Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 51
- −4 vs. Q3 2022
- Shares held
- 42.7M
- −2.05M (−4.6%) vs. Q3 2022
- Total value
- $19.2M
- −$4.32M (−18.4%) vs. Q3 2022
- New holders
- 9
- 12 more added
- Sold out
- 13
- 11 more reduced
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Simplex Trading, LLC | 56 | $0 | 0.00% | −13,065−99.6% | Reduced |
| JPMorgan Chase & Co | 1,068 | $0 | 0.00% | −2,578−70.7% | Reduced |
| UBS Group AG | 8 | $4 | 0.00% | +8 | New |
| Barclays PLC | 99 | $45 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 2,543 | $1.15K | 0.00% | +13+0.5% | Added |
| BNP Paribas Arbitrage, SA | 2,968 | $1.33K | 0.00% | +1,393+88.4% | Added |
| Group One Trading, L.P. | 3,182 | $1.43K | 0.00% | +82+2.6% | Added |
| Two Sigma Securities, LLC | 11,272 | $5.07K | 0.00% | −19,771−63.7% | Reduced |
| Ergoteles LLC | 14,722 | $6.62K | 0.00% | +14,722 | New |
| Citadel Advisors LLC | 15,472 | $6.96K | 0.00% | −45,303−74.5% | Reduced |
| Bank of America Corp | 15,770 | $7.08K | 0.00% | +4,094+35.1% | Added |
| Prudential Financial Inc | 17,200 | $7.74K | 0.00% | +17,200 | New |
| Tower Research Capital LLC (TRC) | 17,844 | $8.00K | 0.00% | −9,042−33.6% | Reduced |
| Bank of New York Mellon Corp | 23,233 | $10.5K | 0.00% | 00.0% | Unchanged |
| Franklin Resources Inc | 31,364 | $14.1K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 49,978 | $22.0K | 0.00% | +49,978 | New |
| Susquehanna International Group, LLP | 50,943 | $22.9K | 0.00% | +50,943 | New |
| Ritholtz Wealth Management | 76,490 | $34.4K | 0.00% | 00.0% | Unchanged |
| Blair William & Co | 76,594 | $34.5K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 80,461 | $36.2K | 0.00% | −87,797−52.2% | Reduced |
| Northern Trust Corp | 86,425 | $38.9K | 0.00% | +17,216+24.9% | Added |
| ExodusPoint Capital Management, LP | 105,262 | $47.0K | 0.00% | +105,262 | New |
| Franklin Street Advisors Inc | 105,800 | $48.0K | 0.00% | 00.0% | Unchanged |
| Fan Yu | 112,044 | $50.4K | 0.68% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 150,000 | $67.5K | 0.00% | +150,000 | New |
| Renaissance Technologies LLC | 151,100 | $68.0K | 0.00% | −98,700−39.5% | Reduced |
| State Street Corp | 214,989 | $96.7K | 0.00% | +56,000+35.2% | Added |
| Abingworth LLP | 240,500 | $108.2K | 0.04% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $111.0K | 0.04% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 272,800 | $122.7K | 0.00% | −137,100−33.4% | Reduced |
| Assenagon Asset Management S.A. | 318,451 | $143.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 393,638 | $177.1K | 0.00% | +290,049+280.0% | Added |
| Sphera Funds Management Ltd. | 440,837 | $198.3K | 0.06% | +440,837 | New |
| Geode Capital Management, LLC | 600,455 | $270.0K | 0.00% | +206,435+52.4% | Added |
| BlackRock Inc. | 645,954 | $290.6K | 0.00% | −386,711−37.4% | Reduced |
| Ghost Tree Capital, LLC | 800,000 | $360.0K | 0.15% | −200,000−20.0% | Reduced |
| Samsara BioCapital, LLC | 883,720 | $397.6K | 0.09% | 00.0% | Unchanged |
| Pura Vida Investments, LLC | 1,048,697 | $471.8K | 0.08% | +1,048,697 | New |
| Acadian Asset Management LLC | 1,391,381 | $625.0K | 0.00% | +922,823+196.9% | Added |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $674.9K | 0.00% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,691,151 | $761.0K | 0.50% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 1,797,221 | $808.6K | 0.02% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,997,597 | $898.7K | 0.00% | +110,201+5.8% | Added |
| Sio Capital Management, LLC | 3,004,959 | $1.35M | 0.72% | −1,663,577−35.6% | Reduced |
| Millennium Management LLC | 3,131,479 | $1.41M | 0.00% | +2,316,807+284.4% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $1.53M | 0.01% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 3,413,906 | $1.54M | 0.04% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 4,059,894 | $1.83M | 0.08% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 4,611,302 | $2.07M | 0.19% | +900,524+24.3% | Added |
| Bain Capital Life Sciences Investors, LLC | 5,347,689 | $2.41M | 0.27% | 00.0% | Unchanged |
| IFP Advisors, Inc | 2,860 | – | – | 00.0% | Unchanged |
| Pictet Asset Management SA | 0 | $0 | 0.00% | −2,542,925−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −2,500,000−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −915,695−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −36,475−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −34,478−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −19,220−100.0% | Sold out |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −10,439−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −1,401−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −1,930−100.0% | Sold out |
| Citigroup Inc | 0 | $0 | 0.00% | −633−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −98−100.0% | Sold out |
| China Universal Asset Management Co., Ltd. | 0 | $0 | 0.00% | −573−100.0% | Sold out |