Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Verition Fund Management LLC | 26,792 | $2.34M | 0.01% | +26,792 | New |
| Louisiana State Employees Retirement System | 26,900 | $2.35M | 0.04% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 30,789 | $2.69M | 0.00% | −82−0.3% | Reduced |
| Guggenheim Capital LLC | 31,096 | $2.72M | 0.02% | +12,513+67.3% | Added |
| Illinois Municipal Retirement Fund | 31,244 | $2.73M | 0.03% | −1,939−5.8% | Reduced |
| MetLife Investment Management | 32,440 | $2.83M | 0.01% | −1,406−4.2% | Reduced |
| Deeter Investments LLP | 300,000 | $2.87M | 0.62% | +300,000 | New |
| Jane Street Group, LLC | 34,307 | $3.00M | 0.00% | −10,032−22.6% | Reduced |
| State of Wisconsin Investment Board | 34,786 | $3.04M | 0.01% | −6,120−15.0% | Reduced |
| Exchange Traded Concepts, LLC | 35,039 | $3.06M | 0.03% | +1,487+4.4% | Added |
| Aquatic Capital Management LLC | 36,615 | $3.20M | 0.09% | +36,615 | New |
| SEI Investments Co | 37,346 | $3.26M | 0.00% | −6,665−15.1% | Reduced |
| Elmind Capital, LP | 38,000 | $3.32M | 0.98% | +38,000 | New |
| State of Alaska, Department of Revenue | 38,099 | $3.33M | 0.04% | +8,674+29.5% | Added |
| LMR Partners LLP | 40,000 | $3.49M | 0.03% | +40,000 | New |
| Thrivent Financial for Lutherans | 40,380 | $3.53M | 0.01% | −1,808−4.3% | Reduced |
| Creative Planning | 41,254 | $3.60M | 0.00% | +5,040+13.9% | Added |
| SummitTX Capital, L.P. | 42,266 | $3.69M | 0.11% | +10,776+34.2% | Added |
| J. Goldman & Co LP | 46,325 | $4.05M | 0.16% | +28,257+156.4% | Added |
| First Trust Advisors LP | 46,454 | $4.06M | 0.00% | −16,270−25.9% | Reduced |
| California State Teachers Retirement System | 48,033 | $4.20M | 0.00% | +596+1.3% | Added |
| Northwestern Mutual Wealth Management Co | 48,894 | $4.27M | 0.00% | −10,000−17.0% | Reduced |
| New York State Teachers Retirement System | 49,350 | $4.31M | 0.01% | −200−0.4% | Reduced |
| Great West Life Assurance Co | 49,640 | $4.33M | 0.01% | +1,233+2.5% | Added |
| Pentwater Capital Management LP | 50,000 | $4.37M | 0.03% | +50,000 | New |
| Eversept Partners, LP | 52,961 | $4.63M | 0.26% | +52,961 | New |
| KVP Capital Advisors, LP | 53,000 | $4.63M | 4.78% | +53,000 | New |
| Silvercrest Asset Management Group LLC | 53,217 | $4.65M | 0.03% | 00.0% | Unchanged |
| Bessemer Group Inc | 54,162 | $4.73M | 0.01% | +49,887+1,166.9% | Added |
| Birchview Capital, LP | 55,000 | $4.80M | 2.81% | +7,000+14.6% | Added |
| Quinn Opportunity Partners LLC | 55,259 | $4.83M | 0.21% | +55,259 | New |
| Eagle Health Investments LP | 57,300 | $5.00M | 1.10% | +57,300 | New |
| StemPoint Capital LP | 59,430 | $5.19M | 0.89% | +11,476+23.9% | Added |
| Rafferty Asset Management, LLC | 63,661 | $5.56M | 0.02% | −11,166−14.9% | Reduced |
| Fisher Asset Management, LLC | 65,114 | $5.69M | 0.00% | +65,114 | New |
| Wells Fargo & Company | 71,645 | $6.26M | 0.00% | +23,851+49.9% | Added |
| EFG International AG | 72,623 | $6.34M | 0.12% | +72,623 | New |
| Knott David M Jr | 73,000 | $6.38M | 2.95% | −10,000−12.0% | Reduced |
| Alliancebernstein L.P. | 73,222 | $6.40M | 0.00% | −187,632−71.9% | Reduced |
| HighVista Strategies LLC | 73,545 | $6.42M | 1.65% | −48,137−39.6% | Reduced |
| Great Lakes Advisors, LLC | 73,966 | $6.46M | 0.05% | −15,205−17.1% | Reduced |
| Franklin Resources Inc | 76,442 | $6.68M | 0.00% | −6,476−7.8% | Reduced |
| EAM Investors, LLC | 78,498 | $6.86M | 0.76% | −1,569−2.0% | Reduced |
| Victory Capital Management Inc | 80,571 | $7.04M | 0.00% | −4,923−5.8% | Reduced |
| Moody Aldrich Partners LLC | 80,623 | $7.04M | 1.31% | −62,437−43.6% | Reduced |
| Atika Capital Management LLC | 86,000 | $7.51M | 1.05% | +3,000+3.6% | Added |
| Axiom Investors LLC | 89,468 | $7.81M | 0.07% | +9,355+11.7% | Added |
| Citigroup Inc | 94,909 | $8.29M | 0.01% | −57,671−37.8% | Reduced |
| BNP Paribas Arbitrage, SA | 97,764 | $8.54M | 0.01% | +84,627+644.2% | Added |
| Swiss National Bank | 98,200 | $8.58M | 0.01% | +2,100+2.2% | Added |
| Neuberger Berman Group LLC | 98,473 | $8.60M | 0.01% | −24,904−20.2% | Reduced |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 100,000 | $8.73M | 0.12% | +100,000 | New |
| UBS Asset Management Americas Inc | 104,528 | $9.13M | 0.00% | −5,701−5.2% | Reduced |
| Opaleye Management Inc. | 105,000 | $9.17M | 1.21% | 00.0% | Unchanged |
| Deutsche Bank AG | 105,460 | $9.21M | 0.00% | −11,752−10.0% | Reduced |
| Hudson Bay Capital Management LP | 109,615 | $9.57M | 0.05% | +109,615 | New |
| Prudential Financial Inc | 110,360 | $9.64M | 0.01% | −16,043−12.7% | Reduced |
| Manufacturers Life Insurance Company, The | 113,340 | $9.89M | 0.01% | −21,756−16.1% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 114,036 | $9.96M | 0.02% | +23,719+26.3% | Added |
| Panagora Asset Management Inc | 125,384 | $11.0M | 0.04% | −23,345−15.7% | Reduced |
| Nuveen, LLC | 125,861 | $11.0M | 0.00% | −2,523−2.0% | Reduced |
| Segall Bryant & Hamill, LLC | 129,060 | $11.3M | 0.15% | +5,935+4.8% | Added |
| Legal & General Group Plc | 149,164 | $13.0M | 0.00% | −6,665−4.3% | Reduced |
| Qube Research & Technologies Ltd | 153,876 | $13.4M | 0.02% | +153,876 | New |
| Rhumbline Advisers | 154,950 | $13.5M | 0.01% | −9,030−5.5% | Reduced |
| JPMorgan Chase & Co | 155,300 | $13.6M | 0.00% | −97,100−38.5% | Reduced |
| TD Asset Management Inc | 158,730 | $13.9M | 0.01% | +8,302+5.5% | Added |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 159,700 | $13.9M | 0.33% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 169,518 | $14.8M | 0.00% | +16,327+10.7% | Added |
| Boxer Capital Management, LLC | 170,000 | $14.8M | 3.25% | +60,000+54.5% | Added |
| Affinity Asset Advisors, LLC | 172,125 | $15.0M | 1.08% | −48,475−22.0% | Reduced |
| Nan Fung Trinity (HK) Ltd | 180,670 | $15.8M | 1.25% | +35,778+24.7% | Added |
| Raymond James Financial Inc | 181,503 | $15.8M | 0.00% | −112,793−38.3% | Reduced |
| Barclays PLC | 187,642 | $16.4M | 0.01% | +16,236+9.5% | Added |
| AIHC Capital Management Ltd | 189,823 | $16.6M | 15.54% | +189,823 | New |
| MPM Oncology Impact Management LP | 199,471 | $17.4M | 1.99% | +199,471 | New |
| Alyeska Investment Group, L.P. | 199,523 | $17.4M | 0.05% | +199,523 | New |
| Public Sector Pension Investment Board | 203,426 | $17.8M | 0.06% | −24,720−10.8% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 205,574 | $18.0M | 0.07% | +126,778+160.9% | Added |
| Holocene Advisors, LP | 210,019 | $18.3M | 0.04% | +210,019 | New |
| Kennedy Capital Management, Inc. | 221,444 | $19.3M | 0.41% | +13,007+6.2% | Added |
| NEXTBio Capital Management LP | 229,619 | $20.1M | 11.76% | +229,619 | New |
| Adage Capital Partners GP, L.L.C. | 232,836 | $20.3M | 0.03% | −485,366−67.6% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 330,804 | $28.9M | 0.03% | −120,962−26.8% | Reduced |
| Jennison Associates LLC | 331,164 | $28.9M | 0.02% | +331,164 | New |
| Principal Financial Group Inc | 347,932 | $30.4M | 0.02% | +21,844+6.7% | Added |
| Bank of New York Mellon Corp | 350,388 | $30.6M | 0.01% | −12,873−3.5% | Reduced |
| Voya Investment Management LLC | 366,165 | $32.0M | 0.03% | +60,746+19.9% | Added |
| 683 Capital Management, LLC | 380,669 | $33.2M | 2.76% | −26,831−6.6% | Reduced |
| Dimensional Fund Advisors LP | 414,415 | $36.2M | 0.01% | −24,100−5.5% | Reduced |
| Commodore Capital LP | 450,000 | $39.3M | 2.62% | −575,000−56.1% | Reduced |
| Clearbridge Investments, LLC | 489,842 | $42.8M | 0.03% | +489,842 | New |
| Pictet Asset Management Holding SA | 529,631 | $46.3M | 0.04% | −292,581−35.6% | Reduced |
| American Century Companies Inc | 535,423 | $46.8M | 0.02% | −64,624−10.8% | Reduced |
| FMR LLC | 539,878 | $47.2M | 0.00% | +19,214+3.7% | Added |
| Charles Schwab Investment Management Inc | 556,762 | $48.6M | 0.01% | +3,885+0.7% | Added |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 571,825 | $49.9M | 4.43% | +571,825 | New |
| Northern Trust Corp | 575,118 | $50.2M | 0.01% | −28,104−4.7% | Reduced |
| Bank of America Corp | 867,580 | $75.8M | 0.01% | +37,703+4.5% | Added |
| Morgan Stanley | 879,024 | $76.8M | 0.00% | +110,665+14.4% | Added |