Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 198
- +47 vs. Q4 2025
- Shares held
- 82.7M
- +5.74M (+7.5%) vs. Q4 2025
- Total value
- $4.16B
- +$1.64B (+65.2%) vs. Q4 2025
- New holders
- 58
- 67 more added
- Sold out
- 11
- 49 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| New York State Common Retirement Fund | 22,265 | $1.12M | 0.00% | +3,100+16.2% | Added |
| Ellsworth Advisors, LLC | 21,963 | $1.11M | 0.21% | +21,963 | New |
| AQR Capital Management LLC | 20,874 | $1.05M | 0.00% | +3,054+17.1% | Added |
| Raymond James Financial Inc | 19,755 | $996.4K | 0.00% | +19,755 | New |
| Seven Fleet Capital Management LP | 19,690 | $993.2K | 0.31% | +19,690 | New |
| Assenagon Asset Management S.A. | 18,647 | $940.6K | 0.00% | −3,489−15.8% | Reduced |
| BNP Paribas Arbitrage, SA | 18,630 | $939.7K | 0.00% | +6,786+57.3% | Added |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $926.1K | 0.01% | 00.0% | Unchanged |
| Global Endowment Management, LP | 18,184 | $917.0K | 0.10% | 00.0% | Unchanged |
| Kennedy Capital Management, Inc. | 16,873 | $851.1K | 0.02% | +16,873 | New |
| State of New Jersey Common Pension Fund D | 16,720 | $843.4K | 0.00% | +22+0.1% | Added |
| Intech Investment Management LLC | 16,443 | $829.4K | 0.01% | −1,831−10.0% | Reduced |
| Creative Planning | 15,486 | $781.1K | 0.00% | +15,486 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,955 | $703.9K | 0.00% | +2,791+25.0% | Added |
| China Universal Asset Management Co., Ltd. | 13,938 | $703.0K | 0.05% | +1,294+10.2% | Added |
| State Board of Administration of Florida Retirement System | 13,905 | $701.4K | 0.00% | +4,875+54.0% | Added |
| ProShare Advisors LLC | 13,498 | $680.8K | 0.00% | −2,491−15.6% | Reduced |
| Arizona State Retirement System | 13,438 | $677.8K | 0.00% | −359−2.6% | Reduced |
| SG Americas Securities, LLC | 13,396 | $676.0K | 0.00% | −9,947−42.6% | Reduced |
| Vanguard Investments Australia, Ltd. | 12,813 | $646.3K | 0.00% | +12,813 | New |
| Brown Advisory Inc | 12,400 | $625.5K | 0.00% | +12,400 | New |
| Citigroup Inc | 12,006 | $605.6K | 0.00% | −88,052−88.0% | Reduced |
| KLP Kapitalforvaltning AS | 10,900 | $549.8K | 0.00% | +500+4.8% | Added |
| Russell Investments Group, Ltd. | 9,931 | $500.9K | 0.00% | +4,377+78.8% | Added |
| Carlyle Group Inc. | 9,620 | $485.2K | 0.00% | 00.0% | Unchanged |
| Man Group plc | 9,546 | $481.5K | 0.00% | +9,546 | New |
| Martingale Asset Management L P | 9,080 | $458.0K | 0.01% | +2,150+31.0% | Added |
| SEI Investments Co | 8,975 | $452.7K | 0.00% | +2,858+46.7% | Added |
| Tower Research Capital LLC (TRC) | 8,790 | $443.4K | 0.01% | +8,365+1,968.2% | Added |
| Bridgefront Capital, LLC | 8,652 | $436.4K | 0.11% | +8,652 | New |
| Tudor Investment Corp Et Al | 8,364 | $421.9K | 0.00% | −1,763−17.4% | Reduced |
| RWC Asset Management LLP | 8,166 | $411.9K | 0.02% | +8,166 | New |
| Virtus Investment Advisers, Inc. | 8,110 | $409.1K | 0.11% | +197+2.5% | Added |
| Virtu Financial LLC | 8,091 | $408.0K | 0.02% | +8,091 | New |
| Capstone Investment Advisors, LLC | 7,537 | $380.2K | 0.00% | +7,537 | New |
| E Fund Management Co., Ltd. | 7,156 | $360.9K | 0.01% | +7,156 | New |
| Scientech Research LLC | 7,088 | $357.5K | 0.30% | +7,088 | New |
| Two Sigma Securities, LLC | 6,851 | $345.6K | 0.04% | +6,851 | New |
| AlphaCentric Advisors LLC | 6,634 | $334.6K | 0.33% | +6,634 | New |
| Xponance, Inc. | 6,445 | $325.1K | 0.00% | +6,445 | New |
| Teacher Retirement System of Texas | 6,280 | $316.8K | 0.00% | −893−12.4% | Reduced |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6,140 | $309.7K | 0.45% | −7,584−55.3% | Reduced |
| High Net Worth Advisory Group LLC | 6,000 | $302.6K | 0.07% | +6,000 | New |
| Los Angeles Capital Management LLC | 5,858 | $295.5K | 0.00% | −7,024−54.5% | Reduced |
| Ameritas Investment Partners, Inc. | 5,593 | $282.1K | 0.01% | 00.0% | Unchanged |
| Landscape Capital Management, L.L.C. | 5,200 | $262.3K | 0.02% | +5,200 | New |
| PSP Research LLC | 5,159 | $260.2K | 0.18% | −10,681−67.4% | Reduced |
| Persistent Asset Partners Ltd | 4,803 | $242.3K | 0.09% | +2,557+113.8% | Added |
| DeepCurrents Investment Group LLC | 4,740 | $239.1K | 0.01% | +4,740 | New |
| Quantinno Capital Management LP | 4,561 | $230.1K | 0.00% | +4,561 | New |
| STRS Ohio | 4,500 | $227.0K | 0.00% | +4,500 | New |
| JustInvest LLC | 4,397 | $221.8K | 0.00% | +4,397 | New |
| Principal Financial Group Inc | 4,299 | $216.8K | 0.00% | +4,299 | New |
| Mirae Asset Global Investments Co., Ltd. | 4,097 | $206.7K | 0.00% | +327+8.7% | Added |
| ABS Direct Equity Fund LLC | 2,800 | $193.6K | 0.15% | +2,800 | New |
| Royal Bank of Canada | 3,250 | $164.0K | 0.00% | +1,262+63.5% | Added |
| Union Bancaire Privee, UBP SA | 3,880 | $158.8K | 0.00% | +3,880 | New |
| CWM, LLC | 2,105 | $106.2K | 0.00% | +135+6.9% | Added |
| Nisa Investment Advisors, LLC | 1,916 | $96.6K | 0.00% | +1,211+171.8% | Added |
| GF Fund Management Co. Ltd. | 1,743 | $87.9K | 0.00% | +220+14.4% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $80.0K | 0.00% | 00.0% | Unchanged |
| KBC Group NV | 1,372 | $69.0K | 0.00% | +1,372 | New |
| Sterling Capital Management LLC | 1,051 | $53.0K | 0.00% | −559−34.7% | Reduced |
| Patient Square Capital LP | 1,000 | $50.4K | 0.01% | −149,000−99.3% | Reduced |
| Group One Trading, L.P. | 901 | $45.4K | 0.00% | +501+125.3% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 888 | $44.8K | 0.00% | +232+35.4% | Added |
| Neo Ivy Capital Management | 598 | $30.2K | 0.01% | −17,663−96.7% | Reduced |
| Kemnay Advisory Services Inc. | 574 | $29.0K | 0.00% | +574 | New |
| Clear Street Markets LLC | 562 | $28.3K | 0.01% | +562 | New |
| GAMMA Investing LLC | 523 | $26.4K | 0.00% | +193+58.5% | Added |
| Advisor Group Holdings, Inc. | 498 | $25.1K | 0.00% | +131+35.7% | Added |
| Optiver Holding B.V. | 288 | $14.5K | 0.00% | +48+20.0% | Added |
| Caitong International Asset Management Co., Ltd | 286 | $14.4K | 0.00% | +286 | New |
| Delos Wealth Advisors, LLC | 250 | $12.6K | 0.01% | +250 | New |
| Quadrant Capital Group LLC | 146 | $7.37K | 0.00% | +146 | New |
| Smartleaf Asset Management LLC | 157 | $7.13K | 0.00% | +157 | New |
| The PNC Financial Services Group, Inc. | 123 | $6.20K | 0.00% | +37+43.0% | Added |
| Allworth Financial LP | 117 | $5.90K | 0.00% | +59+101.7% | Added |
| Rothschild Investment LLC | 99 | $4.99K | 0.00% | +17+20.7% | Added |
| US Bancorp | 97 | $4.89K | 0.00% | +87+870.0% | Added |
| Quantbot Technologies LP | 88 | $4.44K | 0.00% | +88 | New |
| EverSource Wealth Advisors, LLC | 79 | $3.98K | 0.00% | +14+21.5% | Added |
| Farther Finance Advisors, LLC | 74 | $3.62K | 0.00% | +37+100.0% | Added |
| Signaturefd, LLC | 70 | $3.53K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 36 | $1.82K | 0.00% | −108−75.0% | Reduced |
| Parkside Financial Bank & Trust | 35 | $1.77K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 32 | $1.61K | 0.00% | +32 | New |
| IFP Advisors, Inc | 24 | $1.21K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 18 | $908 | 0.00% | +18 | New |
| Bare Financial Services, Inc | 16 | $807 | 0.00% | +16 | New |
| MAI Capital Management | 13 | $656 | 0.00% | +13 | New |
| SBI Securities Co., Ltd. | 5 | $252 | 0.00% | 00.0% | Unchanged |
| Fifth Third Bancorp | 5 | $252 | 0.00% | +5 | New |
| Keating Financial Advisory Services, Inc. | 4 | $202 | 0.00% | +4 | New |
| Massmutual Trust Co FSB | 3 | $151 | 0.00% | +3 | New |
| Twin Peaks Wealth Advisors, LLC | 3 | $151 | 0.00% | +3 | New |
| Essential Partners LLC | 2 | $101 | 0.00% | +2 | New |
| Covestor Ltd | 4 | $0 | 0.00% | −2−33.3% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −710,626−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −662,351−100.0% | Sold out |