Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 84
- −2 vs. Q4 2021
- Shares held
- 41.5M
- +1.54M (+3.9%) vs. Q4 2021
- Total value
- $95.4M
- −$94.1M (−49.7%) vs. Q4 2021
- New holders
- 10
- 29 more added
- Sold out
- 12
- 25 more reduced
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Toronto Dominion Bank | 5 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| FMR LLC | 121 | $0 | 0.00% | +121 | New |
| Glassman Wealth Services | 88 | $0 | 0.00% | +88 | New |
| Allspring Global Investments Holdings, LLC | 1,151 | $2.00K | 0.00% | −183−13.7% | Reduced |
| Captrust Financial Advisors | 1,084 | $2.00K | 0.00% | +913+533.9% | Added |
| Royal Bank of Canada | 2,483 | $6.00K | 0.00% | −5,677−69.6% | Reduced |
| Russell Investments Group, Ltd. | 3,008 | $6.00K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 3,000 | $7.00K | 0.00% | −2,300−43.4% | Reduced |
| Legal & General Group Plc | 3,264 | $8.00K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 3,580 | $8.23K | 0.00% | −7,579−67.9% | Reduced |
| Ameritas Investment Partners, Inc. | 3,710 | $9.00K | 0.00% | 00.0% | Unchanged |
| Point72 Hong Kong Ltd | 3,921 | $9.00K | 0.00% | +3,768+2,462.7% | Added |
| Citigroup Inc | 4,319 | $10.0K | 0.00% | −7,575−63.7% | Reduced |
| Amalgamated Bank | 4,887 | $11.0K | 0.00% | +4,887 | New |
| Amalgamated Financial Corp. | 4,887 | $11.0K | 0.00% | +4,887 | New |
| Barclays PLC | 6,660 | $16.0K | 0.00% | −42,493−86.5% | Reduced |
| Wells Fargo & Company | 7,025 | $16.0K | 0.00% | −14,307−67.1% | Reduced |
| Public Employees Retirement System of Ohio | 8,189 | $19.0K | 0.00% | +4,296+110.4% | Added |
| Manufacturers Life Insurance Company, The | 11,679 | $26.9K | 0.00% | −8,460−42.0% | Reduced |
| Cubist Systematic Strategies, LLC | 12,096 | $28.0K | 0.00% | −43,849−78.4% | Reduced |
| ProShare Advisors LLC | 12,680 | $29.0K | 0.00% | −3,091−19.6% | Reduced |
| Invesco Ltd. | 12,350 | $29.0K | 0.00% | +138+1.1% | Added |
| Voya Investment Management LLC | 15,466 | $36.0K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 17,041 | $39.0K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 17,202 | $40.0K | 0.00% | −4,112−19.3% | Reduced |
| Bank of America Corp | 18,005 | $41.0K | 0.00% | −13,062−42.0% | Reduced |
| American International Group, Inc. | 20,064 | $46.0K | 0.00% | −1,412−6.6% | Reduced |
| Alliancebernstein L.P. | 21,600 | $50.0K | 0.00% | −4,000−15.6% | Reduced |
| Tower Research Capital LLC (TRC) | 22,079 | $51.0K | 0.00% | +17,127+345.9% | Added |
| BIT Capital GmbH | 25,000 | $57.5K | 0.01% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 24,923 | $58.0K | 0.00% | +4,045+19.4% | Added |
| AQR Capital Management LLC | 36,787 | $85.0K | 0.00% | +36,787 | New |
| Franklin Resources Inc | 46,300 | $106.0K | 0.00% | +46,300 | New |
| Rhumbline Advisers | 48,918 | $113.0K | 0.00% | −5,000−9.3% | Reduced |
| Alps Advisors Inc | 50,735 | $117.0K | 0.00% | −6,345−11.1% | Reduced |
| Algert Global LLC | 56,944 | $131.0K | 0.01% | +24,520+75.6% | Added |
| UBS Group AG | 65,276 | $150.0K | 0.00% | −71,360−52.2% | Reduced |
| Citadel Advisors LLC | 73,414 | $169.0K | 0.00% | +73,414 | New |
| Blair William & Co | 76,594 | $176.0K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $176.0K | 0.01% | 00.0% | Unchanged |
| Franklin Street Advisors Inc | 105,800 | $243.0K | 0.02% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 106,810 | $246.0K | 0.00% | +7,333+7.4% | Added |
| Fan Yu | 112,044 | $258.0K | 3.49% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 123,000 | $283.0K | 0.01% | +123,000 | New |
| Walleye Capital LLC | 135,611 | $312.0K | 0.01% | +135,611 | New |
| Acadian Asset Management LLC | 149,399 | $342.0K | 0.00% | +18,564+14.2% | Added |
| Renaissance Technologies LLC | 151,868 | $349.0K | 0.00% | −96,332−38.8% | Reduced |
| Marshall Wace, LLP | 154,175 | $355.0K | 0.00% | +112,551+270.4% | Added |
| Bank of New York Mellon Corp | 157,657 | $362.0K | 0.00% | −1,617−1.0% | Reduced |
| Two Sigma Advisers, LP | 161,300 | $371.0K | 0.00% | +123,100+322.3% | Added |
| Parametric Portfolio Associates LLC | 178,016 | $409.0K | 0.00% | +136,033+324.0% | Added |
| Morgan Stanley | 181,701 | $418.0K | 0.00% | −14,517−7.4% | Reduced |
| ClariVest Asset Management LLC | 184,119 | $424.0K | 0.02% | +9,200+5.3% | Added |
| Nuveen Asset Management, LLC | 169,120 | $425.0K | 0.00% | +298+0.2% | Added |
| Two Sigma Investments, LP | 216,601 | $498.0K | 0.00% | +152,090+235.8% | Added |
| Abingworth LLP | 240,500 | $553.0K | 0.16% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $565.0K | 0.29% | 00.0% | Unchanged |
| Lion Point Capital, LP | 300,000 | $690.0K | 0.23% | 00.0% | Unchanged |
| Northern Trust Corp | 333,741 | $768.0K | 0.00% | −15,947−4.6% | Reduced |
| Millennium Management LLC | 423,914 | $975.0K | 0.00% | +233,432+122.5% | Added |
| Jacobs Levy Equity Management, Inc | 436,183 | $1.00M | 0.01% | +292,090+202.7% | Added |
| D. E. Shaw & Co., Inc. | 454,093 | $1.04M | 0.00% | +226,585+99.6% | Added |
| Deutsche Bank AG | 515,133 | $1.19M | 0.00% | +490,598+1,999.6% | Added |
| Assenagon Asset Management S.A. | 523,142 | $1.20M | 0.00% | +106,968+25.7% | Added |
| Dimensional Fund Advisors LP | 680,964 | $1.57M | 0.00% | −9,609−1.4% | Reduced |
| Ghost Tree Capital, LLC | 686,599 | $1.58M | 0.78% | +686,599 | New |
| Geode Capital Management, LLC | 692,221 | $1.59M | 0.00% | +6,476+0.9% | Added |
| State Street Corp | 787,048 | $1.81M | 0.00% | +29,007+3.8% | Added |
| Sio Capital Management, LLC | 871,101 | $2.00M | 0.81% | +372,601+74.7% | Added |
| Samsara BioCapital, LLC | 883,720 | $2.03M | 0.51% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,124,789 | $2.59M | 0.00% | −9,562−0.8% | Reduced |
| Laurion Capital Management LP | 1,575,638 | $3.62M | 0.09% | +125,000+8.6% | Added |
| Aisling Capital Management LP | 1,691,151 | $3.89M | 2.10% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 1,811,425 | $4.17M | 0.10% | +234,129+14.8% | Added |
| Vanguard Group Inc | 2,117,323 | $4.87M | 0.00% | −3,302−0.2% | Reduced |
| Pictet Asset Management SA | 2,552,434 | $5.87M | 0.01% | +84,305+3.4% | Added |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $6.55M | 0.64% | 00.0% | Unchanged |
| BlackRock Inc. | 2,921,810 | $6.72M | 0.00% | −76,669−2.6% | Reduced |
| OrbiMed Advisors LLC | 2,956,124 | $6.80M | 0.11% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 3,200,593 | $7.36M | 0.51% | +387,033+13.8% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $7.84M | 0.05% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 4,059,894 | $9.34M | 0.29% | +1,488,894+57.9% | Added |
| IFP Advisors, Inc | 5,840 | – | – | +2,860+96.0% | Added |
| Artal Group S.A. | 0 | $0 | 0.00% | −1,045,000−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −910,251−100.0% | Sold out |
| AXA S.A. | 0 | $0 | 0.00% | −444,931−100.0% | Sold out |
| Altium Capital Management LP | 0 | $0 | 0.00% | −293,764−100.0% | Sold out |
| Aristides Capital LLC | 0 | $0 | 0.00% | −35,763−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −15,000−100.0% | Sold out |
| Delphia (USA) Inc. | 0 | $0 | 0.00% | −12,944−100.0% | Sold out |
| Nisa Investment Advisors, LLC | 0 | $0 | 0.00% | −13,192−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −11,033−100.0% | Sold out |
| Pinnacle Wealth Planning Services, Inc. | 0 | $0 | 0.00% | −10,130−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −1,137−100.0% | Sold out |