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 35 | $587 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 32 | $537 | 0.00% | +2+6.7% | Added |
| IFP Advisors, Inc | 24 | $402 | 0.00% | +1+4.3% | Added |
| Larson Financial Group LLC | 12 | $201 | 0.00% | +6+100.0% | Added |
| US Bancorp | 10 | $168 | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 10 | $168 | 0.00% | +10 | New |
| Comerica Bank | 5 | $84 | 0.00% | +5 | New |
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −610,200−100.0% | Sold out |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −219,015−100.0% | Sold out |
| Capitolis Liquid Global Markets LLC | 0 | $0 | 0.00% | −183,000−100.0% | Sold out |
| Foresite Capital Management VI LLC | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −59,816−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −30,936−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −20,040−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −13,589−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −10,843−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −520−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −145−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −102−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −16−100.0% | Sold out |
| NBW Capital LLC | – | – | – | – | Not filed |