Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 77
- 0 vs. Q2 2021
- Shares held
- 40.6M
- +2.04M (+5.3%) vs. Q2 2021
- Total value
- $322.5M
- +$54.3M (+20.2%) vs. Q2 2021
- New holders
- 10
- 24 more added
- Sold out
- 10
- 23 more reduced
1 institution that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Berman Capital Advisors, LLC | 56 | $0 | 0.00% | +56 | New |
| Daiwa Securities Group Inc. | 98 | $1.00K | 0.00% | 00.0% | Unchanged |
| Penserra Capital Management LLC | 1,120 | $8.00K | 0.00% | +5+0.4% | Added |
| Quadrant Capital Group LLC | 1,137 | $9.00K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 2,212 | $18.0K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 3,008 | $23.0K | 0.00% | −21,027−87.5% | Reduced |
| IFP Advisors, Inc | 2,980 | $24.0K | 0.00% | −1,000−25.1% | Reduced |
| Legal & General Group Plc | 3,264 | $26.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 3,250 | $26.0K | 0.00% | +229+7.6% | Added |
| Ameritas Investment Partners, Inc. | 3,710 | $29.0K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 5,468 | $44.0K | 0.00% | +2,502+84.4% | Added |
| Citigroup Inc | 7,133 | $57.0K | 0.00% | +2,150+43.1% | Added |
| Lazard Asset Management LLC | 8,801 | $69.0K | 0.00% | +8,801 | New |
| BNP Paribas Arbitrage, SA | 10,756 | $85.5K | 0.00% | +6,051+128.6% | Added |
| Personal Cfo Solutions, LLC | 10,888 | $87.0K | 0.02% | −500−4.4% | Reduced |
| Gsa Capital Partners LLP | 11,242 | $89.0K | 0.01% | +11,242 | New |
| Susquehanna International Group, LLP | 11,192 | $89.0K | 0.00% | +11,192 | New |
| Metropolitan Life Insurance Co | 11,616 | $92.3K | 0.00% | +11,616 | New |
| HighVista Strategies LLC | 13,137 | $105.0K | 0.07% | +13,137 | New |
| Invesco Ltd. | 14,726 | $117.0K | 0.00% | +1,681+12.9% | Added |
| MetLife Investment Management | 15,353 | $122.1K | 0.00% | +15,353 | New |
| ProShare Advisors LLC | 15,658 | $124.0K | 0.00% | −3,635−18.8% | Reduced |
| Barclays PLC | 16,524 | $131.0K | 0.00% | +10,856+191.5% | Added |
| New York State Common Retirement Fund | 17,079 | $136.0K | 0.00% | −14,405−45.8% | Reduced |
| JPMorgan Chase & Co | 19,187 | $152.0K | 0.00% | −68,446−78.1% | Reduced |
| Voya Investment Management LLC | 19,878 | $158.0K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 21,698 | $172.0K | 0.00% | −34,163−61.2% | Reduced |
| American International Group, Inc. | 22,120 | $176.0K | 0.00% | −525−2.3% | Reduced |
| Deutsche Bank AG | 23,243 | $185.0K | 0.00% | −750−3.1% | Reduced |
| Manufacturers Life Insurance Company, The | 25,323 | $201.0K | 0.00% | −1,200−4.5% | Reduced |
| Alliancebernstein L.P. | 25,600 | $204.0K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 25,639 | $204.0K | 0.00% | +5,423+26.8% | Added |
| D. E. Shaw & Co., Inc. | 28,503 | $227.0K | 0.00% | −17,478−38.0% | Reduced |
| SG Americas Securities, LLC | 28,578 | $227.0K | 0.00% | +28,578 | New |
| Algert Global LLC | 36,804 | $293.0K | 0.04% | −4,696−11.3% | Reduced |
| Parametric Portfolio Associates LLC | 45,106 | $359.0K | 0.00% | +11,958+36.1% | Added |
| Blair William & Co | 52,204 | $415.0K | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 54,143 | $430.0K | 0.00% | +1,476+2.8% | Added |
| UBS Group AG | 54,220 | $431.0K | 0.00% | +2,143+4.1% | Added |
| Ritholtz Wealth Management | 76,490 | $608.0K | 0.04% | −98,156−56.2% | Reduced |
| Charles Schwab Investment Management Inc | 99,477 | $791.0K | 0.00% | −6,302−6.0% | Reduced |
| Renaissance Technologies LLC | 100,300 | $797.0K | 0.00% | +49,513+97.5% | Added |
| Franklin Street Advisors Inc | 103,600 | $824.0K | 0.07% | 00.0% | Unchanged |
| AlphaCentric Advisors LLC | 110,000 | $875.0K | 0.22% | +17,500+18.9% | Added |
| Fan Yu | 112,044 | $891.0K | 15.31% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 159,488 | $1.27M | 0.00% | +12,087+8.2% | Added |
| Nuveen Asset Management, LLC | 179,642 | $1.34M | 0.00% | −4,629−2.5% | Reduced |
| Morgan Stanley | 194,225 | $1.54M | 0.00% | −1,310−0.7% | Reduced |
| Abingworth LLP | 240,500 | $1.91M | 0.43% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $1.95M | 1.12% | −23,900−8.9% | Reduced |
| Assenagon Asset Management S.A. | 267,066 | $2.12M | 0.01% | −15,002−5.3% | Reduced |
| Lion Point Capital, LP | 300,000 | $2.38M | 0.63% | 00.0% | Unchanged |
| Marshall Wace, LLP | 315,823 | $2.51M | 0.01% | −335,580−51.5% | Reduced |
| Northern Trust Corp | 365,703 | $2.91M | 0.00% | −2,637−0.7% | Reduced |
| AXA S.A. | 439,667 | $3.50M | 0.01% | +15,315+3.6% | Added |
| Sio Capital Management, LLC | 446,000 | $3.55M | 1.14% | +43,347+10.8% | Added |
| Millennium Management LLC | 535,222 | $4.25M | 0.01% | −7,963−1.5% | Reduced |
| Laurion Capital Management LP | 606,638 | $4.82M | 0.07% | +606,638 | New |
| Altium Capital Management LP | 609,689 | $4.85M | 1.29% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 632,833 | $5.03M | 0.00% | +28,721+4.8% | Added |
| Geode Capital Management, LLC | 689,997 | $5.49M | 0.00% | +12,271+1.8% | Added |
| State Street Corp | 766,941 | $6.10M | 0.00% | +9,441+1.2% | Added |
| Samsara BioCapital, LLC | 883,720 | $7.03M | 1.17% | 00.0% | Unchanged |
| Great Point Partners LLC | 900,000 | $7.16M | 1.69% | 00.0% | Unchanged |
| Artal Group S.A. | 1,045,000 | $8.31M | 0.20% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,136,050 | $9.03M | 0.00% | +4,991+0.4% | Added |
| Nantahala Capital Management, LLC | 1,516,955 | $12.1M | 0.71% | −160,081−9.5% | Reduced |
| Rock Springs Capital Management LP | 1,577,296 | $12.5M | 0.26% | 00.0% | Unchanged |
| Aisling Capital Management LP | 1,691,151 | $13.4M | 2.68% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,108,760 | $16.8M | 0.00% | +11,594+0.6% | Added |
| Suvretta Capital Management, LLC | 2,157,727 | $17.2M | 0.29% | +63,627+3.0% | Added |
| Pictet Asset Management SA | 2,532,799 | $20.1M | 0.02% | +2,532,799 | New |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $22.6M | 1.40% | +147,689+5.5% | Added |
| BlackRock Inc. | 2,983,895 | $23.7M | 0.00% | −119,984−3.9% | Reduced |
| Baker Bros. Advisors LP | 3,410,106 | $27.1M | 0.12% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 3,500,000 | $27.8M | 0.05% | +450,419+14.8% | Added |
| OrbiMed Advisors LLC | 4,015,524 | $31.9M | 0.35% | 00.0% | Unchanged |
| Boxer Capital, LLC | 0 | $0 | 0.00% | −550,000−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −469,765−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −59,294−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −34,100−100.0% | Sold out |
| California Public Employees Retirement System | 0 | $0 | 0.00% | −20,841−100.0% | Sold out |
| Cerity Partners LLC | 0 | $0 | 0.00% | −18,000−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −11,722−100.0% | Sold out |
| O'Shaughnessy Asset Management, LLC | 0 | $0 | 0.00% | −1,654−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −300−100.0% | Sold out |
| Ellevest, Inc. | 0 | $0 | 0.00% | −150−100.0% | Sold out |
| Pictet Asset Management Ltd | – | – | – | – | Not filed |