Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2024
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 119
- +13 vs. Q2 2024
- Shares held
- 51.4M
- +3.40M (+7.1%) vs. Q2 2024
- Total value
- $1.51B
- +$384.1M (+34.1%) vs. Q2 2024
- New holders
- 31
- 42 more added
- Sold out
- 18
- 24 more reduced
1 institution that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Tower Research Capital LLC (TRC) | 520 | $15.3K | 0.00% | −2,864−84.6% | Reduced |
| nVerses Capital, LLC | 500 | $14.7K | 0.01% | +500 | New |
| CWM, LLC | 227 | $7.00K | 0.00% | +226+22,600.0% | Added |
| Russell Investments Group, Ltd. | 129 | $3.79K | 0.00% | +129 | New |
| Sterling Capital Management LLC | 115 | $3.38K | 0.00% | +115 | New |
| IFP Advisors, Inc | 114 | $3.35K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 111 | $3.27K | 0.00% | +111 | New |
| Advisor Group Holdings, Inc. | 83 | $2.44K | 0.00% | 00.0% | Unchanged |
| Capital Performance Advisors LLP | 46 | $1.35K | 0.00% | +46 | New |
| Rothschild Investment LLC | 40 | $1.18K | 0.00% | +35+700.0% | Added |
| Bessemer Group Inc | 45 | $1.00K | 0.00% | +45 | New |
| Lindbrook Capital, LLC | 19 | $559 | 0.00% | +19 | New |
| True Wealth Design, LLC | 16 | $471 | 0.00% | +16 | New |
| US Bancorp | 9 | $265 | 0.00% | +9 | New |
| Pacific Capital Wealth Advisors, Inc | 8 | $235 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 7 | $206 | 0.00% | +7 | New |
| GAMMA Investing LLC | 5 | $147 | 0.00% | +5 | New |
| National Bank of Canada | 1 | $29 | 0.00% | +1 | New |
| Covestor Ltd | 3 | $0 | 0.00% | +3 | New |
| Farallon Capital Management, L.L.C. | 0 | $0 | 0.00% | −666,000−100.0% | Sold out |
| First Turn Management, LLC | 0 | $0 | 0.00% | −464,435−100.0% | Sold out |
| Darwin Global Management, Ltd. | 0 | $0 | 0.00% | −452,040−100.0% | Sold out |
| Avidity Partners Management LP | 0 | $0 | 0.00% | −195,000−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −150,450−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −134,612−100.0% | Sold out |
| Suvretta Capital Management, LLC | 0 | $0 | 0.00% | −107,310−100.0% | Sold out |
| Integral Health Asset Management, LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Norges Bank | 0 | $0 | 0.00% | −70,843−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −64,900−100.0% | Sold out |
| Bridgeway Capital Management, LLC | 0 | $0 | 0.00% | −36,100−100.0% | Sold out |
| Alpine Global Management, LLC | 0 | $0 | 0.00% | −33,858−100.0% | Sold out |
| EAM Investors, LLC | 0 | $0 | 0.00% | −17,938−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −12,672−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −11,800−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −11,016−100.0% | Sold out |
| Pacer Advisors, Inc. | 0 | $0 | 0.00% | −382−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −64−100.0% | Sold out |
| BlackRock Inc. | – | – | – | – | Not filed |