Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 54
- +25 vs. Q3 2023
- Shares held
- 28.0M
- +24.4M (+683.2%) vs. Q3 2023
- Total value
- $601.0M
- +$557.1M (+1,269.8%) vs. Q3 2023
- New holders
- 29
- 15 more added
- Sold out
- 4
- 6 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Parallel Advisors, LLC | 1 | $22 | 0.00% | +1 | New |
| Pacific Capital Wealth Advisors, Inc | 8 | $172 | 0.00% | +8 | New |
| Wells Fargo & Company | 23 | $495 | 0.00% | +1+4.5% | Added |
| Morgan Stanley | 40 | $861 | 0.00% | −6−13.0% | Reduced |
| JPMorgan Chase & Co | 41 | $882 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 114 | $2.45K | 0.00% | −2,860−96.2% | Reduced |
| Advisor Group Holdings, Inc. | 283 | $6.09K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 365 | $7.86K | 0.00% | +365 | New |
| Acadian Asset Management LLC | 1,169 | $25.0K | 0.00% | −10,719−90.2% | Reduced |
| Tower Research Capital LLC (TRC) | 2,580 | $55.5K | 0.00% | +2,158+511.4% | Added |
| UBS Group AG | 3,726 | $80.2K | 0.00% | +3,726 | New |
| Virtus ETF Advisers LLC | 6,239 | $134.3K | 0.09% | +6,239 | New |
| ADAR1 Capital Management, LLC | 6,440 | $138.6K | 0.06% | +6,440 | New |
| Carlyle Group Inc. | 9,620 | $203.9K | 0.01% | +9,620 | New |
| Citigroup Inc | 10,297 | $221.6K | 0.00% | +10,297 | New |
| BlackRock Inc. | 19,762 | $425.3K | 0.00% | −60.0% | Reduced |
| Blackstone Group Inc. | 19,991 | $430.2K | 0.00% | +19,991 | New |
| Marshall Wace, LLP | 20,252 | $435.8K | 0.00% | +20,252 | New |
| Cubist Systematic Strategies, LLC | 26,150 | $562.7K | 0.01% | +26,150 | New |
| ExodusPoint Capital Management, LP | 26,210 | $564.0K | 0.01% | +26,210 | New |
| Two Sigma Investments, LP | 28,095 | $604.6K | 0.00% | +28,095 | New |
| Geode Capital Management, LLC | 30,326 | $652.8K | 0.00% | +3,526+13.2% | Added |
| Vanguard Group Inc | 39,446 | $848.9K | 0.00% | +6,369+19.3% | Added |
| Barclays PLC | 45,498 | $979.1K | 0.00% | +45,498 | New |
| Renaissance Technologies LLC | 48,536 | $1.04M | 0.00% | +25,307+108.9% | Added |
| Prosight Management, LP | 55,000 | $1.18M | 0.48% | +55,000 | New |
| Millennium Management LLC | 108,486 | $2.33M | 0.00% | +70,673+186.9% | Added |
| Great Point Partners LLC | 125,000 | $2.69M | 0.46% | +125,000 | New |
| Logos Global Management LP | 150,000 | $3.23M | 0.36% | −60,000−28.6% | Reduced |
| Suvretta Capital Management, LLC | 162,395 | $3.49M | 0.16% | 00.0% | Unchanged |
| Boxer Capital, LLC | 250,000 | $5.38M | 0.27% | +250,000 | New |
| Fairmount Funds Management LLC | 378,421 | $8.14M | 0.86% | 00.0% | Unchanged |
| StemPoint Capital LP | 378,766 | $8.15M | 2.20% | +378,766 | New |
| Polar Capital Holdings Plc | 500,000 | $10.8M | 0.07% | +200,000+66.7% | Added |
| Global Endowment Management, LP | 513,436 | $11.0M | 1.23% | +513,436 | New |
| Braidwell LP | 515,000 | $11.1M | 0.41% | +515,000 | New |
| Affinity Asset Advisors, LLC | 517,554 | $11.1M | 2.22% | +275,257+113.6% | Added |
| Citadel Advisors LLC | 576,711 | $12.4M | 0.01% | +479,658+494.2% | Added |
| University of Notre Dame du Lac | 577,616 | $12.4M | 12.73% | +577,616 | New |
| HighVista Strategies LLC | 577,616 | $12.4M | 4.51% | +577,616 | New |
| Wellington Management Group LLP | 635,455 | $13.7M | 0.00% | +335,526+111.9% | Added |
| BVF Inc | 687,080 | $14.8M | 0.37% | +687,080 | New |
| Franklin Resources Inc | 687,090 | $14.8M | 0.01% | +687,090 | New |
| Driehaus Capital Management LLC | 771,902 | $16.6M | 0.20% | −28,951−3.6% | Reduced |
| EcoR1 Capital, LLC | 887,076 | $19.1M | 0.50% | +687,080+343.5% | Added |
| Cormorant Asset Management, LP | 937,080 | $20.2M | 0.97% | +937,080 | New |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $21.5M | 0.04% | +1,000,000 | New |
| Avoro Capital Advisors LLC | 1,839,138 | $39.6M | 0.55% | +1,827,680+15,951.1% | Added |
| Commodore Capital LP | 1,884,084 | $40.5M | 3.54% | +1,767,760+1,519.7% | Added |
| Deep Track Capital, LP | 1,952,760 | $42.0M | 1.47% | +1,952,760 | New |
| RTW Investments, LP | 2,232,760 | $48.0M | 0.75% | +2,232,760 | New |
| VR Adviser, LLC | 2,372,714 | $51.1M | 3.50% | +2,077,680+704.2% | Added |
| Perceptive Advisors LLC | 2,606,679 | $56.1M | 1.25% | +2,525,563+3,113.5% | Added |
| FMR LLC | 3,785,877 | $79.7M | 0.01% | +3,785,877 | New |
| Rock Springs Capital Management LP | 0 | $0 | 0.00% | −136,556−100.0% | Sold out |
| Aisling Capital Management LP | 0 | $0 | 0.00% | −67,645−100.0% | Sold out |
| Fan Yu | 0 | $0 | 0.00% | −20,592−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −437−100.0% | Sold out |