Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 322
- +10 vs. Q4 2025
- Shares held
- 78.9M
- +13.3M (+20.3%) vs. Q4 2025
- Total value
- $8.31B
- +$2.61B (+45.7%) vs. Q4 2025
- New holders
- 60
- 111 more added
- Sold out
- 50
- 104 more reduced
7 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| PSP Research LLC | 3,000 | $316.2K | 0.22% | −3,121−51.0% | Reduced |
| Swiss Life Asset Management Ltd | 3,104 | $327.2K | 0.00% | +673+27.7% | Added |
| Pinnacle Wealth Planning Services, Inc. | 3,132 | $330.1K | 0.03% | +268+9.4% | Added |
| Burney Co | 3,179 | $335.1K | 0.01% | −501−13.6% | Reduced |
| Gabelli Funds LLC | 3,229 | $340.3K | 0.00% | +3,229 | New |
| Mirae Asset Global Investments Co., Ltd. | 3,328 | $350.8K | 0.00% | +290+9.5% | Added |
| Crossmark Global Holdings, Inc. | 3,489 | $367.7K | 0.01% | −471−11.9% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 3,657 | $379.5K | 0.00% | +103+2.9% | Added |
| Jane Street Group, LLC | 3,607 | $380.2K | 0.00% | −30,700−89.5% | Reduced |
| Velan Capital Investment Management LP | 3,700 | $390.0K | 0.24% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 3,760 | $396.3K | 0.00% | −105,855−96.6% | Reduced |
| Vestcor Inc | 3,765 | $397.0K | 0.01% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 3,802 | $400.7K | 0.00% | +22+0.6% | Added |
| M&T Bank Corp | 3,858 | $406.8K | 0.00% | +105+2.8% | Added |
| US Bancorp | 3,914 | $412.5K | 0.00% | −481−10.9% | Reduced |
| The PNC Financial Services Group, Inc. | 3,998 | $421.4K | 0.00% | +1,039+35.1% | Added |
| Seven Fleet Capital Management LP | 4,000 | $421.6K | 0.13% | −4,000−50.0% | Reduced |
| King Wealth | 4,000 | $422.0K | 0.05% | 00.0% | Unchanged |
| Abacus Wealth Partners, LLC | 4,094 | $431.5K | 0.04% | +331+8.8% | Added |
| Amundi | 4,113 | $433.5K | 0.00% | +4,113 | New |
| Abel Hall, LLC | 4,258 | $448.8K | 0.10% | +4,258 | New |
| Keybank National Association | 4,286 | $451.7K | 0.00% | +4,286 | New |
| Vident Advisory, LLC | 4,481 | $472.3K | 0.00% | +290+6.9% | Added |
| Ensign Peak Advisors, Inc | 4,486 | $472.8K | 0.00% | 00.0% | Unchanged |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 4,600 | $484.8K | 0.11% | −5,400−54.0% | Reduced |
| Cynosure Management, LLC | 4,635 | $488.5K | 0.06% | +4,635 | New |
| Advisors Asset Management, Inc. | 4,644 | $489.5K | 0.01% | −60−1.3% | Reduced |
| Ameritas Investment Partners, Inc. | 4,725 | $498.0K | 0.02% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 4,727 | $498.2K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 4,828 | $508.9K | 0.00% | +1,536+46.7% | Added |
| Pacer Advisors, Inc. | 4,916 | $518.0K | 0.00% | +4,916 | New |
| Skopos Labs, Inc. | 4,925 | $519.1K | 0.02% | +594+13.7% | Added |
| Tower Research Capital LLC (TRC) | 4,961 | $522.9K | 0.01% | +2,914+142.4% | Added |
| CWM Advisors, LLC | 5,036 | $530.8K | 0.03% | −424−7.8% | Reduced |
| Kestra Advisory Services, LLC | 5,054 | $532.7K | 0.00% | −88−1.7% | Reduced |
| Bridgewater Associates, LP | 5,276 | $556.1K | 0.00% | +5,276 | New |
| HighTower Advisors, LLC | 5,386 | $567.7K | 0.00% | −1,741−24.4% | Reduced |
| Xponance, Inc. | 5,472 | $576.7K | 0.00% | +884+19.3% | Added |
| JustInvest LLC | 5,672 | $597.8K | 0.01% | +2,099+58.7% | Added |
| Cerity Partners LLC | 5,693 | $600.0K | 0.00% | −3,356−37.1% | Reduced |
| Bank of Montreal | 5,757 | $606.8K | 0.00% | +1,949+51.2% | Added |
| Public Employees Retirement Association of Colorado | 6,001 | $633.0K | 0.00% | 00.0% | Unchanged |
| E Fund Management Co., Ltd. | 6,033 | $635.9K | 0.02% | +6,033 | New |
| Palumbo Wealth Management LLC | 6,083 | $641.1K | 0.16% | −257−4.1% | Reduced |
| Brinker Capital Investments, LLC | 6,407 | $675.3K | 0.01% | +2,011+45.7% | Added |
| Quantinno Capital Management LP | 6,437 | $678.5K | 0.00% | +1,489+30.1% | Added |
| Teacher Retirement System of Texas | 6,448 | $679.6K | 0.00% | −902−12.3% | Reduced |
| Mutual of America Capital Management LLC | 6,725 | $708.8K | 0.01% | +9+0.1% | Added |
| Cambria Investment Management, L.P. | 6,865 | $723.6K | 0.04% | −95−1.4% | Reduced |
| Maryland State Retirement & Pension System | 8,567 | $903.0K | 0.02% | −36−0.4% | Reduced |
| AlphaCentric Advisors LLC | 9,040 | $952.8K | 0.95% | +491+5.7% | Added |
| Glenmede Trust Co NA | 9,235 | $973.4K | 0.00% | −3,520−27.6% | Reduced |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 9,334 | $983.8K | 1.43% | +9,334 | New |
| Allianz Asset Management GmbH | 9,600 | $1.01M | 0.00% | −3,400−26.2% | Reduced |
| J. Goldman & Co LP | 9,714 | $1.02M | 0.05% | −36,611−79.0% | Reduced |
| Weiss Asset Management LP | 9,780 | $1.03M | 0.02% | +9,780 | New |
| Cache Advisors, LLC | 10,143 | $1.07M | 0.12% | 00.0% | Unchanged |
| Nomura Holdings Inc | 10,479 | $1.10M | 0.01% | −7,042−40.2% | Reduced |
| Hussman Strategic Advisors, Inc. | 10,500 | $1.11M | 0.24% | −2,100−16.7% | Reduced |
| KLP Kapitalforvaltning AS | 11,000 | $1.16M | 0.00% | +400+3.8% | Added |
| Toroso Investments, LLC | 11,034 | $1.16M | 0.00% | +11,034 | New |
| Franklin Street Advisors Inc | 11,085 | $1.17M | 0.07% | −215−1.9% | Reduced |
| AQR Capital Management LLC | 11,874 | $1.25M | 0.00% | +4,920+70.8% | Added |
| ProShare Advisors LLC | 11,918 | $1.26M | 0.00% | −2,166−15.4% | Reduced |
| Vanguard Investments Australia, Ltd. | 12,130 | $1.28M | 0.00% | +12,130 | New |
| Winton Group Ltd | 12,673 | $1.34M | 0.05% | +1,202+10.5% | Added |
| Erste Asset Management GmbH | 13,500 | $1.35M | 0.01% | 00.0% | Unchanged |
| Bleakley Financial Group, LLC | 12,802 | $1.35M | 0.02% | +12,802 | New |
| Virginia Retirement Systems Et Al | 13,000 | $1.37M | 0.01% | −12,400−48.8% | Reduced |
| Intech Investment Management LLC | 13,006 | $1.37M | 0.01% | −9,479−42.2% | Reduced |
| Fifth Third Bancorp | 13,202 | $1.39M | 0.00% | +12,875+3,937.3% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,412 | $1.41M | 0.00% | +3,339+33.1% | Added |
| Oregon Public Employees Retirement Fund | 13,456 | $1.42M | 0.02% | +63+0.5% | Added |
| Arizona State Retirement System | 13,738 | $1.45M | 0.01% | −287−2.0% | Reduced |
| Royce & Associates LP | 14,349 | $1.51M | 0.01% | −2,640−15.5% | Reduced |
| Barclays PLC | 14,405 | $1.52M | 0.00% | −173,237−92.3% | Reduced |
| Bellevue Group AG | 14,447 | $1.52M | 0.04% | −2,096−12.7% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 14,532 | $1.53M | 0.01% | −16−0.1% | Reduced |
| China Universal Asset Management Co., Ltd. | 14,923 | $1.57M | 0.12% | +1,136+8.2% | Added |
| Bamco Inc | 15,000 | $1.58M | 0.00% | +6,700+80.7% | Added |
| Guggenheim Capital LLC | 15,280 | $1.61M | 0.01% | −15,816−50.9% | Reduced |
| STRS Ohio | 15,400 | $1.62M | 0.01% | −500−3.1% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 15,834 | $1.67M | 0.01% | 00.0% | Unchanged |
| Yousif Capital Management, LLC | 16,232 | $1.71M | 0.02% | −49−0.3% | Reduced |
| State Board of Administration of Florida Retirement System | 16,303 | $1.72M | 0.00% | 00.0% | Unchanged |
| Envestnet Asset Management Inc | 16,317 | $1.72M | 0.00% | +1,644+11.2% | Added |
| Amalgamated Bank | 16,852 | $1.78M | 0.01% | −211−1.2% | Reduced |
| State of New Jersey Common Pension Fund D | 17,092 | $1.80M | 0.01% | +105+0.6% | Added |
| SG Americas Securities, LLC | 18,097 | $1.91M | 0.00% | −1,900−9.5% | Reduced |
| New York State Common Retirement Fund | 18,382 | $1.94M | 0.00% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 19,900 | $2.10M | 0.01% | 00.0% | Unchanged |
| Gotham Asset Management, LLC | 21,155 | $2.23M | 0.01% | −440−2.0% | Reduced |
| Natixis Advisors, L.P. | 22,638 | $2.39M | 0.00% | +2,143+10.5% | Added |
| Profund Advisors LLC | 22,867 | $2.41M | 0.09% | −2,707−10.6% | Reduced |
| Artia Global Partners LP | 22,931 | $2.42M | 0.54% | −20−0.1% | Reduced |
| State of Tennessee, Treasury Department | 23,297 | $2.46M | 0.01% | −229−1.0% | Reduced |
| Calamos Advisors LLC | 23,473 | $2.47M | 0.01% | +23,473 | New |
| Exchange Traded Concepts, LLC | 23,773 | $2.51M | 0.02% | −11,266−32.2% | Reduced |
| Polen Capital Management LLC | 24,337 | $2.57M | 0.02% | +3,988+19.6% | Added |
| Vanguard Global Advisers, LLC | 24,665 | $2.60M | 0.00% | +24,665 | New |