Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 265
- +69 vs. Q1 2026
- Shares held
- 95.8M
- +14.8M (+18.3%) vs. Q1 2026
- Total value
- $8.52B
- +$4.44B (+108.8%) vs. Q1 2026
- New holders
- 91
- 105 more added
- Sold out
- 22
- 55 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Zions Bancorporation, National Association | 1 | $89 | 0.00% | +1 | New |
| Caitong International Asset Management Co., Ltd | 2 | $178 | 0.00% | −284−99.3% | Reduced |
| Essential Partners LLC | 2 | $178 | 0.00% | 00.0% | Unchanged |
| Quarry LP | 2 | $178 | 0.00% | +2 | New |
| Silver Grove Financial Group, Inc. | 3 | $266 | 0.00% | +3 | New |
| Keating Financial Advisory Services, Inc. | 4 | $355 | 0.00% | 00.0% | Unchanged |
| Stone House Investment Management, LLC | 4 | $355 | 0.00% | +4 | New |
| Hughes Financial Services, LLC | 4 | $355 | 0.00% | +4 | New |
| SBI Securities Co., Ltd. | 5 | $444 | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 5 | $444 | 0.00% | +5 | New |
| Ares Financial Consulting, LLC | 11 | $977 | 0.00% | +11 | New |
| Covestor Ltd | 13 | $1.00K | 0.00% | +9+225.0% | Added |
| Bare Financial Services, Inc | 16 | $1.42K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 24 | $2.13K | 0.00% | 00.0% | Unchanged |
| Meeder Asset Management Inc | 30 | $2.66K | 0.00% | +30 | New |
| Parkside Financial Bank & Trust | 45 | $4.00K | 0.00% | +10+28.6% | Added |
| Signaturefd, LLC | 59 | $5.24K | 0.00% | −11−15.7% | Reduced |
| Larson Financial Group LLC | 63 | $5.59K | 0.00% | +27+75.0% | Added |
| Rothschild Investment LLC | 99 | $8.79K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 103 | $9.05K | 0.00% | +103 | New |
| National Bank of Canada | 124 | $11.0K | 0.00% | +124 | New |
| Smartleaf Asset Management LLC | 157 | $14.2K | 0.00% | 00.0% | Unchanged |
| IFG Advisory, LLC | 161 | $14.3K | 0.00% | +161 | New |
| J.Safra Asset Management Corp | 167 | $14.8K | 0.00% | +167 | New |
| SRS Capital Advisors, Inc. | 169 | $15.0K | 0.00% | +151+838.9% | Added |
| Axiom Investment Management LLC | 200 | $17.8K | 0.01% | +200 | New |
| Allworth Financial LP | 226 | $20.1K | 0.00% | +109+93.2% | Added |
| Sterling Capital Management LLC | 262 | $23.3K | 0.00% | −789−75.1% | Reduced |
| Toronto Dominion Bank | 270 | $24.0K | 0.00% | +270 | New |
| Simplex Trading, LLC | 278 | $24.7K | 0.00% | +278 | New |
| EverSource Wealth Advisors, LLC | 345 | $30.6K | 0.00% | +266+336.7% | Added |
| Optiver Holding B.V. | 400 | $35.5K | 0.00% | +112+38.9% | Added |
| Pacer Advisors, Inc. | 614 | $55.0K | 0.00% | +614 | New |
| GAMMA Investing LLC | 663 | $58.9K | 0.00% | +140+26.8% | Added |
| Parallel Advisors, LLC | 720 | $63.9K | 0.00% | +688+2,150.0% | Added |
| Kemnay Advisory Services Inc. | 741 | $65.8K | 0.01% | +167+29.1% | Added |
| Union Bancaire Privee, UBP SA | 880 | $79.3K | 0.00% | −3,000−77.3% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 897 | $79.6K | 0.00% | +9+1.0% | Added |
| The PNC Financial Services Group, Inc. | 914 | $81.1K | 0.00% | +791+643.1% | Added |
| Farther Finance Advisors, LLC | 1,129 | $100.2K | 0.00% | +1,055+1,425.7% | Added |
| US Bancorp | 1,507 | $133.8K | 0.00% | +1,410+1,453.6% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $141.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,664 | $147.7K | 0.00% | −79−4.5% | Reduced |
| KBC Group NV | 1,796 | $159.0K | 0.00% | +424+30.9% | Added |
| Mitsubishi UFJ Trust & Banking Corp | 1,844 | $163.7K | 0.00% | +1,844 | New |
| Nykredit A/S | 1,953 | $173.4K | 0.00% | +1,953 | New |
| Fulcrum Asset Management LLP | 2,114 | $190.6K | 0.02% | +2,114 | New |
| CFC Planning Co LLC | 2,277 | $202.2K | 0.12% | +2,277 | New |
| Acadian Asset Management LLC | 2,296 | $203.0K | 0.00% | +2,296 | New |
| Bayforest Capital Ltd | 2,305 | $204.6K | 0.19% | +2,305 | New |
| Los Angeles Capital Management LLC | 2,310 | $205.1K | 0.00% | −3,548−60.6% | Reduced |
| Royal Bank of Canada | 2,338 | $208.0K | 0.00% | −912−28.1% | Reduced |
| Nisa Investment Advisors, LLC | 2,347 | $208.4K | 0.00% | +431+22.5% | Added |
| CIBC Asset Management Inc | 2,429 | $215.6K | 0.00% | +2,429 | New |
| Brinker Capital Investments, LLC | 2,577 | $228.8K | 0.00% | +2,577 | New |
| Tudor Investment Corp Et Al | 2,645 | $234.8K | 0.00% | −5,719−68.4% | Reduced |
| DnB Asset Management AS | 2,661 | $236.2K | 0.00% | +2,661 | New |
| Empowered Funds, LLC | 2,731 | $242.5K | 0.00% | +2,731 | New |
| Amundi | 2,793 | $248.0K | 0.00% | +2,793 | New |
| Aster Capital Management (DIFC) Ltd | 2,865 | $254.4K | 0.05% | +2,865 | New |
| VARCOV Co. | 2,895 | $257.0K | 0.10% | +2,895 | New |
| Jane Street Group, LLC | 2,909 | $258.3K | 0.00% | +2,909 | New |
| Tower Research Capital LLC (TRC) | 3,001 | $266.4K | 0.01% | −5,789−65.9% | Reduced |
| Two Sigma Securities, LLC | 3,003 | $266.6K | 0.02% | −3,848−56.2% | Reduced |
| Stifel Financial Corp | 3,011 | $267.3K | 0.00% | +3,011 | New |
| Bridgefront Capital, LLC | 3,577 | $317.6K | 0.08% | −5,075−58.7% | Reduced |
| Swiss Life Asset Management Ltd | 3,601 | $319.7K | 0.00% | +3,601 | New |
| Jump Financial, LLC | 3,813 | $338.5K | 0.00% | +3,813 | New |
| Landscape Capital Management, L.L.C. | 3,875 | $344.0K | 0.02% | −1,325−25.5% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 3,884 | $344.8K | 0.00% | −213−5.2% | Reduced |
| PSP Research LLC | 4,000 | $355.1K | 0.19% | −1,159−22.5% | Reduced |
| Wexford Capital LP | 4,000 | $355.1K | 0.05% | +4,000 | New |
| Artia Global Partners LP | 4,000 | $355.1K | 0.07% | +4,000 | New |
| Virtus Investment Advisers, Inc. | 4,050 | $359.6K | 0.08% | −4,060−50.1% | Reduced |
| CIBC Bancorp USA Inc. | 4,122 | $366.0K | 0.00% | +4,122 | New |
| Virtu Financial LLC | 4,351 | $386.0K | 0.01% | −3,740−46.2% | Reduced |
| Martingale Asset Management L P | 4,425 | $392.9K | 0.01% | −4,655−51.3% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 4,801 | $426.2K | 0.00% | +4,801 | New |
| Captrust Financial Advisors | 5,023 | $445.9K | 0.00% | +5,023 | New |
| JustInvest LLC | 5,118 | $454.4K | 0.00% | +721+16.4% | Added |
| E Fund Management Co., Ltd. | 5,184 | $460.2K | 0.01% | −1,972−27.6% | Reduced |
| Dark Forest Capital Management LP | 5,192 | $460.9K | 0.03% | +5,192 | New |
| Omers Administration Corp | 5,200 | $461.7K | 0.00% | +5,200 | New |
| High Net Worth Advisory Group LLC | 6,000 | $532.7K | 0.11% | 00.0% | Unchanged |
| Quantinno Capital Management LP | 6,015 | $534.0K | 0.00% | +1,454+31.9% | Added |
| Allspring Global Investments Holdings, LLC | 6,090 | $541.3K | 0.00% | +6,090 | New |
| Fieldview Capital Management, LLC | 6,392 | $567.5K | 0.16% | +6,392 | New |
| Harvest Investment Services, LLC | 6,432 | $571.0K | 0.09% | +6,432 | New |
| Boothbay Fund Management, LLC | 6,453 | $572.9K | 0.01% | −186,578−96.7% | Reduced |
| Teacher Retirement System of Texas | 6,554 | $581.9K | 0.00% | +274+4.4% | Added |
| AlphaCentric Advisors LLC | 6,670 | $592.2K | 0.50% | +36+0.5% | Added |
| State of Wyoming | 6,690 | $593.9K | 0.06% | +6,690 | New |
| Ameritas Investment Partners, Inc. | 6,760 | $600.2K | 0.02% | +1,167+20.9% | Added |
| Xponance, Inc. | 7,291 | $647.3K | 0.00% | +846+13.1% | Added |
| Envestnet Asset Management Inc | 7,666 | $680.6K | 0.00% | +7,666 | New |
| Man Group plc | 7,714 | $684.8K | 0.00% | −1,832−19.2% | Reduced |
| Brevan Howard Capital Management LP | 8,288 | $735.8K | 0.01% | +8,288 | New |
| Persistent Asset Partners Ltd | 8,760 | $777.7K | 0.25% | +3,957+82.4% | Added |
| Quantbot Technologies LP | 8,884 | $788.7K | 0.03% | +8,796+9,995.5% | Added |
| First Trust Advisors LP | 9,779 | $868.2K | 0.00% | −168,610−94.5% | Reduced |