Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +16 vs. Q3 2025
- Shares held
- 81.0M
- +16.7M (+25.9%) vs. Q3 2025
- Total value
- $2.65B
- +$1.57B (+146.2%) vs. Q3 2025
- New holders
- 30
- 76 more added
- Sold out
- 14
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 5 | $164 | 0.00% | −118−95.9% | Reduced |
| Comerica Bank | 5 | $164 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 10 | $328 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 24 | $786 | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 35 | $1.15K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 37 | $1.21K | 0.00% | +27+270.0% | Added |
| Allworth Financial LP | 58 | $1.90K | 0.00% | +26+81.3% | Added |
| EverSource Wealth Advisors, LLC | 65 | $2.13K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 70 | $2.29K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 82 | $2.69K | 0.00% | +2+2.5% | Added |
| The PNC Financial Services Group, Inc. | 86 | $2.82K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 144 | $4.72K | 0.00% | +132+1,100.0% | Added |
| Meeder Asset Management Inc | 181 | $5.93K | 0.00% | −35−16.2% | Reduced |
| Optiver Holding B.V. | 240 | $7.86K | 0.00% | −260−52.0% | Reduced |
| Daiwa Securities Group Inc. | 258 | $8.00K | 0.00% | +52+25.2% | Added |
| GAMMA Investing LLC | 330 | $10.8K | 0.00% | +122+58.7% | Added |
| Advisor Group Holdings, Inc. | 367 | $12.0K | 0.00% | +53+16.9% | Added |
| Group One Trading, L.P. | 400 | $13.1K | 0.00% | +400 | New |
| Tower Research Capital LLC (TRC) | 425 | $13.9K | 0.00% | −4,171−90.8% | Reduced |
| Rockefeller Capital Management L.P. | 549 | $18.0K | 0.00% | +148+36.9% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 656 | $21.0K | 0.00% | +321+95.8% | Added |
| Nisa Investment Advisors, LLC | 705 | $23.1K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,523 | $49.9K | 0.00% | +224+17.2% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $52.0K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 1,610 | $52.7K | 0.00% | +396+32.6% | Added |
| Royal Bank of Canada | 1,988 | $65.0K | 0.00% | −5,895−74.8% | Reduced |
| CWM, LLC | 1,970 | $65.0K | 0.00% | +10+0.5% | Added |
| Amalgamated Bank | 2,165 | $71.0K | 0.00% | +786+57.0% | Added |
| Persistent Asset Partners Ltd | 2,246 | $73.6K | 0.04% | +2,246 | New |
| Quest Partners LLC | 3,538 | $115.9K | 0.01% | −62,625−94.7% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 3,770 | $123.5K | 0.00% | +1,435+61.5% | Added |
| Russell Investments Group, Ltd. | 5,554 | $181.9K | 0.00% | +1,320+31.2% | Added |
| Ameritas Investment Partners, Inc. | 5,593 | $183.2K | 0.01% | +1,427+34.3% | Added |
| Susquehanna International Group, LLP | 6,111 | $200.2K | 0.00% | +6,111 | New |
| SEI Investments Co | 6,117 | $200.4K | 0.00% | +6,117 | New |
| Brevan Howard Capital Management LP | 6,198 | $203.0K | 0.00% | +6,198 | New |
| Martingale Asset Management L P | 6,930 | $227.0K | 0.01% | +6,930 | New |
| Teacher Retirement System of Texas | 7,173 | $235.0K | 0.00% | +7,173 | New |
| Virtus Investment Advisers, Inc. | 7,913 | $259.2K | 0.07% | +1,488+23.2% | Added |
| VARCOV Co. | 8,008 | $262.3K | 0.10% | +8,008 | New |
| Caxton Corp | 8,919 | $292.2K | 6.83% | +8,919 | New |
| State Board of Administration of Florida Retirement System | 9,030 | $295.8K | 0.00% | +9,030 | New |
| Los Angeles Capital Management LLC | 12,882 | $312.5K | 0.00% | −5,290−29.1% | Reduced |
| Carlyle Group Inc. | 9,620 | $315.1K | 0.00% | +9,620 | New |
| Tudor Investment Corp Et Al | 10,127 | $331.8K | 0.00% | +10,127 | New |
| KLP Kapitalforvaltning AS | 10,400 | $340.7K | 0.00% | +2,600+33.3% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,164 | $365.7K | 0.00% | +290+2.7% | Added |
| BNP Paribas Arbitrage, SA | 11,844 | $388.0K | 0.00% | −304,065−96.3% | Reduced |
| China Universal Asset Management Co., Ltd. | 12,644 | $414.2K | 0.03% | +2,057+19.4% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 13,724 | $449.6K | 0.07% | +13,724 | New |
| Arizona State Retirement System | 13,797 | $452.0K | 0.00% | +3,104+29.0% | Added |
| PSP Research LLC | 15,840 | $518.9K | 0.45% | +15,840 | New |
| ProShare Advisors LLC | 15,989 | $523.8K | 0.00% | +5,311+49.7% | Added |
| State of New Jersey Common Pension Fund D | 16,698 | $547.0K | 0.00% | +16,698 | New |
| AQR Capital Management LLC | 17,820 | $583.8K | 0.00% | +773+4.5% | Added |
| Global Endowment Management, LP | 18,184 | $596.0K | 0.07% | 00.0% | Unchanged |
| Neo Ivy Capital Management | 18,261 | $598.2K | 0.09% | +18,261 | New |
| Intech Investment Management LLC | 18,274 | $598.7K | 0.01% | −2,086−10.2% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $601.5K | 0.01% | +4,551+33.0% | Added |
| New York State Common Retirement Fund | 19,165 | $627.8K | 0.00% | +2,600+15.7% | Added |
| Profund Advisors LLC | 20,593 | $674.6K | 0.02% | +7,370+55.7% | Added |
| Assenagon Asset Management S.A. | 22,136 | $725.2K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 23,343 | $765.0K | 0.00% | +23,343 | New |
| Virginia Retirement Systems Et Al | 24,950 | $817.4K | 0.00% | +6,450+34.9% | Added |
| Optimize Financial Inc | 25,331 | $829.8K | 0.42% | +364+1.5% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $845.0K | 0.01% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 25,954 | $850.3K | 0.01% | +10.0% | Added |
| State of Wisconsin Investment Board | 27,252 | $892.8K | 0.00% | −6,294−18.8% | Reduced |
| Voya Investment Management LLC | 27,277 | $893.6K | 0.00% | +27,277 | New |
| StemPoint Capital LP | 32,377 | $1.06M | 0.18% | +32,377 | New |
| ADAR1 Capital Management, LLC | 34,051 | $1.12M | 0.08% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 35,144 | $1.15M | 0.00% | +8,696+32.9% | Added |
| Cinctive Capital Management LP | 35,935 | $1.18M | 0.07% | +35,935 | New |
| ExodusPoint Capital Management, LP | 37,871 | $1.24M | 0.01% | −30,692−44.8% | Reduced |
| MetLife Investment Management | 38,011 | $1.25M | 0.01% | +8,093+27.1% | Added |
| Ameriprise Financial Inc | 38,256 | $1.25M | 0.00% | +38,256 | New |
| California State Teachers Retirement System | 48,038 | $1.57M | 0.00% | +14,835+44.7% | Added |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $1.74M | 0.03% | +31,362+144.3% | Added |
| Rafferty Asset Management, LLC | 53,410 | $1.75M | 0.01% | −6,257−10.5% | Reduced |
| Legal & General Group Plc | 56,448 | $1.85M | 0.00% | +9,607+20.5% | Added |
| Schroder Investment Management Group | 61,574 | $1.96M | 0.00% | −46,164−42.8% | Reduced |
| UBS Asset Management Americas Inc | 62,216 | $2.04M | 0.00% | +22,718+57.5% | Added |
| JPMorgan Chase & Co | 62,951 | $2.06M | 0.00% | −213,033−77.2% | Reduced |
| Alps Advisors Inc | 63,708 | $2.09M | 0.01% | +63,708 | New |
| Citadel Advisors LLC | 63,904 | $2.09M | 0.00% | +63,904 | New |
| Alliancebernstein L.P. | 67,500 | $2.21M | 0.00% | +31,270+86.3% | Added |
| Balyasny Asset Management LLC | 73,465 | $2.41M | 0.00% | +73,465 | New |
| Millennium Management LLC | 76,194 | $2.50M | 0.00% | −332,005−81.3% | Reduced |
| Dimensional Fund Advisors LP | 77,290 | $2.53M | 0.00% | −6,926−8.2% | Reduced |
| Wells Fargo & Company | 82,416 | $2.70M | 0.00% | +43,097+109.6% | Added |
| Rhumbline Advisers | 82,956 | $2.72M | 0.00% | +12,042+17.0% | Added |
| Swiss National Bank | 96,500 | $3.16M | 0.00% | +26,300+37.5% | Added |
| B Group, Inc. | 100,000 | $3.28M | 2.43% | 00.0% | Unchanged |
| Seven Grand Managers, LLC | 100,000 | $3.28M | 0.25% | +100,000 | New |
| Citigroup Inc | 100,058 | $3.28M | 0.00% | +67,162+204.2% | Added |
| F/M Investments LLC | 103,718 | $3.40M | 0.13% | +48,825+88.9% | Added |
| Mercer Global Advisors Inc | 106,316 | $3.48M | 0.01% | −348−0.3% | Reduced |
| Deutsche Bank AG | 121,941 | $3.99M | 0.00% | +83,398+216.4% | Added |
| Parkman Healthcare Partners LLC | 124,485 | $4.08M | 0.39% | −76,268−38.0% | Reduced |