Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 103
- +49 vs. Q4 2023
- Shares held
- 32.4M
- +4.37M (+15.6%) vs. Q4 2023
- Total value
- $1.21B
- +$612.4M (+101.9%) vs. Q4 2023
- New holders
- 55
- 20 more added
- Sold out
- 6
- 15 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Macquarie Group Ltd | 2,523 | $96 | 0.00% | +2,523 | New |
| Pacific Capital Wealth Advisors, Inc | 8 | $303 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 11 | $417 | 0.00% | −30−73.2% | Reduced |
| Point72 (DIFC) Ltd | 22 | $847 | 0.00% | +22 | New |
| Royal Bank of Canada | 56 | $2.00K | 0.00% | +56 | New |
| Advisor Group Holdings, Inc. | 83 | $3.15K | 0.00% | −200−70.7% | Reduced |
| IFP Advisors, Inc | 114 | $4.32K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 298 | $11.3K | 0.00% | +298 | New |
| Wells Fargo & Company | 2,242 | $85.0K | 0.00% | +2,219+9,647.8% | Added |
| UBS Group AG | 2,601 | $98.7K | 0.00% | −1,125−30.2% | Reduced |
| Tower Research Capital LLC (TRC) | 3,828 | $145.2K | 0.00% | +1,248+48.4% | Added |
| Arizona State Retirement System | 5,445 | $206.5K | 0.00% | +5,445 | New |
| Virtus ETF Advisers LLC | 5,838 | $221.4K | 0.12% | −401−6.4% | Reduced |
| Bank of New York Mellon Corp | 6,050 | $229.5K | 0.00% | +6,050 | New |
| Chartwell Investment Partners, LLC | 6,835 | $259.0K | 0.01% | +6,835 | New |
| Jane Street Group, LLC | 7,210 | $273.5K | 0.00% | +7,210 | New |
| Susquehanna Fundamental Investments, LLC | 8,075 | $306.3K | 0.01% | +8,075 | New |
| Squarepoint Ops LLC | 8,161 | $309.5K | 0.00% | +8,161 | New |
| Carlyle Group Inc. | 9,620 | $364.8K | 0.02% | 00.0% | Unchanged |
| Polymer Capital Management (HK) LTD | 10,520 | $399.0K | 0.10% | +10,520 | New |
| LMR Partners LLP | 11,093 | $420.8K | 0.01% | +11,093 | New |
| EFG Asset Management (North America) Corp. | 11,151 | $423.2K | 0.07% | +11,151 | New |
| Legato Capital Management LLC | 11,458 | $434.6K | 0.05% | +11,458 | New |
| Scientech Research LLC | 13,143 | $498.5K | 0.26% | +13,143 | New |
| Two Sigma Investments, LP | 13,355 | $506.6K | 0.00% | −14,740−52.5% | Reduced |
| Janus Henderson Group PLC | 13,977 | $530.5K | 0.00% | +13,977 | New |
| State of Wisconsin Investment Board | 14,632 | $555.0K | 0.00% | +14,632 | New |
| New York State Common Retirement Fund | 14,670 | $556.4K | 0.00% | +14,305+3,919.2% | Added |
| Charles Schwab Investment Management Inc | 15,000 | $569.0K | 0.00% | +15,000 | New |
| Engineers Gate Manager LP | 15,653 | $593.7K | 0.02% | +15,653 | New |
| Virtu Financial LLC | 16,213 | $615.0K | 0.05% | +16,213 | New |
| Legal & General Group Plc | 17,032 | $646.0K | 0.00% | +17,032 | New |
| California State Teachers Retirement System | 17,803 | $675.3K | 0.00% | +17,803 | New |
| EAM Investors, LLC | 17,938 | $680.4K | 0.11% | +17,938 | New |
| Fred Alger Management, LLC | 18,158 | $688.7K | 0.00% | +18,158 | New |
| Global Endowment Management, LP | 18,184 | $689.7K | 0.07% | −495,252−96.5% | Reduced |
| Blackstone Group Inc. | 19,991 | $758.3K | 0.00% | 00.0% | Unchanged |
| Credit Suisse AG | 22,056 | $836.6K | 0.00% | +22,056 | New |
| Jump Financial, LLC | 22,800 | $864.8K | 0.02% | +22,800 | New |
| ExodusPoint Capital Management, LP | 24,472 | $928.0K | 0.01% | −1,738−6.6% | Reduced |
| Manufacturers Life Insurance Company, The | 24,657 | $935.2K | 0.00% | +24,657 | New |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 30,038 | $1.14M | 0.03% | +30,038 | New |
| Citigroup Inc | 31,757 | $1.20M | 0.00% | +21,460+208.4% | Added |
| Allianz Asset Management GmbH | 31,800 | $1.21M | 0.00% | +31,800 | New |
| Balyasny Asset Management LLC | 32,397 | $1.23M | 0.00% | +32,397 | New |
| NBW Capital LLC | 34,360 | $1.30M | 0.27% | +34,360 | New |
| Schonfeld Strategic Advisors LLC | 35,500 | $1.35M | 0.01% | +35,500 | New |
| Bank of America Corp | 36,332 | $1.38M | 0.00% | +36,332 | New |
| Swiss National Bank | 39,100 | $1.48M | 0.00% | +39,100 | New |
| Barclays PLC | 45,962 | $1.74M | 0.00% | +464+1.0% | Added |
| Cubist Systematic Strategies, LLC | 49,303 | $1.87M | 0.02% | +23,153+88.5% | Added |
| Renaissance Technologies LLC | 49,468 | $1.88M | 0.00% | +932+1.9% | Added |
| ADAR1 Capital Management, LLC | 49,500 | $1.88M | 0.51% | +43,060+668.6% | Added |
| Morgan Stanley | 51,188 | $1.94M | 0.00% | +51,148+127,870.0% | Added |
| Qube Research & Technologies Ltd | 57,678 | $2.19M | 0.00% | +57,678 | New |
| TD Asset Management Inc | 60,968 | $2.31M | 0.00% | +60,968 | New |
| StemPoint Capital LP | 62,253 | $2.36M | 0.63% | −316,513−83.6% | Reduced |
| Assenagon Asset Management S.A. | 64,400 | $2.44M | 0.01% | +64,400 | New |
| Northern Trust Corp | 66,340 | $2.52M | 0.00% | +66,340 | New |
| Price T Rowe Associates Inc | 78,529 | $2.98M | 0.00% | +78,529 | New |
| HRT Financial LP | 78,996 | $3.00M | 0.02% | +78,996 | New |
| Nicholas Investment Partners, LP | 89,962 | $3.41M | 0.35% | +89,962 | New |
| Ghost Tree Capital, LLC | 100,000 | $3.79M | 1.22% | +100,000 | New |
| Integral Health Asset Management, LLC | 100,000 | $3.79M | 0.37% | +100,000 | New |
| Woodline Partners LP | 100,527 | $3.81M | 0.04% | +100,527 | New |
| Susquehanna International Group, LLP | 101,503 | $3.85M | 0.01% | +101,503 | New |
| Candriam Luxembourg S.C.A. | 105,000 | $3.98M | 0.03% | +105,000 | New |
| Walleye Capital LLC | 111,478 | $4.23M | 0.05% | +111,478 | New |
| Great Point Partners LLC | 125,000 | $4.74M | 0.74% | 00.0% | Unchanged |
| State Street Corp | 134,426 | $5.10M | 0.00% | +134,426 | New |
| Invesco Ltd. | 152,578 | $5.79M | 0.00% | +152,578 | New |
| HighVista Strategies LLC | 154,381 | $5.86M | 2.09% | −423,235−73.3% | Reduced |
| Marshall Wace, LLP | 161,921 | $6.14M | 0.01% | +141,669+699.5% | Added |
| Suvretta Capital Management, LLC | 162,395 | $6.16M | 0.26% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 188,053 | $7.13M | 0.03% | +188,053 | New |
| Goldman Sachs Group Inc | 239,915 | $9.10M | 0.00% | +239,915 | New |
| Cormorant Asset Management, LP | 250,000 | $9.48M | 0.42% | −687,080−73.3% | Reduced |
| Boxer Capital, LLC | 250,000 | $9.48M | 0.47% | 00.0% | Unchanged |
| Logos Global Management LP | 250,000 | $9.48M | 1.00% | +100,000+66.7% | Added |
| Millennium Management LLC | 319,563 | $12.1M | 0.01% | +211,077+194.6% | Added |
| Geode Capital Management, LLC | 330,225 | $12.5M | 0.00% | +299,899+988.9% | Added |
| Fairmount Funds Management LLC | 378,421 | $14.4M | 1.56% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 410,000 | $15.6M | 2.53% | −107,554−20.8% | Reduced |
| Fan Yu | 737,000 | $16.4M | 22.68% | +737,000 | New |
| First Turn Management, LLC | 464,435 | $17.6M | 2.64% | +464,435 | New |
| Farallon Capital Management, L.L.C. | 466,000 | $17.7M | 0.10% | +466,000 | New |
| Darwin Global Management, Ltd. | 473,200 | $17.9M | 2.39% | +473,200 | New |
| Vanguard Group Inc | 497,181 | $18.9M | 0.00% | +457,735+1,160.4% | Added |
| Polar Capital Holdings Plc | 500,000 | $19.0M | 0.11% | 00.0% | Unchanged |
| Braidwell LP | 515,000 | $19.5M | 0.63% | 00.0% | Unchanged |
| BlackRock Inc. | 556,691 | $21.1M | 0.00% | +536,929+2,717.0% | Added |
| Driehaus Capital Management LLC | 687,080 | $26.1M | 0.26% | −84,822−11.0% | Reduced |
| Citadel Advisors LLC | 707,590 | $26.8M | 0.03% | +130,879+22.7% | Added |
| Franklin Resources Inc | 741,904 | $28.1M | 0.01% | +54,814+8.0% | Added |
| Wellington Management Group LLP | 812,860 | $30.8M | 0.01% | +177,405+27.9% | Added |
| Adage Capital Partners GP, L.L.C. | 1,105,200 | $41.9M | 0.08% | +105,200+10.5% | Added |
| Deep Track Capital, LP | 1,213,420 | $46.0M | 1.32% | −739,340−37.9% | Reduced |
| Avoro Capital Advisors LLC | 1,839,138 | $69.8M | 0.81% | 00.0% | Unchanged |
| Commodore Capital LP | 1,884,084 | $71.5M | 4.78% | 00.0% | Unchanged |
| VR Adviser, LLC | 2,171,782 | $82.4M | 3.92% | −200,932−8.5% | Reduced |