Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Nisa Investment Advisors, LLC | 3,780 | $330.1K | 0.00% | −205−5.1% | Reduced |
| Bank of Montreal | 3,808 | $332.3K | 0.00% | −56−1.4% | Reduced |
| CIBC World Markets Corp | 3,851 | $336.3K | 0.00% | +3,851 | New |
| Crossmark Global Holdings, Inc. | 3,960 | $345.9K | 0.00% | −6−0.2% | Reduced |
| Allspring Global Investments Holdings, LLC | 3,985 | $347.4K | 0.00% | +3,985 | New |
| King Wealth | 4,000 | $349.0K | 0.04% | −2,000−33.3% | Reduced |
| New Vernon Capital Holdings II LLC | 4,137 | $361.3K | 0.17% | −3,061−42.5% | Reduced |
| Vident Advisory, LLC | 4,191 | $366.0K | 0.00% | −879−17.3% | Reduced |
| Advisor Group Holdings, Inc. | 4,201 | $366.9K | 0.00% | +2,810+202.0% | Added |
| Los Angeles Capital Management LLC | 4,727 | $368.0K | 0.00% | +4,727 | New |
| Skopos Labs, Inc. | 4,331 | $380.8K | 0.02% | +4,331 | New |
| O'Shaughnessy Asset Management, LLC | 4,369 | $381.6K | 0.00% | +4,369 | New |
| US Bancorp | 4,395 | $383.9K | 0.00% | −1,457−24.9% | Reduced |
| Brinker Capital Investments, LLC | 4,396 | $383.9K | 0.00% | −2,532−36.5% | Reduced |
| Ensign Peak Advisors, Inc | 4,486 | $391.8K | 0.00% | −6,500−59.2% | Reduced |
| Xponance, Inc. | 4,588 | $400.7K | 0.00% | +54+1.2% | Added |
| Cornerstone Investment Partners, LLC | 4,634 | $404.7K | 0.02% | +20.0% | Added |
| Advisors Asset Management, Inc. | 4,704 | $410.8K | 0.01% | −20.0% | Reduced |
| Ameritas Investment Partners, Inc. | 4,725 | $412.7K | 0.01% | −138−2.8% | Reduced |
| Quantinno Capital Management LP | 4,948 | $432.2K | 0.00% | +901+22.3% | Added |
| Jefferies Financial Group Inc. | 5,000 | $436.7K | 0.00% | −816,503−99.4% | Reduced |
| Taconic Capital Advisors LP | 5,000 | $436.7K | 0.16% | +5,000 | New |
| Arrowstreet Capital, Limited Partnership | 5,076 | $443.3K | 0.00% | +5,076 | New |
| Algert Global LLC | 5,090 | $444.6K | 0.01% | +5,090 | New |
| Kestra Advisory Services, LLC | 5,142 | $449.1K | 0.00% | −81−1.6% | Reduced |
| CWM Advisors, LLC | 5,460 | $476.9K | 0.04% | −1,478−21.3% | Reduced |
| DekaBank Deutsche Girozentrale | 15,800 | $489.0K | 0.00% | 00.0% | Unchanged |
| Aviva PLC | 5,609 | $489.9K | 0.00% | −2,183−28.0% | Reduced |
| Russell Investments Group, Ltd. | 5,723 | $499.8K | 0.00% | −201−3.4% | Reduced |
| Fieldview Capital Management, LLC | 5,841 | $510.2K | 0.09% | +5,841 | New |
| CAPROCK Group, Inc. | 5,991 | $523.3K | 0.01% | +189+3.3% | Added |
| Public Employees Retirement Association of Colorado | 6,001 | $524.0K | 0.00% | 00.0% | Unchanged |
| PSP Research LLC | 6,121 | $534.6K | 0.47% | +6,121 | New |
| Palumbo Wealth Management LLC | 6,340 | $553.7K | 0.14% | +1,072+20.3% | Added |
| Fox Run Management, L.L.C. | 6,654 | $581.2K | 0.09% | +3,551+114.4% | Added |
| Mutual of America Capital Management LLC | 6,716 | $586.6K | 0.01% | +165+2.5% | Added |
| AQR Capital Management LLC | 6,954 | $607.4K | 0.00% | −1,616−18.9% | Reduced |
| Cambria Investment Management, L.P. | 6,960 | $607.9K | 0.04% | −3,984−36.4% | Reduced |
| HighTower Advisors, LLC | 7,127 | $622.5K | 0.00% | −1,486−17.3% | Reduced |
| Teacher Retirement System of Texas | 7,350 | $641.9K | 0.00% | −4,756−39.3% | Reduced |
| Horizon Investments, LLC | 7,461 | $651.6K | 0.01% | +7,461 | New |
| Mariner, LLC | 7,620 | $665.6K | 0.00% | −5,931−43.8% | Reduced |
| Tudor Investment Corp Et Al | 7,718 | $674.1K | 0.00% | +7,718 | New |
| Persistent Asset Partners Ltd | 7,908 | $690.7K | 0.33% | −3,872−32.9% | Reduced |
| Seven Fleet Capital Management LP | 8,000 | $698.7K | 0.47% | +8,000 | New |
| Renaissance Technologies LLC | 8,167 | $713.3K | 0.00% | +8,167 | New |
| Bamco Inc | 8,300 | $724.9K | 0.00% | +8,300 | New |
| AlphaCentric Advisors LLC | 8,549 | $746.7K | 0.74% | +8,549 | New |
| Maryland State Retirement & Pension System | 8,603 | $751.4K | 0.02% | +196+2.3% | Added |
| FORA Capital, LLC | 9,130 | $788.4K | 0.10% | +5,445+147.8% | Added |
| Cerity Partners LLC | 9,049 | $790.3K | 0.00% | +431+5.0% | Added |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 10,000 | $873.4K | 0.19% | +10,000 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,073 | $879.8K | 0.00% | 00.0% | Unchanged |
| Cache Advisors, LLC | 10,143 | $885.9K | 0.11% | 00.0% | Unchanged |
| KLP Kapitalforvaltning AS | 10,600 | $925.8K | 0.00% | +200+1.9% | Added |
| Franklin Street Advisors Inc | 11,300 | $986.9K | 0.06% | 00.0% | Unchanged |
| Winton Group Ltd | 11,471 | $1.00M | 0.03% | −7,090−38.2% | Reduced |
| Susquehanna International Group, LLP | 11,762 | $1.03M | 0.00% | −51,426−81.4% | Reduced |
| Hussman Strategic Advisors, Inc. | 12,600 | $1.10M | 0.27% | −8,400−40.0% | Reduced |
| Glenmede Trust Co NA | 12,755 | $1.11M | 0.01% | +12,755 | New |
| Jain Global LLC | 12,850 | $1.12M | 0.01% | −2,000−13.5% | Reduced |
| Allianz Asset Management GmbH | 13,000 | $1.14M | 0.00% | −6,678−33.9% | Reduced |
| Comerica Bank | 13,005 | $1.14M | 0.00% | −3,390−20.7% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 13,270 | $1.16M | 0.00% | +13,270 | New |
| Oregon Public Employees Retirement Fund | 13,393 | $1.17M | 0.01% | +193+1.5% | Added |
| Erste Asset Management GmbH | 13,500 | $1.19M | 0.01% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 13,787 | $1.20M | 0.09% | −2,118−13.3% | Reduced |
| Arizona State Retirement System | 14,025 | $1.22M | 0.01% | −644−4.4% | Reduced |
| ProShare Advisors LLC | 14,084 | $1.23M | 0.00% | +897+6.8% | Added |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 14,548 | $1.27M | 0.01% | −345−2.3% | Reduced |
| Envestnet Asset Management Inc | 14,673 | $1.28M | 0.00% | −9,585−39.5% | Reduced |
| Yousif Capital Management, LLC | 16,281 | $1.36M | 0.01% | −2,145−11.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 15,834 | $1.38M | 0.01% | −285−1.8% | Reduced |
| STRS Ohio | 15,900 | $1.39M | 0.01% | −1,900−10.7% | Reduced |
| State Board of Administration of Florida Retirement System | 16,303 | $1.42M | 0.00% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 16,441 | $1.44M | 0.01% | +3,079+23.0% | Added |
| Bellevue Group AG | 16,543 | $1.44M | 0.03% | −4,038−19.6% | Reduced |
| State of New Jersey Common Pension Fund D | 16,987 | $1.48M | 0.01% | −20,969−55.2% | Reduced |
| Royce & Associates LP | 16,989 | $1.48M | 0.02% | 00.0% | Unchanged |
| Amalgamated Bank | 17,063 | $1.49M | 0.01% | +237+1.4% | Added |
| Headlands Technologies LLC | 17,079 | $1.49M | 0.12% | +17,079 | New |
| Millennium Management LLC | 17,391 | $1.52M | 0.00% | −110,169−86.4% | Reduced |
| Nomura Holdings Inc | 17,521 | $1.53M | 0.00% | +17,521 | New |
| New York State Common Retirement Fund | 18,382 | $1.61M | 0.00% | −1,200−6.1% | Reduced |
| Handelsbanken Fonder AB | 19,900 | $1.74M | 0.01% | +1,000+5.3% | Added |
| SG Americas Securities, LLC | 19,997 | $1.75M | 0.00% | −21,249−51.5% | Reduced |
| Polen Capital Management LLC | 20,349 | $1.78M | 0.01% | +24+0.1% | Added |
| Natixis Advisors, L.P. | 20,495 | $1.79M | 0.00% | +3,640+21.6% | Added |
| Campbell & CO Investment Adviser LLC | 21,054 | $1.84M | 0.09% | +21,054 | New |
| Gotham Asset Management, LLC | 21,595 | $1.89M | 0.01% | −603−2.7% | Reduced |
| OrbiMed Advisors LLC | 21,700 | $1.90M | 0.04% | +21,700 | New |
| State of Tennessee, Treasury Department | 23,526 | $1.92M | 0.01% | −2,964−11.2% | Reduced |
| Intech Investment Management LLC | 22,485 | $1.96M | 0.02% | +842+3.9% | Added |
| Diadema Partners LP | 22,700 | $1.98M | 1.18% | −28,485−55.7% | Reduced |
| Artia Global Partners LP | 22,951 | $2.00M | 0.32% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 25,400 | $2.22M | 0.01% | +9,800+62.8% | Added |
| Profund Advisors LLC | 25,574 | $2.23M | 0.07% | +7,417+40.8% | Added |
| Parkman Healthcare Partners LLC | 25,973 | $2.27M | 0.22% | −35,876−58.0% | Reduced |
| Keystone Investors Pte Ltd | 26,390 | $2.30M | 0.21% | +26,390 | New |
| Teachers Retirement System of the State of Kentucky | 26,528 | $2.32M | 0.02% | +9,232+53.4% | Added |