Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +16 vs. Q3 2025
- Shares held
- 81.0M
- +16.7M (+25.9%) vs. Q3 2025
- Total value
- $2.65B
- +$1.57B (+146.2%) vs. Q3 2025
- New holders
- 30
- 76 more added
- Sold out
- 14
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| PSP Research LLC | 15,840 | $518.9K | 0.45% | +15,840 | New |
| Arizona State Retirement System | 13,797 | $452.0K | 0.00% | +3,104+29.0% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 13,724 | $449.6K | 0.07% | +13,724 | New |
| China Universal Asset Management Co., Ltd. | 12,644 | $414.2K | 0.03% | +2,057+19.4% | Added |
| BNP Paribas Arbitrage, SA | 11,844 | $388.0K | 0.00% | −304,065−96.3% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,164 | $365.7K | 0.00% | +290+2.7% | Added |
| KLP Kapitalforvaltning AS | 10,400 | $340.7K | 0.00% | +2,600+33.3% | Added |
| Tudor Investment Corp Et Al | 10,127 | $331.8K | 0.00% | +10,127 | New |
| Carlyle Group Inc. | 9,620 | $315.1K | 0.00% | +9,620 | New |
| Los Angeles Capital Management LLC | 12,882 | $312.5K | 0.00% | −5,290−29.1% | Reduced |
| State Board of Administration of Florida Retirement System | 9,030 | $295.8K | 0.00% | +9,030 | New |
| Caxton Corp | 8,919 | $292.2K | 6.83% | +8,919 | New |
| VARCOV Co. | 8,008 | $262.3K | 0.10% | +8,008 | New |
| Virtus Investment Advisers, Inc. | 7,913 | $259.2K | 0.07% | +1,488+23.2% | Added |
| Teacher Retirement System of Texas | 7,173 | $235.0K | 0.00% | +7,173 | New |
| Martingale Asset Management L P | 6,930 | $227.0K | 0.01% | +6,930 | New |
| Brevan Howard Capital Management LP | 6,198 | $203.0K | 0.00% | +6,198 | New |
| SEI Investments Co | 6,117 | $200.4K | 0.00% | +6,117 | New |
| Susquehanna International Group, LLP | 6,111 | $200.2K | 0.00% | +6,111 | New |
| Ameritas Investment Partners, Inc. | 5,593 | $183.2K | 0.01% | +1,427+34.3% | Added |
| Russell Investments Group, Ltd. | 5,554 | $181.9K | 0.00% | +1,320+31.2% | Added |
| Mirae Asset Global Investments Co., Ltd. | 3,770 | $123.5K | 0.00% | +1,435+61.5% | Added |
| Quest Partners LLC | 3,538 | $115.9K | 0.01% | −62,625−94.7% | Reduced |
| Persistent Asset Partners Ltd | 2,246 | $73.6K | 0.04% | +2,246 | New |
| Amalgamated Bank | 2,165 | $71.0K | 0.00% | +786+57.0% | Added |
| Royal Bank of Canada | 1,988 | $65.0K | 0.00% | −5,895−74.8% | Reduced |
| CWM, LLC | 1,970 | $65.0K | 0.00% | +10+0.5% | Added |
| Sterling Capital Management LLC | 1,610 | $52.7K | 0.00% | +396+32.6% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $52.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,523 | $49.9K | 0.00% | +224+17.2% | Added |
| Nisa Investment Advisors, LLC | 705 | $23.1K | 0.00% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 656 | $21.0K | 0.00% | +321+95.8% | Added |
| Rockefeller Capital Management L.P. | 549 | $18.0K | 0.00% | +148+36.9% | Added |
| Tower Research Capital LLC (TRC) | 425 | $13.9K | 0.00% | −4,171−90.8% | Reduced |
| Group One Trading, L.P. | 400 | $13.1K | 0.00% | +400 | New |
| Advisor Group Holdings, Inc. | 367 | $12.0K | 0.00% | +53+16.9% | Added |
| GAMMA Investing LLC | 330 | $10.8K | 0.00% | +122+58.7% | Added |
| Daiwa Securities Group Inc. | 258 | $8.00K | 0.00% | +52+25.2% | Added |
| Optiver Holding B.V. | 240 | $7.86K | 0.00% | −260−52.0% | Reduced |
| Meeder Asset Management Inc | 181 | $5.93K | 0.00% | −35−16.2% | Reduced |
| Larson Financial Group LLC | 144 | $4.72K | 0.00% | +132+1,100.0% | Added |
| The PNC Financial Services Group, Inc. | 86 | $2.82K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 82 | $2.69K | 0.00% | +2+2.5% | Added |
| Signaturefd, LLC | 70 | $2.29K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 65 | $2.13K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 58 | $1.90K | 0.00% | +26+81.3% | Added |
| Farther Finance Advisors, LLC | 37 | $1.21K | 0.00% | +27+270.0% | Added |
| Parkside Financial Bank & Trust | 35 | $1.15K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 24 | $786 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 10 | $328 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 5 | $164 | 0.00% | −118−95.9% | Reduced |
| Comerica Bank | 5 | $164 | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 6 | $0 | 0.00% | 00.0% | Unchanged |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −1,388,854−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −264,317−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −96,057−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −81,474−100.0% | Sold out |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −65,000−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −48,496−100.0% | Sold out |
| DLD Asset Management, LP | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −27,100−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −20,232−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −19,366−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −14,733−100.0% | Sold out |
| DRW Securities, LLC | 0 | $0 | 0.00% | −11,475−100.0% | Sold out |
| Huntington National Bank | 0 | $0 | 0.00% | −1,470−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −121−100.0% | Sold out |