Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 131
- +13 vs. Q3 2024
- Shares held
- 59.9M
- +8.57M (+16.7%) vs. Q3 2024
- Total value
- $1.39B
- −$116.0M (−7.7%) vs. Q3 2024
- New holders
- 34
- 63 more added
- Sold out
- 21
- 20 more reduced
1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| KLP Kapitalforvaltning AS | 7,800 | $181.6K | 0.00% | +7,800 | New |
| Police & Firemen's Retirement System of New Jersey | 7,378 | $171.8K | 0.00% | +7,378 | New |
| Bank of America Corp | 7,142 | $166.3K | 0.00% | −250,655−97.2% | Reduced |
| Royal Bank of Canada | 4,022 | $94.0K | 0.00% | +236+6.2% | Added |
| Ameritas Investment Partners, Inc. | 3,392 | $79.0K | 0.00% | 00.0% | Unchanged |
| Virtus ETF Advisers LLC | 2,972 | $69.2K | 0.03% | +124+4.4% | Added |
| Quest Partners LLC | 2,198 | $51.2K | 0.01% | −3,456−61.1% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 1,955 | $46.3K | 0.00% | +1,955 | New |
| Public Employees Retirement Association of Colorado | 1,589 | $37.0K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1,470 | $34.2K | 0.00% | +1,470 | New |
| GF Fund Management Co. Ltd. | 1,232 | $28.7K | 0.00% | +1,232 | New |
| Amalgamated Bank | 1,198 | $28.0K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 1,009 | $23.5K | 0.00% | +894+777.4% | Added |
| R Squared Ltd | 710 | $16.5K | 0.02% | +710 | New |
| Venturi Wealth Management, LLC | 231 | $5.38K | 0.00% | +231 | New |
| Sugar Maple Asset Management, LLC | 180 | $4.19K | 0.00% | +180 | New |
| Nisa Investment Advisors, LLC | 120 | $2.79K | 0.00% | +9+8.1% | Added |
| Skopos Labs, Inc. | 120 | $2.79K | 0.00% | +120 | New |
| IFP Advisors, Inc | 109 | $2.77K | 0.00% | −5−4.4% | Reduced |
| Advisor Group Holdings, Inc. | 105 | $2.44K | 0.00% | +22+26.5% | Added |
| Signaturefd, LLC | 68 | $1.58K | 0.00% | +68 | New |
| Simplex Trading, LLC | 55 | $1.00K | 0.00% | +55 | New |
| Rothschild Investment LLC | 40 | $931 | 0.00% | 00.0% | Unchanged |
| Amundi | 32 | $769 | 0.00% | +32 | New |
| Caitong International Asset Management Co., Ltd | 14 | $326 | 0.00% | +14 | New |
| Allworth Financial LP | 9 | $197 | 0.00% | +2+28.6% | Added |
| Pacific Capital Wealth Advisors, Inc | 8 | $186 | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 8 | $186 | 0.00% | +8 | New |
| SBI Securities Co., Ltd. | 5 | $116 | 0.00% | +5 | New |
| CWM, LLC | 8 | $0 | 0.00% | −219−96.5% | Reduced |
| Covestor Ltd | 4 | $0 | 0.00% | +1+33.3% | Added |
| Boxer Capital, LLC | 0 | $0 | 0.00% | −696,480−100.0% | Sold out |
| Avoro Capital Advisors LLC | 0 | $0 | 0.00% | −598,600−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −243,372−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −227,950−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −46,072−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −37,287−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −35,003−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −31,138−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −20,641−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −12,589−100.0% | Sold out |
| ADAR1 Capital Management, LLC | 0 | $0 | 0.00% | −12,560−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −814−100.0% | Sold out |
| nVerses Capital, LLC | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| Russell Investments Group, Ltd. | 0 | $0 | 0.00% | −129−100.0% | Sold out |
| Capital Performance Advisors LLP | 0 | $0 | 0.00% | −46−100.0% | Sold out |
| Bessemer Group Inc | 0 | $0 | 0.00% | −45−100.0% | Sold out |
| Lindbrook Capital, LLC | 0 | $0 | 0.00% | −19−100.0% | Sold out |
| True Wealth Design, LLC | 0 | $0 | 0.00% | −16−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −9−100.0% | Sold out |
| GAMMA Investing LLC | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Ghost Tree Capital, LLC | – | – | – | – | Not filed |