Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2024
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 119
- +13 vs. Q2 2024
- Shares held
- 51.4M
- +3.40M (+7.1%) vs. Q2 2024
- Total value
- $1.51B
- +$384.1M (+34.1%) vs. Q2 2024
- New holders
- 31
- 42 more added
- Sold out
- 18
- 24 more reduced
1 institution that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 3 | $0 | 0.00% | +3 | New |
| National Bank of Canada | 1 | $29 | 0.00% | +1 | New |
| GAMMA Investing LLC | 5 | $147 | 0.00% | +5 | New |
| Allworth Financial LP | 7 | $206 | 0.00% | +7 | New |
| Pacific Capital Wealth Advisors, Inc | 8 | $235 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 9 | $265 | 0.00% | +9 | New |
| True Wealth Design, LLC | 16 | $471 | 0.00% | +16 | New |
| Lindbrook Capital, LLC | 19 | $559 | 0.00% | +19 | New |
| Bessemer Group Inc | 45 | $1.00K | 0.00% | +45 | New |
| Rothschild Investment LLC | 40 | $1.18K | 0.00% | +35+700.0% | Added |
| Capital Performance Advisors LLP | 46 | $1.35K | 0.00% | +46 | New |
| Advisor Group Holdings, Inc. | 83 | $2.44K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 111 | $3.27K | 0.00% | +111 | New |
| IFP Advisors, Inc | 114 | $3.35K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 115 | $3.38K | 0.00% | +115 | New |
| Russell Investments Group, Ltd. | 129 | $3.79K | 0.00% | +129 | New |
| CWM, LLC | 227 | $7.00K | 0.00% | +226+22,600.0% | Added |
| nVerses Capital, LLC | 500 | $14.7K | 0.01% | +500 | New |
| Tower Research Capital LLC (TRC) | 520 | $15.3K | 0.00% | −2,864−84.6% | Reduced |
| Acadian Asset Management LLC | 814 | $23.0K | 0.00% | +814 | New |
| Amalgamated Bank | 1,198 | $35.0K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 1,589 | $47.0K | 0.00% | +1,589 | New |
| Virtus ETF Advisers LLC | 2,848 | $83.8K | 0.04% | +51+1.8% | Added |
| Ameritas Investment Partners, Inc. | 3,392 | $99.8K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 3,786 | $111.0K | 0.00% | +530+16.3% | Added |
| Quest Partners LLC | 5,654 | $166.3K | 0.01% | +4,131+271.2% | Added |
| Arizona State Retirement System | 7,310 | $215.0K | 0.00% | +7,310 | New |
| Intech Investment Management LLC | 8,371 | $246.2K | 0.00% | +8,371 | New |
| Squarepoint Ops LLC | 8,477 | $249.3K | 0.00% | +8,477 | New |
| State Board of Administration of Florida Retirement System | 9,030 | $265.6K | 0.00% | 00.0% | Unchanged |
| Carlyle Group Inc. | 9,620 | $282.4K | 0.03% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 9,733 | $286.0K | 0.00% | +9,733 | New |
| Two Sigma Investments, LP | 9,803 | $288.3K | 0.00% | −39−0.4% | Reduced |
| New York State Common Retirement Fund | 10,265 | $301.9K | 0.00% | −4,100−28.5% | Reduced |
| Voya Investment Management LLC | 11,351 | $333.8K | 0.00% | −256−2.2% | Reduced |
| ADAR1 Capital Management, LLC | 12,560 | $369.4K | 0.06% | −22,620−64.3% | Reduced |
| SG Americas Securities, LLC | 12,589 | $370.0K | 0.00% | +7,044+127.0% | Added |
| Susquehanna International Group, LLP | 13,198 | $388.2K | 0.00% | +13,198 | New |
| Profund Advisors LLC | 14,075 | $413.9K | 0.02% | +1,469+11.7% | Added |
| Wells Fargo & Company | 17,810 | $523.8K | 0.00% | +635+3.7% | Added |
| Global Endowment Management, LP | 18,184 | $534.8K | 0.05% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 18,315 | $538.6K | 0.00% | +4,383+31.5% | Added |
| Corebridge Financial, Inc. | 18,512 | $544.4K | 0.00% | −113−0.6% | Reduced |
| MetLife Investment Management | 20,132 | $592.1K | 0.00% | +11,344+129.1% | Added |
| Jane Street Group, LLC | 20,641 | $607.1K | 0.00% | +9,090+78.7% | Added |
| Teachers Retirement System of the State of Kentucky | 21,154 | $622.0K | 0.01% | +21,154 | New |
| Deutsche Bank AG | 21,508 | $632.5K | 0.00% | +5,263+32.4% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 21,825 | $639.3K | 0.00% | +19,299+764.0% | Added |
| California State Teachers Retirement System | 24,675 | $725.7K | 0.00% | +5,570+29.2% | Added |
| Citigroup Inc | 25,191 | $740.9K | 0.00% | +5,871+30.4% | Added |
| UBS Asset Management Americas Inc | 26,441 | $777.6K | 0.00% | −3,680−12.2% | Reduced |
| NBW Capital LLC | 26,930 | $792.0K | 0.15% | −7,430−21.6% | Reduced |
| Legal & General Group Plc | 29,155 | $857.5K | 0.00% | +5,892+25.3% | Added |
| JPMorgan Chase & Co | 29,473 | $866.8K | 0.00% | +6,701+29.4% | Added |
| Tudor Investment Corp Et Al | 31,138 | $915.8K | 0.01% | +31,138 | New |
| AQR Capital Management LLC | 35,003 | $1.03M | 0.00% | +35,003 | New |
| Alliancebernstein L.P. | 36,230 | $1.07M | 0.00% | 00.0% | Unchanged |
| Superstring Capital Management LP | 37,287 | $1.10M | 0.98% | −8,284−18.2% | Reduced |
| Manufacturers Life Insurance Company, The | 43,460 | $1.28M | 0.00% | +5,678+15.0% | Added |
| Schonfeld Strategic Advisors LLC | 46,072 | $1.35M | 0.01% | −32,428−41.3% | Reduced |
| Swiss National Bank | 49,600 | $1.46M | 0.00% | +13,500+37.4% | Added |
| TD Asset Management Inc | 52,768 | $1.50M | 0.00% | +17,600+50.0% | Added |
| EFG Asset Management (North America) Corp. | 52,210 | $1.53M | 0.26% | +15,429+41.9% | Added |
| Rhumbline Advisers | 53,935 | $1.59M | 0.00% | +2,039+3.9% | Added |
| UBS Group AG | 57,838 | $1.70M | 0.00% | +13,334+30.0% | Added |
| Ghost Tree Capital, LLC | 60,000 | $1.76M | 0.60% | −190,237−76.0% | Reduced |
| Cinctive Capital Management LP | 61,256 | $1.80M | 0.10% | +61,256 | New |
| Rafferty Asset Management, LLC | 70,586 | $2.08M | 0.01% | +3,477+5.2% | Added |
| Ensign Peak Advisors, Inc | 82,475 | $2.43M | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 91,775 | $2.70M | 0.09% | +91,775 | New |
| Bank of New York Mellon Corp | 104,806 | $3.08M | 0.00% | −12,880−10.9% | Reduced |
| Candriam Luxembourg S.C.A. | 105,000 | $3.09M | 0.02% | 00.0% | Unchanged |
| HighVista Strategies LLC | 105,351 | $3.10M | 1.07% | −8,199−7.2% | Reduced |
| Barclays PLC | 105,467 | $3.10M | 0.00% | +41,424+64.7% | Added |
| Nuveen Asset Management, LLC | 125,290 | $3.68M | 0.00% | +8,150+7.0% | Added |
| Armistice Capital, LLC | 136,000 | $4.00M | 0.10% | 00.0% | Unchanged |
| Invesco Ltd. | 137,858 | $4.05M | 0.00% | +121,494+742.4% | Added |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 145,000 | $4.26M | 0.09% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 156,481 | $4.60M | 0.02% | −118,745−43.1% | Reduced |
| Goldman Sachs Group Inc | 169,314 | $4.98M | 0.00% | −723,769−81.0% | Reduced |
| Logos Global Management LP | 200,000 | $5.88M | 0.66% | −375,000−65.2% | Reduced |
| Balyasny Asset Management LLC | 227,950 | $6.70M | 0.02% | −44,686−16.4% | Reduced |
| Walleye Capital LLC | 243,372 | $7.16M | 0.08% | +92,552+61.4% | Added |
| Morgan Stanley | 243,742 | $7.17M | 0.00% | −165,111−40.4% | Reduced |
| Emerald Mutual Fund Advisers Trust | 253,550 | $7.46M | 0.39% | +253,550 | New |
| Bank of America Corp | 257,797 | $7.58M | 0.00% | +66,628+34.9% | Added |
| Woodline Partners LP | 264,256 | $7.77M | 0.07% | +1,640+0.6% | Added |
| Emerald Advisers, LLC | 292,569 | $8.60M | 0.33% | +292,569 | New |
| Blackstone Group Inc. | 292,995 | $8.62M | 0.04% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 302,247 | $8.89M | 2.76% | +302,247 | New |
| Northern Trust Corp | 314,290 | $9.24M | 0.00% | +228,702+267.2% | Added |
| Charles Schwab Investment Management Inc | 333,275 | $9.80M | 0.00% | +235,094+239.4% | Added |
| Price T Rowe Associates Inc | 429,127 | $12.6M | 0.00% | +121,151+39.3% | Added |
| Jefferies Financial Group Inc. | 454,807 | $13.4M | 0.22% | +357,234+366.1% | Added |
| Affinity Asset Advisors, LLC | 498,420 | $14.7M | 2.27% | −15,000−2.9% | Reduced |
| Polar Capital Holdings Plc | 500,000 | $14.7M | 0.09% | 00.0% | Unchanged |
| Avoro Capital Advisors LLC | 598,600 | $17.6M | 0.26% | −1,240,538−67.5% | Reduced |
| Driehaus Capital Management LLC | 687,080 | $20.2M | 0.17% | 00.0% | Unchanged |
| Boxer Capital, LLC | 696,480 | $20.5M | 1.01% | 00.0% | Unchanged |
| Citadel Advisors LLC | 707,586 | $20.8M | 0.02% | 00.0% | Unchanged |