Spyre Therapeutics, Inc.

SYRE

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001636282

SEC filings (opens in a new tab)

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

Q3 2024 vs. Q2 2024

How the institutions holding Spyre Therapeutics, Inc. changed between Q2 2024 and Q3 2024.

All holders in Q3 2024 All holders in Q2 2024

13F holders of SYRE: Q2 2024 compared with Q3 2024
Measure	Q2 2024	Of which not filed for Q3 2024	Q3 2024	Change
Holders	107	1	119	+13
Shares	50.4M	2.40M	51.4M	+3.40M (+7.1%)
Value	$1.18B	$56.5M	$1.51B	+$384.1M (+34.1%)

1 institution that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so the changes leave them out.

New holders (31)

Institutions that held Spyre Therapeutics, Inc. at the end of Q3 2024 but not at the end of Q2 2024.

Institutions new to SYRE in Q3 2024
Institution	Shares	Value	% of portfolio
BlackRock, Inc.	2,663,147	$78.3M	0.00%
Paradigm Biocapital Advisors LP	1,267,581	$37.3M	1.30%
Assenagon Asset Management S.A.	1,142,768	$33.6M	0.07%
Ikarian Capital, LLC	302,247	$8.89M	2.76%
Emerald Advisers, LLC	292,569	$8.60M	0.33%
Emerald Mutual Fund Advisers Trust	253,550	$7.46M	0.39%
Boothbay Fund Management, LLC	91,775	$2.70M	0.09%
Cinctive Capital Management LP	61,256	$1.80M	0.10%
AQR Capital Management LLC	35,003	$1.03M	0.00%
Tudor Investment Corp Et Al	31,138	$915.8K	0.01%
Teachers Retirement System of the State of Kentucky	21,154	$622.0K	0.01%
Susquehanna International Group, LLP	13,198	$388.2K	0.00%
ExodusPoint Capital Management, LP	9,733	$286.0K	0.00%
Squarepoint Ops LLC	8,477	$249.3K	0.00%
Intech Investment Management LLC	8,371	$246.2K	0.00%
Arizona State Retirement System	7,310	$215.0K	0.00%
Public Employees Retirement Association of Colorado	1,589	$47.0K	0.00%
Acadian Asset Management LLC	814	$23.0K	0.00%
nVerses Capital, LLC	500	$14.7K	0.01%
Russell Investments Group, Ltd.	129	$3.79K	0.00%
Sterling Capital Management LLC	115	$3.38K	0.00%
Nisa Investment Advisors, LLC	111	$3.27K	0.00%
Capital Performance Advisors LLP	46	$1.35K	0.00%
Bessemer Group Inc	45	$1.00K	0.00%
Lindbrook Capital, LLC	19	$559	0.00%
True Wealth Design, LLC	16	$471	0.00%
US Bancorp	9	$265	0.00%
Allworth Financial LP	7	$206	0.00%
GAMMA Investing LLC	5	$147	0.00%
National Bank of Canada	1	$29	0.00%
Covestor Ltd	3	$0	0.00%

Sold out (18)

Institutions that held Spyre Therapeutics, Inc. at the end of Q2 2024 and filed for Q3 2024 without it.

Institutions that sold out of SYRE in Q3 2024
Institution	Shares, Q2 2024	Value, Q2 2024
Farallon Capital Management, L.L.C.	666,000	$15.7M
First Turn Management, LLC	464,435	$10.9M
Darwin Global Management, Ltd.	452,040	$10.3M
Avidity Partners Management LP	195,000	$4.58M
StemPoint Capital LP	150,450	$3.54M
Great Point Partners LLC	134,612	$3.16M
Suvretta Capital Management, LLC	107,310	$2.52M
Integral Health Asset Management, LLC	100,000	$2.35M
Norges Bank	70,843	$1.67M
Jump Financial, LLC	64,900	$1.53M
Bridgeway Capital Management, LLC	36,100	$848.7K
Alpine Global Management, LLC	33,858	$796.0K
EAM Investors, LLC	17,938	$421.7K
Qube Research & Technologies Ltd	12,672	$297.9K
Aquatic Capital Management LLC	11,800	$277.4K
Virtu Financial LLC	11,016	$259.0K
Pacer Advisors, Inc.	382	$8.98K
Simplex Trading, LLC	64	$1.00K

Not filed for Q3 2024 yet (1)

Institutions that held Spyre Therapeutics, Inc. at the end of Q2 2024 and haven't filed a 13F for Q3 2024. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding SYRE in Q2 2024 that haven't filed for Q3 2024
Institution	Shares, Q2 2024	Value, Q2 2024
BlackRock Inc.	2,403,441	$56.5M